{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:45:30Z","timestamp":1790423130607,"version":"4.1.0"},"reference-count":55,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12,1]]},"DOI":"10.1210\/en.2003-0331","type":"journal-article","created":{"date-parts":[[2003,9,9]],"date-time":"2003-09-09T02:30:06Z","timestamp":1063074606000},"page":"5430-5440","source":"Crossref","is-referenced-by-count":40,"title":["Hormonal-Neural Integration in the Female Rat Ventromedial Hypothalamus: Triple Labeling for Estrogen Receptor-\u03b1, Retrograde Tract Tracing from the Periaqueductal Gray, and Mating-Induced Fos Expression"],"prefix":"10.1210","volume":"144","author":[{"given":"Lyngine H.","family":"Calizo","sequence":"first","affiliation":[{"name":"Institute of Neurological Sciences (L.H.C., L.M.F.-C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loretta M.","family":"Flanagan-Cato","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences (L.H.C., L.M.F.-C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104"},{"name":"Department of Psychology (L.M.F.-C.), University of Pennsylvania, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041120465427600_R1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF02935628","article-title":"Patterns of steroid hormone effects on electrical and molecular events in hypothalamic neurons","volume":"3","author":"Pfaff","year":"1989","journal-title":"Mol Neurobiol"},{"key":"2019041120465427600_R2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1210\/endo-106-2-504","article-title":"Priming of estrous responsiveness by implants of 17 \u03b2-estradiol in the ventromedial hypothalamic nucleus of female rats","volume":"106","author":"Rubin","year":"1980","journal-title":"Endocrinology"},{"key":"2019041120465427600_R3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000122231","article-title":"New facts concerning the role played by the ventromedial nucleus in the control of estrous cycle duration and sexual receptivity in the rat","volume":"13","author":"Carrer","year":"1973","journal-title":"Neuroendocrinology"},{"key":"2019041120465427600_R4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000121734","article-title":"Homo- and hyper-sexuality in rats with hypothalamic lesions","volume":"4","author":"Dorner","year":"1969","journal-title":"Neuroendocrinology"},{"key":"2019041120465427600_R5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1113\/jphysiol.1964.sp007426","article-title":"Hypothalamic control of the endocrine and behavioral changes associated with oestrus in the rat","volume":"172","author":"Kennedy","year":"1964","journal-title":"J Physiol"},{"key":"2019041120465427600_R6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000124726","article-title":"Antagonism of sexual behavior in female rats by ventromedial hypothalamic implants of antiestrogen","volume":"45","author":"Meisel","year":"1987","journal-title":"Neuroendocrinology"},{"key":"2019041120465427600_R7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0306-4530(84)90002-7","article-title":"Behavioral effects of progestin in the brain","volume":"9","author":"Barfield","year":"1984","journal-title":"Psychoneuroendocrinology"},{"key":"2019041120465427600_R8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000123546","article-title":"Induction of estrous behavior in ovariectomized rats by sequential replacement of estrogen and progesterone to the ventromedial hypothalamus","volume":"37","author":"Rubin","year":"1983","journal-title":"Neuroendocrinology"},{"key":"2019041120465427600_R9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1113\/jphysiol.1979.sp012690","article-title":"Facilitation of the lordosis reflex of female rats from the ventromedial nucleus of the hypothalamus","volume":"288","author":"Pfaff","year":"1979","journal-title":"J Physiol"},{"key":"2019041120465427600_R10","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/978-1-59259-707-9_31","article-title":"Anatomical markers of activity in hypothalamic systems","volume-title":"Neuroendocrinology in physiology and medicine","author":"Hoffman","year":"2000","edition":"1st ed."