{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:57:18Z","timestamp":1772135838827,"version":"3.50.1"},"reference-count":32,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Concanavalin A-induced hepatotoxicity was compared in lipodystrophic aP2-nSREBP-1c transgenic mice (LD mice) lacking adipose tissue, obese leptin-deficient ob\/ob mice, and lean wild-type (WT) mice. Serum leptin and adiponectin were low in LD mice, whereas ob\/ob mice had undetectable leptin, but high adiponectin. Protection from hepatotoxicity was observed in ob\/ob, but not in LD mice, despite low cytokine levels and reduced T cell activation and hepatic natural killer T cells in both groups. Administration of adiponectin protected LD mice from hepatotoxicity without altering cytokine levels. In contrast, administration of leptin heightened disease susceptibility by restoring cytokine production. Neutralization of TNF\u03b1 protected LD mice from liver damage. Increased in vivo susceptibility to the hepatotoxic effect of TNF\u03b1 was observed in LD mice. In vitro, adiponectin protected primary hepatocytes from TNF\u03b1-induced death, whereas leptin had no protective effect. In conclusion, although leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNF\u03b1-induced death.<\/jats:p>","DOI":"10.1210\/en.2004-1572","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T01:25:30Z","timestamp":1106875530000},"page":"2157-2164","source":"Crossref","is-referenced-by-count":70,"title":["Regulation of T Cell-Mediated Hepatic Inflammation by Adiponectin and Leptin"],"prefix":"10.1210","volume":"146","author":[{"given":"Joseph A.","family":"Sennello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Fayad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M.","family":"Morris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Eckel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Asilmaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Montez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Friedman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Dinarello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giamila","family":"Fantuzzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071612373826100_R1","first-page":"E827","article-title":"The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation","volume":"280","author":"Fruhbeck","year":"2001","journal-title":"Am J Physiol"},{"key":"2020071612373826100_R2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1189\/jlb.68.4.437","article-title":"Leptin in the regulation of immunity, inflammation and hematopoiesis","volume":"68","author":"Fantuzzi","year":"2000","journal-title":"J Leukocyte Biol"},{"key":"2020071612373826100_R3","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1210\/en.2003-0580","article-title":"The adipocyte: at the crossroads of energy homeostasis, inflammation, and atherosclerosis","volume":"144","author":"Rajala","year":"2003","journal-title":"Endocrinology"},{"key":"2020071612373826100_R4","first-page":"RA55","article-title":"Adiponectin and resistin: new hormones of white adipose tissue","volume":"9","author":"Beltowski","year":"2003","journal-title":"Med Sci Monit"},{"key":"2020071612373826100_R5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbrc.2003.12.058","article-title":"Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPAR\u03b1, PPAR\u03b3 and LXR","volume":"314","author":"Chinetti","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071612373826100_R6","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.bbrc.2004.08.145","article-title":"Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes","volume":"15","author":"Wolf","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071612373826100_R7","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1161\/01.CIR.100.25.2473","article-title":"Novel modulator for endothelial adhesion molecules. 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