{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:00:35Z","timestamp":1791090035514,"version":"4.1.0"},"reference-count":52,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"DOI":"10.1210\/en.2004-1630","type":"journal-article","created":{"date-parts":[[2005,3,11]],"date-time":"2005-03-11T02:54:01Z","timestamp":1110509641000},"page":"2674-2683","source":"Crossref","is-referenced-by-count":209,"title":["The Role of Androgens in Sertoli Cell Proliferation and Functional Maturation: Studies in Mice with Total or Sertoli Cell-Selective Ablation of the Androgen Receptor"],"prefix":"10.1210","volume":"146","author":[{"given":"Karen A. L.","family":"Tan","sequence":"first","affiliation":[{"name":"Medical Research Council Human Reproductive Sciences Unit (K.A.L.T., M.W., R.M.S., P.T.K.S.), Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"De Gendt","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology (K.D.G., E.D., G.V.), Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Atanassova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Morphology and Anthropology (N.A.), Bulgarian Academy of Science, 1113 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Walker","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Reproductive Sciences Unit (K.A.L.T., M.W., R.M.S., P.T.K.S.), Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Reproductive Sciences Unit (K.A.L.T., M.W., R.M.S., P.T.K.S.), Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa T. K.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Reproductive Sciences Unit (K.A.L.T., M.W., R.M.S., P.T.K.S.), Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4SB, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evi","family":"Denolet","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology (K.D.G., E.D., G.V.), Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Verhoeven","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology (K.D.G., E.D., G.V.), Laboratory for Experimental Medicine and Endocrinology, Catholic University of Leuven, B-3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041121075653700_R1","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1210\/endo.142.8.8406","article-title":"Minireview: sex differentiation","volume":"142","author":"Hughes","year":"2001","journal-title":"Endocrinology"},{"key":"2019041121075653700_R2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/humupd\/7.3.314","article-title":"Disorders linked to insufficient androgen action in male children","volume":"7","author":"Sultan","year":"2001","journal-title":"Hum Reprod Update"},{"key":"2019041121075653700_R3","first-page":"1363","article-title":"Regulation of spermatogenesis","author":"Sharpe","year":"1994"},{"key":"2019041121075653700_R4","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1095\/biolreprod.104.029249","article-title":"Intratesticular androgen levels, androgen receptor localization, and androgen receptor expression in adult rat Sertoli cells","volume":"71","author":"Hill","year":"2004","journal-title":"Biol Reprod"},{"key":"2019041121075653700_R5","first-page":"199","article-title":"Sertoli cell endocrinology and signal transduction: androgen regulation","author":"Sharpe","year":"2005"},{"key":"2019041121075653700_R6","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1530\/rep.0.1250769","article-title":"Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood","volume":"125","author":"Sharpe","year":"2003","journal-title":"Reproduction"},{"key":"2019041121075653700_R7","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1095\/biolreprod31.4.785","article-title":"Quantification of the human Sertoli cell population: its distribution, relation to germ cell numbers, and age-related decline","volume":"31","author":"Johnson","year":"1984","journal-title":"Biol Reprod"},{"key":"2019041121075653700_R8","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/endo-122-3-787","article-title":"Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development","volume":"122","author":"Orth","year":"1988","journal-title":"Endocrinology"},{"key":"2019041121075653700_R9","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1210\/endo.135.3.8070367","article-title":"Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens","volume":"135","author":"Bremner","year":"1994","journal-title":"Endocrinology"},{"key":"2019041121075653700_R10","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1210\/en.2003-1055","article-title":"Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse","volume":"145","author":"Johnston","year":"2004","journal-title":"Endocrinology"},{"key":"2019041121075653700_R11","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1095\/biolreprod.104.035915","article-title":"Androgen-regulated transcripts in the neonatal mouse testis as determined through microarray analysis","volume":"72","author":"Zhou","year":"2005","journal-title":"Biol Reprod"},{"key":"2019041121075653700_R12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1677\/joe.1.05884","article-title":"Evidence that androgens and oestrogens, as well as follicle-stimulating hormone, can alter Sertoli cell number in the neonatal rat","volume":"184","author":"Atanassova","year":"2005","journal-title":"J Endocrinol"},{"key":"2019041121075653700_R13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1530\/eje.0.1330235","article-title":"Endocrine control of testicular somatic and premeiotic germ cell development in the immature testis of the primate Macaca mulatta","volume":"133","author":"Schlatt","year":"1995","journal-title":"Eur J Endocrinol"},{"key":"2019041121075653700_R14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1095\/biolreprod63.1.82","article-title":"Pulsatile stimulation with recombinant single chain human luteinizing hormone elicits precocious Sertoli cell proliferation in the juvenile male rhesus monkey (Macaca mulatta)","volume":"63","author":"Ramaswamy","year":"2000","journal-title":"Biol