{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:21:53Z","timestamp":1791069713496,"version":"4.1.0"},"reference-count":427,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,2,1]]},"DOI":"10.1210\/edrv.22.1.0421","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T18:26:18Z","timestamp":1389205578000},"page":"2-35","source":"Crossref","is-referenced-by-count":22,"title":["POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease*"],"prefix":"10.1210","volume":"22","author":[{"given":"Bogi","family":"Andersen","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism (B.A.), Department of Medicine, University of California, San Diego, La Jolla, California 92093-0648"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute (M.G.R.), Department of Medicine, University of California, San Diego, La Jolla, California 92093-0648"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"2019041121495735000_R1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(88)90037-2","article-title":"The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein.","volume":"55","author":"Bodner","year":"1988","journal-title":"Cell"},{"key":"2019041121495735000_R2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0092-8674(88)90038-4","article-title":"A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype.","volume":"55","author":"Ingraham","year":"1988","journal-title":"Cell"},{"key":"2019041121495735000_R3","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1101\/gad.2.12a.1582","article-title":"The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.","volume":"2","author":"Sturm","year":"1988","journal-title":"Genes Dev"},{"key":"2019041121495735000_R4","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/336544a0","article-title":"A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells.","volume":"336","author":"Muller","year":"1988","journal-title":"Nature"},{"key":"2019041121495735000_R5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0092-8674(88)90016-5","article-title":"A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain.","volume":"55","author":"Ko","year":"1988","journal-title":"Cell"},{"key":"2019041121495735000_R6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/336551a0","article-title":"A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein.","volume":"336","author":"Scheidereit","year":"1988","journal-title":"Nature"},{"key":"2019041121495735000_R7","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1101\/gad.2.12a.1570","article-title":"The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.","volume":"2","author":"Clerc","year":"1988","journal-title":"Genes Dev"},{"key":"2019041121495735000_R8","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0092-8674(90)90493-X","article-title":"The unc-86 gene product couples cell lineage and cell identity in C. elegans.","volume":"63","author":"Finney","year":"1990","journal-title":"Cell"},{"key":"2019041121495735000_R9","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1101\/gad.2.12a.1513","article-title":"The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.","volume":"2","author":"Herr","year":"1988","journal-title":"Genes Dev"},{"key":"2019041121495735000_R10","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/0888-7543(90)90502-L","article-title":"The gene for the ubiquitous octamer-binding protein Oct-1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1.","volume":"6","author":"Hsieh","year":"1990","journal-title":"Genomics"},{"key":"2019041121495735000_R11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0888-7543(91)90314-5","article-title":"Chromosomal location of the octamer transcription factors, Otf-1, Otf- 2, and Otf-3, defines multiple Otf-3-related sequences dispersed in the mouse genome.","volume":"10","author":"Siracusa","year":"1991","journal-title":"Genomics"},{"key":"2019041121495735000_R12","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1242\/dev.122.3.881","article-title":"Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells.","volume":"122","author":"Yeom","year":"1996","journal-title":"Development"},{"key":"2019041121495735000_R13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1006\/geno.1993.1194","article-title":"Chromosomal structure and expression of the human OTF1 locus encoding the Oct-1 protein.","volume":"16","author":"Sturm","year":"1993","journal-title":"Genomics"},{"key":"2019041121495735000_R14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000133919","article-title":"The human OTF1 locus which overlaps the CD3Z gene is located at 1q22\u2013 >q23.","volume":"68","author":"Sturm","year":"1995","journal-title":"Cytogenet Cell Genet"},{"key":"2019041121495735000_R15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00431256","article-title":"The gene for the POU domain transcription factor Oct-6 maps to the distal end of mouse chromosome 4.","volume":"3","author":"Rohdewohld","year":"1992","journal-title":"Mamm Genome"},{"key":"2019041121495735000_R16","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1002\/j.1460-2075.1990.tb07388.x","article-title":"Oct-4: a germline-specific transcription factor mapping to the mouse t- complex.","volume":"9","author":"Scholer","year":"1990","journal-title":"EMBO J"},{"key":"2019041121495735000_R17","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1093\/nar\/20.17.4613","article-title":"Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues.","volume":"20","author":"Takeda","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s003359900721","article-title":"Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2.","volume":"9","author":"Sumiyama","year":"1998","journal-title":"Mamm Genome"},{"key":"2019041121495735000_R19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1006\/geno.1993.1435","article-title":"Chromosomal organization of mammalian POU domain factors.","volume":"18","author":"Xia","year":"1993","journal-title":"Genomics"},{"key":"2019041121495735000_R20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/341239a0","article-title":"Caenorhabditis elegans has scores of homoeobox-containing genes.","volume":"341","author":"Burglin","year":"1989","journal-title":"Nature"},{"key":"2019041121495735000_R21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0925-4773(91)90045-8","article-title":"Isolation of a family of Drosophila POU domain genes expressed in early development.","volume":"34","author":"Billin","year":"1991","journal-title":"Mech Dev"},{"key":"2019041121495735000_R22","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/343467a0","article-title":"Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons.","volume":"343","author":"Johnson","year":"1990","journal-title":"Nature"},{"key":"2019041121495735000_R23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/336598a0","article-title":"Jan 19;337(6204):290].","volume":"336","author":"Thali","year":"1989","journal-title":"Nature"},{"key":"2019041121495735000_R24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0012-1606(91)90294-D","article-title":"XLPOU 1 and XLPOU 2, two novel POU domain genes expressed in the dorsoanterior region of Xenopus embryos.","volume":"147","author":"Agarwal","year":"1991","journal-title":"Dev Biol"},{"key":"2019041121495735000_R25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/nar\/21.3.475","article-title":"Zebrafish pou[c]: a divergent POU family gene ubiquitously expressed during embryogenesis.","volume":"21","author":"Johansen","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R26","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1093\/nar\/24.24.4874","article-title":"Class III POU genes of zebrafish are predominantly expressed in the central nervous system.","volume":"24","author":"Spaniol","year":"1996","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R27","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/347528a0","article-title":"Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.","volume":"347","author":"Li","year":"1990","journal-title":"Nature"},{"key":"2019041121495735000_R28","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1128\/MCB.15.11.6169","article-title":"The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer.","volume":"15","author":"Clark","year":"1995","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1210\/mend.12.4.0092","article-title":"Oct-1 binds promoter elements required for transcription of the GnRH gene.","volume":"12","author":"Eraly","year":"1998","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R30","doi-asserted-by":"crossref","first-page":"17086","DOI":"10.1074\/jbc.273.27.17086","article-title":"Five discrete cis-active domains direct cell type-specific transcription of the vasoactive intestinal peptide (VIP) gene.","volume":"273","author":"Hahm","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R31","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1210\/endo.140.8.6941","article-title":"The Oct-2 POU domain gene in the neuroendocrine brain: a transcriptional regulator of mammalian puberty.","volume":"140","author":"Ojeda","year":"1999","journal-title":"Endocrinology"},{"key":"2019041121495735000_R32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0378-1119(93)90634-F","article-title":"Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and thymic stromal cells.","volume":"133","author":"Yukawa","year":"1993","journal-title":"Gene"},{"key":"2019041121495735000_R33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/nar\/21.1.127","article-title":"Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11.","volume":"21","author":"Goldsborough","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R34","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.7682011","article-title":"Dec 3;262(5139):1499].","volume":"260","author":"Andersen","year":"1993","journal-title":"Science"},{"key":"2019041121495735000_R35","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1101\/gad.11.14.1873","article-title":"Functions of the POU domain genes Skn-1a\/i and Tst-1\/Oct-6\/SCIP in epidermal differentiation.","volume":"11","author":"Andersen","year":"1997","journal-title":"Genes Dev"},{"key":"2019041121495735000_R36","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1073\/pnas.89.8.3280","article-title":"Structure and evolution of four POU domain genes expressed in mouse brain.","volume":"89","author":"Hara","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R37","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1101\/gad.9.24.3109","article-title":"The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse.","volume":"9","author":"Nakai","year":"1995","journal-title":"Genes Dev"},{"key":"2019041121495735000_R38","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1101\/gad.9.24.3122","article-title":"Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2.","volume":"9","author":"Schonemann","year":"1995","journal-title":"Genes Dev"},{"key":"2019041121495735000_R39","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.1093\/nar\/20.19.5093","article-title":"A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells.","volume":"20","author":"Lillycrop","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R40","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1093\/nar\/20.18.4919","article-title":"A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system.","volume":"20","author":"Collum","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R41","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1093\/nar\/21.14.3175","article-title":"A novel Brn3-like POU transcription factor expressed in subsets of rat sensory and spinal cord neurons.","volume":"21","author":"Ninkina","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R42","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0896-6273(93)90079-7","article-title":"Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells.","volume":"11","author":"Xiang","year":"1993","journal-title":"Neuron"},{"key":"2019041121495735000_R43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0896-6273(94)90164-3","article-title":"Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid.","volume":"12","author":"Turner","year":"1994","journal-title":"Neuron"},{"key":"2019041121495735000_R44","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1073\/pnas.93.9.3920","article-title":"POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells.","volume":"93","author":"Gan","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R45","doi-asserted-by":"crossref","first-page":"11950","DOI":"10.1073\/pnas.93.21.11950","article-title":"Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling.","volume":"93","author":"Xiang","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R46","doi-asserted-by":"crossref","first-page":"9445","DOI":"10.1073\/pnas.94.17.9445","article-title":"Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development.","volume":"94","author":"Xiang","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R47","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/381603a0","article-title":"Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development.","volume":"381","author":"Erkman","year":"1996","journal-title":"Nature"},{"key":"2019041121495735000_R48","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/384574a0","article-title":"Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons.","volume":"384","author":"McEvilly","year":"1996","journal-title":"Nature"},{"key":"2019041121495735000_R49","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0092-8674(00)81769-9","article-title":"Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.","volume":"95","author":"Nichols","year":"1998","journal-title":"Cell"},{"key":"2019041121495735000_R50","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1242\/dev.125.16.3087","article-title":"POU transcription factors control expression of CNS stem cell-specific genes.","volume":"125","author":"Josephson","year":"1998","journal-title":"Development"},{"key":"2019041121495735000_R51","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0092-8674(90)90597-8","article-title":"A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells.","volume":"60","author":"Okamoto","year":"1990","journal-title":"Cell"},{"key":"2019041121495735000_R52","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0092-8674(91)90265-Z","article-title":"May 29;69(5):724].","volume":"64","author":"Rosner","year":"1992","journal-title":"Cell"},{"key":"2019041121495735000_R53","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/344435a0","article-title":"New type of POU domain in germ line-specific protein Oct-4.","volume":"344","author":"Scholer","year":"1990","journal-title":"Nature"},{"key":"2019041121495735000_R54","doi-asserted-by":"crossref","first-page":"11084","DOI":"10.1073\/pnas.90.23.11084","article-title":"Sperm 1: a POU-domain gene transiently expressed immediately before meiosis I in the male germ cell.","volume":"90","author":"Andersen","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R55","doi-asserted-by":"crossref","first-page":"7555","DOI":"10.1073\/pnas.94.14.7555","article-title":"Reduced fertility in mice deficient for the POU protein sperm-1.","volume":"94","author":"Pearse II","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R56","doi-asserted-by":"crossref","first-page":"23390","DOI":"10.1016\/S0021-9258(19)49475-1","article-title":"Brn-5 is a divergent POU domain factor highly expressed in layer IV of the neocortex.","volume":"268","author":"Andersen","year":"1993","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R57","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1016\/S0021-9258(18)53195-1","article-title":"A