{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:34:08Z","timestamp":1791326048887,"version":"4.3.1"},"reference-count":82,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:p>As a first step in investigating the role of retinoic acid (RA) in mouse testis, we analyzed the distribution pattern of the enzymes involved in vitamin A storage (lecithin:retinol acyltransferase), RA synthesis (\u03b2-carotene 15,15\u2032-monoxygenase and retinaldehyde dehydrogenases) and RA degradation (cytochrome P450 hydroxylases) as well as those of all isotypes of receptors transducing the RA signal [RA receptors (RARs) and rexinoid receptors (RXRs)]. Our data indicate that in adult testis 1) cytochrome P450 hydroxylase enzymes may generate in peritubular myoid cells a catabolic barrier that prevents circulating RA and RA synthesized by Leydig cells to enter the seminiferous epithelium; 2) the compartmentalization of RA synthesis within this epithelium may modulate, through paracrine mechanisms, the coupling between spermatogonia proliferation and spermatogenesis; 3) retinyl esters synthesized in round spermatids by lecithin:retinol acyltransferase may be transferred and stored in Sertoli cells, in the form of adipose differentiation-related protein-coated lipid droplets. We also show that RAR\u03b1 and RXR\u03b2 are confined to Sertoli cells, whereas RAR\u03b3 is expressed in spermatogonia and RAR\u03b2, RXR\u03b1, and RXR\u03b3 are colocalized in step 7\u20138 spermatids. Correlating these expression patterns with the pathological phenotypes generated in response to RAR and RXR mutations and to postnatal vitamin A deficiency suggests that spermiation requires RXR\u03b2\/RAR\u03b1 heterodimers in Sertoli cells, whereas spermatogonia proliferation involves, independently of RXR, two distinct RAR-mediated signaling pathways in both Sertoli cells and spermatogonia. Our data also suggest that the involvement of RA in testis development starts when primary spermatogonia first appear.<\/jats:p>","DOI":"10.1210\/en.2005-0953","type":"journal-article","created":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T20:24:19Z","timestamp":1128630259000},"page":"96-110","source":"Crossref","is-referenced-by-count":242,"title":["Retinoic Acid Metabolism and Signaling Pathways in the Adult and Developing Mouse Testis"],"prefix":"10.1210","volume":"147","author":[{"given":"Nade\u0300ge","family":"Vernet","sequence":"first","affiliation":[{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire (IGBMC) (N.V., C.D., C.R.-E., M.O.-A., P.C., N.B.G., M.M.), Centre National de la Recherche Scientifique (CNRS)\/Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM)\/Universite\u0301 Louis Pasteur de Strasbourg (ULP)\/Colle\u0300ge de France, 67404 Illkirch Cedex, Communaute\u0301 Urbaine de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Dennefeld","sequence":"additional","affiliation":[{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire (IGBMC) (N.V., C.D., C.R.-E., M.O.-A., P.C., N.B.G., M.M.), Centre National de la Recherche Scientifique (CNRS)\/Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM)\/Universite\u0301 Louis Pasteur de Strasbourg (ULP)\/Colle\u0300ge de France, 67404 Illkirch Cedex, Communaute\u0301 Urbaine de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce\u0301cile","family":"Rochette-Egly","sequence":"additional","affiliation":[{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire (IGBMC) (N.V., C.D., C.R.-E., M.O.-A., P.C., N.B.G., M.M.), Centre National de la Recherche Scientifique (CNRS)\/Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale 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Sante\u0301 et de la Recherche Me\u0301dicale (INSERM)\/Universite\u0301 Louis Pasteur de Strasbourg (ULP)\/Colle\u0300ge de France, 67404 Illkirch Cedex, Communaute\u0301 Urbaine de Strasbourg, France"},{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire (IGBMC) (N.V., C.D., C.R.-E., M.O.-A., P.C., N.B.G., M.M.), Centre National de la Recherche Scientifique (CNRS)\/Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM)\/Universite\u0301 Louis Pasteur de Strasbourg (ULP)\/Colle\u0300ge de France, 67404 Illkirch Cedex, Communaute\u0301 Urbaine de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert B.","family":"Ghyselinck","sequence":"additional","affiliation":[{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire (IGBMC) (N.V., C.D., C.R.-E., M.O.-A., P.C., N.B.G., M.M.), Centre National de la Recherche Scientifique (CNRS)\/Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM)\/Universite\u0301 Louis Pasteur de Strasbourg (ULP)\/Colle\u0300ge de France, 67404 Illkirch Cedex, Communaute\u0301 Urbaine de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mark","sequence":"additional","affiliation":[{"name":"Institut Clinique de la Souris (ICS) (P.C., M.M.), Centre National de la Recherche Scientifique (CNRS)\/Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM)\/Universite\u0301 Louis Pasteur de Strasbourg (ULP)\/Colle\u0300ge de France, 67404 Illkirch Cedex, Communaute\u0301 Urbaine de Strasbourg, France"},{"name":"Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire (IGBMC) (N.V., C.D., C.R.-E., M.O.-A., P.C., N.B.G., M.M.), Centre National de la Recherche Scientifique (CNRS)\/Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM)\/Universite\u0301 Louis Pasteur de Strasbourg 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