{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:34:55Z","timestamp":1791758095673,"version":"4.3.4"},"reference-count":59,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,8,1]]},"DOI":"10.1210\/en.2004-0383","type":"journal-article","created":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T00:33:41Z","timestamp":1084840421000},"page":"3850-3857","source":"Crossref","is-referenced-by-count":59,"title":["Leptin-Induced Increase in Leukemia Inhibitory Factor and Its Receptor by Human Endometrium Is Partially Mediated by Interleukin 1 Receptor Signaling"],"prefix":"10.1210","volume":"145","author":[{"given":"R. R.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Boston Biomedical Research Institute (R.R.G., M.P.R., P.C.L.), Watertown, Massachusetts 02472"},{"name":"Vincent Center for Reproductive Biology (R.R.G., B.R.R., M.P.R., R.D.L.), Massachusetts General Hospital, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. R.","family":"Rueda","sequence":"additional","affiliation":[{"name":"Vincent Center for Reproductive Biology (R.R.G., B.R.R., M.P.R., R.D.L.), Massachusetts General Hospital, Boston, Massachusetts 02114"},{"name":"Harvard Medical School (B.R.R., R.D.L.), Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Vincent Center for Reproductive Biology (R.R.G., B.R.R., M.P.R., R.D.L.), Massachusetts General Hospital, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Littell","sequence":"additional","affiliation":[{"name":"Vincent Center for Reproductive Biology (R.R.G., B.R.R., M.P.R., R.D.L.), Massachusetts General Hospital, Boston, Massachusetts 02114"},{"name":"Harvard Medical School (B.R.R., R.D.L.), Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Glasser","sequence":"additional","affiliation":[{"name":"Boston Biomedical Research Institute (R.R.G., M.P.R., P.C.L.), Watertown, Massachusetts 02472"},{"name":"Department of Molecular and Cellular Biology (S.G.), Baylor College of Medicine, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"Leavis","sequence":"additional","affiliation":[{"name":"Boston Biomedical Research Institute (R.R.G., M.P.R., P.C.L.), Watertown, Massachusetts 02472"},{"name":"Department of Physiology (P.C.L.), Tufts University School of Medicine, Boston, Massachusetts 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041122261736100_R1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/359076a0","article-title":"Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor.","volume":"359","author":"Stewart","year":"1992","journal-title":"Nature"},{"key":"2019041122261736100_R2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/humupd\/6.3.290","article-title":"Leptin and reproduction.","volume":"6","author":"Gonzalez","year":"2000","journal-title":"Hum Reprod Update"},{"key":"2019041122261736100_R3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1634\/stemcells.21-1-5","article-title":"The unsolved enigmas of leukemia inhibitory factor.","volume":"21","author":"Metcalf","year":"2003","journal-title":"Stem Cells"},{"key":"2019041122261736100_R4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/363361a0","article-title":"Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation.","volume":"363","author":"Escary","year":"1993","journal-title":"Nature"},{"key":"2019041122261736100_R5","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1242\/dev.121.5.1283","article-title":"Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.","volume":"121","author":"Ware","year":"1995","journal-title":"Development"},{"key":"2019041122261736100_R6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1073\/pnas.93.1.407","article-title":"Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.","volume":"93","author":"Yoshida","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122261736100_R7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0015-0282(02)03240-5","article-title":"Biochemical evaluation of endometrial function at the time of implantation.","volume":"78","author":"Lindhard","year":"2002","journal-title":"Fertil Steril"},{"key":"2019041122261736100_R8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/mrd.1080380205","article-title":"Temporal and spatial expression of leukemia inhibitory factor in rabbit uterus during early pregnancy.","volume":"38","author":"Yang","year":"1994","journal-title":"Mol Reprod Dev"},{"key":"2019041122261736100_R9","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1006\/cbir.2001.0749","article-title":"Effects of leukaemia inhibitory factor on endometrial receptivity and its hormonal regulation in rabbits.","volume":"25","author":"Liu","year":"2001","journal-title":"Cell Biol Int"},{"key":"2019041122261736100_R10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1600-0897.1998.tb00345.x","article-title":"Endometrial leukemia inhibitory factor (LIF) as a possible cause of unexplained infertility and multiple failures