novel class of murine POU gene predominantly expressed in central nervous system.","volume":"268","author":"Okamoto","year":"1993","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R58","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1128\/MCB.13.9.5450","article-title":"A novel POU domain protein which binds to the T-cell receptor \u03b2 enhancer.","volume":"13","author":"Messier","year":"1993","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R59","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1523\/JNEUROSCI.16-07-02261.1996","article-title":"Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells.","volume":"16","author":"Zhou","year":"1996","journal-title":"J Neurosci"},{"key":"2019041121495735000_R60","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1101\/gad.2.11.1400","article-title":"OBP100 binds remarkably degenerate octamer motifs through specific interactions with flanking sequences.","volume":"2","author":"Baumruker","year":"1988","journal-title":"Genes Dev"},{"key":"2019041121495735000_R61","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1432-1033.1993.tb18308.x","article-title":"Broad binding-site specificity and affinity properties of octamer 1 and brain octamer-binding proteins.","volume":"217","author":"Bendall","year":"1993","journal-title":"Eur J Biochem"},{"key":"2019041121495735000_R62","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1128\/MCB.15.4.2090","article-title":"Mechanisms for flexibility in DNA sequence recognition and VP16-induced complex formation by the Oct-1 POU domain.","volume":"15","author":"Cleary","year":"1995","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R63","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1101\/gad.7.12b.2483","article-title":"Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors.","volume":"7","author":"Li","year":"1993","journal-title":"Genes Dev"},{"key":"2019041121495735000_R64","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1101\/gad.4.11.1964","article-title":"The oct-1 homeo domain contacts only part of the octamer sequence and full oct-1 DNA-binding activity requires the POU-specific domain.","volume":"4","author":"Verrijzer","year":"1990","journal-title":"Genes Dev"},{"key":"2019041121495735000_R65","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1002\/j.1460-2075.1992.tb05606.x","article-title":"The DNA binding specificity of the bipartite POU domain and its subdomains.","volume":"11","author":"Verrijzer","year":"1992","journal-title":"EMBO J"},{"key":"2019041121495735000_R66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0092-8674(94)90231-3","article-title":"Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules.","volume":"77","author":"Klemm","year":"1994","journal-title":"Cell"},{"key":"2019041121495735000_R67","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1093\/emboj\/16.8.2043","article-title":"Linker length and composition influence the flexibility of Oct-1 DNA binding.","volume":"16","author":"van Leeuwen","year":"1997","journal-title":"EMBO J"},{"key":"2019041121495735000_R68","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/345829a0","article-title":"Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues.","volume":"345","author":"McCormick","year":"1990","journal-title":"Nature"},{"key":"2019041121495735000_R69","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/346583a0","article-title":"Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements.","volume":"346","author":"Chen","year":"1990","journal-title":"Nature"},{"key":"2019041121495735000_R70","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1101\/gad.7.6.913","article-title":"A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene.","volume":"7","author":"Rhodes","year":"1993","journal-title":"Genes Dev"},{"key":"2019041121495735000_R71","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1073\/pnas.88.8.3130","article-title":"Thyrotropin-releasing hormone regulation of human TSHB expression: role of a pituitary-specific transcription factor (Pit-1\/GHF-1) and potential interaction with a thyroid hormone-inhibitory element.","volume":"88","author":"Steinfelder","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R72","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1242\/dev.120.3.515","article-title":"Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1dependent origins of the thyrotrope.","volume":"120","author":"Lin","year":"1994","journal-title":"Development"},{"key":"2019041121495735000_R73","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0303-7207(93)90097-4","article-title":"Analysis of Pit-1 in regulating mouse TSH\u03b2 promoter activity in thyrotropes.","volume":"96","author":"Gordon","year":"1993","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121495735000_R74","doi-asserted-by":"crossref","first-page":"12108","DOI":"10.1074\/jbc.274.17.12108","article-title":"Cloning and characterization of the 5\u2032-flanking region of the human growth hormone-releasing hormone receptor gene.","volume":"274","author":"Iguchi","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R75","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1210\/endo.140.9.6977","article-title":"The rat growth hormone-releasing hormone receptor gene: structure, regulation, and generation of receptor isoforms with different signaling properties.","volume":"140","author":"Miller","year":"1999","journal-title":"Endocrinology"},{"key":"2019041121495735000_R76","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1210\/mend.14.2.0419","article-title":"Dual regulation of somatostatin receptor subtype 1 gene expression by pit-1 in anterior pituitary GH3 cells.","volume":"14","author":"Baumeister","year":"2000","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R77","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1749-6632.1998.tb11202.x","article-title":"Involvement of a Pit-1 binding site in the regulation of the rat somatostatin receptor 1 gene expression.","volume":"865","author":"Baumeister","year":"1998","journal-title":"Ann NY Acad Sci"},{"key":"2019041121495735000_R78","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1046\/j.1471-4159.1999.0720040.x","article-title":"Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.","volume":"72","author":"Matre","year":"1999","journal-title":"J Neurochem"},{"key":"2019041121495735000_R79","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1101\/gad.4.1.43","article-title":"A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression.","volume":"4","author":"Elsholtz","year":"1990","journal-title":"Genes Dev"},{"key":"2019041121495735000_R80","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0092-8674(90)90067-O","article-title":"The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.","volume":"61","author":"Ingraham","year":"1990","journal-title":"Cell"},{"key":"2019041121495735000_R81","first-page":"1551","article-title":"An alternative Pit-1 RNA splicing product reveals modular binding and nonmodular transcriptional activities of the POU-specific domain.","volume":"7","author":"Voss","year":"1993","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R82","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1101\/gad.5.7.1309","article-title":"POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter.","volume":"5","author":"Voss","year":"1991","journal-title":"Genes Dev"},{"key":"2019041121495735000_R83","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1128\/MCB.9.2.747","article-title":"Octamer transcription factors 1 and 2 each bind to two different functional elements in the immunoglobulin heavy-chain promoter.","volume":"9","author":"Poellinger","year":"1989","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R84","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1128\/MCB.12.7.3247","article-title":"Oct-1 and Oct-2 potentiate functional interactions of a transcription factor with the proximal sequence element of small nuclear RNA genes.","volume":"12","author":"Murphy","year":"1992","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R85","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1101\/gad.2.12b.1764","article-title":"Apr;3(4):584].","volume":"2","author":"Tanaka","year":"1989","journal-title":"Genes Dev"},{"key":"2019041121495735000_R86","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1128\/MCB.11.12.5825","article-title":"Histone gene transcription factor binding in extracts of normal human cells.","volume":"11","author":"La Bella","year":"1991","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R87","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1128\/JVI.63.6.2798-2812.1989","article-title":"Overlapping octamer and TAATGARAT motifs in the VF65response elements in herpes simplex virus immediate-early promoters represent independent binding sites for cellular nuclear factor III.","volume":"63","author":"apRhys","year":"1989","journal-title":"J Virol"},{"key":"2019041121495735000_R88","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1101\/gad.1.10.1147","article-title":"A 100-kD HeLa cell octamer binding protein (OBP100) interacts differently with two separate octamer-related sequences within the SV40 enhancer.","volume":"1","author":"Sturm","year":"1987","journal-title":"Genes Dev"},{"key":"2019041121495735000_R89","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(94)90073-6","article-title":"Site-specific conformational alteration of the Oct-1 POU domain-DNA complex as the basis for differential recognition by Vmw65 (VP16).","volume":"79","author":"Walker","year":"1994","journal-title":"Cell"},{"key":"2019041121495735000_R90","doi-asserted-by":"crossref","first-page":"8450","DOI":"10.1073\/pnas.94.16.8450","article-title":"Structural flexibility in transcription complex formation revealed by protein-DNA photocrosslinking.","volume":"94","author":"Cleary","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R91","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/337573a0","article-title":"Functional cooperativity between protein molecules bound at two distinct sequence elements of the immunoglobulin heavy-chain promoter.","volume":"337","author":"Poellinger","year":"1989","journal-title":"Nature"},{"key":"2019041121495735000_R92","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1101\/gad.3.10.1625","article-title":"The Oct-2 protein binds cooperatively to adjacent octamer sites.","volume":"3","author":"LeBowitz","year":"1989","journal-title":"Genes Dev"},{"key":"2019041121495735000_R93","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/j.1460-2075.1989.tb03607.x","article-title":"Octamer transcription factors bind to two different sequence motifs of the immunoglobulin heavy chain promoter.","volume":"8","author":"Kemler","year":"1989","journal-title":"EMBO J"},{"key":"2019041121495735000_R94","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1046\/j.1432-1327.1999.00732.x","article-title":"The activity of the human interleukin-5 conserved lymphokine element 0 is regulated by octamer factors in human cells.","volume":"265","author":"Thomas","year":"1999","journal-title":"Eur J Biochem"},{"key":"2019041121495735000_R95","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0091-6749(99)70188-0","article-title":"Binding of YY1 and Oct1 to a novel element that downregulates expression of IL-5 in human T cells.","volume":"103","author":"Mordvinov","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"2019041121495735000_R96","doi-asserted-by":"crossref","first-page":"15905","DOI":"10.1074\/jbc.272.25.15905","article-title":"Characterization of Skn-1a\/i POU domain factors and linkage to papillomavirus gene expression.","volume":"272","author":"Andersen","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R97","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1002\/j.1460-2075.1990.tb07585.x","article-title":"Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain.","volume":"9","author":"Suzuki","year":"1990","journal-title":"EMBO J"},{"key":"2019041121495735000_R98","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.1093\/nar\/18.24.7357","article-title":"The octamer binding factor Oct6: cDNA cloning and expression in early embryonic cells.","volume":"18","author":"Meijer","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R99","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1128\/MCB.11.3.1739","article-title":"Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule Po.","volume":"11","author":"He","year":"1991","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R100","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1128\/MCB.17.3.1652","article-title":"Repression of gonadotropin-releasing hormone promoter activity by the POU homeodomain transcription factor SCIP\/Oct-6\/Tst-1: a regulatory mechanism of phenotype expression?","volume":"17","author":"Wierman","year":"1997","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R101","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1073\/pnas.90.10.4743","article-title":"Regulation of JC virus by the POU-domain transcription factor Tst-1: implications for progressive multifocal leukoencephalopathy.","volume":"90","author":"Wegner","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R102","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/nar\/21.2.253","article-title":"cDna cloning of human N-Oct3, a nervous-system specific Pou domain transcription factor binding to the octamer Dna motif.","volume":"21","author":"Schreiber","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R103","doi-asserted-by":"crossref","first-page":"34196","DOI":"10.1074\/jbc.273.51.34196","article-title":"Highly cooperative homodimerization is a conserved property of neural POU proteins.","volume":"273","author":"Rhee","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R104","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0169-328X(98)00048-5","article-title":"Winged helix hepatocyte nuclear factor 3 and POU-domain protein brn-2\/N- oct-3 bind overlapping sites on the neuronal promoter of human aromatic L-amino acid decarboxylase gene.","volume":"56","author":"Raynal","year":"1998","journal-title":"Brain Res Mol Brain Res"},{"key":"2019041121495735000_R105","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0169-328X(95)00308-F","article-title":"Binding preferences of the POU domain protein Brain-4: implications for autoregulation.","volume":"38","author":"Malik","year":"1996","journal-title":"Brain Res Mol Brain Res"},{"key":"2019041121495735000_R106","doi-asserted-by":"crossref","first-page":"11933","DOI":"10.1073\/pnas.93.21.11933","article-title":"Regulation of striatal D1A dopamine receptor gene transcription by Brn- 4.","volume":"93","author":"Okazawa","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R107","doi-asserted-by":"crossref","first-page":"7186","DOI":"10.1128\/MCB.17.12.7186","article-title":"POU domain transcription factor brain 4 confers pancreatic\u03b1 -cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element.","volume":"17","author":"Hussain","year":"1997","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R108","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1128\/MCB.18.4.1866","article-title":"Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3\/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site.","volume":"18","author":"Ben-Shushan","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R109","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1128\/MCB.17.11.6321","article-title":"Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites.","volume":"17","author":"Ambrosetti","year":"1997","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R110","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/j.1460-2075.1989.tb08393.x","article-title":"Octamer