{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:19:16Z","timestamp":1790741956888,"version":"4.1.0"},"reference-count":59,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:p>Type 2 iodothyronine deiodinase (D2) activates T4 by deiodination to T3, a process being the source of most T3 present in the brain. In the mediobasal hypothalamus, expression of the dio2 gene is potently activated by administration of bacterial lipopolysaccharide (LPS), which in turn mediates the modifications in thyroid homeostasis typically observed in patients with nonthyroidal illness syndrome. Here we show that LPS-induced D2 expression is also observed in human MSTO-211H cells that endogenously express D2. Exposure to LPS rapidly doubled D2 activity by a mechanism that was partially blocked by the nuclear factor-\u03baB (NF-\u03baB) inhibitor sulfasalazine. Next, the human dio2 5\u2032-flanking region promoter assay was used in HC11 cells and the p65\/NF-\u03baB responsiveness mapped to the 3\u2032 approximately 600-bp region of hdio2 5\u2032-flanking region, with an approximately 15-fold induction. Semiquantitative EMSA identified the strongest NF-\u03baB binding sites at the positions \u2212683 bp (called no. 2) and \u2212198 bp (no. 5) 5\u2032 to the transcriptional starting site. Despite the very similar NF-\u03baB binding affinity of these two sites, site-directed mutagenesis and promoter assay indicated that only site no. 5 possessed transactivation potency in the presence of the p65 subunit of NF-\u03baB. Other cytokine mediators such as signal transducer and activator of transcription-3 (STAT3) or signal transducer and activator of transcription-5 (STAT5) did not induce transcription of the dio2 gene. Our results indicate that inflammatory signals regulate D2 expression predominantly via the NF-\u03baB pathway in a direct transcriptional manner and could contribute to the changes in thyroid economy observed in nonthyroidal illness syndrome during infection.<\/jats:p>","DOI":"10.1210\/en.2005-1608","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T00:45:11Z","timestamp":1148604311000},"page":"4419-4429","source":"Crossref","is-referenced-by-count":59,"title":["Characterization of the Nuclear Factor-\u03baB Responsiveness of the Human dio2 Gene"],"prefix":"10.1210","volume":"147","author":[{"given":"Aniko\u0301","family":"Zeo\u0308ld","sequence":"first","affiliation":[{"name":"Laboratory of Endocrine Neurobiology (A.Z., J.M., Z.L., C.F., B.G.), Faculty of Information Technology, Pe\u0301ter Pa\u0301zma\u0301ny Catholic University, Budapest H-1083, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0301rton","family":"Doleschall","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry (M.D., I.K.), Faculty of Veterinary Science, Szent Istva\u0301n University, H-1400 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Haffner","sequence":"additional","affiliation":[{"name":"Division Medical Biochemistry (M.C.H.), Biocenter, Innsbruck Medical University, A-6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane P.","family":"Capelo","sequence":"additional","affiliation":[{"name":"Thyroid Section (L.P.C., W.S.d.S., A.C.B.), Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Menyhe\u0301rt","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrine Neurobiology (A.Z., J.M., Z.L., C.F., B.G.), Faculty of Information Technology, Pe\u0301ter Pa\u0301zma\u0301ny Catholic University, Budapest H-1083, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Liposits","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrine Neurobiology (A.Z., J.M., Z.L., C.F., B.G.), Faculty of Information Technology, Pe\u0301ter Pa\u0301zma\u0301ny Catholic University, Budapest H-1083, Hungary"},{"name":"Institute of Experimental Medicine, Hungarian Academy of Sciences, and Department of Neuroscience (Z.L.), Faculty of Information Technology, Pe\u0301ter Pa\u0301zma\u0301ny Catholic University, Budapest H-1083, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner S.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Thyroid Section (L.P.C., W.S.d.S., A.C.B.), Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio C.","family":"Bianco","sequence":"additional","affiliation":[{"name":"Thyroid Section (L.P.C., W.S.d.S., A.C.B.), Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"Kacskovics","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry (M.D., I.K.), Faculty of Veterinary Science, Szent Istva\u0301n University, H-1400 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Fekete","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrine Neurobiology (A.Z., J.M., Z.L., C.F., B.G.), Faculty of Information Technology, Pe\u0301ter Pa\u0301zma\u0301ny Catholic University, Budapest H-1083, Hungary"},{"name":"Tupper Research Institute and Department of Medicine (C.F.), Division of Endocrinology, Diabetes, and Metabolism, Boston, Massachusetts 02111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bala\u0301zs","family":"Gereben","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrine Neurobiology (A.Z., J.M., Z.L., C.F., B.G.), Faculty of Information Technology, Pe\u0301ter Pa\u0301zma\u0301ny Catholic University, Budapest H-1083, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071615011996000_R1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1210\/edrv.23.1.0455","article-title":"Biochemistry, cellular and molecular biology and physiological roles