{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:06:41Z","timestamp":1790978801936,"version":"4.1.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"DOI":"10.1210\/en.2004-1246","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T01:25:47Z","timestamp":1109899547000},"page":"2629-2638","source":"Crossref","is-referenced-by-count":39,"title":["Ectoderm-Targeted Overexpression of the Glucocorticoid Receptor Induces Hypohidrotic Ectodermal Dysplasia"],"prefix":"10.1210","volume":"146","author":[{"given":"Jose Luis","family":"Cascallana","sequence":"first","affiliation":[{"name":"Department of Animal Pathology, Veterinary Faculty (J.L.C., A.B., H.L.), University of Santiago de Compostela, E-27002 Lugo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Bravo","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, Veterinary Faculty (J.L.C., A.B., H.L.), University of Santiago de Compostela, E-27002 Lugo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Donet","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Valencia-Consejo Superior de Investigaciones Cientifica (IBV-CSIC) (E.D., H.L., P.P.), E-46010 Valencia"},{"name":"Fundacio\u0301n Valenciana de Investigaciones Biome\u0301dicas (FVIB) (E.D., H.L., P.P.), 46013 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Leis","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, Veterinary Faculty (J.L.C., A.B., H.L.), University of Santiago de Compostela, E-27002 Lugo"},{"name":"Instituto de Biomedicina de Valencia-Consejo Superior de Investigaciones Cientifica (IBV-CSIC) (E.D., H.L., P.P.), E-46010 Valencia"},{"name":"Fundacio\u0301n Valenciana de Investigaciones Biome\u0301dicas (FVIB) (E.D., H.L., P.P.), 46013 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda","family":"Lara","sequence":"additional","affiliation":[{"name":"Department of Animal Pathology, Veterinary Faculty (J.L.C., A.B., H.L.), University of Santiago de Compostela, E-27002 Lugo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesu\u0301s M.","family":"Paramio","sequence":"additional","affiliation":[{"name":"Project on Cell and Molecular Biology and Gene Therapy (J.M.P., J.L.J.), Centro de Investigaciones Energeticas Medioambientales y Tecnologicas, E-28040 Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301 L.","family":"Jorcano","sequence":"additional","affiliation":[{"name":"Project on Cell and Molecular Biology and Gene Therapy (J.M.P., J.L.J.), Centro de Investigaciones Energeticas Medioambientales y Tecnologicas, E-28040 Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Pe\u0301rez","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Valencia-Consejo Superior de Investigaciones Cientifica (IBV-CSIC) (E.D., H.L., P.P.), E-46010 Valencia"},{"name":"Fundacio\u0301n Valenciana de Investigaciones Biome\u0301dicas (FVIB) (E.D., H.L., P.P.), 46013 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041121563559600_R1","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1210\/me.2002-0106","article-title":"The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene","volume":"16","author":"Yudt","year":"2002","journal-title":"Mol Endocrinol"},{"key":"2019041121563559600_R2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1046\/j.1365-2230.2003.01319.x","article-title":"Towards a new classification of ectodermal dysplasias","volume":"28","author":"Lamartine","year":"2003","journal-title":"Clin Exp Dermatol"},{"key":"2019041121563559600_R3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1359-6101(03)00020-0","article-title":"Ectodysplasin signaling in development","volume":"14","author":"Mikkola","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"2019041121563559600_R4","first-page":"35","article-title":"Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs","volume":"39","author":"Thesleff","year":"1995","journal-title":"Int J Dev Biol"},{"key":"2019041121563559600_R5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0959-437X(00)00194-5","article-title":"NF-\u03baB signaling and human disease","volume":"11","author":"Aradhya","year":"2001","journal-title":"Curr Opin Genet Dev"},{"key":"2019041121563559600_R6","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1093\/hmg\/11.20.2371","article-title":"The NF-\u03baB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes","volume":"11","author":"Smahi","year":"2002","journal-title":"Hum Mol Genet"},{"key":"2019041121563559600_R7","first-page":"17","article-title":"The IKK\/NF-\u03baB system: a treasure trove for drug development","volume":"3","author":"Karin","year":"2004","journal-title":"Nat