{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:18:55Z","timestamp":1793157535846,"version":"4.5.0"},"reference-count":61,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cardiometabolic Health, Diabetes and Obesity Research Network"},{"DOI":"10.13039\/501100000156","name":"FRQS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008082","name":"Institute of Nutrition and Functional Foods","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003151","name":"FRQNT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Adipose tissue is an important site for extragonadal steroid hormone biosynthesis through the expression and activity of P450 aromatase, 11\u03b2-hydroxysteroid dehydrogenase (HSD) 1, and 17\u03b2-HSDs. The contribution of steroid hormones produced by adjacent adipose tissue for the progression and survival of breast tumors is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To quantify estrogens (estradiol, estrone) and glucocorticoids (cortisol, cortisone) in breast adipose tissue from both healthy and diseased women and their relationships with adiposity indices and breast cancer prognostic markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>Breast adipose tissue was collected at time of surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Pre- and postmenopausal women undergoing partial mastectomy for treatment of breast cancer (n = 17) or reduction mammoplasty (n = 6) were studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Relative estrogen and glucocorticoid amounts were determined by liquid chromatography tandem mass spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The targeted steroids were reliably detected and quantified in mammary adipose tissues. Women with ER+\/PR+ tumor had higher relative estradiol amount than women with ER\u2013\/PR\u2013 tumor (P &amp;lt; .05). The ratio of estradiol-to-estrone was higher in lean women than in women with a body mass index (BMI) \u2265 25 kg\/m2 (P &amp;lt; .05). Mixed-model analyses showed that estradiol, cortisone, and cortisol were negatively associated with tumor size (P &amp;lt; .05). Relationships between glucocorticoids and tumor size remained significant after adjustment for BMI. The cortisol-to-cortisone ratio was negatively associated with tumor stage (P &amp;lt; .05) independently of BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We reliably quantified estrogens and glucocorticoids in breast adipose tissue from healthy women and women suffering from breast cancer. Our findings suggest that smaller breast tumors are associated with higher relative amounts of estradiol and cortisol in adipose tissue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgz268","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T02:27:25Z","timestamp":1576722445000},"page":"e1504-e1516","source":"Crossref","is-referenced-by-count":21,"title":["Estrogens and Glucocorticoids in Mammary Adipose Tissue: Relationships with Body Mass Index and Breast Cancer Features"],"prefix":"10.1210","volume":"105","author":[{"given":"Sofia","family":"Laforest","sequence":"first","affiliation":[{"name":"CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center (Endocrinology and Nephrology division), School of Nutrition, Faculty of Agriculture and Food Sciences, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, 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