{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:45:03Z","timestamp":1790171103443,"version":"4.1.0"},"reference-count":45,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"<jats:p>The role of TNF-related apoptosis-inducing ligand (TRAIL) in autoimmune thyroiditis is unclear. We used experimental autoimmune thyroiditis to clarify the contribution of TRAIL to the development of autoimmune thyroiditis. CBA\/J mice were immunized with murine thyroglobulin, and spleen cells from these mice were subsequently injected into irradiated recipient CBA\/J mice. One week later, the recipient mice were treated with recombinant TRAIL or a control protein. Compared with control animals, TRAIL-treated mice developed a milder form of the disease with a significant decrease in mononuclear cell infiltration in the thyroid and less thyroid follicular destruction. Furthermore, the number of apoptotic thyrocytes and also thyroglobulin-specific T helper-1 cell responses in TRAIL-treated mice was lower than that in the control animals. This study suggests that exogenous TRAIL suppresses the development of autoimmune thyroiditis via altering the function of cells involved in the immune response. These findings may contribute toward a novel treatment autoimmune thyroiditis.<\/jats:p>","DOI":"10.1210\/en.2005-0627","type":"journal-article","created":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T00:33:35Z","timestamp":1125016415000},"page":"4721-4726","source":"Crossref","is-referenced-by-count":38,"title":["Death Ligand Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis"],"prefix":"10.1210","volume":"146","author":[{"given":"Su He","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyi","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Wolf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Van Antwerp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071612513819600_R1","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.7533326","article-title":"The Fas death factor.","volume":"267","author":"Nagata","year":"1995","journal-title":"Science"},{"key":"2020071612513819600_R2","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0092-8674(95)90013-6","article-title":"Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome.","volume":"81","author":"Fisher","year":"1995","journal-title":"Cell"},{"key":"2020071612513819600_R3","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1126\/science.7539157","article-title":"Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity.","volume":"268","author":"Rieux-Laucat","year":"1995","journal-title":"Science"},{"key":"2020071612513819600_R4","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1056\/NEJM199611283352204","article-title":"Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity.","volume":"335","author":"Drappa","year":"1996","journal-title":"N Engl J Med"},{"key":"2020071612513819600_R5","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0140-6736(96)02293-3","article-title":"Clinical, immunological, and pathological consequences of Fas-deficient conditions.","volume":"348","author":"Le Deist","year":"1996","journal-title":"Lancet"},{"key":"2020071612513819600_R6","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1084\/jem.191.7.1095","article-title":"Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression.","volume":"191","author":"Song","year":"2000","journal-title":"J Exp Med"},{"key":"2020071612513819600_R7","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.4049\/jimmunol.168.5.2470","article-title":"A unique combination of inflammatory cytokines enhances apoptosis of thyroid follicular cells and transforms non-destructive to destructive thyroiditis in experimental autoimmune thyroiditis.","volume":"168","author":"Wang","year":"2002","journal-title":"J Immunol"},{"key":"2020071612513819600_R8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/bbrc.1994.1412","article-title":"Apoptosis in dog thyroid cells.","volume":"200","author":"Dremier","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071612513819600_R9","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/BF01213321","article-title":"Enhanced cellular proliferative activity and cell death in chronic thyroiditis and thyroid papillary carcinoma.","volume":"121","author":"Okayasu","year":"1995","journal-title":"J Cancer Res Clin Oncol"},{"key":"2020071612513819600_R10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1507\/endocrj.42.193","article-title":"Apoptosis in thyroid diseases: a histochemical study.","volume":"42","author":"Tanimoto","year":"1995","journal-title":"Endocr J"},{"key":"2020071612513819600_R11","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1210\/jcem-69-4-832","article-title":"Phenotypic and functional analysis at the clonal level of infiltrating T lymphocytes in papillary carcinoma of the thyroid: prevalence of cytolytic T cells with natural killer-like or lymphokine-activated killer activity.","volume":"69","author":"Bagnasco","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612513819600_R12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3109\/08916939508995700","article-title":"Apoptosis in