Rev"},{"key":"2019041121563559600_R8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tibs.2003.12.003","article-title":"I\u03baB kinases: key regulators of the NF-\u03baB pathway","volume":"29","author":"Yamamoto","year":"2004","journal-title":"Trends Biochem Sci"},{"key":"2019041121563559600_R9","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1126\/science.1098387","article-title":"Activation of transcription factor NF-\u03baB requires ELKS, an I\u03baB kinase regulatory subunit","volume":"304","author":"Ducut Sigala","year":"2004","journal-title":"Science"},{"key":"2019041121563559600_R10","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S1097-2765(00)80262-2","article-title":"Female mice heterozygous for IKK\u03b3\/NEMO deficiencies develop a dermopathy similar to the human X-linked disorder incontinentia pigmenti","volume":"5","author":"Makris","year":"2000","journal-title":"Mol Cell"},{"key":"2019041121563559600_R11","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S1097-2765(00)80263-4","article-title":"NEMO\/IKK\u03b3-deficient mice model incontinentia pigmenti","volume":"5","author":"Schmidt-Supprian","year":"2000","journal-title":"Mol Cell"},{"key":"2019041121563559600_R12","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1242\/dev.128.19.3843","article-title":"Requirement of NF-\u03baB\/Rel for the development of hair follicles and other epidermal appendices","volume":"128","author":"Schmidt-Ullrich","year":"2001","journal-title":"Development"},{"key":"2019041121563559600_R13","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1096\/fj.00-0772fje","article-title":"Altered skin development and impaired proliferative and inflammatory responses in transgenic mice overexpressing the glucocorticoid receptor","volume":"15","author":"Pe\u0301rez","year":"2001","journal-title":"FASEB J"},{"key":"2019041121563559600_R14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1387\/17","article-title":"Disruption of eyelid and cornea development by targeted overexpression of the glucocorticoid receptor","volume":"47","author":"Cascallana","year":"2003","journal-title":"Int J Dev Biol"},{"key":"2019041121563559600_R15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/002215540004800216","article-title":"Quantitative immunohistochemistry by measuring cumulative signal strength using commercially available software Photoshop and MatLab","volume":"48","author":"Matkowskyj","year":"2000","journal-title":"J Histochem Cytochem"},{"key":"2019041121563559600_R16","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1210\/endo.141.7.7541","article-title":"Increased fetal glucocorticoid exposure delays puberty onset in postnatal life","volume":"141","author":"Smith","year":"2000","journal-title":"Endocrinology"},{"key":"2019041121563559600_R17","first-page":"87","article-title":"Glucocorticoid receptor expression during the development of the embryonic mouse secondary palate","volume":"14","author":"Abbott","year":"1994","journal-title":"Craniofac Genet Dev Biol"},{"key":"2019041121563559600_R18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1210\/me.2003-0350","article-title":"Glucocorticoid receptor counteracts tumorigenic activity of Akt in skin through interference with the phosphatidylinositol 3-kinase (PI3K) signaling pathway","volume":"18","author":"Leis","year":"2004","journal-title":"Mol Endocrinol"},{"key":"2019041121563559600_R19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S1357-2725(01)00086-3","article-title":"Molecules in focus: p63","volume":"34","author":"Little","year":"2002","journal-title":"Int J Biochem Cell Biol"},{"key":"2019041121563559600_R20","doi-asserted-by":"crossref","first-page":"51408","DOI":"10.1074\/jbc.M309943200","article-title":"Delta Np63 \u03b1 expression is regulated by the phosphoinositide 3-kinase pathway","volume":"278","author":"Barbieri","year":"2003","journal-title":"J Biol Chem"},{"key":"2019041121563559600_R21","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S1534-5807(02)00163-6","article-title":"Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcription repressor blocking neural specification in the ventral ectoderm","volume":"2","author":"Bakkers","year":"2002","journal-title":"Dev Cell"},{"key":"2019041121563559600_R22","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1126\/science.282.5391.1136","article-title":"Transformation of tooth type induced by inhibition of BMP