{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:50:36Z","timestamp":1791618636697,"version":"4.3.4"},"reference-count":63,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,1]]},"DOI":"10.1210\/en.2002-221054","type":"journal-article","created":{"date-parts":[[2003,5,14]],"date-time":"2003-05-14T00:48:44Z","timestamp":1052873324000},"page":"2425-2436","source":"Crossref","is-referenced-by-count":339,"title":["Estrogen-Like Activity of Metals in Mcf-7 Breast Cancer Cells"],"prefix":"10.1210","volume":"144","author":[{"given":"Mary Beth","family":"Martin","sequence":"first","affiliation":[{"name":"Departments of Biochemistry and Molecular Biology (M.B.M., T.P., Y.R.A., J.C., M.L., S.D., A.S.) and Oncology, Washington, D.C. 20007"},{"name":"Lombardi Cancer Center (M.B.M., R.R., E.P., K.P., B.A.G., R.S.D., A.S.), Georgetown University;, Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Reiter","sequence":"additional","affiliation":[{"name":"Lombardi Cancer Center (M.B.M., R.R., E.P., K.P., B.A.G., R.S.D., A.S.), Georgetown University;, Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung","family":"Pham","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Molecular Biology (M.B.M., T.P., Y.R.A., J.C., M.L., S.D., A.S.) and Oncology, Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniris R.","family":"Avellanet","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Molecular Biology (M.B.M., T.P., Y.R.A., J.C., M.L., S.D., A.S.) and Oncology, Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Camara","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Molecular Biology (M.B.M., T.P., Y.R.A., J.C., M.L., S.D., A.S.) and Oncology, Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lahm","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Molecular Biology (M.B.M., T.P., Y.R.A., J.C., M.L., S.D., A.S.) and Oncology, Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Pentecost","sequence":"additional","affiliation":[{"name":"Lombardi Cancer Center (M.B.M., R.R., E.P., K.P., B.A.G., R.S.D., A.S.), Georgetown University;, Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Pratap","sequence":"additional","affiliation":[{"name":"Lombardi Cancer Center (M.B.M., R.R., E.P., K.P., B.A.G., R.S.D., A.S.), Georgetown University;, Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent A.","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Lombardi Cancer Center (M.B.M., R.R., E.P., K.P., B.A.G., R.S.D., A.S.), Georgetown University;, Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailaja","family":"Divekar","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Molecular Biology (M.B.M., T.P., Y.R.A., J.C., M.L., S.D., A.S.) and Oncology, Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross S.","family":"Dagata","sequence":"additional","affiliation":[{"name":"Lombardi Cancer Center (M.B.M., R.R., E.P., K.P., B.A.G., R.S.D., A.S.), Georgetown University;, Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime L.","family":"Bull","sequence":"additional","affiliation":[{"name":"Georgetown University School of Nursing and Health Studies (J.L.B., A.S.), Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Stoica","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Molecular Biology (M.B.M., T.P., Y.R.A., J.C., M.L., S.D., A.S.) and Oncology, Washington, D.C. 20007"},{"name":"Lombardi Cancer Center (M.B.M., R.R., E.P., K.P., B.A.G., R.S.D., A.S.), Georgetown University;, Washington, D.C. 20007"},{"name":"Georgetown University School of Nursing and Health Studies (J.L.B., A.S.), Washington, D.C. 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041120310225400_R1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1210\/edrv.22.3.0432","article-title":"Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals.","volume":"22","author":"McLachlan","year":"2001","journal-title":"Endocr Rev"},{"key":"2019041120310225400_R2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1289\/ehp.93101378","article-title":"Developmental effects of endocrine-disrupting chemicals in wildlife and humans.","volume":"101","author":"Colborn","year":"1993","journal-title":"Environ Health Perspect"},{"key":"2019041120310225400_R3","doi-asserted-by":"crossref","first-page":"16896","DOI":"10.1016\/S0021-9258(19)89474-7","article-title":"Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells.","volume":"269","author":"Garcia-Morales","year":"1994","journal-title":"J Biol Chem"},{"key":"2019041120310225400_R4","first-page":"545","article-title":"Activation of estrogen receptor-alpha by the heavy metal cadmium.","volume":"14","author":"Stoica","year":"2000","journal-title":"Mol Endocrinol"},{"key":"2019041120310225400_R5","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1210\/endo.141.10.7704","article-title":"Effect of arsenite on estrogen receptor-\u03b1 expression and activity in MCF-7 breast cancer cells.","volume":"141","author":"Stoica","year":"2000","journal-title":"Endocrinol"},{"key":"2019041120310225400_R6","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/1097-4644(20001101)79:2<282::AID-JCB110>3.0.CO;2-V","article-title":"Effects of selenite on estrogen receptor-\u03b1 expression and activity in MCF-7 breast cancer cells.","volume":"79","author":"Stoica","year":"2000","journal-title":"J