of the iodothyronine selenodeiodinases","volume":"23","author":"Bianco","year":"2002","journal-title":"Endocr Rev"},{"key":"2020071615011996000_R2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1089\/thy.2005.15.855","article-title":"Pretranslational regulation of type 2 deiodinase","volume":"15","author":"Gereben","year":"2005","journal-title":"Thyroid"},{"key":"2020071615011996000_R3","first-page":"2179","article-title":"Phenolic and tyrosyl ring iodothyronine deiodination and thyroid hormone concentrations in the human central nervous system","volume":"81","author":"Campos-Barros","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615011996000_R4","doi-asserted-by":"crossref","first-page":"10391","DOI":"10.1073\/pnas.94.19.10391","article-title":"The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain","volume":"94","author":"Guadano-Ferraz","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071615011996000_R5","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1210\/endo.138.8.5318","article-title":"Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone","volume":"138","author":"Tu","year":"1997","journal-title":"Endocrinology"},{"key":"2020071615011996000_R6","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1210\/en.2004-0229","article-title":"Ontogenic redistribution of type 2 deiodinase messenger ribonucleic acid in the brain of chicken","volume":"145","author":"Gereben","year":"2004","journal-title":"Endocrinology"},{"key":"2020071615011996000_R7","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1210\/jc.2004-2567","article-title":"Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus","volume":"90","author":"Alkemade","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615011996000_R8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.7291997","article-title":"Cerebral cortex responds rapidly to thyroid hormones","volume":"214","author":"Leonard","year":"1981","journal-title":"Science"},{"key":"2020071615011996000_R9","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1172\/JCI118353","article-title":"Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats","volume":"96","author":"Escobar-Morreale","year":"1995","journal-title":"J Clin Invest"},{"key":"2020071615011996000_R10","doi-asserted-by":"crossref","first-page":"E470","DOI":"10.1152\/ajpendo.00043.2003","article-title":"Effects of hyper- and hypothyroidism on thyroid hormone concentrations in regions of the rat brain","volume":"285","author":"Broedel","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2020071615011996000_R11","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1089\/thy.2005.15.883","article-title":"Role of thyroid hormone deiodination in the hypothalamus","volume":"15","author":"Lechan","year":"2005","journal-title":"Thyroid"},{"key":"2020071615011996000_R12","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1210\/en.2003-1439","article-title":"Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome","volume":"145","author":"Fekete","year":"2004","journal-title":"Endocrinology"},{"key":"2020071615011996000_R13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainres.2005.07.021","article-title":"Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels","volume":"1056","author":"Fekete","year":"2005","journal-title":"Brain Res"},{"key":"2020071615011996000_R14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1677\/joe.0.1820315","article-title":"Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice","volume":"182","author":"Boelen","year":"2004","journal-title":"J Endocrinol"},{"key":"2020071615011996000_R15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"2020071615011996000_R16","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/ni712","article-title":"Toll-like receptors control activation of adaptive immune responses","volume":"2","author":"Schnare","year":"2001","journal-title":"Nat Immunol"},{"key":"2020071615011996000_R17","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1085536","article-title":"Toll-like receptor signaling pathways","volume":"300","author":"Barton","year":"2003","journal-title":"Science"},{"key":"2020071615011996000_R18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0952-7915(01)00308-9","article-title":"The role of chemokines in linking innate and adaptive immunity","volume":"14","author":"Luster","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"2020071615011996000_R19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1359-6101(02)00026-6","article-title":"Regulation of cytokine signaling and inflammation","volume":"13","author":"Hanada","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"2020071615011996000_R20","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-\u03baB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"2020071615011996000_R21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1096\/fj.00-0339com","article-title":"Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components","volume":"15","author":"Laflamme","year":"2001","journal-title":"FASEB J"},{"key":"2020071615011996000_R22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological impact","volume":"3","author":"Levy","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2020071615011996000_R23","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1210\/mend.15.1.0579","article-title":"The Human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1)","volume":"15","author":"Gereben","year":"2001","journal-title":"Mol