of implantation.","volume":"39","author":"Hambartsoumian","year":"1998","journal-title":"Am J Reprod Immunol"},{"key":"2019041122261736100_R11","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1095\/biolreprod53.4.974","article-title":"Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos.","volume":"53","author":"Sharkey","year":"1995","journal-title":"Biol Reprod"},{"key":"2019041122261736100_R12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/oxfordjournals.humrep.a019016","article-title":"Leukaemia inhibitory factor significantly enhances the blastocyst formation rates of human embryos cultured in serum-free medium.","volume":"11","author":"Dunglison","year":"1996","journal-title":"Hum Reprod"},{"key":"2019041122261736100_R13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/(SICI)1520-6408(1997)21:1<91::AID-DVG11>3.0.CO;2-D","article-title":"Preimplantation development of the mammalian embryo and its regulation by growth factors.","volume":"21","author":"Stewart","year":"1997","journal-title":"Dev Genet"},{"key":"2019041122261736100_R14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1530\/jrf.0.1010421","article-title":"Leukaemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time.","volume":"101","author":"Charnock-Jones","year":"1994","journal-title":"J Reprod Fertil"},{"key":"2019041122261736100_R15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1095\/biolreprod50.4.882","article-title":"Expression of leukemia inhibitory factor in human endometrium and placenta.","volume":"50","author":"Kojima","year":"1994","journal-title":"Biol Reprod"},{"key":"2019041122261736100_R16","first-page":"1908","article-title":"Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium.","volume":"80","author":"Arici","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122261736100_R17","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/oxfordjournals.humrep.a136060","article-title":"Leukaemia inhibitory factor in human endometrium during the menstrual cycle: cellular origin and action on production of glandular epithelial cell prostaglandin in vitro.","volume":"10","author":"Chen","year":"1995","journal-title":"Hum Reprod"},{"key":"2019041122261736100_R18","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1073\/pnas.93.7.3115","article-title":"Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine\/paracrine function in regulating embryo implantation.","volume":"93","author":"Cullinan","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122261736100_R19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1677\/joe.0.1480095","article-title":"Leukaemia inhibitory factor in human endometrium throughout the menstrual cycle.","volume":"148","author":"Vogiagis","year":"1996","journal-title":"J Endocrinol"},{"key":"2019041122261736100_R20","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1093\/oxfordjournals.humrep.a136328","article-title":"In-vitro endometrial secretion of human interleukin for DA cells\/leukaemia inhibitory factor by explant cultures from fertile and infertile women.","volume":"10","author":"Delage","year":"1995","journal-title":"Hum Reprod"},{"key":"2019041122261736100_R21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/humrep\/12.3.569","article-title":"The production of leukaemia inhibitory factor by human endometrium: presence in uterine flushings and production by cells in culture.","volume":"12","author":"Laird","year":"1997","journal-title":"Hum Reprod"},{"key":"2019041122261736100_R22","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1095\/biolreprod63.2.508","article-title":"Leukemia inhibitory factor, leukemia inhibitory factor receptor, and glycoprotein 130 in rhesus monkey uterus during menstrual cycle and early pregnancy.","volume":"63","author":"Yue","year":"2000","journal-title":"Biol Reprod"},{"key":"2019041122261736100_R23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0015-0282(01)03010-2","article-title":"Leptin and reproduction: a review.","volume":"77","author":"Moschos","year":"2002","journal-title":"Fertil Steril"},{"key":"2019041122261736100_R24","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1210\/endo.143.5.8818","article-title":"Leptin promotes the development of mouse preimplantation embryos in vitro.","volume":"143","author":"Kawamura","year":"2002","journal-title":"Endocrinology"},{"key":"2019041122261736100_R25","first-page":"4883","article-title":"Leptin and leptin receptor are expressed in the human endometrium and endometrial leptin secretion is regulated by the human blastocyst.","volume":"85","author":"Gonzalez","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122261736100_R26","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/molehr\/8.5.456","article-title":"Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation.","volume":"8","author":"Wu","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"2019041122261736100_R27","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1210\/jcem.85.5.6567","article-title":"Expression