binding proteins confer transcriptional activity in early mouse embryogenesis.","volume":"8","author":"Scholer","year":"1989","journal-title":"EMBO J"},{"key":"2019041121495735000_R111","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1101\/gad.12.13.2073","article-title":"New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2.","volume":"12","author":"Botquin","year":"1998","journal-title":"Genes Dev"},{"key":"2019041121495735000_R112","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.1128\/MCB.19.8.5453","article-title":"The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3\/4 and Sox-2.","volume":"19","author":"Nishimoto","year":"1999","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R113","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0092-8674(93)90171-L","article-title":"The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage\u03bb repressor DNA-binding domain.","volume":"73","author":"Assa-Munt","year":"1993","journal-title":"Cell"},{"key":"2019041121495735000_R114","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.1021\/bi00074a014","article-title":"NMR studies of the POU-specific DNA-binding domain of Oct-1: sequential 1H and 15N assignments and secondary structure.","volume":"32","author":"Cox","year":"1993","journal-title":"Biochemistry"},{"key":"2019041121495735000_R115","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/362852a0","article-title":"Solution structure of the POU-specific DNA-binding domain of Oct-1.","volume":"362","author":"Dekker","year":"1993","journal-title":"Nature"},{"key":"2019041121495735000_R116","doi-asserted-by":"crossref","first-page":"9845","DOI":"10.1021\/bi00199a005","article-title":"Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2.","volume":"33","author":"Sivaraja","year":"1994","journal-title":"Biochemistry"},{"key":"2019041121495735000_R117","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1101\/gad.11.2.198","article-title":"Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility.","volume":"11","author":"Jacobson","year":"1997","journal-title":"Genes Dev"},{"key":"2019041121495735000_R118","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/jmbi.1998.2147","article-title":"Engrailed homeodomain-DNA complex at 2.2 A resolution: a detailed view of the interface and comparison with other engrailed structures.","volume":"284","author":"Fraenkel","year":"1998","journal-title":"J Mol Biol"},{"key":"2019041121495735000_R119","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/1382","article-title":"Comparison of X-ray and NMR structures for the Antennapedia homeodomain-DNA complex.","volume":"5","author":"Fraenkel","year":"1998","journal-title":"Nat Struct Biol"},{"key":"2019041121495735000_R120","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0092-8674(90)90453-L","article-title":"Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions.","volume":"63","author":"Kissinger","year":"1990","journal-title":"Cell"},{"key":"2019041121495735000_R121","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1101\/gad.10.1.27","article-title":"Oct-1 POU domain-DNA interactions: cooperative binding of isolated subdomains and effects of covalent linkage.","volume":"10","author":"Klemm","year":"1996","journal-title":"Genes Dev"},{"key":"2019041121495735000_R122","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1074\/jbc.272.6.3398","article-title":"The Oct-1 POU homeodomain stabilizes the adenovirus preinitiation complex via a direct interaction with the priming protein and is displaced when the replication fork passes.","volume":"272","author":"van Leeuwen","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R123","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1128\/MCB.12.2.455","article-title":"Segments of the POU domain influence one another\u2019s DNA-binding specificity.","volume":"12","author":"Aurora","year":"1992","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R124","doi-asserted-by":"crossref","first-page":"7397","DOI":"10.1128\/MCB.18.12.7397","article-title":"Coactivator OBF-1 makes selective contacts with both the POU-specific domain and the POU homeodomain and acts as a molecular clamp on DNA.","volume":"18","author":"Sauter","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R125","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1126\/science.1684878","article-title":"Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity.","volume":"254","author":"Segil","year":"1991","journal-title":"Science"},{"key":"2019041121495735000_R126","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1652153","article-title":"Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements.","volume":"253","author":"Kapiloff","year":"1991","journal-title":"Science"},{"key":"2019041121495735000_R127","first-page":"1559","article-title":"Pit-1 binding sites mediate transcriptional responses to cyclic adenosine 3\u2032,5\u2032-monophosphate through a mechanism that does not require inducible phosphorylation of Pit-1.","volume":"8","author":"Okimura","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R128","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1073\/pnas.89.13.5942","article-title":"Hormonal regulation of the thyrotropin beta-subunit gene by phosphorylation of the pituitary-specific transcription factor Pit-1.","volume":"89","author":"Steinfelder","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R129","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1128\/MCB.19.3.2021","article-title":"Jun kinase phosphorylates and regulates the DNA binding activity of an octamer binding protein, T-cell factor \u03b21.","volume":"19","author":"Kasibhatla","year":"1999","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R130","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1073\/pnas.96.7.3652","article-title":"Factor-specific modulation of CREB-binding protein acetyltransferase activity.","volume":"96","author":"Perissi","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R131","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1101\/gad.9.14.1679","article-title":"The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain.","volume":"9","author":"Herr","year":"1995","journal-title":"Genes Dev"},{"key":"2019041121495735000_R132","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1128\/MCB.12.2.542","article-title":"The Oct-1 POU domain mediates interactions between Oct-1 and other POU proteins.","volume":"12","author":"Verrijzer","year":"1992","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R133","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1210\/mend.12.9.0168","article-title":"Visualization of Pit-1 transcription factor interactions in the living cell nucleus by fluorescence resonance energy transfer microscopy.","volume":"12","author":"Day","year":"1998","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R134","doi-asserted-by":"crossref","first-page":"17733","DOI":"10.1074\/jbc.271.30.17733","article-title":"An activation function in Pit-1 required selectively for synergistic transcription.","volume":"271","author":"Chang","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R135","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1096\/fasebj.12.12.1201","article-title":"A direct protein-protein interaction is involved in the cooperation between thyroid hormone and retinoic acid receptors and the transcription factor GHF-1.","volume":"12","author":"Palomino","year":"1998","journal-title":"FASEB J"},{"key":"2019041121495735000_R136","first-page":"656","article-title":"Synergistic activation of the rat growth hormone promoter by Pit-1 and the thyroid hormone receptor.","volume":"6","author":"Schaufele","year":"1992","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R137","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1210\/mend-4-12-1964","article-title":"Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene.","volume":"4","author":"Day","year":"1990","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R138","doi-asserted-by":"crossref","first-page":"19103","DOI":"10.1074\/jbc.274.27.19103","article-title":"Functional interaction between Oct-1 and retinoid X receptor.","volume":"274","author":"Kakizawa","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R139","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1101\/gad.4.5.695","article-title":"Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.","volume":"4","author":"Simmons","year":"1990","journal-title":"Genes Dev"},{"key":"2019041121495735000_R140","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0960-0760(99)00020-5","article-title":"Interaction between estrogen receptor and Pit-1 protein is influenced by estrogen in pituitary cells.","volume":"68","author":"Ying","year":"1999","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2019041121495735000_R141","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1210\/mend.13.7.0320","article-title":"Synergistic activation of the prolactin promoter by vitamin D receptor and GHF-1: role of the coactivators, CREB-binding protein and steroid hormone receptor coactivator-1 (SRC-1).","volume":"13","author":"Castillo","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R142","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0303-7207(97)00176-7","article-title":"The glucocorticoid receptor inhibits the human prolactin gene expression by interference with Pit-1 activity.","volume":"134","author":"Nalda","year":"1997","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121495735000_R143","doi-asserted-by":"crossref","first-page":"7706","DOI":"10.1073\/pnas.93.15.7706","article-title":"P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.","volume":"93","author":"Szeto","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R144","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1210\/mend.12.3.0073","article-title":"The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the Lim-homeodomain gene Lim3\/Lhx3.","volume":"12","author":"Tremblay","year":"1998","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R145","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1101\/gad.13.4.484","article-title":"Role of the bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development.","volume":"13","author":"Szeto","year":"1999","journal-title":"Genes Dev"},{"key":"2019041121495735000_R146","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1128\/MCB.19.10.7001","article-title":"Multifunctional role of the Pitx2 homeodomain protein C-terminal tail.","volume":"19","author":"Amendt","year":"1999","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R147","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1073\/pnas.92.7.2720","article-title":"P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1.","volume":"92","author":"Bach","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R148","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1128\/MCB.17.3.1065","article-title":"Interaction of Ets-1 and the POU-homeodomain protein GHF-1\/Pit-1 reconstitutes pituitary-specific gene expression.","volume":"17","author":"Bradford","year":"1997","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R149","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1074\/jbc.275.5.3100","article-title":"The pit-1 homeodomain and \u03b2 -domain interact with ets-1 and modulate synergistic activation of the rat prolactin promoter.","volume":"275","author":"Bradford","year":"2000","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R150","doi-asserted-by":"crossref","first-page":"24339","DOI":"10.1074\/jbc.272.39.24339","article-title":"Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin \u03b2-subunit promoter.","volume":"272","author":"Gordon","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R151","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80770-9","article-title":"Reciprocal interactions of Pit1 and GATA2 mediate signaling gradientinduced determination of pituitary cell types.","volume":"97","author":"Dasen","year":"1999","journal-title":"Cell"},{"key":"2019041121495735000_R152","first-page":"268","article-title":"A novel mechanism for cyclic adenosine 3\u2032,5\u2032-monophosphate regulation of gene expression by CREB-binding protein.","volume":"13","author":"Zanger","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R153","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/26270","article-title":"Signal-specific co-activator domain requirements for Pit-1 activation.","volume":"395","author":"Xu","year":"1998","journal-title":"Nature"},{"key":"2019041121495735000_R154","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1093\/nar\/24.11.2112","article-title":"Transcriptional activation by Oct-3: evidence for a specific role of the POU-specific domain in mediating functional interaction with Oct-1.","volume":"24","author":"Vigano","year":"1996","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R155","first-page":"1593","article-title":"Transcriptional synergism between the vitamin D3 receptor and other nonreceptor transcription factors.","volume":"8","author":"Liu","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R156","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1128\/MCB.18.6.3416","article-title":"Recruitment of octamer transcription factors to DNA by glucocorticoid receptor.","volume":"18","author":"Prefontaine","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R157","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.1128\/MCB.19.10.7106","article-title":"Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding.","volume":"19","author":"Wang","year":"1999","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R158","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1074\/jbc.274.4.2372","article-title":"The glucocorticoid receptor is tethered to DNA-bound Oct-1 at the mouse gonadotropin-releasing hormone distal negative glucocorticoid response element.","volume":"274","author":"Chandran","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R159","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0092-8674(91)90240-Y","article-title":"Ubiquitous transcription factor OTF-1 mediates induction of the MMTV promoter through synergistic interaction with hormone receptors.","volume":"64","author":"Bruggemeier","year":"1991","journal-title":"Cell"},{"key":"2019041121495735000_R160","doi-asserted-by":"crossref","first-page":"26713","DOI":"10.1074\/jbc.274.38.26713","article-title":"Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter.","volume":"274","author":"Prefontaine","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R161","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/j.1460-2075.1995.tb07163.x","article-title":"Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo.","volume":"14","author":"Truss","year":"1995","journal-title":"EMBO J"},{"key":"2019041121495735000_R162","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0092-8674(90)90087-U","article-title":"Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter.","volume":"60","author":"Pina","year":"1990","journal-title":"Cell"},{"key":"2019041121495735000_R163","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1002\/j.1460-2075.1991.tb07791.x","article-title":"Interference and synergism of glucocorticoid receptor and octamer factors.","volume":"10","author":"Wieland","year":"1991","journal-title":"EMBO