{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:26:27Z","timestamp":1791300387873,"version":"4.1.0"},"reference-count":28,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Kisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor known as GPR54. Mutations or targeted disruptions in the GPR54 gene cause hypogonadotropic hypogonadism in humans and mice, suggesting that kisspeptin signaling may be important for the regulation of gonadotropin secretion. To examine the effects of kisspeptin-54 (metastin) and kisspeptin-10 (the biologically active C-terminal decapeptide) on gonadotropin secretion in the mouse, we administered the kisspeptins directly into the lateral cerebral ventricle of the brain and demonstrated that both peptides stimulate LH secretion. Further characterization of kisspeptin-54 demonstrated that it stimulated both LH and FSH secretion, at doses as low as 1 fmol; moreover, this effect was shown to be blocked by pretreatment with acyline, a potent GnRH antagonist. To learn more about the functional anatomy of kisspeptins, we mapped the distribution of KiSS-1 mRNA in the hypothalamus. We observed that KiSS-1 mRNA is expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, including the anteroventral periventricular nucleus, the periventricular nucleus, and the arcuate nucleus. We conclude that kisspeptin-GPR54 signaling may be part of the hypothalamic circuitry that governs the hypothalamic secretion of GnRH.<\/jats:p>","DOI":"10.1210\/en.2004-0431","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T20:35:36Z","timestamp":1088109336000},"page":"4073-4077","source":"Crossref","is-referenced-by-count":977,"title":["A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse"],"prefix":"10.1210","volume":"145","author":[{"given":"M. L.","family":"Gottsch","sequence":"first","affiliation":[{"name":"Departments of Physiology & Biophysics (M.L.G., M.J.C., J.T.S., S.M.P., R.A.S.), University of Washington, Seattle, Washington 98195-7290"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Departments of Physiology & Biophysics (M.L.G., M.J.C., J.T.S., S.M.P., R.A.S.), University of Washington, Seattle, Washington 98195-7290"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. T.","family":"Smith","sequence":"additional","affiliation":[{"name":"Departments of Physiology & Biophysics (M.L.G., M.J.C., J.T.S., S.M.P., R.A.S.), University of Washington, Seattle, Washington 98195-7290"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Popa","sequence":"additional","affiliation":[{"name":"Departments of Physiology & Biophysics (M.L.G., M.J.C., J.T.S., S.M.P., R.A.S.), University of Washington, Seattle, Washington 98195-7290"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. V.","family":"Acohido","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics & Gynecology (B.V.A., D.K.C., R.A.S.), University of Washington, Seattle, Washington 98195-7290"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. F.","family":"Crowley","sequence":"additional","affiliation":[{"name":"The Massachusetts General Hospital (W.F.C., S.S.), Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Seminara","sequence":"additional","affiliation":[{"name":"The Massachusetts General Hospital (W.F.C., S.S.), Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. K.","family":"Clifton","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics & Gynecology (B.V.A., D.K.C., R.A.S.), University of Washington, Seattle, Washington 98195-7290"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Departments of Physiology & Biophysics (M.L.G., M.J.C., J.T.S., S.M.P., R.A.S.), University of Washington, Seattle, Washington 98195-7290"},{"name":"Departments of Obstetrics & Gynecology (B.V.A., D.K.C., R.A.S.), University of Washington, Seattle, Washington 98195-7290"},{"name":"Department of Biology (R.A.S.), University of Washington, Seattle, Washington 98195-7290"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071618584513300_R1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0014-5793(99)00009-5","article-title":"Discovery of a receptor related to the galanin receptors.","volume":"446","author":"Lee","year":"1999","journal-title":"FEBS Lett"},{"key":"2020071618584513300_R2","doi-asserted-by":"crossref","first-page":"34631","DOI":"10.1074\/jbc.M104847200","article-title":"The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural 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