{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:30:38Z","timestamp":1770067838356,"version":"3.49.0"},"reference-count":35,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"DOI":"10.1210\/en.2005-1524","type":"journal-article","created":{"date-parts":[[2006,2,24]],"date-time":"2006-02-24T01:31:07Z","timestamp":1140744667000},"page":"3016-3026","source":"Crossref","is-referenced-by-count":66,"title":["Dimethandrolone Undecanoate: A New Potent Orally Active Androgen with Progestational Activity"],"prefix":"10.1210","volume":"147","author":[{"given":"Barbara J.","family":"Attardi","sequence":"first","affiliation":[{"name":"BIOQUAL, Inc., Rockville, Maryland 20850"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheri A.","family":"Hild","sequence":"additional","affiliation":[{"name":"BIOQUAL, Inc., Rockville, Maryland 20850"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry R.","family":"Reel","sequence":"additional","affiliation":[{"name":"BIOQUAL, Inc., Rockville, Maryland 20850"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2019041121341647900_R1","first-page":"119","article-title":"Diagnosis and partial androgen deficiency in the aging male.","volume":"64","author":"Vermeulen","year":"2003","journal-title":"Ann Endocrinol (Paris)"},{"key":"2019041121341647900_R2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s00114-003-0494-4","article-title":"The endocrine pharmacology of testosterone therapy in men.","volume":"91","author":"Oettel","year":"2004","journal-title":"Naturwissenschaften"},{"key":"2019041121341647900_R3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1365-2265.2004.02002.x","article-title":"Age-related changes in testosterone and the role of replacement therapy in older men.","volume":"60","author":"Allan","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2019041121341647900_R4","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.1210\/jc.2003-031719","article-title":"Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts male aging study.","volume":"89","author":"Araujo","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121341647900_R5","first-page":"587","author":"Marcelli","year":"1998"},{"key":"2019041121341647900_R6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0303-7207(99)00227-0","article-title":"Hormone substitution in male hypogonadism.","volume":"161","author":"Zitzmann","year":"2000","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121341647900_R7","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/BF03345206","article-title":"Testosterone replacement therapy in male hypogonadism.","volume":"26","author":"Byrne","year":"2003","journal-title":"J Endocrinol Invest"},{"key":"2019041121341647900_R8","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.bmcl.2004.11.076","article-title":"7\u03b1,11\u03b2-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties.","volume":"15","author":"Cook","year":"2005","journal-title":"Bioorg Medi Chem Lett"},{"key":"2019041121341647900_R9","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1210\/jcem-55-6-1089","article-title":"Simultaneous measurement of progesterone and androgen receptors in human prostate: a microassay.","volume":"55","author":"Ekman","year":"1982","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121341647900_R10","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/0277-5379(93)90018-Z","article-title":"Binding of [3H]methyltrienolone (R1881) by human breast cancers.","volume":"19","author":"Miller","year":"1983","journal-title":"Eur J Cancer Clin Oncol"},{"key":"2019041121341647900_R11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0960-0760(99)00143-0","article-title":"7\u03b1-Methyl-19-nortestosterone, a synthetic androgen with high potency: structure activity comparisons with other androgens.","volume":"71","author":"Kumar","year":"1999","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2019041121341647900_R12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tips.2003.11.009","article-title":"Progress toward hormonal male contraception.","volume":"25","author":"Kamischke","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"2019041121341647900_R13","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1210\/jc.2003-030574","article-title":"Testosterone undecanoate maintains spermatogenic suppression induced by cyproterone acetate plus testosterone undecanoate in normal men.","volume":"88","author":"Meriggiola","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121341647900_R14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3181\/00379727-83-20301","article-title":"Myotrophic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method.","volume":"83","author":"Hershberger","year":"1953","journal-title":"Proc Soc Exp Biol Med"},{"key":"2019041121341647900_R15","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1210\/jcem-33-6-988","article-title":"A method for producing specific antisera with small doses of immunogen.","volume":"33","author":"Vaitukaitis","year":"1971","journal-title":"J Clin Endocrinol"},{"key":"2019041121341647900_R16","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/humrep\/15.5.1100","article-title":"Circulating concentrations of the antiprogestins CDB-2914 and mifepristone in the female rhesus monkey following various routes of administration.","volume":"15","author":"Larner","year":"2000","journal-title":"Hum Reprod"},{"key":"2019041121341647900_R17","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/humrep\/15.4.822","article-title":"CDB-2914: Anti-progestational\/ antiglucocorticoid profile and post-coital anti-fertility activity in rats and rabbits.","volume":"15","author":"Hild","year":"2000","journal-title":"Hum Reprod"},{"key":"2019041121341647900_R18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1113\/jphysiol.1934.sp003217","article-title":"The assay of