{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:55:15Z","timestamp":1790430915416,"version":"4.1.0"},"reference-count":47,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:p>The role of glucocorticoid receptors (GRs) in the protective effect of restraint stress (RS) before acoustic trauma was studied in spiral ganglion neurons of CBA mice. RS increased corticosterone and protected against elevated auditory brain stem thresholds caused by acoustic trauma. This protection was inhibited by the pretreatment with a corticosterone synthesis inhibitor, metyrapone (MET), and a GR antagonist (RU486). RS followed by acoustic trauma caused an immediate increase in corticosterone that triggered nuclear translocation of GR, without a change in the expression of GR protein. RU486 + MET before RS and acoustic trauma caused an immediate increase in GR mRNA followed by increased GR protein expression (24 h after trauma). GR signaling was further characterized by analyzing nuclear factor-\u03baB (NF\u03baB) nuclear translocation and protein expression. NF\u03baB nuclear translocation was reduced after acoustic trauma or pretreatment with RU486 + MET before RS and acoustic trauma. On the contrary, RS protected against the trauma-induced NF\u03baB reduction of its nuclear translocation in inhibitory-\u03baB (I\u03baB)-dependent manner. RU486 + MET caused a simultaneous decreased I\u03baB expression and NF\u03baB nuclear translocation, demonstrating an interference with the I\u03baB-mediated activation of NF\u03baB. In summary, RS protects the cochlea from acoustic trauma by increasing corticosterone and activating GRs. These results emphasis how GR activity modulates hearing sensitivity and its importance for the rationale use of glucocorticoids in inner ear diseases.<\/jats:p>","DOI":"10.1210\/en.2006-0260","type":"journal-article","created":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T00:57:23Z","timestamp":1150419443000},"page":"4430-4437","source":"Crossref","is-referenced-by-count":57,"title":["Glucocorticoid Receptor and Nuclear Factor-\u03baB Interactions in Restraint Stress-Mediated Protection against Acoustic Trauma"],"prefix":"10.1210","volume":"147","author":[{"given":"Yeasmin","family":"Tahera","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology (Y.T., I.M., P.J., B.C.), Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Meltser","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology (Y.T., I.M., P.J., B.C.), Karolinska Institutet, 171 77 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