Cell Biochem"},{"key":"2019041120310225400_R7","author":"Danielsen","year":"1991"},{"key":"2019041120310225400_R8","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.1016\/S0021-9258(18)42630-0","article-title":"Effect of replacement of \u201czinc fingers\u201d zinc on estrogen receptor DNA interactions.","volume":"267","author":"Predki","year":"1992","journal-title":"J Biol Chem"},{"key":"2019041120310225400_R9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1021\/bi00427a029","article-title":"Metal binding sites of the estradiol receptor from calf uterus and their possible role in the regulation of receptor function.","volume":"28","author":"Medici","year":"1989","journal-title":"Biochemistry"},{"key":"2019041120310225400_R10","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1095\/biolreprod31.3.531","article-title":"Effects of copper on cytoplasmic and nuclear binding of 17\u03b2-estradiol in rat uterus.","volume":"31","author":"Smith","year":"1984","journal-title":"Biol Reprod"},{"key":"2019041120310225400_R11","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3109\/10799899709039159","article-title":"Decrease of hormone binding capacity of estrogen receptor by calcium.","volume":"17","author":"Maaroufi","year":"1997","journal-title":"J Receptor Signal Transduct Res"},{"key":"2019041120310225400_R12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0015-0282(16)42498-2","article-title":"Effect of metal ions on the binding of 17\u03b2-estradiol to human endometrial cytosol.","volume":"28","author":"Young","year":"1977","journal-title":"Fertil Steril"},{"key":"2019041120310225400_R13","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1210\/mend-2-12-1157","article-title":"Regulation of the estrogen receptor in MCF-7 cells by estradiol.","volume":"2","author":"Saceda","year":"1988","journal-title":"Mol Endocrinol"},{"key":"2019041120310225400_R14","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.1093\/nar\/10.24.7895","article-title":"Cloning of cDNA sequences of hormone-regulated genes from MCF-7 human breast cancer cell line.","volume":"10","author":"Masiakowski","year":"1982","journal-title":"Nucleic Acids Res"},{"key":"2019041120310225400_R15","first-page":"2168","article-title":"Fibroblast growth factor 4 transfection of MCF-7 cells produces cell lines that are tumorigenic and metastatic in ovariectomized or tamoxifen-treated athymic nude mice.","volume":"53","author":"McLeskey","year":"1993","journal-title":"Cancer Res"},{"key":"2019041120310225400_R16","doi-asserted-by":"crossref","first-page":"10880","DOI":"10.1016\/S0021-9258(18)99101-5","article-title":"Mutagensis of cysteines in the hormone binding domain of the human estrogen receptor.","volume":"266","author":"Reese","year":"1991","journal-title":"J Biol Chem"},{"key":"2019041120310225400_R17","doi-asserted-by":"crossref","first-page":"24089","DOI":"10.1016\/S0021-9258(20)80497-9","article-title":"Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.","volume":"268","author":"Wrenn","year":"1993","journal-title":"J Biol Chem"},{"key":"2019041120310225400_R18","first-page":"1408","article-title":"Identification of charged residues in an N-terminal portion of the hormone-binding domain of the human estrogen receptor important in transcriptional activity of the receptor.","volume":"7","author":"Pakdel","year":"1993","journal-title":"Mol Endocrinol"},{"key":"2019041120310225400_R19","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1016\/S0021-9258(19)50749-9","article-title":"Human estrogen receptor mutants with altered estrogen and antiestrogen ligand discrimination.","volume":"267","author":"Pakdel","year":"1992","journal-title":"J Biol Chem"},{"key":"2019041120310225400_R20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/334629a0","article-title":"Induction of proto-oncogene JUN\/AP1 by serum and TPA.","volume":"334","author":"Lamph","year":"1988","journal-title":"Nature"},{"key":"2019041120310225400_R21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0960-0760(96)00118-5","article-title":"Estrogen induction of TGF-\u03b1 is mediated by an estrogen response element composed of two imperfect palindromes.","volume":"59","author":"El-Ashry","year":"1996","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2019041120310225400_R22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0092-8674(88)90552-1","article-title":"The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcriptional activation function.","volume":"54","author":"Webster","year":"1988","journal-title":"Cell"},{"key":"2019041120310225400_R23","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1749-6632.1949.tb27297.x","article-title":"The attractions of protein for small molecules and ions.","volume":"51","author":"Scatchard","year":"1949","journal-title":"Ann NY Acad Sci"},{"key":"2019041120310225400_R24","first-page":"21","article-title":"Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.","volume":"8","author":"Tzuderman","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2019041120310225400_R25","doi-asserted-by":"crossref","first-page":"39736","DOI":"10.1074\/jbc.M104744200","article-title":"An isoform of the coactivator AIB1 that increases hormone and growth factor sensitivity is overexpressed