{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:40:41Z","timestamp":1789026041841,"version":"build-2803163510"},"reference-count":39,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T00:00:00Z","timestamp":1578096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100010120","name":"Fondazione Cassa di Risparmio di Cuneo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010120","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The frequency of adrenal incidentalomas and their association with comorbid conditions have been assessed mostly in retrospective studies that may be prone to ascertainment bias.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objective of this work is to evaluate the frequency of adrenal incidentalomas and their associated comorbid conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>A prospective cohort study was conducted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>This study took place at a radiology department at a public hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Unselected outpatients who underwent an abdominal computed tomography (CT) from January 2017 to June 2018. Patients with known or suspected adrenal disease or malignancy were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Exposure<\/jats:title>\n                  <jats:p>All abdominal CT scans were evaluated by an experienced radiologist. Hormonal workup including a 1-mg dexamethasone suppression test was performed in patients bearing adrenal incidentalomas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome and Measure<\/jats:title>\n                  <jats:p>Frequency of adrenal incidentalomas in abdominal CT of unselected patients; frequency of comorbid conditions, and hormonal workup in patients bearing adrenal incidentalomas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We recruited 601 patients, and in 7.3% of them an adrenal tumor was found serendipitously. The patients bearing an adrenal incidentaloma had higher body mass index (P\u2005=\u2005.009) and waist circumference (P\u2005=\u2005.004) and were more frequently diabetic (P\u2005=\u2005.0038). At multivariable regression analysis, diabetes was significantly associated with the presence of adrenal incidentalomas (P\u2005=\u2005.003). Autonomous cortisol secretion was observed in 50% of patients who did not suppress cortisol less than 50 nmol\/L after 1 mg dexamethasone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The frequency of adrenal incidentalomas is higher than previously reported. Moreover, adrenal incidentalomas are tied to increased risk of type 2 diabetes. This finding is free from ascertainment bias because patients with adrenal incidentalomas were drawn from a prospective cohort with the same risk of diabetes as the background population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgz284","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T05:37:53Z","timestamp":1578116273000},"page":"e973-e981","source":"Crossref","is-referenced-by-count":133,"title":["Adrenal Incidentalomas are Tied to Increased Risk of Diabetes: Findings from a Prospective Study"],"prefix":"10.1210","volume":"105","author":[{"given":"Giuseppe","family":"Reimondo","sequence":"first","affiliation":[{"name":"Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Castellano","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Santa Croce and Carle, Cuneo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Grosso","sequence":"additional","affiliation":[{"name":"Department of Radiology, Santa Croce and Carle, Cuneo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Priotto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Santa Croce and Carle, Cuneo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Puglisi","sequence":"additional","affiliation":[{"name":"Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pia","sequence":"additional","affiliation":[{"name":"Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Santa Croce and Carle, Cuneo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Borretta","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Santa Croce and Carle, Cuneo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Terzolo","sequence":"additional","affiliation":[{"name":"Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,1,4]]},"reference":[{"issue":"1","key":"2021122210042566300_CIT0001","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2214\/ajr.139.1.81","article-title":"Nonfunctioning adrenal masses: incidental discovery on computed tomography","volume":"139","author":"Glazer","year":"1982","journal-title":"AJR Am J Roentgenol."},{"issue":"6","key":"2021122210042566300_CIT0002","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/jama.1982.03330060041031","article-title":"Incidental asymptomatic adrenal masses detected by computed tomographic scanning. 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