},{"key":"2019041120465427600_R11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0006-8993(94)01395-X","article-title":"Pattern of fos and jun expression in the female rat forebrain after sexual behavior","volume":"673","author":"Flanagan-Cato","year":"1995","journal-title":"Brain Res"},{"key":"2019041120465427600_R12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1365-2826.1993.tb00500.x","article-title":"Fos expression in the rat brain following vaginal-cervical stimulation by mating and manual probing","volume":"5","author":"Tetel","year":"1993","journal-title":"J Neuroendocrinol"},{"key":"2019041120465427600_R13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000054429","article-title":"Fos expression in the female rat brain during the proestrous prolactin surge and following mating","volume":"69","author":"Yang","year":"1999","journal-title":"Neuroendocrinology"},{"key":"2019041120465427600_R14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000127027","article-title":"Patterns of induction of the immediate early genes c-fos and egr-1 in the female rat brain following differential amounts of mating stimulation","volume":"62","author":"Polston","year":"1995","journal-title":"Neuroendocrinology"},{"key":"2019041120465427600_R15","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1046\/j.1365-2826.1996.02684.x","article-title":"Reproductively-relevant stimuli induce fos-immunoreactivity within progestin-containing neurons in localized regions of female rat forebrain","volume":"8","author":"Auger","year":"1996","journal-title":"J Neuroendocrinol"},{"key":"2019041120465427600_R16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1365-2826.1994.tb00574.x","article-title":"Intraneuronal convergence of tactile and hormonal stimuli associated with female reproduction in rats","volume":"6","author":"Tetel","year":"1994","journal-title":"J Neuroendocrinol"},{"key":"2019041120465427600_R17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/(SICI)1096-9861(19971201)388:4<507::AID-CNE1>3.0.CO;2-6","article-title":"Comparative distribution of estrogen receptor-\u03b1 and -\u03b2 mRNA in the rat central nervous system","volume":"388","author":"Shughrue","year":"1997","journal-title":"J Comp Neurol"},{"key":"2019041120465427600_R18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/cne.1054","article-title":"Distribution of estrogen receptor \u03b2 immunoreactivity in the rat central nervous system","volume":"436","author":"Shughrue","year":"2001","journal-title":"J Comp Neurol"},{"key":"2019041120465427600_R19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/cne.902940107","article-title":"Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study","volume":"294","author":"Simerly","year":"1990","journal-title":"J Comp Neurol"},{"key":"2019041120465427600_R20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/cne.901510204","article-title":"Atlas of estradiol-concentrating cells in the central nervous system of the female rat","volume":"151","author":"Pfaff","year":"1973","journal-title":"J Comp Neurol"},{"key":"2019041120465427600_R21","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1210\/endo.139.12.6357","article-title":"Roles of estrogen receptor-\u03b1 gene expression in reproduction-related behaviors in female mice","volume":"139","author":"Ogawa","year":"1998","journal-title":"Endocrinology"},{"key":"2019041120465427600_R22","doi-asserted-by":"crossref","first-page":"12887","DOI":"10.1073\/pnas.96.22.12887","article-title":"Survival of reproductive behaviors in estrogen receptor \u03b2 gene-deficient (\u03b2ERKO) male and female mice","volume":"96","author":"Ogawa","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041120465427600_R23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0006-8993(96)00763-9","article-title":"Fos immunoreactivity in the rat brain following consummatory elements of sexual behavior: a sex comparison","volume":"738","author":"Coolen","year":"1996","journal-title":"Brain Res"},{"key":"2019041120465427600_R24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0006-8993(93)90085-2","article-title":"Sexual stimulation activates c-fos within estrogen-concentrating regions of the female rat forebrain","volume":"624","author":"Pfaus","year":"1993","journal-title":"Brain Res"},{"key":"2019041120465427600_R25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0006-8993(94)90088-4","article-title":"Estradiol and progesterone influence the response of ventromedial hypothalamic neurons to tactile stimuli associated with female reproduction","volume":"646","author":"Tetel","year":"1994","journal-title":"Brain Res"},{"key":"2019041120465427600_R26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/cne.903480103","article-title":"Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat","volume":"348","author":"Canteras","year":"1994","journal-title":"J Comp Neurol"},{"key":"2019041120465427600_R27","first-page":"R285","article-title":"Mesencephalic mechanisms for integration of female reproductive behavior in the