progestin.","volume":"83","author":"McPhail","year":"1934","journal-title":"J Physiol (Lond)"},{"key":"2019041121341647900_R19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0303-7207(01)00743-2","article-title":"CDB-4124 and its putative metabolite CDB-4453 are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914.","volume":"188","author":"Attardi","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121341647900_R20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mce.2004.04.013","article-title":"Steroid hormonal regulation of growth, prostate specific antigen secretion, and transcription mediated by the mutated androgen receptor in CWR22Rv1 human prostate carcinoma cells.","volume":"222","author":"Attardi","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121341647900_R21","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0092-8674(82)90218-5","article-title":"Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance.","volume":"28","author":"Horwitz","year":"1982","journal-title":"Cell"},{"key":"2019041121341647900_R22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0960-0760(94)90254-2","article-title":"Estrogenic and progestagenic activities coexisting in steroidal drugs: quantitative evaluation by in vitro bioassays with human cells.","volume":"48","author":"Markiewicz","year":"1993","journal-title":"J Steroid Biochem"},{"key":"2019041121341647900_R23","doi-asserted-by":"crossref","first-page":"14196","DOI":"10.1016\/S0021-9258(18)89877-5","article-title":"The rabbit progesterone receptor. Evidence for a single steroid-binding subunit and characterization of receptor mRNA.","volume":"259","author":"Loosfelt","year":"1984","journal-title":"J Biol Chem"},{"key":"2019041121341647900_R24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0960-0760(95)00056-6","article-title":"Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens.","volume":"53","author":"Sundaram","year":"1995","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2019041121341647900_R25","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0015-0282(16)44003-3","article-title":"Competitive progesterone antagonists: receptor binding and biologic activity of testosterone and 19-nortestosterone derivatives.","volume":"31","author":"Reel","year":"1979","journal-title":"Fertil Steril"},{"key":"2019041121341647900_R26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0960-0760(98)00114-9","article-title":"Estrogenic and progestational activity of 7\u03b1-methyl-19-nortestosterone, a synthetic androgen.","volume":"67","author":"Beri","year":"1998","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2019041121341647900_R27","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/humrep\/12.5.967","article-title":"Pharmacokinetics and pharmacodynamics of 7\u03b1-methyl-19-nortestosterone after intramuscular administration in healthy men.","volume":"12","author":"Suvisaari","year":"1997","journal-title":"Hum Reprod"},{"key":"2019041121341647900_R28","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/j.1939-4640.1997.tb01938.x","article-title":"Pharmacokinetics of 7\u03b1-methyl-19-nortestosterone in men and cynomolgus monkeys.","volume":"18","author":"Kumar","year":"1997","journal-title":"J Androl"},{"key":"2019041121341647900_R29","first-page":"4212","article-title":"Prostate-sparing effects in primates of the potent androgen 7\u03b1-methyl-19-nortestosterone: a potential alternative to testosterone for androgen replacement and male contraception.","volume":"83","author":"Cummings","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121341647900_R30","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1093\/humrep\/14.9.2200","article-title":"Gonadotrophin and testosterone suppression by 7\u03b1-methyl-19-nortestosterone acetate administered by subdermal implant to healthy men.","volume":"9","author":"Noe\u0301","year":"1999","journal-title":"Hum Reprod"},{"key":"2019041121341647900_R31","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bone.2005.01.003","article-title":"Bone and muscle protective potential of the prostate-sparing synthetic androgen 7\u03b1-methyl-19-nortestosterone: evidence from the aged orchidectomized male rat model.","volume":"36","author":"Venken","year":"2005","journal-title":"Bone"},{"key":"2019041121341647900_R32","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2164\/jandrol.04135","article-title":"Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: a randomized clinical trial.","volume":"26","author":"Anawalt","year":"2005","journal-title":"J Androl"},{"key":"2019041121341647900_R33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0303-7207(01)00562-7","article-title":"Endocrine regulation of testicular function in men: implications for contraceptive development.","volume":"182","author":"Amory","year":"2001","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121341647900_R34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/j.1939-4640.1987.tb00959.x","article-title":"Reversal of testicular function after prolonged suppression with an LHRH agonist in rhesus monkeys.","volume":"8","author":"Sundaram","year":"1987","journal-title":"J Androl"},{"key":"2019041121341647900_R35","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1210\/jc.2002-022043","article-title":"A clinical trial of 7\u03b1-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men.","volume":"88","author":"Von Eckardstein","year":"2003","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/147\/6\/3016\/10804595\/endo3016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T02:53:00Z","timestamp":1706928780000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/147\/6\/3016\/2879734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,1]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2005-1524","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,1]]}}}