{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:37:32Z","timestamp":1792705052598,"version":"4.5.0"},"reference-count":54,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,1,1]]},"DOI":"10.1210\/en.2003-0831","type":"journal-article","created":{"date-parts":[[2003,10,7]],"date-time":"2003-10-07T00:17:17Z","timestamp":1065485837000},"page":"437-446","source":"Crossref","is-referenced-by-count":30,"title":["Immortalization of Epididymal Epithelium in Transgenic Mice Expressing Simian Virus 40 T Antigen: Characterization of Cell Lines and Regulation of the Polyoma Enhancer Activator 3"],"prefix":"10.1210","volume":"145","author":[{"given":"Petra","family":"Sipila\u0308","sequence":"first","affiliation":[{"name":"Department of Physiology (P.S., R.S., I.T.H., M.P.), Institute of Biomedicine, University of Turku, FIN-20520 Turku, Finland"},{"name":"Turku Graduate School of Biomedical Sciences (P.S.), University of Turku, FIN-20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Shariatmadari","sequence":"additional","affiliation":[{"name":"Department of Physiology (P.S., R.S., I.T.H., M.P.), Institute of Biomedicine, University of Turku, FIN-20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilpo T.","family":"Huhtaniemi","sequence":"additional","affiliation":[{"name":"Department of Physiology (P.S., R.S., I.T.H., M.P.), Institute of Biomedicine, University of Turku, FIN-20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Poutanen","sequence":"additional","affiliation":[{"name":"Department of Physiology (P.S., R.S., I.T.H., M.P.), Institute of Biomedicine, University of Turku, FIN-20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041120225561200_R1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0092-8674(88)90184-5","article-title":"Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene.","volume":"54","author":"Muller","year":"1988","journal-title":"Cell"},{"key":"2019041120225561200_R2","first-page":"i","article-title":"Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer","volume":"78","author":"Kasper","year":"1998","journal-title":"Lab Invest"},{"key":"2019041120225561200_R3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0303-7207(96)03802-6","article-title":"The mouse inhibin \u03b1-subunit promoter directs SV40 T-antigen to Leydig cells in transgenic mice.","volume":"119","author":"Kananen","year":"1996","journal-title":"Mol Cell Endocrinol"},{"key":"2019041120225561200_R4","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1038\/sj.onc.1201137","article-title":"Immortalization of neuro-endocrine cells from adrenal tumors arising in SV40 T-transgenic mice.","volume":"14","author":"Cairns","year":"1997","journal-title":"Oncogene"},{"key":"2019041120225561200_R5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0092-8674(89)90331-0","article-title":"Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV\/c-neu oncogene.","volume":"57","author":"Bouchard","year":"1989","journal-title":"Cell"},{"key":"2019041120225561200_R6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/(SICI)1097-0215(19971127)73:5<749::AID-IJC23>3.0.CO;2-#","article-title":"In vivo effects of activated H-ras oncogene expressed in the liver and in urogenital tissues.","volume":"73","author":"Gilbert","year":"1997","journal-title":"Int J Cancer"},{"key":"2019041120225561200_R7","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1038\/sj.onc.1203851","article-title":"B-Myc is preferentially expressed in hormonally-controlled tissues and inhibits cellular proliferation.","volume":"19","author":"Gregory","year":"2000","journal-title":"Oncogene"},{"key":"2019041120225561200_R8","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1095\/biolreprod64.6.1600","article-title":"B-Myc, a proximal caput epididymal protein, is dependent on androgens and testicular factors for expression.","volume":"64","author":"Cornwall","year":"2001","journal-title":"Biol Reprod"},{"key":"2019041120225561200_R9","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1128\/MCB.13.2.1130","article-title":"B-myc inhibits neoplastic transformation and transcriptional activation by c-myc.","volume":"13","author":"Resar","year":"1993","journal-title":"Mol Cell Biol"},{"key":"2019041120225561200_R10","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1096\/fasebj.12.9.633","article-title":"The molecular role of Myc in growth and transformation: recent discoveries lead to new insights.","volume":"12","author":"Facchini","year":"1998","journal-title":"FASEB