{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:43:36Z","timestamp":1791078216687,"version":"4.1.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:p>Glial cell line-derived neurotrophic factor family receptor (GFR\u03b1) 4, the binding receptor for persephin, is coexpressed with the signaling Ret receptor tyrosine kinase predominantly in thyroid calcitonin-producing C cells. We show by in situ hybridization and immunohistochemistry that the functional, glycolipid-anchored form of GFR\u03b14 is produced in mouse only in the C cells but not in parathyroid gland or in the brain. C cells expressed functional GFR\u03b14 throughout postnatal development, whereas Ret expression in these cells decreased postnatally and was undetectable in adults. To understand the physiological role of GFR\u03b14, we produced GFR\u03b14-deficient [knockout (KO)] mice. No differences were observed between wild-type and GFR\u03b14-KO littermate animals in growth, gross behavior, or viability. The number and morphology of the thyroid C cells were indistinguishable between the genotypes in both newborn and adult age. However, thyroid tissue calcitonin content was reduced by 60% in newborn and by 45% in 3-wk-old GFR\u03b14-KO mice compared with wild-type controls. In contrast, thyroid calcitonin levels were similar in adult animals. Consistent with the reduced calcitonin levels, bone formation rate in juvenile GFR\u03b14-KO mice was increased. In conclusion, this study indicates a novel role for endogenous GFR\u03b14 signaling in regulating calcitonin production in thyroid C cells of young mice.<\/jats:p>","DOI":"10.1210\/en.2005-1620","type":"journal-article","created":{"date-parts":[[2006,2,24]],"date-time":"2006-02-24T01:31:07Z","timestamp":1140744667000},"page":"2237-2244","source":"Crossref","is-referenced-by-count":33,"title":["Ablation of Persephin Receptor Glial Cell Line-Derived Neurotrophic Factor Family Receptor \u03b14 Impairs Thyroid Calcitonin Production in Young Mice"],"prefix":"10.1210","volume":"147","author":[{"given":"Pa\u0308ivi 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