{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:54:38Z","timestamp":1774583678594,"version":"3.50.1"},"reference-count":44,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,10,1]]},"DOI":"10.1210\/en.2003-0147","type":"journal-article","created":{"date-parts":[[2003,6,30]],"date-time":"2003-06-30T20:14:44Z","timestamp":1057004084000},"page":"4536-4543","source":"Crossref","is-referenced-by-count":30,"title":["The Role of Calmodulin in the Regulation of Osteoclastogenesis"],"prefix":"10.1210","volume":"144","author":[{"given":"Liang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology (L.Z., X.F., J.M.M.), University of Alabama at Birmingham, Birmingham, Alabama 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pathology (L.Z., X.F., J.M.M.), University of Alabama at Birmingham, Birmingham, Alabama 35294"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay M.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Pathology (L.Z., X.F., J.M.M.), University of Alabama at Birmingham, Birmingham, Alabama 35294"},{"name":"Veterans Administration Medical Center (J.M.M.), Birmingham, Alabama 35233"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2019041120232126300_R1","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts.","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"2019041120232126300_R2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"key":"2019041120232126300_R3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/bbrc.1997.6603","article-title":"Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.","volume":"234","author":"Tsuda","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041120232126300_R4","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin \/osteoclastogenesis-inhibitory factor and is identical with TRANCE\/RANKL.","volume":"95","author":"Yasuda","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041120232126300_R5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"key":"2019041120232126300_R6","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","article-title":"Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.","volume":"402","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"2019041120232126300_R7","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","article-title":"Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.","volume":"96","author":"Hsu","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041120232126300_R8","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.","volume":"397","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"2019041120232126300_R9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1064-2722(08)60060-2","article-title":"Pleitotropic roles for CSF-1 in development defined by the mouse mutation osteopetrotic (op).","volume":"4","author":"Pollard","year":"1996","journal-title":"Adv Dev Biochem"},{"key":"2019041120232126300_R10","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1210\/endo-122-4-1373","article-title":"Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures.","volume":"122","author":"Takahashi","year":"1988","journal-title":"Endocrinology"},{"key":"2019041120232126300_R11","first-page":"109","author":"Takahashi","year":"2002"},{"key":"2019041120232126300_R12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1034\/j.1601-0825.2002.01829.x","article-title":"Regulatory mechanisms of osteoblast and osteoclast differentiation.","volume":"8","author":"Katagiri","year":"2002","journal-title":"Oral Dis"},{"key":"2019041120232126300_R13","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0092-8674(02)00682-7","article-title":"Calmodulin in action: diversity in target recognition and activation mechanisms.","volume":"108","author":"Hoeflich","year":"2002","journal-title":"Cell"},{"key":"2019041120232126300_R14","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1006\/bbrc.1994.1950","article-title":"A reappraisal of the effect of extracellular calcium on osteoclastic bone resorption.","volume":"202","author":"Hall","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041120232126300_R15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1113\/jphysiol.1994.sp020354","article-title":"Inhibition of inwardly rectifying K+ current by external Ca2+ ions in freshly isolated rabbit osteoclasts.","volume":"480","author":"Yamashita","year":"1994","journal-title":"J Physiol"},{"key":"2019041120232126300_R16","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1073\/pnas.92.8.3244","article-title":"Calmodulin is a selective mediator of Ca2+-induced Ca2+ release via the ryanodine receptor-like Ca2+ channel triggered by cyclic ADP-ribose.","volume":"92","author":"Tanaka","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041120232126300_R17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jcp.1041600104","article-title":"Calmodulin concentrated at the osteoclast ruffled border modulates acid secretion.","volume":"160","author":"Radding","year":"1994","journal-title":"J Cell Physiol"},{"key":"2019041120232126300_R18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/(SICI)1097-4652(199612)169:3<411::AID-JCP1>3.0.CO;2-R","article-title":"Effects of cell culture time and bone matrix exposure on calmodulin content and ATP-dependent cell membrane acid transport in avian osteoclasts and macrophages.","volume":"169","author":"Williams","year":"1996","journal-title":"J Cell Physiol"},{"key":"2019041120232126300_R19","doi-asserted-by":"crossref","first-page":"12488","DOI":"10.1074\/jbc.271.21.12488","article-title":"Regulation of avian osteoclastic H+-ATPase and bone resorption by tamoxifen and calmodulin antagonists. Effects independent of steroid receptors.","volume":"271","author":"Williams","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041120232126300_R20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0014-5793(99)01650-6","article-title":"Expression of functional RANK on mature rat and human osteoclasts.","volume":"463","author":"Myers","year":"1999","journal-title":"FEBS Lett"},{"key":"2019041120232126300_R21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1172\/JCI8905","article-title":"Mice lacking \u03b23 integrins are osteosclerotic because of dysfunctional osteoclasts.","volume":"105","author":"McHugh","year":"2000","journal-title":"J Clin Invest"},{"key":"2019041120232126300_R22","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.1074\/jbc.M010764200","article-title":"Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-\u03baB ligand (RANKL)-induced JNK activation.","volume":"276","author":"Srivastava","year":"2001","journal-title":"J Biol Chem"},{"key":"2019041120232126300_R23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0304-3940(94)90568-1","article-title":"The