J"},{"key":"2019041120225561200_R11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1101\/gad.6.3.481","article-title":"Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.","volume":"6","author":"Xin","year":"1992","journal-title":"Genes Dev"},{"key":"2019041120225561200_R12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.3798106","article-title":"Human breast cancer: correlation of relapse and survival with amplification of the HER-2\/neu oncogene.","volume":"235","author":"Slamon","year":"1987","journal-title":"Science"},{"key":"2019041120225561200_R13","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0960-9822(01)00536-X","article-title":"The pea3 subfamily ets genes are required for HER2\/Neu-mediated mammary oncogenesis.","volume":"11","author":"Shepherd","year":"2001","journal-title":"Curr Biol"},{"key":"2019041120225561200_R14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/72294","article-title":"The ets protein PEA3 suppresses HER-2\/neu overexpression and inhibits tumorigenesis.","volume":"6","author":"Xing","year":"2000","journal-title":"Nat Med"},{"key":"2019041120225561200_R15","doi-asserted-by":"crossref","first-page":"S222","DOI":"10.1067\/msy.2002.119792","article-title":"Clinical significance of PEA3 in human breast cancer","volume":"131","author":"Kinoshita","year":"2002","journal-title":"Surgery"},{"key":"2019041120225561200_R16","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0090-4295(98)00275-1","article-title":"Primary adenocarcinoma of the epididymis: case report and review of the literature.","volume":"52","author":"Ganem","year":"1998","journal-title":"Urology"},{"key":"2019041120225561200_R17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1679\/aohc.46.51","article-title":"Ultrastructure of the mouse epididymal duct with special reference to the regional differences of the principal cells.","volume":"46","author":"Abe","year":"1983","journal-title":"Arch Histol Jpn"},{"key":"2019041120225561200_R18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ar.1092090207","article-title":"Regional differences of the proximal part of mouse epididymis: morphological and histochemical characterization.","volume":"209","author":"Abou-Haila","year":"1984","journal-title":"Anat Rec"},{"key":"2019041120225561200_R19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1095\/biolreprod46.5.747","article-title":"Isolation, immunolocalization, and sperm-association of three proteins of 18, 25, and 29 kilodaltons secreted by the mouse epididymis.","volume":"46","author":"Rankin","year":"1992","journal-title":"Biol Reprod"},{"key":"2019041120225561200_R20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/j.1939-4640.1999.tb02507.x","article-title":"Immunocytochemical localization of the Ya, Yb1, Yc, Yf, and Yo subunits of glutathione S-transferases in the cauda epididymidis and vas deferens of adult rats.","volume":"20","author":"Andonian","year":"1999","journal-title":"J Androl"},{"key":"2019041120225561200_R21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0303-7207(92)90212-O","article-title":"Regulation of the epididymal glutathione peroxidase-like protein in the mouse: dependence upon androgens and testicular factors.","volume":"89","author":"Rigaudiere","year":"1992","journal-title":"Mol Cell Endocrinol"},{"key":"2019041120225561200_R22","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1210\/endo.139.6.6074","article-title":"Molecular cloning and hormonal regulation of a murine epididymal retinoic acid-binding protein messenger ribonucleic acid.","volume":"139","author":"Lareyre","year":"1998","journal-title":"Endocrinology"},{"key":"2019041120225561200_R23","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1210\/endo.142.3.8045","article-title":"Gene duplication gives rise to a new 17-kilodalton lipocalin that shows epididymal region-specific expression and testicular factor(s) regulation.","volume":"142","author":"Lareyre","year":"2001","journal-title":"Endocrinology"},{"key":"2019041120225561200_R24","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1210\/endo.137.11.8895349","article-title":"Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.","volume":"137","author":"Eddy","year":"1996","journal-title":"Endocrinology"},{"key":"2019041120225561200_R25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/j.1939-4640.2000.tb03282.x","article-title":"Morphologic changes in efferent ductules and epididymis in estrogen receptor-\u03b1 knockout