{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:49:56Z","timestamp":1790009396486,"version":"4.0.1"},"reference-count":30,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2017sk2022"],"award-info":[{"award-number":["2017sk2022"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Despite a high prevalence of hypertension in diabetes and close relationship between primary aldosteronism (PA) and glucose metabolism, few study concerns the prevalence of PA in diabetes with hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to detect the prevalence of PA in patients with new-onset type 2 diabetes (T2D) and hypertension and to explore the association between PA and diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 256 outpatients with new-onset T2D and hypertension were screened for PA. Plasma aldosterone concentration (PAC), plasma renin activity (PRA) were measured. Patients with an aldosterone renin activity ratio (ARR) \u2265 30 ng\/dL\/ng\/mL\/h and PAC \u2265 15 ng\/dL underwent confirmatory captopril challenge test (CCT) for PA. The diagnostic criteria for PA were, after CCT, (1) PAC decreased &amp;lt; 30%, (2) ARR maintained \u2265 30 ng\/dL\/ng\/mL\/h, and (3) PAC was \u2265 11 ng\/dL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 256 consecutive patients, 99 (39%) were positive for the screening test, and 49 (19%) were diagnosed with PA. Compared with those in groups A (screening test \u2212) and B (screening test +, CCT \u2212), patients in group C (diagnosed with PA) had a higher percentage of systolic blood pressure of \u2265 160 mmHg, less family history of hypertension, and lower serum potassium. Patients in group B and C had higher PAC and ARR levels, but lower PRA than those in group A. Homeostatic model assessment for insulin resistance (HOMA-IR) was positively associated with PAC level among the diabetic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of PA in new-onset T2D patients with hypertension is at least 19%. Higher aldosterone may be related with insulin resistance in patients with diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgz293","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T19:07:28Z","timestamp":1584040048000},"page":"1079-1085","source":"Crossref","is-referenced-by-count":40,"title":["Determining the Prevalence of Primary Aldosteronism in Patients With New-Onset Type 2 Diabetes and Hypertension"],"prefix":"10.1210","volume":"105","author":[{"given":"Yuhang","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China"},{"name":"Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China"},{"name":"Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China"},{"name":"Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6964-4902","authenticated-orcid":false,"given":"Xin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China"},{"name":"Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"issue":"5","key":"2021122210141750500_CIT0001","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society Clinical Practice Guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2021122210141750500_CIT0002","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S2213-8587(17)30319-4","article-title":"Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis","volume":"6","author":"Monticone","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"9","key":"2021122210141750500_CIT0003","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/hr.2017.67","article-title":"Hypertension with diabetes mellitus: significance from an epidemiological perspective for Japanese","volume":"40","author":"Tatsumi","year":"2017","journal-title":"Hypertens Res."},{"issue":"4","key":"2021122210141750500_CIT0004","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/01.HYP.37.4.1053","article-title":"Diabetes, hypertension, and cardiovascular disease: an update","volume":"37","author":"Sowers","year":"2001","journal-title":"Hypertension."},{"issue":"3","key":"2021122210141750500_CIT0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1291\/hypres.27.193","article-title":"Prospective study on the prevalence of secondary hypertension among hypertensive patients visiting a general outpatient clinic in Japan","volume":"27","author":"Omura","year":"2004","journal-title":"Hypertens Res."},{"issue":"11","key":"2021122210141750500_CIT0006","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients","volume":"48","author":"Rossi","year":"2006","journal-title":"J Am Coll Cardiol."},{"issue":"8","key":"2021122210141750500_CIT0007","first-page":"2854","article-title":"Prevalence of primary aldosteronism among Asian hypertensive patients in Singapore","volume":"85","author":"Loh","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2021122210141750500_CIT0008","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1161\/HYPERTENSIONAHA.106.086116","article-title":"Is there an unrecognized epidemic of primary aldosteronism? 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