in breast cancer.","volume":"276","author":"Reiter","year":"2001","journal-title":"J Biol Chem"},{"key":"2019041120310225400_R26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nsb0196-87","article-title":"A canonical structure for the ligand-binding domain of nuclear receptors.","volume":"3","author":"Wurtz","year":"1996","journal-title":"Nat Struct Biol"},{"key":"2019041120310225400_R27","author":"Hughes","year":"1981"},{"key":"2019041120310225400_R28","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/378681a0","article-title":"Crystal structure of the RAR-\u03b3 ligand-binding domain bound to all-trans retinoic acid.","volume":"378","author":"Renaud","year":"1996","journal-title":"Nature"},{"key":"2019041120310225400_R29","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/375377a0","article-title":"Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-\u03b1.","volume":"375","author":"Bourguet","year":"1995","journal-title":"Nature"},{"key":"2019041120310225400_R30","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/39645","article-title":"Molecular basis of agonism and antagonism in the estrogen receptor.","volume":"389","author":"Brzozowski","year":"1997","journal-title":"Nature"},{"key":"2019041120310225400_R31","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/378690a0","article-title":"A structural role for hormone in the thyroid hormone receptor.","volume":"378","author":"Wagner","year":"1995","journal-title":"Nature"},{"key":"2019041120310225400_R32","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1073\/pnas.95.11.5998","article-title":"Crystallographic comparison of the estrogen and progesterone receptor\u2019s ligand binding domain.","volume":"95","author":"Tanenbaum","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041120310225400_R33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0014-5793(00)01672-0","article-title":"Ligand-protein interactions in nuclear receptors of hormones.","volume":"476","author":"Egea","year":"2000","journal-title":"FEBS Lett"},{"key":"2019041120310225400_R34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0165-1110(80)90006-8","article-title":"Toxicity, mutagenicity and teratogenicity of lead.","volume":"76","author":"Gerber","year":"1980","journal-title":"Mutat Res"},{"key":"2019041120310225400_R35","first-page":"9","article-title":"Teratogenesis and mutagenesis associated with the exposure of human males to lead: a review.","volume":"58","author":"Uzych","year":"1985","journal-title":"Yale J Biol Med"},{"key":"2019041120310225400_R36","first-page":"359","article-title":"Reproductive hazards and industrial chemicals.","volume":"24","author":"Barlow","year":"1981","journal-title":"Ann Occup Hyg"},{"key":"2019041120310225400_R37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1097-0274(200001)37:1<23::AID-AJIM4>3.0.CO;2-U","article-title":"Clinical evaluation and management of lead-exposed construction workers.","volume":"37","author":"Levin","year":"2000","journal-title":"Am J Ind Med"},{"key":"2019041120310225400_R38","first-page":"325","article-title":"Trace elements in normal and malignant human breast tissue.","volume":"76","author":"Schwartz","year":"1974","journal-title":"Surgery"},{"key":"2019041120310225400_R39","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/0277-5379(86)90143-4","article-title":"Serum and tissue copper content in two mammary adenocarcinomas with different biological behaviour.","volume":"22","author":"Fuchs","year":"1986","journal-title":"Eur J Cancer Clin Oncol"},{"key":"2019041120310225400_R40","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0006-291X(87)80538-7","article-title":"Copper and the estradiol receptor.","volume":"144","author":"Fishman","year":"1987","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041120310225400_R41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0163-7258(92)90043-Y","article-title":"Metal carcinogenesis: mechanistic implications.","volume":"53","author":"Snow","year":"1992","journal-title":"Pharmacol Ther"},{"key":"2019041120310225400_R42","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1023\/A:1018457305212","article-title":"The carcinogenicity of metals in humans.","volume":"8","author":"Hayes","year":"1997","journal-title":"Cancer Causes Control"},{"key":"2019041120310225400_R43","first-page":"1129","article-title":"The inhibitory effect of copper on dl-ethionine carcinogenesis in rats.","volume":"33","author":"Kamamoto","year":"1973","journal-title":"Cancer Res"},{"key":"2019041120310225400_R44","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.6857269","article-title":"Inhibition of tumor promotion by a biomimetic superoxide dismutase.","volume":"221","author":"Kensler","year":"1983","journal-title":"Science"},{"key":"2019041120310225400_R45","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/carcin\/5.1.129","article-title":"The reduction of tumor initiating activity and cell mediated mutagenicity of dimethylbenz[a]anthracene by a copper coordination compound.","volume":"5","author":"Solanki","year":"1984","journal-title":"Carcinogenesis"},{"key":"2019041120310225400_R46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0048-9697(97)05434-X","article-title":"Environmental contamination and seasonal