mice.","volume":"21","author":"Hess","year":"2000","journal-title":"J Androl"},{"key":"2019041120225561200_R26","doi-asserted-by":"crossref","first-page":"14132","DOI":"10.1073\/pnas.241245898","article-title":"Estrogen action and male fertility: roles of the sodium\/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function.","volume":"98","author":"Zhou","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041120225561200_R27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/sj.leu.2402414","article-title":"Classical and novel retinoids: their targets in cancer therapy.","volume":"16","author":"Fontana","year":"2002","journal-title":"Leukemia"},{"key":"2019041120225561200_R28","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1095\/biolreprod54.5.1111","article-title":"Region-specific localization of retinoic acid receptor-alpha expression in the rat epididymis.","volume":"54","author":"Akmal","year":"1996","journal-title":"Biol Reprod"},{"key":"2019041120225561200_R29","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1095\/biolreprod56.4.985","article-title":"Male infertility caused by epididymal dysfunction in transgenic mice expressing a dominant negative mutation of retinoic acid receptor \u03b11.","volume":"56","author":"Costa","year":"1997","journal-title":"Biol Reprod"},{"key":"2019041120225561200_R30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/(SICI)1098-2795(199802)49:2<131::AID-MRD4>3.0.CO;2-Q","article-title":"The PEA3 protein of the Ets oncogene family is a putative transcriptional modulator of the mouse epididymis-specific glutathione peroxidase gene gpx5.","volume":"49","author":"Drevet","year":"1998","journal-title":"Mol Reprod Dev"},{"key":"2019041120225561200_R31","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1095\/biolreprod60.3.664","article-title":"Involvement of polyomavirus enhancer activator 3 in the regulation of expression of \u03b3-glutamyl transpeptidase messenger ribonucleic acid-IV in the rat epididymis.","volume":"60","author":"Lan","year":"1999","journal-title":"Biol Reprod"},{"key":"2019041120225561200_R32","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1095\/biolreprod65.5.1452","article-title":"CCAAT\/enhancer binding protein beta regulates expression of the cystatin-related epididymal spermatogenic (Cres) gene.","volume":"65","author":"Hsia","year":"2001","journal-title":"Biol Reprod"},{"key":"2019041120225561200_R33","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/molehr\/7.10.935","article-title":"Epididymal epithelium immortalized by simian virus 40 large T antigen: a model to study epididymal gene expression.","volume":"7","author":"Telgmann","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"2019041120225561200_R34","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0301-472X(02)00865-2","article-title":"GATA transcription in a small rhodamine 123lowCD34+ subpopulation of a peripheral blood-derived CD34\u2212CD105+ mesenchymal cell line.","volume":"30","author":"Conrad","year":"2002","journal-title":"Exp Hematol"},{"key":"2019041120225561200_R35","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/j.1939-4640.2002.tb02344.x","article-title":"Immortalized epididymal cell lines from transgenic mice overexpressing temperature-sensitive simian virus 40 large T-antigen gene.","volume":"23","author":"Araki","year":"2002","journal-title":"J Androl"},{"key":"2019041120225561200_R36","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1210\/me.2002-0100","article-title":"Epididymal dysfunction initiated by the expression of simian virus 40 T-antigen leads to angulated sperm flagella and infertility in transgenic mice.","volume":"16","author":"Sipila\u0308","year":"2002","journal-title":"Mol Endocrinol"},{"key":"2019041120225561200_R37","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1095\/biolreprod64.4.1115","article-title":"Evaluation of the 5\u2032-flanking regions of murine glutathione peroxidase five and cysteine-rich secretory protein-1 genes for directing transgene expression in mouse epididymis.","volume":"64","author":"Lahti","year":"2001","journal-title":"Biol Reprod"},{"key":"2019041120225561200_R38","author":"Livak","year":"1997"},{"key":"2019041120225561200_R39","first-page":"1399","article-title":"Dominant negative regulation of trans-activation by the rat androgen receptor: roles of the N-terminal domain and heterodimer formation.","volume":"7","author":"Palvimo","year":"1993","journal-title":"Mol