J"},{"key":"2019041121495735000_R164","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.1128\/MCB.12.11.4960","article-title":"Functional interference between the ubiquitous and constitutive octamer transcription factor 1 (OTF-1) and the glucocorticoid receptor by direct protein-protein interaction involving the homeo subdomain of OTF- 1.","volume":"12","author":"Kutoh","year":"1992","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R165","doi-asserted-by":"crossref","first-page":"21856","DOI":"10.1074\/jbc.273.34.21856","article-title":"Tissue-specific and androgen-repressible regulation of the rat dehydroepiandrosterone sulfotransferase gene promoter.","volume":"273","author":"Song","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R166","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1093\/nar\/24.11.1981","article-title":"The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression.","volume":"24","author":"Strom","year":"1996","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R167","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1073\/pnas.87.12.4732","article-title":"Cooperative interactions between transcription factors Sp1 and OTF-1.","volume":"87","author":"Janson","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R168","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1126\/science.1683003","article-title":"Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40.","volume":"254","author":"Ullman","year":"1991","journal-title":"Science"},{"key":"2019041121495735000_R169","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.4049\/jimmunol.153.12.5572","article-title":"Octamer factors exert a dual effect on the IL-2 and IL-4 promoters.","volume":"153","author":"Pfeuffer","year":"1994","journal-title":"J Immunol"},{"key":"2019041121495735000_R170","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1084\/jem.180.4.1485","article-title":"Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor.","volume":"180","author":"de Grazia","year":"1994","journal-title":"J Exp Med"},{"key":"2019041121495735000_R171","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/1521-4141(200001)30:1<174::AID-IMMU174>3.0.CO;2-T","article-title":"Interaction and functional interference of C\/EBP\u03b2 with octamer factors in immunoglobulin gene transcription.","volume":"30","author":"Hatada","year":"2000","journal-title":"Eur J Immunol"},{"key":"2019041121495735000_R172","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/viro.1995.1053","article-title":"Oct-1 activates the epithelialspecific enhancer of human papillomavirus type 16 via a synergistic interaction with NFI at a conserved composite regulatory element.","volume":"207","author":"O\u2019Connor","year":"1995","journal-title":"Virology"},{"key":"2019041121495735000_R173","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1126\/science.2109351","article-title":"A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons.","volume":"248","author":"Oberdick","year":"1990","journal-title":"Science"},{"key":"2019041121495735000_R174","doi-asserted-by":"crossref","first-page":"15217","DOI":"10.1074\/jbc.273.24.15217","article-title":"MEF-2 and Oct-1 bind to two homologous promoter sequence elements and participate in the expression of a skeletal muscle-specific gene.","volume":"273","author":"Lakich","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R175","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/j.1460-2075.1995.tb07103.x","article-title":"High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.","volume":"14","author":"Zwilling","year":"1995","journal-title":"EMBO J"},{"key":"2019041121495735000_R176","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1084\/jem.182.2.487","article-title":"Functional roles of the transcription factor Oct-2A and the high mobility group protein I\/Y in HLA-DRA gene expression.","volume":"182","author":"Abdulkadir","year":"1995","journal-title":"J Exp Med"},{"key":"2019041121495735000_R177","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/jlb.64.5.681","article-title":"High mobility group I\/Y protein functions as a specific cofactor for Oct-2A: mapping of interaction domains.","volume":"64","author":"Abdulkadir","year":"1998","journal-title":"J Leukoc Biol"},{"key":"2019041121495735000_R178","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/373360a0","article-title":"A B-cell coactivator of octamer-binding transcription factors.","volume":"373","author":"Gstaiger","year":"1995","journal-title":"Nature"},{"key":"2019041121495735000_R179","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1128\/MCB.15.8.4115","article-title":"Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B.","volume":"15","author":"Luo","year":"1995","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R180","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1128\/MCB.18.7.3803","article-title":"Coactivation by OCA-B: definition of critical regions and synergism with general cofactors.","volume":"18","author":"Luo","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R181","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0092-8674(92)90352-D","article-title":"A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors.","volume":"71","author":"Luo","year":"1992","journal-title":"Cell"},{"key":"2019041121495735000_R182","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/383538a0","article-title":"B-cell-specific coactivator OBF-1\/OCA-B\/Bob1 required for immune response and germinal centre formation.","volume":"383","author":"Schubart","year":"1996","journal-title":"Nature"},{"key":"2019041121495735000_R183","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0092-8674(95)90500-6","article-title":"OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins.","volume":"80","author":"Strubin","year":"1995","journal-title":"Cell"},{"key":"2019041121495735000_R184","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1128\/MCB.17.12.7295","article-title":"Apr;18(4):2430].","volume":"17","author":"Babb","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R185","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/smim.1998.0117","article-title":"Lymphoid-specific transcription mediated by the conserved octamer site: who is doing what?","volume":"10","author":"Matthias","year":"1998","journal-title":"Semin Immunol"},{"key":"2019041121495735000_R186","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1006\/jmbi.1999.2711","article-title":"Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding.","volume":"288","author":"Chang","year":"1999","journal-title":"J Mol Biol"},{"key":"2019041121495735000_R187","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1101\/gad.13.20.2650","article-title":"Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain\/octamer DNA complex: specific recognition of a protein-DNA interface.","volume":"13","author":"Chasman","year":"1999","journal-title":"Genes Dev"},{"key":"2019041121495735000_R188","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1002\/j.1460-2075.1989.tb08608.x","article-title":"The octamer-binding proteins form multi-protein\u2013DNA complexes with the HSV\u03b1 TIF regulatory protein.","volume":"8","author":"Kristie","year":"1989","journal-title":"EMBO J"},{"key":"2019041121495735000_R189","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1101\/gad.4.12b.2383","article-title":"Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV\u03b1 -trans-activator protein.","volume":"4","author":"Kristie","year":"1990","journal-title":"Genes Dev"},{"key":"2019041121495735000_R190","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/341624a0","article-title":"The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16.","volume":"341","author":"Stern","year":"1989","journal-title":"Nature"},{"key":"2019041121495735000_R191","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1101\/gad.5.12b.2555","article-title":"The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain.","volume":"5","author":"Stern","year":"1991","journal-title":"Genes Dev"},{"key":"2019041121495735000_R192","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.1073\/pnas.85.17.6347","article-title":"A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins.","volume":"85","author":"Gerster","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R193","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/emboj\/18.2.480","article-title":"HCF-dependent nuclear import of VP16.","volume":"18","author":"La Boissiere","year":"1999","journal-title":"EMBO J"},{"key":"2019041121495735000_R194","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0092-8674(93)90299-6","article-title":"The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein.","volume":"74","author":"Wilson","year":"1993","journal-title":"Cell"},{"key":"2019041121495735000_R195","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0888-7543(95)80046-O","article-title":"The gene encoding the VP16-accessory protein HCF (HCFC1) resides in human Xq28 and is highly expressed in fetal tissues and the adult kidney.","volume":"25","author":"Wilson","year":"1995","journal-title":"Genomics"},{"key":"2019041121495735000_R196","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1093\/nar\/18.23.6871","article-title":"Characterization of a cellular factor which interacts functionally with Oct-1 in the assembly of a multicomponent transcription complex.","volume":"18","author":"Katan","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R197","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1128\/MCB.10.9.4974","article-title":"A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1.","volume":"10","author":"Xiao","year":"1990","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R198","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1101\/gad.7.1.72","article-title":"Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment.","volume":"7","author":"Cleary","year":"1993","journal-title":"Genes Dev"},{"key":"2019041121495735000_R199","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1101\/gad.6.11.2058","article-title":"Dec;6(12B):2663].","volume":"6","author":"Lai","year":"1992","journal-title":"Genes Dev"},{"key":"2019041121495735000_R200","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1101\/gad.6.11.2047","article-title":"Recognition of the surface of a homeo domain protein.","volume":"6","author":"Pomerantz","year":"1992","journal-title":"Genes Dev"},{"key":"2019041121495735000_R201","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1128\/MCB.15.4.2019","article-title":"Proximal sequence element-binding transcription factor (PTF) is a multisubunit complex required for transcription of both RNA polymerase II- and RNA polymerase III-dependent small nuclear RNA genes.","volume":"15","author":"Yoon","year":"1995","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R202","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/374653a0","article-title":"A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III.","volume":"374","author":"Henry","year":"1995","journal-title":"Nature"},{"key":"2019041121495735000_R203","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1128\/MCB.18.1.368","article-title":"The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1.","volume":"18","author":"Wong","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R204","doi-asserted-by":"crossref","first-page":"16048","DOI":"10.1074\/jbc.272.25.16048","article-title":"Characterization of a trimeric complex containing Oct-1, SNAPc, and DNA.","volume":"272","author":"Ford","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R205","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1128\/MCB.16.5.1955","article-title":"The Oct-1 POU-specific domain can stimulate small nuclear RNA gene transcription by stabilizing the basal transcription complex SNAPc.","volume":"16","author":"Mittal","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R206","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1101\/gad.13.14.1807","article-title":"SNAP(c): a core promoter factor with a built-in DNA-binding damper that is deactivated by the Oct-1 POU domain.","volume":"13","author":"Mittal","year":"1999","journal-title":"Genes Dev"},{"key":"2019041121495735000_R207","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/nar\/22.9.1655","article-title":"The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP.","volume":"22","author":"Zwilling","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R208","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/j.1460-2075.1993.tb05641.x","article-title":"Oct-2 facilitates functional preinitiation complex assembly and is continuously required at the promoter for multiple rounds of transcription.","volume":"12","author":"Arnosti","year":"1993","journal-title":"EMBO J"},{"key":"2019041121495735000_R209","doi-asserted-by":"crossref","first-page":"19613","DOI":"10.1074\/jbc.270.33.19613","article-title":"Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter.","volume":"270","author":"Nakshatri","year":"1995","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R210","doi-asserted-by":"crossref","first-page":"29852","DOI":"10.1074\/jbc.272.47.29852","article-title":"The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors.","volume":"272","author":"Inamoto","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R211","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(99)00249-8","article-title":"Mechanism of DNA replication in eukaryotic cells: cellular host factors stimulating adenovirus DNA replication.","volume":"236","author":"de Jong","year":"1999","journal-title":"Gene"},{"key":"2019041121495735000_R212","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1002\/j.1460-2075.1990.tb08314.x","article-title":"The DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication.","volume":"9","author":"Verrijzer","year":"1990","journal-title":"EMBO J"},{"key":"2019041121495735000_R213","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/nar\/27.13.2799","article-title":"Characterisation of the adenovirus preterminal protein and its interaction with the POU homeodomain of NFIII (Oct-1).","volume":"27","author":"Botting","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R214","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1002\/j.1460-2075.1994.tb06875.x","article-title":"The Oct-1 POU domain stimulates adenovirus DNA replication by a direct interaction between the viral precursor terminal protein-DNA polymerase complex and the POU homeodomain.","volume":"13","author":"Coenjaerts","year":"1994","journal-title":"EMBO J"},{"key":"2019041121495735000_R215","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1093\/nar\/20.23.6369","article-title":"POU domain transcription factors from different subclasses stimulate adenovirus DNA replication.","volume":"20","author":"Verrijzer","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R216","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0169-328X(96)00238-0","article-title":"The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.","volume":"45","author":"Malik","year":"1997","journal-title":"Brain Res Mol Brain Res"},{"key":"2019041121495735000_R217","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1128\/MCB.15.7.3738","article-title":"Functional interaction between the POU domain protein Tst-1\/Oct-6 and the high-mobility-group protein HMG-I\/Y.","volume":"15","author":"Leger","year":"1995","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R218","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1126\/science.277.5323.221","article-title":"Inducible expression and phosphorylation of coactivator BOB.1\/OBF.1 in T