{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:05:20Z","timestamp":1770753920238,"version":"3.50.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673201"],"award-info":[{"award-number":["81673201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Plan Project in Shenzhen","award":["JCYJ20160428143108182"],"award-info":[{"award-number":["JCYJ20160428143108182"]}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201511007"],"award-info":[{"award-number":["SZSM201511007"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context and Objective<\/jats:title>\n                  <jats:p>This case control study was designed to investigate the association between mutation of 10 single nucleotide polymorphism (SNP) loci (rs1132506, rs5780218, rs192636495, rs4889, rs184749, rs12985070, rs708910, rs932491, rs8074995, and rs2306877) in all 5 genes (KISS1, GPR54, PLCB1, PRKCA, and ITPR1) in the kisspeptin\/GPR54 pathway and the risk of early puberty in Chinese Han girls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Participants<\/jats:title>\n                  <jats:p>A total of 314 pairs of early puberty girls on their first visit to hospital and age-matched controls (\u00b1 3 months) were recruited. The genotypes of each SNP were determined and the effect of loci variation on early puberty was investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>rs5780218 was significantly associated with early puberty in additive, dominant, and recessive models of inheritance after adjusting for confounding factors (Pr &amp;lt; .05). After stratification, rs5780218 variation (odds ratio [OR], 1.650, 95% confidence interval [CI], 1.155-2.355 in additive models and OR, 2.116; 95% CI, 1.187-3.770 in recessive models) increased the risk of central precocious puberty (CPP); mutation in rs708910 (OR, 2.768; 95% CI, 1.305-5.872 in recessive model) had a positive association with the risk of CPP; and rs932491 variation was negatively associated with early and fast puberty (EFP) (OR, 0.309; 95% CI, 0.144-0.661 in additive models and OR, 0.317; 95% CI, 0.141-0.713 in dominant models).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study suggests that mutation in rs5780218 and rs708910 increases the risk of CPP. rs932491 variation may have a protective effect on the risk of EFP. Further studies in larger populations or with people from different regions are needed to verify our findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgz229","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T19:17:26Z","timestamp":1583954246000},"page":"e1458-e1467","source":"Crossref","is-referenced-by-count":20,"title":["Association of Polymorphisms in the Kisspeptin\/GPR54 Pathway Genes With Risk of Early Puberty in Chinese Girls"],"prefix":"10.1210","volume":"105","author":[{"given":"Di","family":"Li","sequence":"first","affiliation":[{"name":"Department of School Hygiene, Shenzhen Center for Disease Control and Prevention, Shenzhen, China"},{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety and the Ministry of Education (MOE) Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of School Hygiene, Shenzhen Center for Disease Control and Prevention, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinquan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of School Hygiene, Shenzhen Center for Disease Control and Prevention, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liegang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety and the Ministry of Education (MOE) Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of School Hygiene, Shenzhen Center for Disease Control and Prevention, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of School Hygiene, Shenzhen Center for Disease Control and Prevention, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suli","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Environment and Health, Shenzhen Center for Disease Control and Prevention, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Molecular Epidemiology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuebin","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Molecular Epidemiology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Testing and Chemical Analysis, Shenzhen Center for Disease Control and Prevention, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shenzhen Children\u2019s Hospital, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0718-6103","authenticated-orcid":false,"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of School Hygiene, Shenzhen Center for Disease Control and Prevention, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"issue":"3","key":"2021122210031518100_CIT0001","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S2213-8587(15)00380-0","article-title":"Causes, diagnosis, and treatment of central precocious puberty","volume":"4","author":"Latronico","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"2021122210031518100_CIT0002","doi-asserted-by":"crossref","first-page":"e269","DOI":"10.1542\/peds.2008-2638","article-title":"Onset of breast and pubic hair development and menses in urban Chinese girls.%a Ma Hm","volume":"124","author":"Du","year":"2009","journal-title":"Pediatrics"},{"issue":"8","key":"2021122210031518100_CIT0003","doi-asserted-by":"crossref","first-page":"e0134656","DOI":"10.1371\/journal.pone.0134656","article-title":"Association of obesity with onset of puberty and sex hormones in Chinese girls: a 4-year longitudinal study","volume":"10","author":"Zhai","year":"2015","journal-title":"Plos One."