{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T11:10:12Z","timestamp":1783768212032,"version":"3.55.0"},"reference-count":83,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:p>Ghrelin is an endogenous ligand for the GH secretagogue\/ghrelin receptor (GHS-R) and stimulates feeding behavior and GH levels in rodents and humans. A preprandial increase in plasma ghrelin levels is seen in sheep on programmed feeding, followed by a postprandial rise in plasma GH levels, but effects on food intake and endocrine function are not defined in this ruminant species. We administered ghrelin to female sheep in various modes and measured effects on voluntary food intake (VFI) and plasma levels of GH, LH, prolactin, and cortisol. Whether administered intracerebroventricularly or iv, ghrelin consistently failed to stimulate VFI. On the other hand, ghrelin invariably increased plasma GH levels and \u03b1,\u03b2-diaminopropanoic acid-octanoyl3 human ghrelin was more potent than ovine ghrelin. Bolus injection of ghrelin into the third cerebral ventricle reduced plasma LH levels but did not affect levels of prolactin or cortisol. These findings suggested that the preprandial rise in plasma ghrelin that is seen in sheep on programmed feeding does not influence VFI but is likely to be important in the postprandial rise in GH levels. Thus, ghrelin does not appear to be a significant regulator of ingestive behavior in this species of ruminant but acts centrally to indirectly regulate GH and LH secretion.<\/jats:p>","DOI":"10.1210\/en.2005-1048","type":"journal-article","created":{"date-parts":[[2005,10,7]],"date-time":"2005-10-07T00:24:19Z","timestamp":1128644659000},"page":"510-519","source":"Crossref","is-referenced-by-count":114,"title":["Effects of Central Infusion of Ghrelin on Food Intake and Plasma Levels of Growth Hormone, Luteinizing Hormone, Prolactin, and Cortisol Secretion in Sheep"],"prefix":"10.1210","volume":"147","author":[{"given":"Javed","family":"Iqbal","sequence":"first","affiliation":[{"name":"Prince Henry\u2019s Institute of Medical Research (J.I., I.J.C.), Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Kurose","sequence":"first","affiliation":[{"name":"Laboratory of Animal Nutrient Metabolism (Y.K.), Kitasato University, Towada, Aomori 034, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedict","family":"Canny","sequence":"first","affiliation":[{"name":"Department of Physiology (B.C.), Monash University, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain J.","family":"Clarke","sequence":"first","affiliation":[{"name":"Prince Henry\u2019s Institute of Medical Research (J.I., I.J.C.), Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071612475974100_R1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.npep.2004.06.003","article-title":"NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy.","volume":"38","author":"Kalra","year":"2004","journal-title":"Neuropeptides"},{"key":"2020071612475974100_R2","first-page":"95","article-title":"Role of proopiomelanocortin neurons and peptides in the 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