variation of metals in soils, plants and waters in the paddy fields around a Pb-Zn mine in Korea.","volume":"198","author":"Jung","year":"1997","journal-title":"Sci Total Environ"},{"key":"2019041120310225400_R47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1289\/ehp.8140143","article-title":"Role of cobalt, iron, lead, manganese, mercury, platinum, selenium, and titanium in carcinogenesis.","volume":"40","author":"Kazantzis","year":"1981","journal-title":"Environ Health Perspect"},{"key":"2019041120310225400_R48","first-page":"514","article-title":"Effect of silver and copper ions on survival of Legionella pneumophila in tap water.","volume":"198","author":"Rohr","year":"1996","journal-title":"Zentralbl Hyg Umweltmed"},{"key":"2019041120310225400_R49","first-page":"104","article-title":"Lead, mercury and cadmium in newborn infants and their mothers.","volume":"197","author":"Plockinger","year":"1993","journal-title":"Z Geburtshilfe Perinatol"},{"key":"2019041120310225400_R50","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF01091975","article-title":"In vitro mineral binding capacity of five fiber sources and their insoluble components for copper and zinc.","volume":"49","author":"Claye","year":"1996","journal-title":"Plant Foods Hum Nutr"},{"key":"2019041120310225400_R51","first-page":"EPA","article-title":"Ambient water quality criteria for nickel; 440\/5-80-060","volume":"DC","year":"1980","journal-title":"Ambient water quality criteria for lead; 440\/5-80-057. Ambient water quality criteria for chromium; 440\/5-80-035. Washington"},{"key":"2019041120310225400_R52","first-page":"698","article-title":"Copper and the human body.","volume":"136","author":"Krizek","year":"1997","journal-title":"Cas Lek Cesk"},{"issue":"Suppl 1","key":"2019041120310225400_R53","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1289\/ehp.98106s1203","article-title":"Effects of micronutrients on metal toxicity","volume":"106","author":"Peraza","year":"1998","journal-title":"Environ Health Perspect"},{"key":"2019041120310225400_R54","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0015-0282(16)41950-3","article-title":"The mechanism of action of the copper intrauterine device.","volume":"27","author":"Tamaya","year":"1976","journal-title":"Fertil Steril"},{"key":"2019041120310225400_R55","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0048-9697(94)90034-5","article-title":"Cadmium, copper, lead and zinc concentrations in hair and toenails of young children and family members: a follow-up study.","volume":"141","author":"Wilhelm m, Lombeck","year":"1994","journal-title":"Sci Total Environ"},{"key":"2019041120310225400_R56","first-page":"205","article-title":"Analysis of serum levels of selenium, zinc, and copper in 132 patients with malignant tumors.","volume":"25","author":"Jia","year":"1991","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"2019041120310225400_R57","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000225602","article-title":"The serum levels of some trace and bulk elements in cancer patients.","volume":"39","author":"Capel","year":"1982","journal-title":"Oncology"},{"key":"2019041120310225400_R58","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/1097-0142(19830901)52:5<868::AID-CNCR2820520521>3.0.CO;2-K","article-title":"Copper and zinc levels in normal and malignant tissues.","volume":"52","author":"Margalioth","year":"1983","journal-title":"Cancer"},{"key":"2019041120310225400_R59","first-page":"184","article-title":"Copper and ceruloplasmin levels in serum of women with breast cancer.","volume":"52","author":"Vaidya","year":"1998","journal-title":"Indian J Med Sci"},{"key":"2019041120310225400_R60","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1002\/1097-0142(19801215)46:12<2682::AID-CNCR2820461224>3.0.CO;2-T","article-title":"Serum zinc, copper, and the Cu\/Zn ratio in patients with benign and malignant breast lesions.","volume":"46","author":"Garofalo","year":"1980","journal-title":"Cancer"},{"key":"2019041120310225400_R61","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/jso.2930460311","article-title":"Serum trace elements and Cu\/Zn ratio in breast cancer.","volume":"46","author":"Gupta Sk, Shukla","year":"1991","journal-title":"J Surg Oncol"},{"key":"2019041120310225400_R62","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bst024321s","article-title":"Serum copper and ceruloplasmin concentrations in patients with primary breast cancer.","volume":"24","author":"Yenisey","year":"1996","journal-title":"Biochem Soc Trans"},{"key":"2019041120310225400_R63","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/oxfordjournals.aje.a008977","article-title":"Toenail trace element levels and breast cancer: a prospective study.","volume":"144","author":"Garland","year":"1996","journal-title":"Am J Epidemiol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/144\/6\/2425\/9300872\/endo2425.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T22:25:06Z","timestamp":1623018306000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/144\/6\/2425\/2881154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,1]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2002-221054","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,1]]}}}