of leptin receptor in human endometrium and fluctuation during the menstrual cycle.","volume":"85","author":"Kitawaki","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122261736100_R28","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/molehr\/6.7.595","article-title":"The endometrium as a novel target for leptin: differences in fertility and subfertility.","volume":"6","author":"Alfer","year":"2000","journal-title":"Mol Hum Reprod"},{"key":"2019041122261736100_R29","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ng0396-318","article-title":"Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin.","volume":"12","author":"Chehab","year":"1996","journal-title":"Nat Genet"},{"key":"2019041122261736100_R30","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1210\/endo.142.12.8535","article-title":"Leptin requirement for conception, implantation, and gestation in the mouse.","volume":"142","author":"Malik","year":"2001","journal-title":"Endocrinology"},{"key":"2019041122261736100_R31","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1073\/pnas.93.16.8374","article-title":"The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.","volume":"93","author":"Baumann","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122261736100_R32","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1074\/jbc.272.10.6093","article-title":"The leptin receptor.","volume":"272","author":"Tartaglia","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041122261736100_R33","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1073\/pnas.93.13.6231","article-title":"Defective STAT signaling by the leptin receptor in diabetic mice.","volume":"93","author":"Ghilardi","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122261736100_R34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0014-5793(03)00440-X","article-title":"The ins and outs of leptin receptor activation.","volume":"546","author":"Zabeau","year":"2003","journal-title":"FEBS Lett"},{"key":"2019041122261736100_R35","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1073\/pnas.151180898","article-title":"Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation.","volume":"98","author":"Cheng","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122261736100_R36","doi-asserted-by":"crossref","first-page":"12897","DOI":"10.1074\/jbc.272.20.12897","article-title":"Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1\/2 cells.","volume":"272","author":"Takahashi","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041122261736100_R37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1385\/ENDO:16:1:21","article-title":"Leptin upregulates \u03b23-integrin expression and interleukin-1\u03b2, upregulates leptin and leptin receptor expression in human endometrial epithelial cell cultures.","volume":"16","author":"Gonzalez","year":"2001","journal-title":"Endocrine"},{"key":"2019041122261736100_R38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/molehr\/gag022","article-title":"Leptin regulation of the interleukin-1 system in human endometrial cells.","volume":"9","author":"Gonzalez","year":"2003","journal-title":"Mol Hum Reprod"},{"key":"2019041122261736100_R39","first-page":"2607","article-title":"Embryonic regulation of integrins \u03b23, \u03b14, and \u03b11 in human endometrial epithelial cells in vitro.","volume":"82","author":"Simon","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122261736100_R40","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1172\/JCI115835","article-title":"Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle.","volume":"90","author":"Lessey","year":"1992","journal-title":"J Clin Invest"},{"key":"2019041122261736100_R41","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1093\/humrep\/14.10.2485","article-title":"A quantitative evaluation of \u03b11, \u03b14, \u03b1V and \u03b23 endometrial integrins of fertile and unexplained infertile women during the menstrual cycle. A flow cytometric appraisal.","volume":"14","author":"Gonzalez","year":"1999","journal-title":"Hum Reprod"},{"key":"2019041122261736100_R42","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1385\/ENDO:15:2:157","article-title":"Effects of leptin, interleukin-1\u03b1, interleukin-6, and transforming growth factor-\u03b2 on markers of trophoblast invasive phenotype: integrins and metalloproteinases.","volume":"15","author":"Gonzalez","year":"2001","journal-title":"Endocrine"},{"key":"2019041122261736100_R43","first-page":"801","article-title":"The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: a potential role in human