cells.","volume":"277","author":"Zwilling","year":"1997","journal-title":"Science"},{"key":"2019041121495735000_R219","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1074\/jbc.273.26.16050","article-title":"Cooperative function of POU proteins and SOX proteins in glial cells.","volume":"273","author":"Kuhlbrodt","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R220","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1523\/JNEUROSCI.18-01-00237.1998","article-title":"Sox10, a novel transcriptional modulator in glial cells.","volume":"18","author":"Kuhlbrodt","year":"1998","journal-title":"J Neurosci"},{"key":"2019041121495735000_R221","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1073\/pnas.91.14.6433","article-title":"The POU domain protein Tst-1 and papovaviral large tumor antigen function synergistically to stimulate glia-specific gene expression of JC virus.","volume":"91","author":"Renner","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R222","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1089\/dna.1996.15.1057","article-title":"T antigen of human papovavirus JC stimulates transcription of the POU domain factor Tst-1\/Oct6\/SCIP.","volume":"15","author":"Renner","year":"1996","journal-title":"DNA Cell Biol"},{"key":"2019041121495735000_R223","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1128\/MCB.19.4.2455","article-title":"The J domain of papovaviral large tumor antigen is required for synergistic interaction with the POU-domain protein Tst-1\/Oct6\/SCIP.","volume":"19","author":"Sock","year":"1999","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R224","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1101\/gad.9.21.2635","article-title":"Developmentalspecific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.","volume":"9","author":"Yuan","year":"1995","journal-title":"Genes Dev"},{"key":"2019041121495735000_R225","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0092-8674(91)90619-A","article-title":"A nexus between Oct-4 and E1A: implications for gene regulation in embryonic stem cells.","volume":"66","author":"Scholer","year":"1991","journal-title":"Cell"},{"key":"2019041121495735000_R226","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1128\/MCB.19.4.2635","article-title":"Synergism with germ line transcription factor Oct-4: viral oncoproteins share the ability to mimic a stem cell-specific activity.","volume":"19","author":"Brehm","year":"1999","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R227","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0092-8674(90)90589-7","article-title":"Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation.","volume":"60","author":"Tanaka","year":"1990","journal-title":"Cell"},{"key":"2019041121495735000_R228","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0092-8674(92)90150-B","article-title":"Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter.","volume":"68","author":"Tanaka","year":"1992","journal-title":"Cell"},{"key":"2019041121495735000_R229","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1128\/MCB.14.9.6046","article-title":"The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription.","volume":"14","author":"Tanaka","year":"1994","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R230","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/j.1460-2075.1990.tb08282.x","article-title":"Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells.","volume":"9","author":"Muller-Immergluck","year":"1990","journal-title":"EMBO J"},{"key":"2019041121495735000_R231","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/j.1460-2075.1990.tb08283.x","article-title":"The cell type-specific octamer transcription factor OTF-2 has two domains required for the activation of transcription.","volume":"9","author":"Gerster","year":"1990","journal-title":"EMBO J"},{"key":"2019041121495735000_R232","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1128\/MCB.14.9.6056","article-title":"Reconstitution of transcriptional activation domains by reiteration of short peptide segments reveals the modular organization of a glutamine- rich activation domain.","volume":"14","author":"Tanaka","year":"1994","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R233","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1128\/MCB.17.1.154","article-title":"The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain.","volume":"17","author":"Brehm","year":"1997","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R234","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1101\/gad.9.16.1992","article-title":"Pit-1 binding to specific DNA sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain.","volume":"9","author":"Holloway","year":"1995","journal-title":"Genes Dev"},{"key":"2019041121495735000_R235","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1126\/science.1589758","article-title":"Triplet repeat mutations in human disease.","volume":"256","author":"Caskey","year":"1992","journal-title":"Science"},{"key":"2019041121495735000_R236","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/hmg\/8.6.977","article-title":"PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival.","volume":"8","author":"Waragai","year":"1999","journal-title":"Hum Mol Genet"},{"key":"2019041121495735000_R237","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1432-1033.1995.308_c.x","article-title":"Transcriptional activation and repression, two properties of the lymphoid-specific transcription factor Oct-2a.","volume":"234","author":"Friedl","year":"1995","journal-title":"Eur J Biochem"},{"key":"2019041121495735000_R238","doi-asserted-by":"crossref","first-page":"13927","DOI":"10.1074\/jbc.271.24.13927","article-title":"Mapping of the transcriptional repression domain of the lymphoid- specific transcription factor oct-2A.","volume":"271","author":"Friedl","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R239","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-5793(97)01184-8","article-title":"The different inhibitory domains of the Oct-2 transcription factor have distinct functional activities.","volume":"416","author":"Gay","year":"1997","journal-title":"FEBS Lett"},{"key":"2019041121495735000_R240","doi-asserted-by":"crossref","first-page":"7633","DOI":"10.1128\/MCB.14.11.7633","article-title":"Repression of a herpes simplex virus immediate-early promoter by the Oct-2 transcription factor is dependent on an inhibitory region at the N terminus of the protein.","volume":"14","author":"Lillycrop","year":"1994","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R241","doi-asserted-by":"crossref","first-page":"20853","DOI":"10.1074\/jbc.271.34.20853","article-title":"The ability of the inhibitory domain of the POU family transcription factor Oct-2 to interfere with promoter activation by different classes of activation domains is dependent upon the nature of the basal promoter elements.","volume":"271","author":"Liu","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R242","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1093\/nar\/26.10.2464","article-title":"Adjacent proline residues in the inhibitory domain of the Oct-2 transcription factor play distinct functional roles.","volume":"26","author":"Liu","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R243","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0955-0674(99)80046-5","article-title":"Gene activation by histone and factor acetyltransferases.","volume":"11","author":"Berger","year":"1999","journal-title":"Curr Opin Cell Biol"},{"key":"2019041121495735000_R244","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1101\/gad.14.1.45","article-title":"Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.","volume":"14","author":"Huang","year":"2000","journal-title":"Genes Dev"},{"key":"2019041121495735000_R245","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/387043a0","article-title":"A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.","volume":"387","author":"Heinzel","year":"1997","journal-title":"Nature"},{"key":"2019041121495735000_R246","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/377397a0","article-title":"Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.","volume":"377","author":"Horlein","year":"1995","journal-title":"Nature"},{"key":"2019041121495735000_R247","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1097-2765(00)80111-2","article-title":"SAP30, a component of the mSin3 corepressor complex involved in N-CoR- mediated repression by specific transcription factors.","volume":"2","author":"Laherty","year":"1998","journal-title":"Mol Cell"},{"key":"2019041121495735000_R248","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0925-4773(98)00229-9","article-title":"A model for the development of the hypothalamic-pituitary axis: transcribing the hypophysis.","volume":"81","author":"Kioussi","year":"1999","journal-title":"Mech Dev"},{"key":"2019041121495735000_R249","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0955-0674(96)80085-8","article-title":"The hypothalamic-pituitary axis: co-development of two organs.","volume":"8","author":"Treier","year":"1996","journal-title":"Curr Opin Cell Biol"},{"key":"2019041121495735000_R250","doi-asserted-by":"crossref","first-page":"29335","DOI":"10.1016\/S0021-9258(18)43877-X","article-title":"Pit-1 determines cell types during development of the anterior pituitary gland. A model for transcriptional regulation of cell phenotypes in mammalian organogenesis.","volume":"269","author":"Andersen","year":"1994","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R251","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1006\/dbio.1994.1211","article-title":"The contribution of both forebrain and midbrain crest cells to the mesenchyme in the frontonasal mass of mouse embryos.","volume":"164","author":"Osumi-Yamashita","year":"1994","journal-title":"Dev Biol"},{"key":"2019041121495735000_R252","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00210884","article-title":"Effects of brain and mesenchyme upon the cytogenesis of rat adenohypophysis in vitro. I. Differentiation of adrenocorticotropes.","volume":"227","author":"Watanabe","year":"1982","journal-title":"Cell Tissue Res"},{"key":"2019041121495735000_R253","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF00225562","article-title":"Effects of brain and mesenchyme upon the cytogenesis of rat adenohypophysis in vitro. II. Differentiation of LH cells.","volume":"242","author":"Watanabe","year":"1985","journal-title":"Cell Tissue Res"},{"key":"2019041121495735000_R254","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/dbio.1999.9386","article-title":"Tissue interactions in the induction of anterior pituitary: role of the ventral diencephalon, mesenchyme, and notochord.","volume":"213","author":"Gleiberman","year":"1999","journal-title":"Dev Biol"},{"key":"2019041121495735000_R255","first-page":"254","article-title":"[The distribution of competence for adenohypophysis development in the ectoderm of chick embryos].","volume":"21","author":"Fedtsova","year":"1990","journal-title":"Ontogenez"},{"key":"2019041121495735000_R256","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/cne.903550207","article-title":"Model of forebrain regionalization based on spatiotemporal patterns of POU-III homeobox gene expression, birthdates, and morphological features.","volume":"355","author":"Alvarez-Bolado","year":"1995","journal-title":"J Comp Neurol"},{"key":"2019041121495735000_R257","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/338161a0","article-title":"Origin of luteinizing hormone-releasing hormone neurons.","volume":"338","author":"Schwanzel-Fukuda","year":"1989","journal-title":"Nature"},{"key":"2019041121495735000_R258","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/42.8.8027530","article-title":"In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development.","volume":"42","author":"Japon","year":"1994","journal-title":"J Histochem Cytochem"},{"key":"2019041121495735000_R259","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0012-1606(79)90226-4","article-title":"An immunohistochemical study on the cytogenesis of adenohypophysial cells in fetal rats.","volume":"68","author":"Watanabe","year":"1979","journal-title":"Dev Biol"},{"key":"2019041121495735000_R260","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1210\/mend-3-8-1313","article-title":"Analysis of proopiomelanocortin gene expression during prenatal development of the rat pituitary gland.","volume":"3","author":"Lugo","year":"1989","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R261","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1101\/gad.12.11.1691","article-title":"Multistep signaling requirements for pituitary organogenesis in vivo.","volume":"12","author":"Treier","year":"1998","journal-title":"Genes Dev"},{"key":"2019041121495735000_R262","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1242\/dev.125.23.4835","article-title":"Formation of Rathke\u2019s pouch requires dual induction from the diencephalon.","volume":"125","author":"Takuma","year":"1998","journal-title":"Development"},{"key":"2019041121495735000_R263","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/dev.125.6.1005","article-title":"Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary.","volume":"125","author":"Ericson","year":"1998","journal-title":"Development"},{"key":"2019041121495735000_R264","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/342945a0","article-title":"Dissection of functional domains of the pituitary-specific transcription factor GHF-1.","volume":"342","author":"Theill","year":"1989","journal-title":"Nature"},{"key":"2019041121495735000_R265","first-page":"241","article-title":"Functional isoforms of Pit-1 generated by alternative messenger RNA splicing.","volume":"6","author":"Konzak","year":"1992","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R266","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/nar\/20.6.1355","article-title":"An alternatively spliced Pit-1 isoform altered in its ability to trans-activate.","volume":"20","author":"Morris","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R267","first-page":"374","article-title":"An alternatively spliced form of Pit-1 represses prolactin gene expression.","volume":"8","author":"Day","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R268","doi-asserted-by":"crossref","first-page":"20818","DOI":"10.1016\/S0021-9258(19)36858-9","article-title":"A thyrotrope-specific variant of Pit-1 transactivates the thyrotropin \u03b2 promoter.","volume":"268","author":"Haugen","year":"1993","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R269","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1002\/j.1460-2075.1992.tb05285.x","article-title":"Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins.","volume":"11","author":"Theill","year":"1992","journal-title":"EMBO J"},{"key":"2019041121495735000_R270","doi-asserted-by":"crossref","first-page":"10256","DOI":"10.1073\/pnas.93.19.10256","article-title":"Selective constraints on the activation domain of transcription factor Pit-1.","volume":"93","author":"Majumdar","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R271","doi-asserted-by":"crossref","first-page":"28925","DOI":"10.1074\/jbc.271.46.28925","article-title":"A 26-amino acid insertion domain defines a functional transcription switch motif in Pit-1\u03b2.","volume":"271","author":"Diamond","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R272","first-page":"1574","article-title":"The combination of Pit-1 and Pit-1T have a synergistic stimulatory effect on the thyrotropin