{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:44:35Z","timestamp":1791330275248,"version":"4.3.1"},"reference-count":28,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the relative contributions of PTH and PTHrP to the skeletal phenotype of mice deficient in PTH (PTH\u2212\/\u2212). PTH\u2212\/\u2212 mice and PTH\u2212\/\u2212 mice lacking one allele encoding PTHrP (PTH\u2212\/\u2212PTHrP+\/\u2212) were compared. Both mutants displayed similar biochemical abnormalities of hypoparathyroidism, but skeletal PTHrP mRNA and protein were decreased in PTH\u2212\/\u2212PTHrP+\/ \u2212 mice. PTH\u2212\/\u2212 mice had increased trabecular bone volume with diminished bone turnover. PTHrP haploinsufficiency reduced trabecular bone of the PTH\u2212\/\u2212 mice to levels below those in wild-type animals by decreasing osteoprogenitor cell recruitment, enhancing osteoblast apoptosis, and diminishing bone formation. The results show that the increased trabecular bone volume in PTH-deficient mice is due to diminished PTH-induced osteoclastic bone resorption and persistent PTHrP-stimulated osteoblastic bone formation. They also illustrate the changing role of PTHrP during bone development, demonstrate its bone- forming function in the postnatal state, and support its pharmacological potential as an anabolic agent.<\/jats:p>","DOI":"10.1210\/en.2003-1695","type":"journal-article","created":{"date-parts":[[2004,4,20]],"date-time":"2004-04-20T00:36:30Z","timestamp":1082421390000},"page":"3554-3562","source":"Crossref","is-referenced-by-count":103,"title":["Parathyroid Hormone-Related Peptide Is Required for Increased Trabecular Bone Volume in Parathyroid Hormone-Null Mice"],"prefix":"10.1210","volume":"145","author":[{"given":"Dengshun","family":"Miao","sequence":"first","affiliation":[{"name":"Calcium Research Laboratory of the McGill University Health Center (D.M., J.L., Y.X., D.G.), McGill University, Montre\u0301al, Que\u0301bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarong","family":"Li","sequence":"additional","affiliation":[{"name":"Calcium Research Laboratory of the McGill University Health Center (D.M., J.L., Y.X., D.G.), McGill University, Montre\u0301al, Que\u0301bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingben","family":"Xue","sequence":"additional","affiliation":[{"name":"Calcium Research Laboratory of the McGill University Health Center (D.M., J.L., Y.X., D.G.), McGill University, Montre\u0301al, Que\u0301bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyi","family":"Su","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research of the Sir Mortimer B. 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