Endocrinol"},{"key":"2020071615011996000_R24","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1182\/blood-2002-09-2924","article-title":"Regulation of human \u03b22-microglobulin transactivation in hematopoietic cells","volume":"101","author":"Gobin","year":"2003","journal-title":"Blood"},{"key":"2020071615011996000_R25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)81959-5","article-title":"Stat3 as an oncogene","volume":"98","author":"Bromberg","year":"1999","journal-title":"Cell"},{"key":"2020071615011996000_R26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1172\/JCI10741","article-title":"Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling","volume":"107","author":"Harris","year":"2001","journal-title":"J Clin Invest"},{"key":"2020071615011996000_R27","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1038\/sj.onc.1202617","article-title":"INK4 cell cycle inhibitors direct transcriptional inactivation of NF-\u03baB","volume":"18","author":"Wolff","year":"1999","journal-title":"Oncogene"},{"key":"2020071615011996000_R28","doi-asserted-by":"crossref","first-page":"E1119","DOI":"10.1152\/ajpendo.00571.2002","article-title":"Regulation of type II deiodinase expression by EGF and glucocorticoid in HC11 mouse mammary epithelium","volume":"284","author":"Song","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2020071615011996000_R29","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1096\/fasebj.14.9.1159","article-title":"Activation of NF-\u03baB p50\/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated beta-casein gene expression","volume":"14","author":"Geymayer","year":"2000","journal-title":"FASEB J"},{"key":"2020071615011996000_R30","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1073\/pnas.92.16.7297","article-title":"A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine","volume":"92","author":"Boussif","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071615011996000_R31","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1046\/j.1432-1327.1998.2580784.x","article-title":"Selective coupling of STAT factors to the mouse prolactin receptor","volume":"258","author":"Mayr","year":"1998","journal-title":"Eur J Biochem"},{"key":"2020071615011996000_R32","doi-asserted-by":"crossref","first-page":"30183","DOI":"10.1074\/jbc.C100325200","article-title":"The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line","volume":"276","author":"Curcio","year":"2001","journal-title":"J Biol Chem"},{"key":"2020071615011996000_R33","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1172\/JCI992","article-title":"Sulfasalazine: a potent and specific inhibitor of nuclear factor \u03baB","volume":"101","author":"Wahl","year":"1998","journal-title":"J Clin Invest"},{"key":"2020071615011996000_R34","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/cncr.20924","article-title":"Tumor necrosis factor enhances SN38-mediated apoptosis in mesothelioma cells","volume":"103","author":"Russo","year":"2005","journal-title":"Cancer"},{"key":"2020071615011996000_R35","unstructured":"Schug\n              J\n            , OvertonGC\n          1997\n          TESS: Transcription Element Search Software on the WWW. Technical report CBIL-TR-1997-1001-v0.0, http:\/\/www.cbil.upenn.edu\/tess"},{"key":"2020071615011996000_R36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0092-8674(89)90833-7","article-title":"NF-\u03baB: a pleiotropic mediator of inducible and tissue-specific gene control","volume":"58","author":"Lenardo","year":"1989","journal-title":"Cell"},{"key":"2020071615011996000_R37","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/nar\/26.1.362","article-title":"Databases on transcriptional regulation: TRANSFAC, TRRD, and COMPEL","volume":"26","author":"Heinemeyer","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"2020071615011996000_R38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tins.2004.11.002","article-title":"Physiological functions for brain NF-\u03baB","volume":"28","author":"Meffert","year":"2005","journal-title":"Trends Neurosci"},{"key":"2020071615011996000_R39","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1002\/j.1460-2075.1991.tb07707.x","article-title":"NF-\u03baB contacts DNA by a heterodimer of the p50 and p65 subunit","volume":"10","author":"Urban","year":"1991","journal-title":"EMBO J"},{"key":"2020071615011996000_R40","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.4049\/jimmunol.173.9.5583","article-title":"NF-\u03baB regulates expression of the MHC class I-related chain A gene in activated T lymphocytes","volume":"173","author":"Molinero","year":"2004","journal-title":"J Immunol"},{"key":"2020071615011996000_R41","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.3140380","article-title":"I\u03baB: a specific inhibitor of the NF-\u03baB transcription factor","volume":"242","author":"Baeuerle","year":"1988","journal-title":"Science"},{"key":"2020071615011996000_R42","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1128\/MCB.12.10.4412","article-title":"Selection of optimal \u03baB\/Rel DNA-binding motifs: interaction of both subunits of NF-\u03baB with DNA is required for transcriptional activation","volume":"12","author":"Kunsch","year":"1992","journal-title":"Mol Cell Biol"},{"key":"2020071615011996000_R43","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/ni1196","article-title":"Interactions