thyroid tissue from patients with Hashimoto\u2019s thyroiditis.","volume":"20","author":"Kotani","year":"1995","journal-title":"Autoimmunity"},{"key":"2020071612513819600_R13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1096-9896(199706)182:2<138::AID-PATH810>3.0.CO;2-F","article-title":"Analysis of apoptosis in relation to tissue destruction associated with Hashimoto\u2019s autoimmune thyroiditis.","volume":"182","author":"Hammond","year":"1997","journal-title":"J Pathol"},{"key":"2020071612513819600_R14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.123.1.15","article-title":"Regulation of autoimmune response to mouse thyroglobulin: influence of H-2D-end genes.","volume":"123","author":"Kong","year":"1979","journal-title":"J Immunol"},{"key":"2020071612513819600_R15","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1210\/endo.138.11.5548","article-title":"Fas (APO-1, CD95)-mediated apoptosis in thyroid cells is regulated by a labile protein inhibitor.","volume":"138","author":"Arscott","year":"1997","journal-title":"Endocrinology"},{"key":"2020071612513819600_R16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/82725","article-title":"Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins.","volume":"1","author":"Stassi","year":"2000","journal-title":"Nat Immunol"},{"key":"2020071612513819600_R17","doi-asserted-by":"crossref","first-page":"25433","DOI":"10.1074\/jbc.274.36.25433","article-title":"Inflammatory cytokine regulation of fas-mediated apoptosis in thyroid follicular cells.","volume":"274","author":"Bretz","year":"1999","journal-title":"J Biol Chem"},{"key":"2020071612513819600_R18","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/sj.onc.1207213","article-title":"IFN\u03b3 sensitization to TRAIL-induced apoptosis in human thyroid carcinoma cells by upregulating Bak expression.","volume":"23","author":"Wang","year":"2004","journal-title":"Oncogene"},{"key":"2020071612513819600_R19","first-page":"3330","article-title":"Antitumor activity and bystander effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene.","volume":"61","author":"Kagawa","year":"2001","journal-title":"Cancer Res"},{"key":"2020071612513819600_R20","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.4049\/jimmunol.162.5.2639","article-title":"Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity.","volume":"162","author":"Kayagaki","year":"1999","journal-title":"J Immunol"},{"key":"2020071612513819600_R21","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1073\/pnas.030545097","article-title":"Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy.","volume":"97","author":"Chinnaiyan","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612513819600_R22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/cimm.1995.1066","article-title":"Distinctive modulation by IL-4 and IL-10 of the effector function of murine thyroglobulin-primed cells in \u201ctransfer-experimental autoimmune thyroiditis.\u201d","volume":"162","author":"Mignon-Godefroy","year":"1995","journal-title":"Cell Immunol"},{"key":"2020071612513819600_R23","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/0003-4975(92)90271-5","article-title":"Flow cytometric analysis of organ preservation-induced endothelial cell membrane damage.","volume":"53","author":"Killinger Jr","year":"1992","journal-title":"Ann Thorac Surg"},{"key":"2020071612513819600_R24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/(SICI)1097-0320(19991101)37:3<191::AID-CYTO5>3.0.CO;2-U","article-title":"Comparative analysis of apoptosis in HL60 detected by annexin-V and fluorescein-diacetate.","volume":"37","author":"Bartkowiak","year":"1999","journal-title":"Cytometry"},{"key":"2020071612513819600_R25","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.4049\/jimmunol.166.2.1314","article-title":"Roles of TNF-related apoptosis-inducing ligand in experimental autoimmune encephalomyelitis.","volume":"166","author":"Hilliard","year":"2001","journal-title":"J Immunol"},{"key":"2020071612513819600_R26","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1210\/me.2004-0286","article-title":"Induction and regulation of Fas-mediated apoptosis in human thyroid epithelial cells.","volume":"19","author":"Mezosi","year":"2005","journal-title":"Mol Endocrinol"},{"key":"2020071612513819600_R27","first-page":"1","article-title":"Autoimmune thyroid disease.","volume":"81","author":"Wang","year":"2001","journal-title":"Clinical Immunology"},{"key":"2020071612513819600_R28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<201::AID-IMMU201>3.0.CO;2-N","article-title":"Experimental autoimmune thyroiditis (EAT) in mice lacking the IFN-\u03b3 receptor gene.","volume":"28","author":"Alimi","year":"1998","journal-title":"Eur J Immunol"},{"key":"2020071612513819600_R29","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0960-5428(97)00027-7","article-title":"Cytokines and thyroid function.","volume":"6","author":"Ajjan","year":"1996","journal-title":"Adv Neuroimmunol"},{"key":"2020071612513819600_R30","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.4049\/jimmunol.146.7.2227","article-title":"T-depend destruction of thyroid isografts