implantation.","volume":"81","author":"Nachtigall","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122261736100_R44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1385\/ENDO:21:2:185","article-title":"A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells.","volume":"21","author":"Gonzalez","year":"2003","journal-title":"Endocrine"},{"key":"2019041122261736100_R45","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/emboj\/cdg057","article-title":"SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation.","volume":"22","author":"Takahashi","year":"2003","journal-title":"EMBO J"},{"key":"2019041122261736100_R46","doi-asserted-by":"crossref","first-page":"40649","DOI":"10.1074\/jbc.M007577200","article-title":"SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.","volume":"275","author":"Bjorbak","year":"2000","journal-title":"J Biol Chem"},{"key":"2019041122261736100_R47","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1095\/biolreprod.103.019034","article-title":"Effects of leptin and leukemia inhibitory factor on preimplantation development and STAT3 signaling of mouse embryos in vitro.","volume":"69","author":"Fedorcsak","year":"2003","journal-title":"Biol Reprod"},{"key":"2019041122261736100_R48","doi-asserted-by":"crossref","first-page":"41547","DOI":"10.1074\/jbc.M205148200","article-title":"Regulation of Jak kinases by intracellular leptin receptor sequences.","volume":"277","author":"Kloek","year":"2002","journal-title":"J Biol Chem"},{"key":"2019041122261736100_R49","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1034\/j.1600-0897.2003.00071.x","article-title":"Expression of leptin receptor isoforms in vitro: lack of effects of leptin on endometrial cytokine and MMP production.","volume":"50","author":"Quinton","year":"2003","journal-title":"Am J Reprod Immunol"},{"issue":"Suppl 2","key":"2019041122261736100_R50","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0015-0282(03)00776-3","article-title":"Effects of leptin on the production of cytokines by cultured human endometrial stromal and epithelial cells","volume":"80","author":"Fukuda","year":"2003","journal-title":"Fertil Steril"},{"issue":"Suppl 1","key":"2019041122261736100_R51","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0015-0282(02)04830-6","article-title":"Coexpression of pinopodes and leukemia inhibitory factor, as well as its receptor, in human endometrium","volume":"79","author":"Aghajanova","year":"2003","journal-title":"Fertil Steril"},{"key":"2019041122261736100_R52","first-page":"353","article-title":"Leukemia inhibitory factor regulates cell survival of normal human endometrial stromal cells.","volume":"11","author":"Nakajima","year":"2003","journal-title":"Int J Mol Med"},{"key":"2019041122261736100_R53","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/endo.134.2.8299552","article-title":"Embryonic implantation in mice is blocked by interleukin-1 receptor antagonist.","volume":"134","author":"Simon","year":"1994","journal-title":"Endocrinology"},{"key":"2019041122261736100_R54","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1210\/endo.137.8.8754793","article-title":"Reproduction in mice lacking a functional type 1 IL-1 receptor.","volume":"137","author":"Abbondanzo","year":"1996","journal-title":"Endocrinology"},{"key":"2019041122261736100_R55","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1084\/jem.185.1.171","article-title":"Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia.","volume":"185","author":"Sarraf","year":"1997","journal-title":"J Exp Med"},{"key":"2019041122261736100_R56","doi-asserted-by":"crossref","first-page":"6390","DOI":"10.1073\/pnas.101564798","article-title":"Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF.","volume":"98","author":"Cao","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122261736100_R57","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/molehr\/6.3.269","article-title":"Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1\u03b2.","volume":"6","author":"Lebovic","year":"2000","journal-title":"Mol Hum Reprod"},{"key":"2019041122261736100_R58","first-page":"947","article-title":"Interleukin-1\u03b2 stimulates colony-stimulating factor-1 production in placental villous core mesenchymal cells.","volume":"75","author":"Harty","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122261736100_R59","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1677\/joe.0.1600181","article-title":"Review: the role of leukaemia inhibitory factor in the establishment of pregnancy.","volume":"160","author":"Vogiagis","year":"1999","journal-title":"J Endocrinol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/145\/8\/3850\/9282174\/endo3850.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T16:54:16Z","timestamp":1623948856000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/145\/8\/3850\/2878365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,1]]},"references-count":59,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2004-0383","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,1]]}}}