},{"issue":"22","key":"2021122210031518100_CIT0004","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1056\/NEJMcp0800459","article-title":"Clinical practice. Precocious puberty","volume":"358","author":"Carel","year":"2008","journal-title":"N Engl J Med."},{"issue":"12","key":"2021122210031518100_CIT0005","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1210\/jc.2009-1789","article-title":"Early age at menarche associated with cardiovascular disease and mortality","volume":"94","author":"Lakshman","year":"2009","journal-title":"J Clin Endocrinol Metab."},{"issue":"8","key":"2021122210031518100_CIT0006","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/ijo.2012.177","article-title":"Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis","volume":"37","author":"Prentice","year":"2013","journal-title":"Int J Obes (Lond)."},{"issue":"11","key":"2021122210031518100_CIT0007","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1002\/ijc.27913","article-title":"Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer: a cohort study","volume":"132","author":"Ritte","year":"2013","journal-title":"Int J Cancer."},{"issue":"8","key":"2021122210031518100_CIT0008","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1651-2227.1997.tb08602.x","article-title":"Longitudinal study of behavioral and affective patterns in girls with central precocious puberty during long-acting triptorelin therapy","volume":"86","author":"Xhrouet-Heinrichs","year":"1997","journal-title":"Acta Paediatr."},{"issue":"4","key":"2021122210031518100_CIT0009","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.beem.2018.05.008","article-title":"Central precocious puberty: from genetics to treatment","volume":"32","author":"Aguirre","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"issue":"1","key":"2021122210031518100_CIT0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1530\/EJE-07-0061","article-title":"Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls","volume":"157","author":"Luan","year":"2007","journal-title":"Eur J Endocrinol."},{"issue":"2","key":"2021122210031518100_CIT0011","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000107511","article-title":"GPR54 polymorphisms in Chinese girls with central precocious puberty","volume":"86","author":"Luan","year":"2007","journal-title":"Neuroendocrinology."},{"issue":"2","key":"2021122210031518100_CIT0012","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1590\/2359-3997000000144","article-title":"Central precocious puberty: revisiting the diagnosis and therapeutic management","volume":"60","author":"Brito","year":"2016","journal-title":"Arch Endocrinol Metab."},{"issue":"1","key":"2021122210031518100_CIT0013","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1530\/EJE-07-0061","article-title":"Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls","volume":"157","author":"Luan","year":"2007","journal-title":"Eur J Endocrinol."},{"issue":"5","key":"2021122210031518100_CIT0014","doi-asserted-by":"crossref","first-page":"e98018","DOI":"10.1371\/journal.pone.0098018","article-title":"PRKCA polymorphism changes the neural basis of episodic remembering in healthy individuals","volume":"9","author":"MacLeod","year":"2014","journal-title":"Plos One."},{"issue":"4","key":"2021122210031518100_CIT0015","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/pr.2016.107","article-title":"Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls","volume":"80","author":"Hu","year":"2016","journal-title":"Pediatr Res."},{"issue":"2","key":"2021122210031518100_CIT0016","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/bib\/3.2.146","article-title":"Genetic association studies: design, analysis and interpretation","volume":"3","author":"Lewis","year":"2002","journal-title":"Brief Bioinform."},{"key":"2021122210031518100_CIT0017","doi-asserted-by":"crossref","first-page":"24095","DOI":"10.1038\/srep24095","article-title":"SHEsisPlus, a toolset for genetic studies on polyploid species","volume":"6","author":"Shen","year":"2016","journal-title":"Sci Rep."},{"issue":"11","key":"2021122210031518100_CIT0018","doi-asserted-by":"crossref","first-page":"e0225421","DOI":"10.1371\/journal.pone.0225421","article-title":"Correction: interspecific phylogenic relationships within genus melilotus based on nuclear and chloroplast DNA","volume":"14","author":"Di","year":"2019","journal-title":"Plos One."},{"issue":"17","key":"2021122210031518100_CIT0019","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1056\/NEJMoa035322","article-title":"The GPR54 gene as a regulator of puberty","volume":"349","author":"Seminara","year":"2003","journal-title":"N Engl J Med."},{"issue":"3","key":"2021122210031518100_CIT0020","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1210\/jc.2004-1418","article-title":"Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism","volume":"90","author":"Semple","year":"2005","journal-title":"J Clin Endocrinol Metab."},{"key":"2021122210031518100_CIT0021","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-1-4614-6199-9_2","article-title":"Structure, synthesis, and phylogeny of kisspeptin and its receptor","volume":"784","author":"Kanda","year":"2013","journal-title":"Adv Exp Med Biol."},{"issue":"3","key":"2021122210031518100_CIT0022","doi-asserted-by":"crossref","first-page":"T101","DOI":"10.1530\/JME-13-0224","article-title":"Molecular evolution of GPCRs: kisspeptin\/kisspeptin receptors","volume":"52","author":"Pasquier","year":"2014","journal-title":"J Mol Endocrinol."