beta-subunit promoter but not the growth hormone or prolactin promoters.","volume":"8","author":"Haugen","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R273","doi-asserted-by":"crossref","first-page":"28733","DOI":"10.1074\/jbc.270.48.28733","article-title":"Activin increases phosphorylation and decreases stability of the transcription factor Pit-1 in MtTW15 somatotrope cells.","volume":"270","author":"Gaddy-Kurten","year":"1995","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R274","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0092-8674(90)90095-V","article-title":"Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity.","volume":"60","author":"Dolle","year":"1990","journal-title":"Cell"},{"key":"2019041121495735000_R275","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1101\/gad.3.7.946","article-title":"A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally.","volume":"3","author":"Mangalam","year":"1989","journal-title":"Genes Dev"},{"key":"2019041121495735000_R276","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1126\/science.2831625","article-title":"Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor.","volume":"239","author":"Nelson","year":"1988","journal-title":"Science"},{"key":"2019041121495735000_R277","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1128\/MCB.15.12.7010","article-title":"The human growth hormone gene is regulated by a multicomponent locus control region.","volume":"15","author":"Jones","year":"1995","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R278","doi-asserted-by":"crossref","first-page":"10655","DOI":"10.1073\/pnas.95.18.10655","article-title":"DNase I-hypersensitive sites I and II of the human growth hormone locus control region are a major developmental activator of somatotrope gene expression.","volume":"95","author":"Bennani-Baiti","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R279","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1210\/mend.13.8.0332","article-title":"A role for A\/T-rich sequences and Pit-1\/GHF-1 in a distal enhancer located in the human growth hormone locus control region with preferential pituitary activity in culture and transgenic mice.","volume":"13","author":"Jin","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R280","doi-asserted-by":"crossref","first-page":"35725","DOI":"10.1074\/jbc.274.50.35725","article-title":"Pit-1 binding sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gene activation.","volume":"274","author":"Shewchuk","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R281","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/jcb.240500202","article-title":"Homeotic protein binding sites, origins of replication, and nuclear matrix anchorage sites share the ATTA and ATTTA motifs.","volume":"50","author":"Boulikas","year":"1992","journal-title":"J Cell Biochem"},{"key":"2019041121495735000_R282","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/(SICI)1097-4644(19990301)72:3<322::AID-JCB2>3.0.CO;2-9","article-title":"Subnuclear partitioning and functional regulation of the Pit-1 transcription factor.","volume":"72","author":"Mancini","year":"1999","journal-title":"J Cell Biochem"},{"key":"2019041121495735000_R283","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1126\/science.1677216","article-title":"Function of the homeodomain protein GHF1 in pituitary cell proliferation.","volume":"253","author":"Castrillo","year":"1991","journal-title":"Science"},{"key":"2019041121495735000_R284","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1210\/mend.13.5.0275","article-title":"The tissue-specific transcription factor Pit-1\/GHF-1 binds to the c-fos serum response element and activates c-fos transcription.","volume":"13","author":"Gaiddon","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R285","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/360765a0","article-title":"Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth.","volume":"360","author":"Lin","year":"1992","journal-title":"Nature"},{"key":"2019041121495735000_R286","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1210\/mend.12.2.0057","article-title":"Structure and regulation of the human growth hormone-releasing hormone receptor gene.","volume":"12","author":"Petersenn","year":"1998","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R287","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1210\/endo.137.4.8625907","article-title":"Developmental regulation of pituitary growth hormone-releasing hormone receptor gene expression in the rat.","volume":"137","author":"Korytko","year":"1996","journal-title":"Endocrinology"},{"key":"2019041121495735000_R288","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/dbio.1996.8472","article-title":"The Pit-1 gene is regulated by distinct early and late pituitary-specific enhancers.","volume":"182","author":"DiMattia","year":"1997","journal-title":"Dev Biol"},{"key":"2019041121495735000_R289","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1006\/dbio.1995.8040","article-title":"The Ames dwarf gene is required for Pit-1 gene activation.","volume":"172","author":"Andersen","year":"1995","journal-title":"Dev Biol"},{"key":"2019041121495735000_R290","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1101\/gad.3.7.959","article-title":"Cell-specific expression of the prolactin gene in transgenic mice is controlled by synergistic interactions between promoter and enhancer elements.","volume":"3","author":"Crenshaw III","year":"1989","journal-title":"Genes Dev"},{"key":"2019041121495735000_R291","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1128\/MCB.16.8.4366","article-title":"A soluble transcription factor, Oct-1, is also found in the insoluble nuclear matrix and possesses silencing activity in its alanine-rich domain.","volume":"16","author":"Kim","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R292","doi-asserted-by":"crossref","first-page":"27541","DOI":"10.1074\/jbc.273.42.27541","article-title":"Role of GHF-1 in the regulation of the rat growth hormone gene promoter by thyroid hormone and retinoic acid receptors.","volume":"273","author":"Palomino","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R293","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1101\/gad.7.9.1674","article-title":"Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression.","volume":"7","author":"Lipkin","year":"1993","journal-title":"Genes Dev"},{"key":"2019041121495735000_R294","doi-asserted-by":"crossref","first-page":"21484","DOI":"10.1074\/jbc.271.35.21484","article-title":"CCAAT\/enhancer-binding protein alpha activation of the rat growth hormone promoter in pituitary progenitor GHFT1\u20135 cells.","volume":"271","author":"Schaufele","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R295","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1210\/mend.13.6.0298","article-title":"Regulation of estrogen receptor activation of the prolactin enhancer\/promoter by antagonistic activation function-2-interacting proteins.","volume":"13","author":"Schaufele","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R296","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1210\/mend.11.9.9978","article-title":"Activities in Pit-1 determine whether receptor interacting protein 140 activates or inhibits Pit-1\/nuclear receptor transcriptional synergy.","volume":"11","author":"Chuang","year":"1997","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R297","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1128\/MCB.15.5.2849","article-title":"Functional interaction of c-Ets-1 and GHF-1\/Pit-1 mediates Ras activation of pituitary-specific gene expression: mapping of the essential c-Ets-1 domain.","volume":"15","author":"Bradford","year":"1995","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R298","doi-asserted-by":"crossref","first-page":"24639","DOI":"10.1074\/jbc.271.40.24639","article-title":"GHF-1\/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1\/GHF-1 response element.","volume":"271","author":"Bradford","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R299","doi-asserted-by":"crossref","first-page":"20930","DOI":"10.1074\/jbc.270.36.20930","article-title":"A composite Ets\/Pit-1 binding site in the prolactin gene can mediate transcriptional responses to multiple signal transduction pathways.","volume":"270","author":"Howard","year":"1995","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R300","doi-asserted-by":"crossref","first-page":"31909","DOI":"10.1074\/jbc.273.48.31909","article-title":"Selective inhibition of prolactin gene transcription by the ETS-2 repressor factor.","volume":"273","author":"Day","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R301","doi-asserted-by":"crossref","first-page":"23366","DOI":"10.1016\/S0021-9258(19)49472-6","article-title":"An AP-1-like factor and the pituitary-specific factor Pit-1 are both necessary to mediate hormonal induction of human thyrotropin beta gene expression.","volume":"268","author":"Kim","year":"1993","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R302","first-page":"1447","article-title":"INSIGHT: Pit-1\/GHF-1: a pituitary-specific transcription factor linking general signaling pathways to cell-specific gene expression.","volume":"8","author":"Gutierrez-Hartmann","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R303","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1172\/JCI7308","article-title":"CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression.","volume":"104","author":"Cohen","year":"1999","journal-title":"J Clin Invest"},{"key":"2019041121495735000_R304","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/0303-7207(91)90110-E","article-title":"Either isoform of the dopamine D2 receptor can mediate dopaminergic repression of the rat prolactin promoter","volume":"79","author":"McChesney","year":"1991","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121495735000_R305","first-page":"1566","article-title":"A Pit-1 phosphorylation mutant can mediate both basal and induced prolactin and growth hormone promoter activity.","volume":"8","author":"Fischberg","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R306","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1210\/mend.13.2.0227","article-title":"Reconstitution of the protein kinase A response of the rat prolactin promoter: differential effects of distinct Pit-1 isoforms and functional interaction with Oct-1.","volume":"13","author":"Diamond","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R307","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1210\/mend-5-10-1488","article-title":"Mediation by calcium of thyrotropin-releasing hormone action on the prolactin promoter via transcription factor pit-1.","volume":"5","author":"Yan","year":"1991","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R308","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1210\/mend-5-4-535","article-title":"Thyrotropin-releasing hormone action on the prolactin promoter is mediated by the POU protein pit-1.","volume":"5","author":"Yan","year":"1991","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R309","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0167-4781(93)90071-K","article-title":"The POU-domain protein Oct-1 is widely expressed in adult rat organs.","volume":"1171","author":"Kambe","year":"1993","journal-title":"Biochim Biophys Acta"},{"key":"2019041121495735000_R310","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/(SICI)1097-4644(19980301)68:3<309::AID-JCB3>3.0.CO;2-Y","article-title":"Oct-1 enhances the in vitro replication of a mammalian autonomously replicating DNA sequence.","volume":"68","author":"Matheos","year":"1998","journal-title":"J Cell Biochem"},{"key":"2019041121495735000_R311","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1128\/JVI.64.11.5510-5518.1990","article-title":"Transcription factors NFI and NFIII\/oct-1 function independently, employing different mechanisms to enhance adenovirus DNA replication.","volume":"64","author":"Mul","year":"1990","journal-title":"J Virol"},{"key":"2019041121495735000_R312","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0169-328X(94)00183-F","article-title":"Down regulation of the octamer binding protein Oct-1 during growth arrest and differentiation of a neuronal cell line.","volume":"28","author":"Lakin","year":"1995","journal-title":"Brain Res Mol Brain Res"},{"key":"2019041121495735000_R313","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1242\/dev.109.2.349","article-title":"Structure and expression of the mouse Oct2a and Oct2b, two differentially spliced products of the same gene.","volume":"109","author":"Hatzopoulos","year":"1990","journal-title":"Development"},{"key":"2019041121495735000_R314","first-page":"848","article-title":"Regulation of gonadotropin-releasing hormone transcription by protein kinase C is mediated by evolutionarily conserved promoter-proximal elements.","volume":"9","author":"Eraly","year":"1995","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R315","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0303-7207(95)03723-3","article-title":"Direct binding of progesterone receptor to nonconsensus DNA sequences represses rat GnRH.","volume":"117","author":"Kepa","year":"1996","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121495735000_R316","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/j.1460-2075.1996.tb00386.x","article-title":"NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression.","volume":"15","author":"Belsham","year":"1996","journal-title":"EMBO J"},{"key":"2019041121495735000_R317","first-page":"212","article-title":"Transcription factors Oct-1 and C\/EBP\u03b2 (CCAAT\/enhancer-binding protein-\u03b2) are involved in the glutamate\/nitric oxide\/cyclic- guanosine 5\u2032-monophosphatemediated repression of mediated repression of gonadotropinreleasing hormone gene expression.","volume":"14","author":"Belsham","year":"2000","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R318","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0024-3205(97)01172-7","article-title":"Nitric oxide inhibits Oct-1 DNA binding activity in cultured vascular smooth muscle cells.","volume":"62","author":"Liu","year":"1998","journal-title":"Life Sci"},{"key":"2019041121495735000_R319","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0166-4328(99)00080-7","article-title":"Regulation of gonadotropin-releasing hormone gene transcription.","volume":"105","author":"Chandran","year":"1999","journal-title":"Behav Brain Res"},{"key":"2019041121495735000_R320","doi-asserted-by":"crossref","first-page":"20412","DOI":"10.1074\/jbc.271.34.20412","article-title":"Glucocorticoid repression of the mouse gonadotropin-releasing hormone gene is mediated by promoter elements that are recognized by heteromeric complexes containing glucocorticoid receptor.","volume":"271","author":"Chandran","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R321","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02740606","article-title":"VIP: molecular biology and neurobiological function.","volume":"3","author":"Gozes","year":"1989","journal-title":"Mol Neurobiol"},{"key":"2019041121495735000_R322","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0301-0082(84)90022-4","article-title":"Neurobiological and neuroendocrine functions of the vasoactive intestinal peptide (VIP).","volume":"22","author":"Rostene","year":"1984","journal-title":"Prog Neurobiol"},{"key":"2019041121495735000_R323","first-page":"4105","article-title":"Cloning, sequencing, and functional analysis of the 5\u2032-flanking region of the rat 3\u03b1 -hydroxysteroid\/dihydrodiol dehydrogenase gene.","volume":"55","author":"Lin","year":"1995","journal-title":"Cancer Res"},{"key":"2019041121495735000_R324","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.4049\/jimmunol.164.5.2550","article-title":"An upstream oct-1- and oct-2-binding silencer governs B29 (Ig\u03b2) gene expression.","volume":"164","author":"Malone","year":"2000","journal-title":"J Immunol"},{"key":"2019041121495735000_R325","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1091\/mbc.8.12.2407","article-title":"Dissociation of Oct-1 from the nuclear peripheral structure induces the cellular aging-associated collagenase gene expression.","volume":"8","author":"Imai","year":"1997","journal-title":"Mol Biol Cell"},{"key":"2019041121495735000_R326","doi-asserted-by":"crossref","first-page":"8397","DOI":"10.1021\/bi00084a003","article-title":"Nuclear matrix association of multiple sequence-specific DNA binding activities related to SP-1, ATF, CCAAT, C\/EBP, OCT-1, and AP-1.","volume":"32","author":"van Wijnen","year":"1993","journal-title":"Biochemistry"},{"key":"2019041121495735000_R327","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0896-6273(92)90282-I","article-title":"Mini-Oct and Oct-2c: two novel, functionally diverse murine Oct-2 gene products are differentially expressed in the CNS.","volume":"8","author":"Stoykova","year":"1992","journal-title":"Neuron"},{"key":"2019041121495735000_R328","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/340035a0","article-title":"Aug 24;340(6235):662].","volume":"340","author":"He","year":"1989","journal-title":"Nature"},{"key":"2019041121495735000_R329","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/nar\/19.1.43","article-title":"Multiple Oct2 isoforms are generated by alternative splicing.","volume":"19","author":"Wirth","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"2019041121495735000_R330","doi-asserted-by":"crossref","first-page":"24960","DOI":"10.1016\/S0021-9258(19)73991-X","article-title":"Alternative splicing of the Oct-2 transcription factor RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer\/TAATGARAT-containing promoters.","volume":"267","author":"Lillycrop","year":"1992","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R331","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/1074-7613(94)90035-3","article-title":"Feb;2(2):following 203].","volume":"1","author":"Corcoran","year":"1995","journal-title":"Immunity"},{"key":"2019041121495735000_R332","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1101\/gad.7.4.570","article-title":"Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival.","volume":"7","author":"Corcoran","year":"1993","journal-title":"Genes Dev"},{"key":"2019041121495735000_R333","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0169-328X(95)00128-F","article-title":"Nerve growth factor-regulated properties of sensory neurones in Oct-2 null mutant mice.","volume":"33","author":"Ninkina","year":"1995","journal-title":"Brain Res Mol Brain Res"},{"key":"2019041121495735000_R334","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/j.1460-2075.1992.tb05320.x","article-title":"Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression.","volume":"11","author":"Mathis","year":"1992","journal-title":"EMBO J"},{"key":"2019041121495735000_R335","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1073\/pnas.89.8.3285","article-title":"RHS2, a POU domain-containing gene, and its expression in developing and adult rat.","volume":"89","author":"Le Moine","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R336","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0925-4773(95)00472-6","article-title":"The restricted expression pattern of the POU factor Oct-6 during early development of the mouse nervous system.","volume":"54","author":"Zwart","year":"1996","journal-title":"Mech Dev"},{"key":"2019041121495735000_R337","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1523\/JNEUROSCI.16-01-00262.1996","article-title":"Sequence of stress-induced alterations in indices of synaptic and transcriptional activation in parvocellular neurosecretory neurons.","volume":"16","author":"Kovacs","year":"1996","journal-title":"J Neurosci"},{"key":"2019041121495735000_R338","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0925-4773(99)00067-2","article-title":"An octamer-binding site is crucial for the activity of an enhancer active at the embryonic met-\/mesencephalic junction.","volume":"84","author":"Mihailescu","year":"1999","journal-title":"Mech Dev"},{"key":"2019041121495735000_R339","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/(SICI)1097-4547(19980615)52:6<625::AID-JNR1>3.0.CO;2-A","article-title":"Expression of the POU transcription factor Brn-5 is an early event in the terminal differentiation of CNS neurons.","volume":"52","author":"Cui","year":"1998","journal-title":"J Neurosci Res"},{"key":"2019041121495735000_R340","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1022512819023","article-title":"Transgenic and transcriptional studies on neurosecretory cell gene expression.","volume":"18","author":"Waller","year":"1998","journal-title":"Cell Mol Neurobiol"},{"key":"2019041121495735000_R341","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1210\/mend.13.8.0327","article-title":"A requirement for the POU transcription factor, Brn-2, in corticotropin- releasing hormone expression in a neuronal cell line.","volume":"13","author":"Ramkumar","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R342","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1101\/gad.12.20.3264","article-title":"Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1.","volume":"12","author":"Michaud","year":"1998","journal-title":"Genes Dev"},{"key":"2019041121495735000_R343","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1126\/science.285.5432.1408","article-title":"Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness.","volume":"285","author":"Minowa","year":"1999","journal-title":"Science"},{"key":"2019041121495735000_R344","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1523\/JNEUROSCI.19-14-05980.1999","article-title":"Targeted mutagenesis of the POU-domain gene Brn4\/Pou3f4 causes developmental defects in the inner ear.","volume":"19","author":"Phippard","year":"1999","journal-title":"J Neurosci"},{"key":"2019041121495735000_R345","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0896-6273(89)90247-X","article-title":"SCIP: a glial POU domain gene regulated by cyclic AMP.","volume":"3","author":"Monuki","year":"1989","journal-title":"Neuron"},{"key":"2019041121495735000_R346","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.1975954","article-title":"Expression and activity of the POU transcription factor SCIP.","volume":"249","author":"Monuki","year":"1990","journal-title":"Science"},{"key":"2019041121495735000_R347","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1126\/science.273.5274.507","article-title":"The POU factor Oct-6 and Schwann cell differentiation.","volume":"273","author":"Jaegle","year":"1996","journal-title":"Science"},{"key":"2019041121495735000_R348","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1101\/gad.10.14.1751","article-title":"Tst-1\/Oct-6\/SCIP regulates a unique step in peripheral myelination and is required for normal respiration.","volume":"10","author":"Bermingham Jr","year":"1996","journal-title":"Genes Dev"},{"key":"2019041121495735000_R349","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/345686a0","article-title":"A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.","volume":"345","author":"Rosner","year":"1990","journal-title":"Nature"},{"key":"2019041121495735000_R350","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1432-1033.1994.tb18676.x","article-title":"A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues.","volume":"220","author":"Wey","year":"1994","journal-title":"Eur J Biochem"},{"key":"2019041121495735000_R351","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1523\/JNEUROSCI.14-03-01584.1994","article-title":"NMDA receptor activation in differentiating cerebellar cell cultures regulates the expression of a new POU gene, Cns-1.","volume":"14","author":"Bulleit","year":"1994","journal-title":"J Neurosci"},{"key":"2019041121495735000_R352","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1006\/bbrc.1997.6996","article-title":"Expression of the POU transcription factor Brn-5 inhibits proliferation of NG108\u201315 cells.","volume":"236","author":"Cui","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121495735000_R353","first-page":"4362","article-title":"Heritable disorders of pituitary development.","volume":"84","author":"Parks","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121495735000_R354","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S1043-2760(99)00180-0","article-title":"Transcription factors and hypopituitarism.","volume":"10","author":"Cohen","year":"1999","journal-title":"Trends Endocrinol Metab"},{"key":"2019041121495735000_R355","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1651-2227.1999.tb14401.x","article-title":"Combined pituitary hormone deficiency: role of Pit-1 and Prop-1.","volume":"88","author":"Pfaffle","year":"1999","journal-title":"Acta Paediatr Suppl"},{"key":"2019041121495735000_R356","first-page":"30","author":"Radovick","year":"1998"},{"key":"2019041121495735000_R357","first-page":"3127","article-title":"The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency.","volume":"80","author":"de Zegher","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121495735000_R358","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1126\/science.257.5073.1118","article-title":"Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia.","volume":"257","author":"Pfaffle","year":"1992","journal-title":"Science"},{"key":"2019041121495735000_R359","first-page":"2790","article-title":"A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency.","volume":"81","author":"Pellegrini-Bouiller","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121495735000_R360","first-page":"2079","article-title":"Pro239Ser: a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth hormone, prolactin, and thyrotropin deficiency.","volume":"83","author":"Pernasetti","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121495735000_R361","first-page":"98","article-title":"Central hypothyroidism reveals compound heterozygous mutations in the Pit-1 gene.","volume":"49","author":"Brown","year":"1998","journal-title":"Horm Res"},{"key":"2019041121495735000_R362","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ng0492-56","article-title":"Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene.","volume":"1","author":"Tatsumi","year":"1992","journal-title":"Nat Genet"},{"key":"2019041121495735000_R363","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0006-291X(92)92281-2","article-title":"Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency.","volume":"189","author":"Ohta","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121495735000_R364","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1507\/endocrj.42.351","article-title":"A novel E250X mutation of the PIT1 gene in a patient with combined pituitary hormone deficiency.","volume":"42","author":"Irie","year":"1995","journal-title":"Endocr J"},{"key":"2019041121495735000_R365","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s004310050722","article-title":"Pituitary dwarfism in the R271W Pit-1 gene mutation.","volume":"156","author":"Aarskog","year":"1997","journal-title":"Eur J Pediatr"},{"key":"2019041121495735000_R366","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.257.5073.1115","article-title":"A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.","volume":"257","author":"Radovick","year":"1992","journal-title":"Science"},{"key":"2019041121495735000_R367","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1093\/hmg\/3.9.1565","article-title":"Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype.","volume":"3","author":"Okamoto","year":"1994","journal-title":"Hum Mol Genet"},{"key":"2019041121495735000_R368","first-page":"679","article-title":"A \u201chot spot\u201d in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates.","volume":"80","author":"Cohen","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121495735000_R369","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s004310050723","article-title":"Combined pituitary deficiencies of growth hormone, thyroid stimulating hormone and prolactin due to Pit-1 gene mutation: a case report.","volume":"156","author":"Holl","year":"1997","journal-title":"Eur J Pediatr"},{"key":"2019041121495735000_R370","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/(SICI)1096-8628(19980605)77:5<360::AID-AJMG4>3.0.CO;2-R","article-title":"Rarity of PIT1 involvement in children from Russia with combined pituitary hormone deficiency.","volume":"77","author":"Fofanova","year":"1998","journal-title":"Am J Med Genet"},{"key":"2019041121495735000_R371","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0022-3476(98)70405-6","article-title":"Severe congenital hypopituitarism with low prolactin levels and age-dependent anterior pituitary hypoplasia: a clue to a PIT-1 mutation.","volume":"132","author":"Ward","year":"1998","journal-title":"J Pediatr"},{"key":"2019041121495735000_R372","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1210\/mend.13.3.0251","article-title":"Defective retinoic acid regulation of the Pit-1 gene enhancer: a novel mechanism of combined pituitary hormone deficiency.","volume":"13","author":"Cohen","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041121495735000_R373","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/384327a0","article-title":"Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.","volume":"384","author":"Sornson","year":"1996","journal-title":"Nature"},{"key":"2019041121495735000_R374","first-page":"390","article-title":"Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301\u2013302delAG) in the prophet of Pit-1 gene.","volume":"85","author":"Pernasetti","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121495735000_R375","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1126\/science.7839145","article-title":"Association between X-linked mixed deafness and mutations in the POU domain gene POU3F4.","volume":"267","author":"de Kok","year":"1995","journal-title":"Science"},{"key":"2019041121495735000_R376","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1210\/jcem.84.7.5974","article-title":"Prop-1 gene expression in human pituitary tumors.","volume":"84","author":"Nakamura","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121495735000_R377","first-page":"11","article-title":"Expression of Pit-1 mRNA and activin\/inhibin subunits in clinically nonfunctioning pituitary adenomas. In situ hybridization and immunohistochemical analysis.","volume":"50","author":"Sanno","year":"1998","journal-title":"Horm Res"},{"key":"2019041121495735000_R378","first-page":"73","article-title":"Expression of human Pit-1 product in the human pituitary and pituitary adenomas. Immunohistochemical studies using an antibody against synthetic human Pit-1 product.","volume":"120","author":"Sanno","year":"1996","journal-title":"Arch Pathol Lab Med"},{"key":"2019041121495735000_R379","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s004010050424","article-title":"In situ hybridization analysis of Pit-1 mRNA and hormonal production in human pituitary adenomas.","volume":"91","author":"Sanno","year":"1996","journal-title":"Acta Neuropathol (Berl)"},{"key":"2019041121495735000_R380","first-page":"526","article-title":"Expression of Pit-1 and estrogen receptor messenger RNA in prolactin- producing pituitary adenomas.","volume":"9","author":"Sanno","year":"1996","journal-title":"Mod Pathol"},{"key":"2019041121495735000_R381","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1365-2265.1996.00812.x","article-title":"Pit-1 gene expression in human pituitary adenomas using the reverse transcription polymerase chain reaction method.","volume":"45","author":"Yamada","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2019041121495735000_R382","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000185472","article-title":"Pit-1 gene expression in human pituitary adenomas.","volume":"47","author":"Pellegrini-Bouiller","year":"1997","journal-title":"Horm Res"},{"key":"2019041121495735000_R383","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0167-0115(99)00048-8","article-title":"Quantitative analysis of growth-related factors in human pituitary adenomas. Lowered insulin-like growth factor-I and its receptor mRNA in growth hormone-producing adenomas.","volume":"83","author":"Otsuka","year":"1999","journal-title":"Regul Pept"},{"key":"2019041121495735000_R384","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/00006123-199602000-00026","article-title":"Expression and alternative splicing of Pit-1 messenger ribonucleic acid in pituitary adenomas.","volume":"38","author":"Hamada","year":"1996","journal-title":"Neurosurgery"},{"key":"2019041121495735000_R385","first-page":"189","article-title":"Pit-1 gene expression in the human pituitary and pituitary adenomas.","volume":"79","author":"Pellegrini","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121495735000_R386","doi-asserted-by":"crossref","first-page":"22919","DOI":"10.1016\/S0021-9258(18)54442-2","article-title":"Inhibitory control of prolactin and Pit-1 gene promoters by dopamine. Dual signaling pathways required for D2 receptor-regulated expression of the prolactin gene.","volume":"266","author":"Elsholtz","year":"1991","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R387","doi-asserted-by":"crossref","first-page":"12007","DOI":"10.1016\/S0021-9258(17)32674-1","article-title":"G(i) \u03b1 2- and G(o) \u03b1-mediated signaling in the Pit-1-dependent inhibition of the prolactin gene promoter. Control of transcription by dopamine D2 receptors.","volume":"269","author":"Lew","year":"1994","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R388","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1210\/endo.140.11.7118","article-title":"Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice.","volume":"140","author":"Asa","year":"1999","journal-title":"Endocrinology"},{"key":"2019041121495735000_R389","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000185468","article-title":"Abnormal transduction mechanisms in pituitary adenomas.","volume":"47","author":"Barlier","year":"1997","journal-title":"Horm Res"},{"key":"2019041121495735000_R390","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1210\/endo.137.4.8625901","article-title":"Constitutively active G(S) alpha-subunits stimulate Pit-1 promoter activity via a protein kinase A-mediated pathway acting through deoxyribonucleic acid binding sites both for Pit-1 and for adenosine 3\u2032,5\u2032-monophosphate response element-binding protein.","volume":"137","author":"Gaiddon","year":"1996","journal-title":"Endocrinology"},{"key":"2019041121495735000_R391","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1210\/endo.136.10.7664652","article-title":"Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3\u2032,5\u2032-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A.","volume":"136","author":"Gaiddon","year":"1995","journal-title":"Endocrinology"},{"key":"2019041121495735000_R392","first-page":"2759","article-title":"Impact of gsp oncogene on the expression of genes coding for Gs\u03b1, Pit-1, Gi2\u03b1, and somatostatin receptor 2 in human somatotroph adenomas: involvement in octreotide sensitivity.","volume":"84","author":"Barlier","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121495735000_R393","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1242\/dev.122.1.41","article-title":"Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke\u2019s pouch of the mouse embryo.","volume":"122","author":"Hermesz","year":"1996","journal-title":"Development"},{"key":"2019041121495735000_R394","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/477","article-title":"Mutations in the homeobox gene HESX1\/Hesx1 associated with septo-optic dysplasia in human and mouse.","volume":"19","author":"Dattani","year":"1998","journal-title":"Nat Genet"},{"key":"2019041121495735000_R395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1600001","article-title":"The role of corticotropin-releasing factor in depression and anxiety disorders.","volume":"160","author":"Arborelius","year":"1999","journal-title":"J Endocrinol"},{"key":"2019041121495735000_R396","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1750-3639.1998.tb00173.x","article-title":"The pathophysiology of fatal familial insomnia.","volume":"8","author":"Lugaresi","year":"1998","journal-title":"Brain Pathol"},{"key":"2019041121495735000_R397","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-3956(98)00049-1","article-title":"A review of endocrine changes in anorexia nervosa.","volume":"33","author":"Stoving","year":"1999","journal-title":"J Psychiatr Res"},{"key":"2019041121495735000_R398","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/j.1460-2075.1987.tb04847.x","article-title":"Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.","volume":"6","author":"Lefevre","year":"1987","journal-title":"EMBO J"},{"key":"2019041121495735000_R399","doi-asserted-by":"crossref","first-page":"20376","DOI":"10.1074\/jbc.274.29.20376","article-title":"Octamer-dependent in vivo expression of the endothelial cell-specific TIE2 gene.","volume":"274","author":"Fadel","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R400","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/1357-2725(95)00122-0","article-title":"Nuclear transcription factor Oct-1 binds to the 5\u2032-upstream region of CYP1A1 and negatively regulates its expression.","volume":"28","author":"Bhat","year":"1996","journal-title":"Int J Biochem Cell Biol"},{"key":"2019041121495735000_R401","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1042\/bj3190669","article-title":"Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter.","volume":"319","author":"Bingle","year":"1996","journal-title":"Biochem J"},{"key":"2019041121495735000_R402","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0303-7207(93)90165-G","article-title":"Proteins interacting with an androgen-responsive unit in the C3(1) gene intron.","volume":"94","author":"Celis","year":"1993","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121495735000_R403","doi-asserted-by":"crossref","first-page":"15743","DOI":"10.1074\/jbc.271.26.15743","article-title":"Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.","volume":"271","author":"Chen","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R404","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.1128\/JVI.65.11.5933-5943.1991","article-title":"The enhancer of human papillomavirus type 16: binding sites for the ubiquitous transcription factors oct-1, NFA, TEF-2, NF1, and AP-1 participate in epithelial cell-specific transcription.","volume":"65","author":"Chong","year":"1991","journal-title":"J Virol"},{"key":"2019041121495735000_R405","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/0003-9861(92)90459-A","article-title":"Characterization of a high affinity octamer transcription factor binding site in the human lipoprotein lipase promoter.","volume":"298","author":"Currie","year":"1992","journal-title":"Arch Biochem Biophys"},{"key":"2019041121495735000_R406","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1074\/jbc.272.4.2396","article-title":"Oct-1 and CCAAT\/enhancer-binding protein (C\/EBP) bind to overlapping elements within the interleukin-8 promoter. The role of Oct-1 as a transcriptional repressor.","volume":"272","author":"Wu","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R407","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.4049\/jimmunol.161.3.1380","article-title":"Th2-specific protein\/DNA interactions at the proximal nuclear factor-AT site contribute to the functional activity of the human IL-4 promoter.","volume":"161","author":"Li-Weber","year":"1998","journal-title":"J Immunol"},{"key":"2019041121495735000_R408","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1074-7613(00)80424-0","article-title":"A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site.","volume":"6","author":"Duncliffe","year":"1997","journal-title":"Immunity"},{"key":"2019041121495735000_R409","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.1128\/MCB.10.10.5464","article-title":"The promoter of the human interleukin-2 gene contains two octamer- binding sites and is partially activated by the expression of Oct-2.","volume":"10","author":"Kamps","year":"1990","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R410","doi-asserted-by":"crossref","first-page":"12633","DOI":"10.1074\/jbc.273.20.12633","article-title":"Transcriptional regulation of interleukin-1\u03b2 gene by interleukin-1\u03b2 itself is mediated in part by Oct-1 in thymic stromal cells.","volume":"273","author":"Tseng","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R411","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.4049\/jimmunol.158.12.5833","article-title":"An octamer element functions as a regulatory element in the differentiation-responsive CD11c integrin gene promoter: OCT-2 inducibility during myelomonocytic differentiation.","volume":"158","author":"Lopez-Rodriguez","year":"1997","journal-title":"J Immunol"},{"key":"2019041121495735000_R412","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1046\/j.1471-4159.1996.67041352.x","article-title":"Identification of an octamer-1 transcription factor binding site in the promoter of the mouse mu-opioid receptor gene.","volume":"67","author":"Liang","year":"1996","journal-title":"J Neurochem"},{"key":"2019041121495735000_R413","doi-asserted-by":"crossref","first-page":"811","DOI":"10.4049\/jimmunol.163.2.811","article-title":"Complex regulation of Ly-6E gene transcription in T cells by IFNs.","volume":"163","author":"Khodadoust","year":"1999","journal-title":"J Immunol"},{"key":"2019041121495735000_R414","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.4049\/jimmunol.159.11.5441","article-title":"Cloning and analysis of the promoter region of CCR5, a coreceptor for HIV-1 entry.","volume":"159","author":"Moriuchi","year":"1997","journal-title":"J Immunol"},{"key":"2019041121495735000_R415","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1074\/jbc.274.8.4646","article-title":"Cloning and functional characterization of the 5\u2032-flanking region of the human monocyte chemoattractant protein-1 receptor (CCR2) gene. Essential role of 5\u2032-untranslated region in tissue-specific expression.","volume":"274","author":"Yamamoto","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R416","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0303-7207(97)00085-3","article-title":"Oct-1, silencer sequence, and GC box regulate thyroid hormone receptor \u03b2 1 promoter.","volume":"130","author":"Nagasawa","year":"1997","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121495735000_R417","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/dna.1997.16.45","article-title":"Involvement of an octamer-like sequence within a crucial region of the androgen-dependent Slp enhancer.","volume":"16","author":"Scarlett","year":"1997","journal-title":"DNA Cell Biol"},{"key":"2019041121495735000_R418","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1006\/bbrc.1994.2395","article-title":"The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells.","volume":"203","author":"Rosfjord","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121495735000_R419","doi-asserted-by":"crossref","first-page":"26069","DOI":"10.1074\/jbc.273.40.26069","article-title":"Functional map of a placenta-specific enhancer of the human leukemia inhibitory factor receptor gene.","volume":"273","author":"Wang","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R420","doi-asserted-by":"crossref","first-page":"15965","DOI":"10.1016\/S0021-9258(18)82346-8","article-title":"Regulation of the calcitonin\/calcitonin gene-related peptide gene by cell-specific synergy between helix-loop-helix and octamer-binding transcription factors.","volume":"268","author":"Tverberg","year":"1993","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R421","doi-asserted-by":"crossref","first-page":"31700","DOI":"10.1074\/jbc.274.44.31700","article-title":"Characterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity.","volume":"274","author":"Sebastian","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R422","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1182\/blood.V92.4.1247","article-title":"Oct-1 is involved in the transcriptional repression of the von Willebrand factor gene promoter.","volume":"92","author":"Schwachtgen","year":"1998","journal-title":"Blood"},{"key":"2019041121495735000_R423","doi-asserted-by":"crossref","first-page":"7601","DOI":"10.1073\/pnas.89.16.7601","article-title":"In vivo footprint analysis of the HLA-DRA gene promoter: cell-specific interaction at the octamer site and up-regulation of X box binding by interferon \u03b3.","volume":"89","author":"Wright","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R424","doi-asserted-by":"crossref","first-page":"7341","DOI":"10.1073\/pnas.86.19.7341","article-title":"Immunoglobulin enhancer and promoter motifs 5\u2032 of the B29 B-cell-specific gene.","volume":"86","author":"Hermanson","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121495735000_R425","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1128\/MCB.16.11.6160","article-title":"CRISP-3, a protein with homology to plant defense proteins, is expressed in mouse B cells under the control of Oct2.","volume":"16","author":"Pfisterer","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2019041121495735000_R426","doi-asserted-by":"crossref","first-page":"27823","DOI":"10.1074\/jbc.270.46.27823","article-title":"Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoter.","volume":"270","author":"Kim","year":"1995","journal-title":"J Biol Chem"},{"key":"2019041121495735000_R427","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.1016\/S0021-9258(18)53411-6","article-title":"Cell type- and stage-specific expression of the CD20\/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter.","volume":"268","author":"Thevenin","year":"1993","journal-title":"J Biol Chem"}],"container-title":["Endocrine Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/edrv\/article-pdf\/22\/1\/2\/8859919\/edrv0002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T15:09:59Z","timestamp":1688915399000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/edrv\/article\/22\/1\/2\/2423863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,1]]},"references-count":427,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,11,7]]},"published-print":{"date-parts":[[2001,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/edrv.22.1.0421","relation":{},"ISSN":["0163-769X","1945-7189"],"issn-type":[{"value":"0163-769X","type":"print"},{"value":"1945-7189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2,1]]}}}