Reprod"},{"key":"2019041121075653700_R15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1073\/pnas.82.1.114","article-title":"Testicular peritubular cells secrete a protein under androgen control that modulates Sertoli cell functions","volume":"82","author":"Skinner","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121075653700_R16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1210\/endo-126-1-142","article-title":"Prostatic stromal cells and testicular peritubular cells produce similar paracrine mediators of androgen action","volume":"126","author":"Swinnen","year":"1990","journal-title":"Endocrinology"},{"key":"2019041121075653700_R17","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1093\/emboj\/19.20.5406","article-title":"Steroid-induced androgen receptor-oestradiol receptor \u03b2-Src complex triggers prostate cancer cell proliferation","volume":"19","author":"Migliaccio","year":"2000","journal-title":"EMBO J"},{"key":"2019041121075653700_R18","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1152\/physrev.00003.2003","article-title":"Nongenomic steroid action: controversies, questions, and answers","volume":"83","author":"Losel","year":"2003","journal-title":"Physiol Rev"},{"key":"2019041121075653700_R19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1530\/eje.0.1470425","article-title":"Rapid signal transduction in Sertoli cells","volume":"147","author":"Silva","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"2019041121075653700_R20","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1073\/pnas.0404278101","article-title":"Testosterone activates mitogen-activated protein kinase and the cAMP response element binding protein transcription factor in Sertoli cells","volume":"101","author":"Fix","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121075653700_R21","doi-asserted-by":"crossref","first-page":"13498","DOI":"10.1073\/pnas.212474399","article-title":"Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues","volume":"99","author":"Yeh","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121075653700_R22","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1073\/pnas.0308114100","article-title":"A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis","volume":"101","author":"De Gendt","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121075653700_R23","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1073\/pnas.0307306101","article-title":"Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells","volume":"101","author":"Chang","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121075653700_R24","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1242\/dev.00957","article-title":"Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids","volume":"131","author":"Holdcraft","year":"2004","journal-title":"Development"},{"key":"2019041121075653700_R25","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1210\/endo.140.11.7108","article-title":"Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood","volume":"140","author":"Atanassova","year":"1999","journal-title":"Endocrinology"},{"key":"2019041121075653700_R26","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1095\/biolreprod62.6.1685","article-title":"Effect of neonatal gonadotropin-releasing hormone antagonist administration on Sertoli cell number and testicular development in the marmoset: comparison with the rat","volume":"62","author":"Sharpe","year":"2000","journal-title":"Biol Reprod"},{"key":"2019041121075653700_R27","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1210\/en.2004-0671","article-title":"Abnormal Leydig cell aggregation in the fetal testis of rats exposed to Di(n-butyl) phthalate and its possible role in testicular dysgenesis","volume":"146","author":"Mahood","year":"2005","journal-title":"Endocrinology"},{"key":"2019041121075653700_R28","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1095\/biolreprod.103.016899","article-title":"Identification of developmentally regulated genes in the somatic cells of the mouse testis using serial analysis of gene expression","volume":"69","author":"O\u2019Shaughnessy","year":"2003","journal-title":"Biol Reprod"},{"key":"2019041121075653700_R29","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1210\/endo.140.4.6638","article-title":"Regulatory role of p27kip1 in the mouse and human testis","volume":"140","author":"Beumer","year":"1999","journal-title":"Endocrinology"},{"key":"2019041121075653700_R30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2605.1993.tb01155.x","article-title":"Relative roles of testosterone and the germ cell complement in determining stage-dependent changes in protein secretion by isolated rat seminiferous tubules","volume":"16","author":"Sharpe","year":"1993","journal-title":"Int J Androl"},{"key":"2019041121075653700_R31","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1242\/dev.120.7.1759","article-title":"Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells","volume":"120","author":"Yomogida","year":"1994","journal-title":"Development"},{"key":"2019041121075653700_R32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/dbio.1996.0276","article-title":"Pem: a testosterone- and LH-regulated homeobox gene expressed in mouse Sertoli cells and epididymis","volume":"179","author":"Lindsey","year":"1996","journal-title":"Dev Biol"},{"key":"2019041121075653700_R33","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1210\/endo-127-6-2829","article-title":"Hormonal regulation of androgen-binding protein in the rat","volume":"127","author":"Danzo","year":"1990","journal-title":"Endocrinology"},{"key":"2019041121075653700_R34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1095\/biolreprod27.1.211","article-title":"Secretion of testicular transferrin by cultured Sertoli cells is regulated by hormones and retinoids","volume":"27","author":"Skinner","year":"1982","journal-title":"Biol Reprod"},{"key":"2019041121075653700_R35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0303-7207(94)03471-5","article-title":"Platelet-derived growth factor