{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:42:35Z","timestamp":1791042155077,"version":"4.1.0"},"reference-count":35,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:p>Effects of amylin and pair feeding (PF) on body weight and metabolic parameters were characterized in diet-induced obesity-prone rats. Peripherally administered rat amylin (300 \u03bcg\/kg\u00b7d, 22d) reduced food intake and slowed weight gain: approximately 10% (P &amp;lt; 0.05), similar to PF. Fat loss was 3-fold greater in amylin-treated rats vs. PF (P &amp;lt; 0.05). Whereas PF decreased lean tissue (P &amp;lt; 0.05 vs. vehicle controls; VEH), amylin did not. During wk 1, amylin and PF reduced 24-h respiratory quotient (mean \u00b1 se, 0.82 \u00b1 0.0, 0.81 \u00b1 0.0, respectively; P &amp;lt; 0.05) similar to VEH (0.84 \u00b1 0.01). Energy expenditure (EE mean \u00b1 se) tended to be reduced by PF (5.67 \u00b1 0.1 kcal\/h\u00b7kg) and maintained by amylin (5.86 \u00b1 0.1 kcal\/h\u00b7kg) relative to VEH (5.77 \u00b1 0.0 kcal\/h\u00b7kg). By wk 3, respiratory quotient no longer differed; however, EE increased with amylin treatment (5.74 \u00b1 0.09 kcal\/\u00b7kg; P &amp;lt; 0.05) relative to VEH (5.49 \u00b1 0.06) and PF (5.38 \u00b1 0.07 kcal\/h\u00b7kg). Differences in EE, attributed to differences in lean mass, argued against specific amylin-induced thermogenesis. Weight loss in amylin and pair-fed rats was accompanied by similar increases arcuate neuropeptide Y mRNA (P &amp;lt; 0.05). Amylin treatment, but not PF, increased proopiomelanocortin mRNA levels (P &amp;lt; 0.05 vs. VEH). In a rodent model of obesity, amylin reduced body weight and body fat, with relative preservation of lean tissue, through anorexigenic and specific metabolic effects.<\/jats:p>","DOI":"10.1210\/en.2006-0393","type":"journal-article","created":{"date-parts":[[2006,8,24]],"date-time":"2006-08-24T20:36:29Z","timestamp":1156451789000},"page":"5855-5864","source":"Crossref","is-referenced-by-count":154,"title":["Antiobesity Effects of the \u03b2-Cell Hormone Amylin in Diet-Induced Obese Rats: Effects on Food Intake, Body Weight, Composition, Energy Expenditure, and Gene Expression"],"prefix":"10.1210","volume":"147","author":[{"given":"Jonathan D.","family":"Roth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Hughes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Kendall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain D.","family":"Baron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen M.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071612474445800_R1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1172\/JCI114528","article-title":"Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment","volume":"85","author":"Ogawa","year":"1990","journal-title":"J Clin Invest"},{"issue":"Suppl 2","key":"2020071612474445800_R2","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1002\/(SICI)1096-9136(199706)14:2+<S14::AID-DIA398>3.3.CO;2-H","article-title":"Role of amylin in nutrient intake\u2014animal studies","volume":"14","author":"Young","year":"1997","journal-title":"Diabet Med"},{"key":"2020071612474445800_R3","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/BF00401833","article-title":"Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin","volume":"38","author":"Young","year":"1995","journal-title":"Diabetologia"},{"key":"2020071612474445800_R4","doi-asserted-by":"crossref","first-page":"E443","DOI":"10.1152\/ajpendo.2001.280.3.E443","article-title":"Selective amylin inhibition of the glucagon response to arginine is extrinsic to the pancreas","volume":"280","author":"Silvestre","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2020071612474445800_R5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2174\/1381612033455387","article-title":"Central amylin signaling and the regulation of energy homeostasis","volume":"9","author":"Rushing","year":"2003","journal-title":"Curr Pharm Des"},{"key":"2020071612474445800_R6","doi-asserted-by":"crossref","first-page":"R114","DOI":"10.1152\/ajpregu.00333.2003","article-title":"The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the gut-brain axis","volume":"286","author":"Riediger","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2020071612474445800_R7","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1210\/endo.141.2.7378","article-title":"Amylin: a novel action in the brain to reduce body weight","volume":"141","author":"Rushing","year":"2000","journal-title":"Endocrinology"},{"key":"2020071612474445800_R8","doi-asserted-by":"crossref","first-page":"R143","DOI":"10.1152\/ajpregu.00393.2003","article-title":"Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset","volume":"286","author":"Levin","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2020071612474445800_R9","doi-asserted-by":"crossref","first-page":"R981","DOI":"10.1152\/ajpregu.00675.2004","article-title":"Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet","volume":"288","author":"Clegg","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2020071612474445800_R10","first-page":"R725","article-title":"Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats","volume":"273","author":"Levin","year":"1997","journal-title":"Am J Physiol"},{"key":"2020071612474445800_R11","first-page":"A389","article-title":"Sustained reduction in food intake and body weight in high fat-fed rats during 28-day amylin infusion","volume":"52","author":"Mack","year":"2003","journal-title":"Diabetes"},{"key":"2020071612474445800_R12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2337\/diabetes.51.1.152","article-title":"Chronic central melanocortin-4 receptor antagonism and central neuropeptide-Y infusion in rats produce increased adiposity by divergent pathways","volume":"51","author":"Baran","year":"2002","journal-title":"Diabetes"},{"key":"2020071612474445800_R13","doi-asserted-by":"crossref","first-page":"944","DOI":"10.2337\/diabetes.33.10.944","article-title":"The onset of liver glycogen synthesis in fasted-refed rats. Effects of streptozocin diabetes and of peripheral insulin replacement","volume":"33","author":"Van de