signaling","volume":"282","author":"Tucker","year":"1998","journal-title":"Science"},{"key":"2019041121563559600_R23","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1242\/dev.00453","article-title":"Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130","volume":"130","author":"Ruiz","year":"2003","journal-title":"Development"},{"key":"2019041121563559600_R24","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/19328","article-title":"Direct control of the Forkhead transcription factor AFX by protein kinase B","volume":"398","author":"Kops","year":"1999","journal-title":"Nature"},{"key":"2019041121563559600_R25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0092-8674(04)00302-2","article-title":"I\u03baB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a","volume":"117","author":"Hu","year":"2004","journal-title":"Cell"},{"key":"2019041121563559600_R26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1210\/edrv-17-3-245","article-title":"Molecular determinants of GR function and tissue sensitivity to glucocorticoids","volume":"17","author":"Bamberger","year":"1996","journal-title":"Endocr Rev"},{"key":"2019041121563559600_R27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000211097","article-title":"Glucocorticoid effect on hair growth initiation: a reconsideration","volume":"6","author":"Stenn","year":"1993","journal-title":"Skin Pharmacol"},{"key":"2019041121563559600_R28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0002-9394(14)76134-3","article-title":"Absent meibomian glands in the ectrodactyly, ectodermal dysplasia, cleft lip-palate syndrome","volume":"97","author":"Mondino","year":"1984","journal-title":"Am J Ophthalmol"},{"key":"2019041121563559600_R29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/eye.1996.73","article-title":"Absent meibomian glands: a marker for EEC syndrome","volume":"10","author":"Bonnard","year":"1996","journal-title":"Eye"},{"key":"2019041121563559600_R30","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S1091-8531(99)70048-0","article-title":"Hidrotic ectodermal dysplasia with corneal involvement","volume":"3","author":"Donahue","year":"1999","journal-title":"J AAPOS"},{"key":"2019041121563559600_R31","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1172\/JCI18714","article-title":"A hypermorphic I\u03baB\u03b1 mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency","volume":"112","author":"Courtois","year":"2003","journal-title":"J Clin Invest"},{"key":"2019041121563559600_R32","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1210\/er.2002-0006","article-title":"The interplay between the glucocorticoid receptor and nuclear factor-\u03baB or activator protein-1: molecular mechanisms for gene repression","volume":"24","author":"De Bosscher","year":"2003","journal-title":"Endocr Rev"},{"key":"2019041121563559600_R33","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1172\/JCI19960","article-title":"Finding NEMO: genetic disorders of NF-\u03baB activation","volume":"112","author":"Orange","year":"2003","journal-title":"J Clin Invest"},{"key":"2019041121563559600_R34","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1101\/gad.13.10.1322","article-title":"IKK1-deficient mice exhibit abnormal development of skin and skeleton","volume":"13","author":"Li","year":"1999","journal-title":"Genes Dev"},{"key":"2019041121563559600_R35","first-page":"3665","article-title":"I\u03baB Kinase \u03b1 is essential for development of the mammalian cornea and conjunctiva","volume":"41","author":"Yoshida","year":"2000","journal-title":"Invest Ophtalmol Vis Sci"},{"key":"2019041121563559600_R36","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1126\/science.1062677","article-title":"Activation by IKK\u03b1 of a second, evolutionary conserved, NF-kB signaling pathway","volume":"293","author":"Senftleben","year":"2001","journal-title":"Science"},{"key":"2019041121563559600_R37","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/35070605","article-title":"IKK\u03b1 controls formation of the epidermis independently of NF-\u03baB","volume":"410","author":"Hu","year":"2001","journal-title":"Nature"},{"key":"2019041121563559600_R38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1534-5807(04)00024-3","article-title":"A dual role for IKK\u03b1 in tooth development","volume":"6","author":"Ohazama","year":"2004","journal-title":"Dev Cell"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/146\/6\/2629\/10379523\/endo2629.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T09:31:01Z","timestamp":1625563861000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/146\/6\/2629\/2500114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,1]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2004-1246","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,1]]}}}