{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:52:28Z","timestamp":1790373148817,"version":"4.1.0"},"reference-count":34,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The enzyme 11\u03b2-hydroxysteroid dehydrogenase type 1 (11\u03b2-HSD-1) amplifies intracellular glucocorticoid action in vivo. 11\u03b2-HSD-1 activity is increased in adipose tissues of obese humans and genetically obese rodents, providing a mechanistic basis for the similarities between metabolic disease arising from high circulating glucocorticoids (Cushing\u2019s syndrome) and idiopathic obesity\/metabolic syndrome where plasma glucocorticoids are typically unaltered. Fat-specific overexpression of 11\u03b2-HSD-1 produces a metabolic syndrome in mice, whereas 11\u03b2-HSD-1 null mice resist high-fat diet (HF)-induced visceral obesity and its metabolic consequences. Here we compared the effects of chronic (18 wk) HF feeding on adipose 11\u03b2-HSD-1 activity in strains of mice that are either resistant (A\/J) or prone (C57BL\/6J) to metabolic disease. 11\u03b2-HSD-1 activity was highest in sc fat, followed by epididymal fat, with lowest activity in the mesenteric visceral depot of both strains. 11\u03b2-HSD-1 activity was lower in white adipose tissues of A\/J compared with C57BL\/6J mice. Chronic HF feeding unexpectedly caused a down-regulation of 11\u03b2-HSD-1 in adipose tissues of both strains, despite comparable adiposity. However, A\/J mice down-regulated adipose 11\u03b2-HSD-1 to a significantly lower level than C57BL\/6J mice in white and thermogenic brown adipose tissues. We propose that a lower adipose 11\u03b2-HSD-1 set point affords a metabolic protection to A\/J mice. Adaptive down-regulation of adipose 11\u03b2-HSD-1 in response to chronic HF represents a novel mechanism that may counteract metabolic disease.<\/jats:p>","DOI":"10.1210\/en.2003-1674","type":"journal-article","created":{"date-parts":[[2004,3,30]],"date-time":"2004-03-30T01:24:49Z","timestamp":1080609889000},"page":"2707-2712","source":"Crossref","is-referenced-by-count":89,"title":["Down-Regulation of Adipose 11\u03b2-Hydroxysteroid Dehydrogenase Type 1 by High-Fat Feeding in Mice: A Potential Adaptive Mechanism Counteracting Metabolic Disease"],"prefix":"10.1210","volume":"145","author":[{"given":"Nicholas M.","family":"Morton","sequence":"first","affiliation":[{"name":"Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Ramage","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Seckl","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071618331194200_R1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1046\/j.1365-2796.2000.00609.x","article-title":"Independent effects of obesity and cortisol in predicting cardiovascular risk factors in men and women.","volume":"247","author":"Walker","year":"2000","journal-title":"J Intern Med"},{"key":"2020071618331194200_R2","first-page":"1853","article-title":"Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic 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Androl"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/145\/6\/2707\/10787845\/endo2707.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/145\/6\/2707\/10787845\/endo2707.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T03:57:15Z","timestamp":1594958235000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/145\/6\/2707\/2878183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,1]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2003-1674","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,1]]}}}