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The focal cortical cold lesion was induced in the primary motor cortex by means of a cooled copper cylinder placed directly onto the cortical surface. One hour later, the animals were killed, the brains cut into 0.4-mm-thick slices, and the sections stained with 1% triphenyltetrazolium chloride. The volume of the hemispheric lesion was calculated for each animal. The results demonstrated that the lesion area was significantly attenuated in both the DHEAS- and E2- pre- and posttreated groups and that in the presence of letrozole, a nonsteroidal aromatase inhibitor, no neuroprotection was observed, suggesting that the beneficial effect of DHEAS on the cold injury might depend on the conversion of DHEAS to E2 within the brain. It is concluded that even a single posttraumatic administration of DHEAS may be of substantial therapeutic benefit in the treatment of focal brain injury with vasogenic edema.<\/jats:p>","DOI":"10.1210\/en.2005-0693","type":"journal-article","created":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T01:24:14Z","timestamp":1132277054000},"page":"683-686","source":"Crossref","is-referenced-by-count":28,"title":["Dehydroepiandrosterone Sulfate Is Neuroprotective when Administered Either before or after Injury in a Focal Cortical Cold Lesion Model"],"prefix":"10.1210","volume":"147","author":[{"given":"Gabriella","family":"Juha\u0301sz-Vedres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E\u0301va","family":"Ro\u0301zsa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Ra\u0301kos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0301rton B.","family":"Dobszay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Kis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja\u0301nos","family":"Wo\u0308lfling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0301zsef","family":"Toldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u0301rpa\u0301d","family":"Pa\u0301rducz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tama\u0301s","family":"Farkas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071612345285800_R1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1210\/er.2001-0031","article-title":"Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone.","volume":"24","author":"Labrie","year":"2003","journal-title":"Endocr Rev"},{"key":"2020071612345285800_R2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0006-8993(87)90807-9","article-title":"Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice.","volume":"406","author":"Roberts","year":"1987","journal-title":"Brain Res"},{"key":"2020071612345285800_R3","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1073\/pnas.95.8.4678","article-title":"Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development.","volume":"95","author":"Compagnone","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612345285800_R4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0006-8993(84)90299-3","article-title":"Modulation of the GABA receptor complex by a steroid anaesthetic.","volume":"323","author":"Harrison","year":"1984","journal-title":"Brain Res"},{"key":"2020071612345285800_R5","first-page":"S33","article-title":"Potentiation by dehydroepiandrosterone of the neuronal response to N-methyl-d-aspartate in the CA3 region of the rat dorsal hippocampus: an effect mediated via sigma receptors","volume":"150","author":"Debonnel","year":"1996","journal-title":"J Endocrinol"},{"key":"2020071612345285800_R6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1749-6632.1995.tb17375.x","article-title":"Neuronal actions of dehydroepiandrosterone. 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