},{"issue":"2","key":"2021122210031518100_CIT0023","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.beem.2018.01.005","article-title":"The kisspeptin receptor: a key G-protein-coupled receptor in the control of the reproductive axis","volume":"32","author":"Franssen","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"key":"2021122210031518100_CIT0024","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev.biochem.70.1.281","article-title":"Regulation of phosphoinositide-specific phospholipase C","volume":"70","author":"Rhee","year":"2001","journal-title":"Annu Rev Biochem."},{"issue":"5","key":"2021122210031518100_CIT0025","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1111\/j.1471-4159.2007.04825.x","article-title":"IP3 receptor\/Ca2+ channel: from discovery to new signaling concepts","volume":"102","author":"Mikoshiba","year":"2007","journal-title":"J Neurochem."},{"issue":"37","key":"2021122210031518100_CIT0026","doi-asserted-by":"crossref","first-page":"34631","DOI":"10.1074\/jbc.M104847200","article-title":"The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54","volume":"276","author":"Kotani","year":"2001","journal-title":"J Biol Chem."},{"issue":"11","key":"2021122210031518100_CIT0027","doi-asserted-by":"crossref","first-page":"E1237","DOI":"10.1152\/ajpendo.00058.2013","article-title":"Kisspeptin inhibits a slow afterhyperpolarization current via protein kinase C and reduces spike frequency adaptation in GnRH neurons","volume":"304","author":"Zhang","year":"2013","journal-title":"Am J Physiol Endocrinol Metab."},{"issue":"9","key":"2021122210031518100_CIT0028","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1210\/en.2008-0321","article-title":"Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C\/calcium-dependent pathway regulating multiple ion channels","volume":"149","author":"Liu","year":"2008","journal-title":"Endocrinology."},{"issue":"6","key":"2021122210031518100_CIT0029","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1080\/13543784.2017.1323869","article-title":"Investigational and experimental GnRH analogs and associated neurotransmitters","volume":"26","author":"Blumenfeld","year":"2017","journal-title":"Expert Opin Investig Drugs."},{"issue":"6","key":"2021122210031518100_CIT0030","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1073\/pnas.0409822102","article-title":"Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates","volume":"102","author":"Shahab","year":"2005","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"2","key":"2021122210031518100_CIT0031","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1210\/en.2005-1261","article-title":"Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges","volume":"147","author":"Plant","year":"2006","journal-title":"Endocrinology."},{"issue":"3","key":"2021122210031518100_CIT0032","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1515\/jpem-2015-0235","article-title":"The relation of urinary bisphenol A with kisspeptin in girls diagnosed with central precocious puberty and premature thelarche","volume":"29","author":"\u00d6zgen","year":"2016","journal-title":"J Pediatr Endocrinol Metab."},{"key":"2021122210031518100_CIT0033","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.3346\/jkms.2014.29.8.1120","article-title":"Kiss1 gene polymorphisms in korean girls with central precocious puberty","volume":"29","author":"Rhie","year":"2014","journal-title":"J Korean Med Sci."},{"issue":"8","key":"2021122210031518100_CIT0034","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1507\/endocrj.K10E-073","article-title":"KISS1 gene analysis in Korean girls with central precocious puberty: a polymorphism, p.P110T, suggested to exert a protective effect","volume":"57","author":"Ko","year":"2010","journal-title":"Endocr J."},{"issue":"1","key":"2021122210031518100_CIT0035","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3346\/jkms.2017.32.1.108","article-title":"Genetic variations of the KISS1R gene in Korean girls with central precocious puberty","volume":"32","author":"Oh","year":"2017","journal-title":"J Korean Med Sci."},{"issue":"2","key":"2021122210031518100_CIT0036","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ando.2018.09.007","article-title":"Association between KISS1 rs5780218 promoter polymorphism and onset of growth hormone secreting pituitary adenoma","volume":"80","author":"Amorim","year":"2019","journal-title":"Ann Endocrinol."},{"key":"2021122210031518100_CIT0037","first-page":"365845","article-title":"Polymorphisms rs12998 and rs5780218 in KiSS1 suppressor metastasis gene in Mexican patients with breast cancer","volume":"2015","author":"Quevedo","year":"2015","journal-title":"Dis Markers."},{"issue":"8","key":"2021122210031518100_CIT0038","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1210\/me.2004-0145","article-title":"Constitutively active Gq impairs gonadotropin-releasing hormone-induced intracellular signaling and luteinizing hormone secretion in LbetaT2 cells","volume":"19","author":"Liu","year":"2005","journal-title":"Mol Endocrinol."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/4\/e1458\/41860902\/jcem_105_4_e1458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/4\/e1458\/41860902\/jcem_105_4_e1458.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T18:09:52Z","timestamp":1640196592000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/105\/4\/e1458\/5803226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,11]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,3,11]]},"published-print":{"date-parts":[[2020,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgz229","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2020,3,11]]}}}