Werve","year":"1984","journal-title":"Diabetes"},{"key":"2020071612474445800_R14","doi-asserted-by":"crossref","first-page":"E501","DOI":"10.1152\/ajpendo.2000.279.3.E501","article-title":"Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism","volume":"279","author":"Heffernan","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2020071612474445800_R15","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.physiol.62.1.413","article-title":"Leptin","volume":"62","author":"Ahima","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"2020071612474445800_R16","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0196-9781(92)90057-A","article-title":"Tests of adipsia and conditioned taste aversion following the intrahypothalamic injection of amylin","volume":"13","author":"Chance","year":"1992","journal-title":"Peptides"},{"key":"2020071612474445800_R17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0196-9781(96)00062-9","article-title":"Behavioral effects of amylin injected intracerebroventricularly in the rat","volume":"17","author":"Clementi","year":"1996","journal-title":"Peptides"},{"key":"2020071612474445800_R18","doi-asserted-by":"crossref","first-page":"R231","DOI":"10.1152\/ajpregu.2000.278.1.R231","article-title":"Defense of body weight against chronic caloric restriction in obesity-prone and -resistant rats","volume":"278","author":"Levin","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2020071612474445800_R19","first-page":"E156","article-title":"Direct plasma radioimmunoassay for rat amylin-(1\u201337): concentrations with acquired and genetic obesity","volume":"267","author":"Pieber","year":"1994","journal-title":"Am J Physiol"},{"key":"2020071612474445800_R20","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0031-9384(95)02067-5","article-title":"Amylin decreases meal size in rats","volume":"58","author":"Lutz","year":"1995","journal-title":"Physiol Behav"},{"key":"2020071612474445800_R21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0091-3057(96)00168-2","article-title":"Amylin and food intake in mice: effects on motivation to eat and mechanism of action","volume":"56","author":"Morley","year":"1997","journal-title":"Pharmacol Biochem Behav"},{"key":"2020071612474445800_R22","first-page":"369","article-title":"Amylin\u2019s inhibitory effect on food intake is not due to malaise in rats","volume":"44","author":"Naeve","year":"2005","journal-title":"Appetite"},{"key":"2020071612474445800_R23","first-page":"375","article-title":"Dissociation of acute food intake and locomotor activity effects in rats after peripheral treatment with rat amylin","volume":"44","author":"Roan","year":"2005","journal-title":"Appetite"},{"key":"2020071612474445800_R24","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/oby.2004.76","article-title":"Effect of pramlintide on weight in overweight and obese insulin-treated type 2 diabetes patients","volume":"12","author":"Hollander","year":"2004","journal-title":"Obes Res"},{"key":"2020071612474445800_R25","first-page":"13","article-title":"No measurable effect of amylin on lipolysis in either white or brown isolated adipocytes from rats","volume":"6","author":"Lupien","year":"1993","journal-title":"Diabet Nutr Metab"},{"key":"2020071612474445800_R26","doi-asserted-by":"crossref","first-page":"7763","DOI":"10.1073\/pnas.85.20.7763","article-title":"Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle","volume":"85","author":"Cooper","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612474445800_R27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0167-0115(97)01034-3","article-title":"Comparison of Fos induced in rat brain by GLP-1 and amylin","volume":"71","author":"Rowland","year":"1997","journal-title":"Regul Pept"},{"key":"2020071612474445800_R28","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0196-9781(01)00348-5","article-title":"Does neuropeptide Y contribute to the anorectic action of amylin?","volume":"22","author":"Morris","year":"2001","journal-title":"Peptides"},{"key":"2020071612474445800_R29","first-page":"779","article-title":"Autoradiographic distribution and receptor binding profile of [125I]Bolton Hunter-rat amylin binding sites in the rat brain","volume":"270","author":"van Rossum","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"2020071612474445800_R30","first-page":"2801","article-title":"Arcuate neurons of overweight rats differ in their responses to amylin from controls","volume":"15","author":"Davidowa","year":"2004","journal-title":"Neuroreport"},{"key":"2020071612474445800_R31","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/0196-9781(91)90148-I","article-title":"Amylin decreases food intake in mice","volume":"12","author":"Morley","year":"1991","journal-title":"Peptides"},{"key":"2020071612474445800_R32","doi-asserted-by":"crossref","first-page":"R1442","DOI":"10.1152\/ajpregu.2001.281.5.R1442","article-title":"Histamine H1 receptors mediate the anorectic action of the pancreatic hormone amylin","volume":"281","author":"Mollet","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2020071612474445800_R33","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0196-9781(02)00288-7","article-title":"Histamine H1 receptors in the ventromedial hypothalamus mediate the anorectic action of the pancreatic hormone amylin","volume":"24","author":"Mollet","year":"2003","journal-title":"Peptides"},{"key":"2020071612474445800_R34","first-page":"R950","article-title":"Efficacy of exogenous recombinant murine leptin in lean and obese 10- to 12-mo-old female CD-1 mice","volume":"275","author":"Pelleymounter","year":"1998","journal-title":"Am J Physiol"},{"key":"2020071612474445800_R35","first-page":"21","article-title":"Pramlintide reduced ad-libitum food intake and meal duration independently of ghrelin, PYY, CCK, and GLP-1: further evidence for a physiological role of amylin agonism in human appetite control","volume":"6","author":"Weyer","year":"2005","journal-title":"Obes Rev"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/147\/12\/5855\/9031914\/endo5855.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/147\/12\/5855\/9031914\/endo5855.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T17:55:07Z","timestamp":1594922107000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/147\/12\/5855\/2501043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,1]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2006-0393","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,1]]}}}