Endocrinol"},{"key":"2019041120225561200_R40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1095\/biolreprod44.1.13","article-title":"Specific distribution of messenger ribonucleic acids for 24-kilodalton proteins in the mouse epididymis as revealed by in situ hybridization: developmental expression and regulation in the adult.","volume":"44","author":"Faure","year":"1991","journal-title":"Biol Reprod"},{"key":"2019041120225561200_R41","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1096\/fasebj.7.10.8344486","article-title":"Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53.","volume":"7","author":"Ludlow","year":"1993","journal-title":"FASEB J"},{"key":"2019041120225561200_R42","first-page":"1183","article-title":"Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.","volume":"8","author":"Ragimov","year":"1993","journal-title":"Oncogene"},{"key":"2019041120225561200_R43","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1128\/MCB.19.3.1864","article-title":"Telomerase activity is sufficient to allow transformed cells to escape from crisis.","volume":"19","author":"Halvorsen","year":"1999","journal-title":"Mol Cell Biol"},{"key":"2019041120225561200_R44","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng1011","article-title":"A role for the Rb family of proteins in controlling telomere length.","volume":"32","author":"Garci\u0301a-Cao","year":"2002","journal-title":"Nat Genet"},{"key":"2019041120225561200_R45","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1469-7793.1999.809ad.x","article-title":"Regulation of anion secretion by cyclo-oxygenase and prostanoids in cultured epididymal epithelia from the rat.","volume":"514","author":"Wong","year":"1999","journal-title":"J Physiol"},{"key":"2019041120225561200_R46","first-page":"27","author":"Orgebin-Crist","year":"1996"},{"key":"2019041120225561200_R47","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1530\/jrf.0.0850631","article-title":"Androgen-dependent messenger RNA(s) related to secretory proteins in the mouse epididymis.","volume":"85","author":"Ghyselinck","year":"1989","journal-title":"J Reprod Fertil"},{"key":"2019041120225561200_R48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1677\/jme.0.0040005","article-title":"Molecular cloning of a cDNA for androgen-regulated proteins secreted by the mouse epididymis.","volume":"4","author":"Ghyselinck","year":"1990","journal-title":"J Mol Endocrinol"},{"key":"2019041120225561200_R49","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1023\/A:1009576801226","article-title":"Role of Ets transcription factors in mammary gland development and oncogenesis.","volume":"6","author":"Shepherd","year":"2001","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"2019041120225561200_R50","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/sj.onc.1201331","article-title":"HER2\/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer.","volume":"15","author":"Benz","year":"1997","journal-title":"Oncogene"},{"key":"2019041120225561200_R51","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1095\/biolreprod57.1.186","article-title":"Identification, expression, and regulation of the transcriptional factor polyomavirus enhancer activator 3, and its putative role in regulating the expression of \u03b3-glutamyl transpeptidase mRNA-IV in the rat epididymis.","volume":"57","author":"Lan","year":"1997","journal-title":"Biol Reprod"},{"key":"2019041120225561200_R52","first-page":"1323","article-title":"The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades.","volume":"13","author":"O\u2019Hagan","year":"1996","journal-title":"Oncogene"},{"key":"2019041120225561200_R53","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/sj.onc.1201547","article-title":"The PEA3 Ets transcription factor is a downstream target of the HER2\/Neu receptor tyrosine kinase.","volume":"16","author":"O\u2019Hagan","year":"1998","journal-title":"Oncogene"},{"key":"2019041120225561200_R54","first-page":"1745","article-title":"The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA.","volume":"13","author":"Janknecht","year":"1996","journal-title":"Oncogene"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/145\/1\/437\/10790833\/endo0437.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T22:13:42Z","timestamp":1704924822000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/145\/1\/437\/2878634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2003-0831","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,1]]}}}