rat","volume":"237","author":"Sakuma","year":"1979","journal-title":"Am J Physiol"},{"key":"2019041120465427600_R28","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/neu.480250406","article-title":"Divergent axon collaterals originate in the estrogen receptive ventromedial nucleus of the hypothalamus in the rat","volume":"25","author":"Akesson","year":"1994","journal-title":"J Neurobiol"},{"key":"2019041120465427600_R29","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1126\/science.7112131","article-title":"Characterization of estrogen-concentrating hypothalamic neurons by their axonal projections","volume":"217","author":"Morrell","year":"1982","journal-title":"Science"},{"key":"2019041120465427600_R30","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/cne.10223","article-title":"Estrogen-induced dendritic spine elimination on female rat ventromedial hypothalamic neurons that project to the periaqueductal gray","volume":"447","author":"Calizo","year":"2002","journal-title":"J Comp Neurol"},{"key":"2019041120465427600_R31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1097-4695(200010)45:1<1::AID-NEU1>3.0.CO;2-W","article-title":"Functionally-defined compartments of the lordosis neural circuit in the ventromedial hypothalamus in female rats","volume":"45","author":"Daniels","year":"2000","journal-title":"J Neurobiol"},{"key":"2019041120465427600_R32","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0166-2236(94)90047-7","article-title":"Columnar organization in midbrain periaqueductal gray: modules for emotional expression?","volume":"17","author":"Bandler","year":"1994","journal-title":"Trends Neurosci"},{"key":"2019041120465427600_R33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0079-6123(08)61871-3","article-title":"Columnar organization in the midbrain periaqueductal gray and the integration of emotional expression","volume":"107","author":"Bandler","year":"1996","journal-title":"Prog Brain Res"},{"key":"2019041120465427600_R34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/cne.902370403","article-title":"The midbrain periaqueductal gray in the rat. I. Nuclear volume, cell number, density, orientation, and regional subdivisions","volume":"237","author":"Beitz","year":"1985","journal-title":"J Comp Neurol"},{"key":"2019041120465427600_R35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0006-8993(98)00642-8","article-title":"Site and behavioral specificity of periaqueductal gray lesions on postpartum sexual, maternal and aggressive behaviors in rats","volume":"804","author":"Lonstein","year":"1998","journal-title":"Brain Res"},{"key":"2019041120465427600_R36","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1523\/JNEUROSCI.19-07-02823.1999","article-title":"Central neuronal circuit innervating the lordosis-producing muscles defined by transneuronal transport of pseudorabies virus","volume":"19","author":"Daniels","year":"1999","journal-title":"J Neurosci"},{"key":"2019041120465427600_R37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/neu.1057","article-title":"Transneuronal tracing from sympathectomized lumbar epaxial muscles in female rats","volume":"48","author":"Daniels","year":"2001","journal-title":"J Neurobiol"},{"key":"2019041120465427600_R38","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0006-8993(96)00985-7","article-title":"Differential induction of fos in the female rat brain following different amounts of vaginocervical stimulation: modulation by steroid hormones","volume":"741","author":"Pfaus","year":"1996","journal-title":"Brain Res"},{"key":"2019041120465427600_R39","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000126562","article-title":"Induction of Fos immunoreactivity in oxytocin neurons after sexual activity in female rats","volume":"58","author":"Flanagan","year":"1993","journal-title":"Neuroendocrinology"},{"key":"2019041120465427600_R40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0006-8993(83)90390-6","article-title":"Estrogenic maintenance of lordotic responsiveness: requirement for hypothalamic action potentials","volume":"268","author":"Harlan","year":"1983","journal-title":"Brain Res"},{"key":"2019041120465427600_R41","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1113\/jphysiol.1979.sp012690","article-title":"Deficit in the lordosis reflex of female rats caused by lesions in the ventromedial nucleus of the hypothalamus","volume":"288","author":"Pfaff","year":"1979","journal-title":"J Physiol"},{"key":"2019041120465427600_R42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/hbeh.2001.1664","article-title":"Sensory cues