ligand and receptor subunit mRNA in the Sertoli and Leydig cells of the rat testis","volume":"108","author":"Loveland","year":"1995","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121075653700_R36","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1095\/biolreprod.102.003368","article-title":"Identification and characterization of testis- and epididymis-specific genes: cystatin SC and cystatin TE-1","volume":"67","author":"Li","year":"2002","journal-title":"Biol Reprod"},{"key":"2019041121075653700_R37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/aja.1001910104","article-title":"Development of Sertoli cell junctional specializations and the distribution of the tight-junction-associated protein ZO-1 in the mouse testis","volume":"191","author":"Byers","year":"1991","journal-title":"Am J Anat"},{"key":"2019041121075653700_R38","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1210\/endo.141.8.7625","article-title":"Developmental and hormonal regulation of the expression of oligodendrocyte-specific protein\/claudin-11 in mouse testis","volume":"141","author":"Hellani","year":"2000","journal-title":"Endocrinology"},{"key":"2019041121075653700_R39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0303-7207(87)90105-5","article-title":"Vectorial secretion of transferrin and androgen binding protein in Sertoli cell cultures: effect of extracellular matrix, peritubular myoid cells and medium composition","volume":"52","author":"Janecki","year":"1987","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121075653700_R40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1210\/endo-129-1-353","article-title":"Actions of the testicular paracrine factor (P-Mod-S) on Sertoli cell transferrin secretion throughout pubertal development","volume":"129","author":"Anthony","year":"1991","journal-title":"Endocrinology"},{"key":"2019041121075653700_R41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0012-1606(87)90112-6","article-title":"Morphogenetic restructuring and formation of basement membranes by Sertoli cells and testis peritubular cells in co-culture: inhibition of the morphogenetic cascade by cyclic AMP derivatives and by blocking direct cell contact","volume":"120","author":"Tung","year":"1987","journal-title":"Dev Biol"},{"key":"2019041121075653700_R42","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1083\/jcb.100.6.1941","article-title":"Cooperativity between Sertoli cells and testicular peritubular cells in the production and deposition of extracellular matrix components","volume":"100","author":"Skinner","year":"1985","journal-title":"J Cell Biol"},{"key":"2019041121075653700_R43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1095\/biolreprod55.2.227","article-title":"Discriminative analysis of rat Sertoli and peritubular cells and their proliferation in vitro: evidence for follicle-stimulating hormone-mediated contact inhibition of Sertoli cell mitosis","volume":"55","author":"Schlatt","year":"1996","journal-title":"Biol Reprod"},{"key":"2019041121075653700_R44","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1210\/en.2002-220595","article-title":"Proliferative phase Sertoli cells display a developmentally regulated response to activin in vitro","volume":"144","author":"Buzzard","year":"2003","journal-title":"Endocrinology"},{"key":"2019041121075653700_R45","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/BF00185969","article-title":"Growth factors as mediators of androgen action during development of the male urogenital tract","volume":"13","author":"Cunha","year":"1995","journal-title":"World J Urol"},{"key":"2019041121075653700_R46","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/mrd.1080330403","article-title":"Developmental expression of the S35\u2013S45\/SGP-2\/TRPM-2 gene in rat testis and epididymis","volume":"33","author":"Zakeri","year":"1992","journal-title":"Mol Reprod Dev"},{"key":"2019041121075653700_R47","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1172\/JCI119653","article-title":"Hormonal and cellular regulation of Sertoli cell anti-Mu\u0308llerian hormone production in the postnatal mouse","volume":"100","author":"Al-Attar","year":"1997","journal-title":"J Clin Invest"},{"key":"2019041121075653700_R48","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1083\/jcb.149.5.1019","article-title":"Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice","volume":"149","author":"Gnessi","year":"2000","journal-title":"J Cell Biol"},{"key":"2019041121075653700_R49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0074-7696(08)60766-4","article-title":"The Sertoli-germ cell communication network in mammals","volume":"147","author":"Jegou","year":"1993","journal-title":"Int Rev Cytol"},{"key":"2019041121075653700_R50","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1210\/mend-4-3-393","article-title":"Germ cell regulation of Sertoli cell transferrin mRNA levels","volume":"4","author":"Stallard","year":"1990","journal-title":"Mol Endocrinol"},{"key":"2019041121075653700_R51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1677\/jme.0.0190067","article-title":"Investigation of the potential role of the germ cell complement in control of the expression of transferrin mRNA in the prepubertal and adult rat testis","volume":"19","author":"Maguire","year":"1997","journal-title":"J Mol Endocrinol"},{"key":"2019041121075653700_R52","first-page":"22","article-title":"Effects of androgens on the germ cell-depleted testes of prenatally irradiated rats","volume":"16","author":"Verhoeven","year":"1995","journal-title":"Int J Androl"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/146\/6\/2674\/10380314\/endo2674.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T20:04:51Z","timestamp":1625601891000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/146\/6\/2674\/2500224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,1]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2004-1630","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,1]]}}}