of NF-\u03baB with chromatin: the art of being at the right place at the right time","volume":"6","author":"Natoli","year":"2005","journal-title":"Nat Immunol"},{"key":"2020071615011996000_R44","doi-asserted-by":"crossref","first-page":"24694","DOI":"10.1074\/jbc.M200006200","article-title":"The x-ray crystal structure of the NF-\u03baB p50.p65 heterodimer bound to the interferon \u03b2-\u03baB site","volume":"277","author":"Berkowitz","year":"2002","journal-title":"J Biol Chem"},{"key":"2020071615011996000_R45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.gene.2005.04.013","article-title":"Genomic structure and functional characterization of the promoter region of human I\u03baB kinase-related kinase IKKi\/IKK\u03b5 gene","volume":"353","author":"Wang","year":"2005","journal-title":"Gene"},{"key":"2020071615011996000_R46","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0303-7207(00)00246-X","article-title":"Isolation and characterization of the 5\u2032-upstream and untranslated regions of the mouse type II iodothyronine deiodinase gene","volume":"165","author":"Song","year":"2000","journal-title":"Mol Cell Endocrinol"},{"key":"2020071615011996000_R47","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S0006-291X(88)80488-1","article-title":"Dibutyryl cAMP induction of type II 5\u2032deiodinase activity in rat brain astrocytes in culture","volume":"151","author":"Leonard","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071615011996000_R48","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF00233891","article-title":"The functional and structural border between the CSF- and blood-milieu in the circumventricular organs (organum vasculosum laminae terminalis, subfornical organ, area postrema) of the rat","volume":"195","author":"Krisch","year":"1978","journal-title":"Cell Tissue Res"},{"key":"2020071615011996000_R49","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1126\/science.1698311","article-title":"CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein","volume":"249","author":"Wright","year":"1990","journal-title":"Science"},{"key":"2020071615011996000_R50","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ni886","article-title":"TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-\u03b2 induction","volume":"4","author":"Oshiumi","year":"2003","journal-title":"Nat Immunol"},{"key":"2020071615011996000_R51","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/ni986","article-title":"TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway","volume":"4","author":"Yamamoto","year":"2003","journal-title":"Nat Immunol"},{"key":"2020071615011996000_R52","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1750-3639.1998.tb00189.x","article-title":"The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations","volume":"8","author":"Lacroix","year":"1998","journal-title":"Brain Pathol"},{"key":"2020071615011996000_R53","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0306-4530(01)00064-6","article-title":"How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis","volume":"26","author":"Rivest","year":"2001","journal-title":"Psychoneuroendocrinology"},{"key":"2020071615011996000_R54","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0306-4522(99)00225-0","article-title":"Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood-brain barrier","volume":"93","author":"Nadeau","year":"1999","journal-title":"Neuroscience"},{"key":"2020071615011996000_R55","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1523\/JNEUROSCI.20-09-03456.2000","article-title":"Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor \u03baB activity in the brain during endotoxemia","volume":"20","author":"Nadeau","year":"2000","journal-title":"J Neurosci"},{"key":"2020071615011996000_R56","doi-asserted-by":"crossref","first-page":"6675","DOI":"10.1074\/jbc.M001748200","article-title":"DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites","volume":"276","author":"Ehret","year":"2001","journal-title":"J Biol Chem"},{"key":"2020071615011996000_R57","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1172\/JCI25083","article-title":"Type 2 iodothyronine deiodinase is the major source of plasma T(3) in euthyroid humans","volume":"115","author":"Luiza Maia","year":"2005","journal-title":"J Clin Invest"},{"key":"2020071615011996000_R58","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1172\/JCI7771","article-title":"A potential role of activated NF-\u03baB in the pathogenesis of euthyroid sick syndrome","volume":"106","author":"Nagaya","year":"2000","journal-title":"J Clin Invest"},{"key":"2020071615011996000_R59","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1210\/en.2005-0608","article-title":"Induction of type 3 deiodinase activity in inflammatory cells of mice with chronic local inflammation","volume":"146","author":"Boelen","year":"2005","journal-title":"Endocrinology"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/147\/9\/4419\/9035160\/endo4419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/147\/9\/4419\/9035160\/endo4419.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T02:32:14Z","timestamp":1594953134000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/147\/9\/4419\/2528348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,1]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2005-1608","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,1]]}}}