mediating mating-induced potentiation of sexual receptivity in female rats","volume":"40","author":"Bennett","year":"2001","journal-title":"Horm Behav"},{"key":"2019041120465427600_R43","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0031-9384(91)90006-A","article-title":"Role of the ventromedial nucleus of hypothalamus in the male-induced enhancement of lordosis in female rats","volume":"50","author":"Rajendren","year":"1991","journal-title":"Physiol Behav"},{"key":"2019041120465427600_R44","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1523\/JNEUROSCI.20-04-01589.2000","article-title":"Estrogen selectively regulates spine density within the dendritic arbor of rat ventromedial hypothalamic neurons","volume":"20","author":"Calizo","year":"2000","journal-title":"J Neurosci"},{"key":"2019041120465427600_R45","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1046\/j.1365-2826.2002.00806.x","article-title":"Response to male odours in progestin receptor- and oestrogen receptor-containing cells in female rat brain","volume":"14","author":"Bennett","year":"2002","journal-title":"J Neuroendocrinol"},{"key":"2019041120465427600_R46","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1365-2826.1993.tb00522.x","article-title":"Mating-induced FOS-like immunoreactivity in the rat forebrain: a sex comparison and a dimorphic effect of pelvic nerve transection","volume":"5","author":"Wersinger","year":"1993","journal-title":"J Neuroendocrinol"},{"key":"2019041120465427600_R47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1037\/h0076442","article-title":"Vaginal stimulation in rats induces prolonged lordosis responsiveness and sexual receptivity","volume":"89","author":"Rodriguez-Sierra","year":"1975","journal-title":"J Comp Physiol Psychol"},{"key":"2019041120465427600_R48","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0031-9384(96)00614-2","article-title":"Function of intromissions on intromission-return latency of female rats during paced sexual behavior","volume":"61","author":"Yang","year":"1997","journal-title":"Physiol Behav"},{"key":"2019041120465427600_R49","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1037\/0735-7036.110.2.176","article-title":"Effects of paced mating and intromissive stimulation of feminine sexual behavior and estrus termination in the cycling rat","volume":"110","author":"Coopersmith","year":"1996","journal-title":"J Comp Psychol"},{"key":"2019041120465427600_R50","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1037\/h0077278","article-title":"Role of pelvic nerves in the postcopulatory abbreviation of behavioral estrus in female rats","volume":"90","author":"Lodder","year":"1976","journal-title":"J Comp Physiol Psychol"},{"key":"2019041120465427600_R51","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0031-9384(84)90288-9","article-title":"The relationship between heat abbreviation and neural progestin receptors in female rats","volume":"32","author":"Reading","year":"1984","journal-title":"Physiol Behav"},{"key":"2019041120465427600_R52","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0306-4522(96)00076-0","article-title":"Induction of members of the Fos\/Jun family of immediate-early genes in identified hypothalamic neurons: in vivo evidence for differential regulation","volume":"73","author":"Luckman","year":"1996","journal-title":"Neuroscience"},{"key":"2019041120465427600_R53","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/jnr.490350502","article-title":"Specific regulation of immediate early genes by patterned neural activity","volume":"35","author":"Sheng","year":"1993","journal-title":"J Neurosci Res"},{"key":"2019041120465427600_R54","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1111\/j.1460-9568.1997.tb01661.x","article-title":"Comparison of the expression of c-fos, nur77 and egr1 mRNAs in rat hypothalamic magnocellular neurons and their putative afferent projection neurons: cell- and stimulus-specific induction","volume":"9","author":"Luckman","year":"1997","journal-title":"Eur J Neurosci"},{"key":"2019041120465427600_R55","volume-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1998","edition":"4th ed."}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/144\/12\/5430\/10789024\/endo5430.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T21:52:08Z","timestamp":1682545928000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/144\/12\/5430\/2881018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,1]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2003-0331","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,1]]}}}