{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:14:48Z","timestamp":1790968488862,"version":"4.1.0"},"reference-count":62,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>GnRH is an evolutionarily conserved neuropeptide, of which there are multiple structural variants; the function of the most widespread variant, GnRH-II, remains undefined. GnRH-II may affect reproductive behavior; GnRH-II administration to female musk shrews reinstates mating behavior previously inhibited by food restriction. To determine whether this action of GnRH-II is universal, we conducted the following studies in mice. Ovariectomized mice were primed with estradiol benzoate and progesterone once a week and tested for sexual behavior. Females showing a lordosis quotient (LQ) of 50 or higher on the fourth trial underwent food deprivation (FD) for either 24 or 48 h before an additional behavior test. FD for 48 h significantly reduced LQ compared with ad libitum-fed females. Next, females were FD for 48 h or maintained on ad libitum feeding and retested for sexual behavior after an intracerebroventricular infusion of either GnRH-I, GnRH-II, or saline. GnRH-II, but not GnRH-I, significantly increased LQ in FD females compared with FD females treated with saline. Lordosis was unaffected by GnRH-II in females maintained on ad libitum feeding. To assess whether the GnRH-I receptor mediates GnRH-II\u2019s behavioral effects, underfed females were pretreated with the type 1 GnRH receptor antagonist Antide and retested for sexual behavior. Antide pretreatment did not prevent GnRH-II from promoting mating behavior, suggesting that GnRH-II\u2019s behavioral actions are mediated through the type 2 GnRH receptor. We speculate that GnRH-II acts via its own receptor as a regulatory signal in mammals to ensure that reproduction is synchronized with energetically favorable conditions.<\/jats:p>","DOI":"10.1210\/en.2004-0148","type":"journal-article","created":{"date-parts":[[2004,4,27]],"date-time":"2004-04-27T00:43:32Z","timestamp":1083026612000},"page":"3639-3646","source":"Crossref","is-referenced-by-count":102,"title":["A Critical Role for the Evolutionarily Conserved Gonadotropin-Releasing Hormone II: Mediation of Energy Status and Female Sexual Behavior"],"prefix":"10.1210","volume":"145","author":[{"given":"Alexander S.","family":"Kauffman","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, and the Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie F.","family":"Rissman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, and the Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071619144878000_R1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000122481","article-title":"Potentiation of lordosis behavior by intrahypothalamic infusion of synthetic luteinizing hormone releasing hormone.","volume":"20","author":"Moss","year":"1976","journal-title":"Neuroendocrinology"},{"key":"2020071619144878000_R2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.181.4095.177","article-title":"Induction of mating behavior in rats by luteinizing hormone releasing factor.","volume":"181","author":"Moss","year":"1973","journal-title":"Science"},{"key":"2020071619144878000_R3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0031-9384(94)00276-B","article-title":"Facilitation of mating behavior in 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