exposed to IFN-\u03b3.","volume":"146","author":"Frohman","year":"1991","journal-title":"J Immunol"},{"key":"2020071612513819600_R31","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.4049\/jimmunol.170.11.5523","article-title":"Thyroid-specific expression of IFN-\u03b3 limits experimental autoimmune thyroiditis by suppressing lymphocyte activation in cervical lymph nodes.","volume":"170","author":"Barin","year":"2003","journal-title":"J Immunol"},{"key":"2020071612513819600_R32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1530\/acta.0.1220041","article-title":"Induction of experimental thyroiditis in mice by recombinant interferon \u03b3 administration.","volume":"122","author":"Kawakami","year":"1990","journal-title":"Acta Endocrinol"},{"key":"2020071612513819600_R33","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2249.1991.tb05589.x","article-title":"Spatial correlation between thyroid epithelial cells expressing class II MHC molecules and interferon-\u03b3-containing lymphocytes in human thyroid autoimmune disease.","volume":"83","author":"Hamilton","year":"1991","journal-title":"Clin Exp Immunol"},{"key":"2020071612513819600_R34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.yexmp.2004.08.004","article-title":"Early chemokine expression induced by interferon-\u03b3 in a murine model of Hashimoto\u2019s thyroiditis.","volume":"77","author":"Kimura","year":"2004","journal-title":"Exp Mol Pathol"},{"key":"2020071612513819600_R35","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1210\/jc.2004-0977","article-title":"High levels of circulating CXC chemokine ligand 10 are associated with chronic autoimmune thyroiditis and hypothyroidism.","volume":"89","author":"Antonelli","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612513819600_R36","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.immuni.2004.11.008","article-title":"TRAIL-R as a negative regulator of innate immune cell responses.","volume":"21","author":"Diehl","year":"2004","journal-title":"Immunity"},{"key":"2020071612513819600_R37","doi-asserted-by":"crossref","first-page":"23627","DOI":"10.1074\/jbc.274.33.23627","article-title":"TRAIL death pathway expression and induction in thyroid follicular cells.","volume":"274","author":"Bretz","year":"1999","journal-title":"J Biol Chem"},{"key":"2020071612513819600_R38","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/sj.cdd.4400965","volume":"9","author":"Bretz","journal-title":"Cell Death Diff"},{"key":"2020071612513819600_R39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0090-1229(85)90043-1","article-title":"Transfer of experimental autoimmune thyroiditis to normal syngeneic mice by injection of mouse thyroglobulin-sensitized T lymphocytes after activation with concanavalin A.","volume":"36","author":"Okayasu","year":"1985","journal-title":"Clin Immunol Immunopathol"},{"key":"2020071612513819600_R40","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/eji.1830120512","article-title":"Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells. III. Induction of thyroiditis by thyroid-sensitized T lymphoblasts.","volume":"12","author":"Charreire","year":"1982","journal-title":"Eur J Immunol"},{"key":"2020071612513819600_R41","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.4049\/jimmunol.138.4.1092","article-title":"Transfer of experimental autoimmune thyroiditis with T cell clones.","volume":"138","author":"Romball","year":"1987","journal-title":"J Immunol"},{"key":"2020071612513819600_R42","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.4049\/jimmunol.131.5.2316","article-title":"T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice.","volume":"131","author":"Maron","year":"1983","journal-title":"J Immunol"},{"key":"2020071612513819600_R43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1084\/jem.157.2.559","article-title":"Experimental autoimmune thyroiditis. In vitro cytotoxic effects of T lymphocytes on thyroid monolayers.","volume":"157","author":"Creemers","year":"1983","journal-title":"J Exp Med"},{"key":"2020071612513819600_R44","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.immunol.17.1.221","article-title":"Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment.","volume":"17","author":"Lenardo","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"2020071612513819600_R45","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.1440-1711.1999.00818.x","article-title":"Activation-induced apoptosis of autoreactive and alloreactive T lymphocytes in the target organ as a major mechanism of tolerance.","volume":"77","author":"Pender","year":"1999","journal-title":"Immunol Cell Biol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/146\/11\/4721\/9021802\/endo4721.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/146\/11\/4721\/9021802\/endo4721.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T09:00:46Z","timestamp":1683190846000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/146\/11\/4721\/2499809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,1]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2005-0627","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,1]]}}}