role of protein kinase C in inducing Alzheimer\u2019s A68 protein expression in the culture of human neuroblastoma cells.","volume":"181","author":"Zhang","year":"1994","journal-title":"Neurosci Lett"},{"key":"2019041120232126300_R24","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0003-2697(91)90243-M","article-title":"Monoclonal antibody to calmodulin: development, characterization, and comparison with polyclonal anti-calmodulin antibodies.","volume":"194","author":"Sacks","year":"1991","journal-title":"Anal Biochem"},{"key":"2019041120232126300_R25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0006-8993(95)00197-X","article-title":"Identification of neuronal programmed cell death in situ in the striatum of normal adult rat brain and its relationship to neuronal death during aging.","volume":"677","author":"Zhang","year":"1995","journal-title":"Brain Res"},{"key":"2019041120232126300_R26","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee.","volume":"2","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res"},{"key":"2019041120232126300_R27","doi-asserted-by":"crossref","first-page":"11400","DOI":"10.1073\/pnas.93.21.11400","article-title":"A stable human-derived packaging cell line for production of high titer retrovirus\/vesicular stomatitis virus G pseudotypes.","volume":"93","author":"Ory","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041120232126300_R28","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1172\/JCI12040","article-title":"A Glanzmann\u2019s mutation in \u03b23 integrin specifically impairs osteoclast function.","volume":"107","author":"Feng","year":"2001","journal-title":"J Clin Invest"},{"key":"2019041120232126300_R29","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/S0024-3205(00)00534-8","article-title":"Studies on the prolactin-releasing mechanism of histones H2A and H2B.","volume":"66","author":"Brown","year":"2000","journal-title":"Life Sci"},{"key":"2019041120232126300_R30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0891-5849(01)00810-3","article-title":"Cellular lipid peroxidation end-products induce apoptosis in human lens epithelial cells.","volume":"32","author":"Choudhary","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"2019041120232126300_R31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1083\/jcb.108.1.141","article-title":"Analysis of the calcium-modulated proteins, S100 and calmodulin, and their target proteins during C6 glioma cell differentiation.","volume":"108","author":"Zimmer","year":"1989","journal-title":"J Cell Biol"},{"key":"2019041120232126300_R32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1677\/joe.0.1040029","article-title":"Possible roles of calcium and calmodulin in mammary gland differentiation in vitro.","volume":"104","author":"Bolander Jr","year":"1985","journal-title":"J Endocrinol"},{"key":"2019041120232126300_R33","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1139\/o00-084","article-title":"Tamoxifen inhibits phorbol ester stimulated osteoclastic bone resorption: an effect mediated by calmodulin.","volume":"78","author":"Williams","year":"2000","journal-title":"Biochem Cell Biol"},{"key":"2019041120232126300_R34","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1210\/endo.141.12.7852","article-title":"Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-\u03baB ligand and osteoprotegerin in osteoblasts.","volume":"141","author":"Takami","year":"2000","journal-title":"Endocrinology"},{"key":"2019041120232126300_R35","doi-asserted-by":"crossref","first-page":"8286","DOI":"10.1074\/jbc.M206421200","article-title":"RANK ligand-induced elevation of cytosolic Ca2+ accelerates nuclear translocation of NF\u03baB in osteoclasts.","volume":"298","author":"Komarova","year":"2003","journal-title":"J Biol Chem"},{"key":"2019041120232126300_R36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-4615-0651-5_9","article-title":"Central control of bone mass: brainstorming of the skeleton.","volume":"496","author":"Amling","year":"2001","journal-title":"Adv Exp Med Biol"},{"key":"2019041120232126300_R37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1749-6632.1980.tb29601.x","article-title":"Immunocytochemical localization of calmodulin in regions of rodent brain.","volume":"356","author":"Wood","year":"1980","journal-title":"Ann NY Acad Sci"},{"key":"2019041120232126300_R38","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1128\/MCB.18.11.6213","article-title":"MFR, a putative receptor mediating the fusion of macrophages.","volume":"18","author":"Saginario","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2019041120232126300_R39","doi-asserted-by":"crossref","first-page":"12210","DOI":"10.1073\/pnas.92.26.12210","article-title":"Identification of an inducible surface molecule specific to fusing macrophages.","volume":"92","author":"Saginario","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041120232126300_R40","doi-asserted-by":"crossref","first-page":"37984","DOI":"10.1074\/jbc.M002334200","article-title":"CD47, a ligand for the macrophage fusion receptor, participates in macrophage multinucleation.","volume":"275","author":"Han","year":"2000","journal-title":"J Biol Chem"},{"key":"2019041120232126300_R41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/excr.1993.1067","article-title":"Calmodulin and calmodulin-binding proteins during cell fusion in Dictyostelium discoideum: developmental regulation by calcium ions.","volume":"205","author":"Lydan","year":"1993","journal-title":"Exp Cell Res"},{"key":"2019041120232126300_R42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0012-1606(92)90237-B","article-title":"Ca2+\/calmodulin-dependent phosphorylation of the 100-kDa protein in chick embryonic muscle cells in culture.","volume":"150","author":"Kim","year":"1992","journal-title":"Dev Biol"},{"key":"2019041120232126300_R43","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0006-291X(86)80043-2","article-title":"Somatostatin inhibits fusion of pituitary secretion vesicles with the plasma membranes.","volume":"139","author":"Draznin","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041120232126300_R44","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev Cell"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/144\/10\/4536\/10382714\/endo4536.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T03:05:14Z","timestamp":1555038314000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/144\/10\/4536\/2502373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,1]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,10,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2003-0147","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,1]]}}}