{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:26:43Z","timestamp":1784215603964,"version":"3.55.0"},"reference-count":54,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Croatian Science Foundation","doi-asserted-by":"publisher","award":["8875"],"award-info":[{"award-number":["8875"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EUROSPAN","award":["LSHG-CT-2006018947"],"award-info":[{"award-number":["LSHG-CT-2006018947"]}]},{"name":"Republic of Croatia Ministry of Science, Education and Sports research","award":["216-1080315-0302"],"award-info":[{"award-number":["216-1080315-0302"]}]},{"name":"CEKOM"},{"DOI":"10.13039\/100015526","name":"Ministry of Science and Education","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015526","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MRC University Unit Programme","award":["MC_PC_U127592696"],"award-info":[{"award-number":["MC_PC_U127592696"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Thyroid peroxidase (TPO) and thyroglobulin (Tg) are main components of the thyroid gland and play an essential role in thyroid hormone synthesis. The development of antibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) is the major diagnostic hallmark and early indicator of autoimmune thyroid disease. TPOAb and TgAb are under strong genetic influence; however, genetic factors that determine thyroid antibody positivity are largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>To identify novel loci associated with TPOAb and\/or TgAb positivity, we performed a genome-wide meta-analysis in a total of 2613 individuals from Croatia. Participants with elevated plasma TPOAb and\/or TgAb were defined as cases (N\u2005=\u2005619) and those with TPOAb and TgAb within reference values were defined as controls (N\u2005=\u20051994).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 2 novel loci, of which 1 is located within the YES1 gene (rs77284350, P = 1.50 \u00d7 10\u20138), and the other resides within the IRF8 gene (rs16939945, P = 5.04 \u00d7 10\u20138).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the observed variants were associated with TPOAb and TgAb positivity for the first time, both YES1 and IRF8 were previously linked to susceptibility to other autoimmune diseases, and represent plausible biological candidates. This study adds to the knowledge of genetics underlying thyroid antibodies and provides a good basis for further research.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgz239","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T16:02:24Z","timestamp":1575388944000},"page":"944-951","source":"Crossref","is-referenced-by-count":8,"title":["Genome-Wide Analysis Identifies Two Susceptibility Loci for Positive Thyroid Peroxidase and Thyroglobulin Antibodies"],"prefix":"10.1210","volume":"105","author":[{"given":"Antonela","family":"Matana","sequence":"first","affiliation":[{"name":"Department of Medical Biology, University of Split, School of Medicine, Split, Croatia"},{"name":"Department of Mathematics, University of Split, Faculty of Science, Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Boutin","sequence":"additional","affiliation":[{"name":"MRC Human Genetics Unit, Institute of Genetics and 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