{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:02:21Z","timestamp":1790877741678,"version":"4.1.0"},"reference-count":44,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,1]]},"abstract":"<jats:p>Species differences have been reported for the nighttime regulation of arylalkylamine N-acetyltransferase (AA-NAT), the melatonin rhythm-generating enzyme. In particular, de novo synthesis of stimulatory transcription factors is required for Aa-nat transcription in the Syrian hamster but not in the rat pineal gland. The present work investigated the contribution of phosphorylated cAMP-responsive element-binding protein, c-FOS, c-JUN, and JUN-B in the regulation of Aa-nat transcription in Syrian hamsters compared with rats. The nighttime pattern of cAMP-responsive element-binding protein phosphorylation and regulation by norepinephrine observed in the Syrian hamster was similar to those reported in the rat. On the contrary, strong divergences in c-FOS, c-JUN, and JUN-B expression were observed between both species. In Syrian hamster, predominant expression of c-FOS and c-JUN was observed at the beginning of night, whereas a predominant expression of c-JUN and JUN-B was observed in the late night in rat. The early peak of c-FOS and c-JUN, known to form a stimulatory transcription dimer, suggests that they are involved in the nighttime stimulation of Aa-nat transcription. Indeed, early-night administration of a protein synthesis inhibitor (cycloheximide) markedly decreased AA-NAT mRNA levels in Syrian hamster. In the rat, high levels of JUN-B and c-JUN, constituting an inhibitory transcription dimer, are probably involved in the late-night inhibition of Aa-nat transcription. Early-night administration of cycloheximide actually increased AA-NAT mRNA levels toward the late night. Therefore, composition and timing of the pineal activator protein-1 complexes differ between rat and Syrian hamster and may be an activator (Syrian hamster) or an inhibitor (rat) of Aa-nat transcription.<\/jats:p>","DOI":"10.1210\/en.2006-0526","type":"journal-article","created":{"date-parts":[[2006,8,4]],"date-time":"2006-08-04T00:34:37Z","timestamp":1154651677000},"page":"5052-5060","source":"Crossref","is-referenced-by-count":13,"title":["Differential Expression of Activator Protein-1 Proteins in the Pineal Gland of Syrian Hamster and Rat May Explain Species Diversity in Arylalkylamine N-Acetyltransferase Gene Expression"],"prefix":"10.1210","volume":"147","author":[{"given":"Natalia","family":"Sinitskaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Salingre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Klosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent 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gland","volume":"137","author":"Roseboom","year":"1996","journal-title":"Endocrinology"},{"key":"2020071613594853200_R3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/378783a0","article-title":"Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland","volume":"378","author":"Borjigin","year":"1995","journal-title":"Nature"},{"key":"2020071613594853200_R4","first-page":"307","article-title":"The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland","volume":"52","author":"Klein","year":"1997","journal-title":"Recent Prog Horm Res"},{"key":"2020071613594853200_R5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1124\/pr.55.2.2","article-title":"Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal 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pinealocytes","volume":"314","author":"Sugden","year":"1985","journal-title":"Nature"},{"key":"2020071613594853200_R9","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.279.5355.1358","article-title":"Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation","volume":"279","author":"Gastel","year":"1998","journal-title":"Science"},{"key":"2020071613594853200_R10","doi-asserted-by":"crossref","first-page":"27319","DOI":"10.1074\/jbc.270.45.27319","article-title":"Circadian expression of transcription factor Fra-2 in the rat pineal gland","volume":"270","author":"Baler","year":"1995","journal-title":"J Biol Chem"},{"key":"2020071613594853200_R11","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1046\/j.1471-4159.2000.0751398.x","article-title":"Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock\u2019s zeitgebers","volume":"75","author":"Guillaumond","year":"2000","journal-title":"J Neurochem"},{"key":"2020071613594853200_R12","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0006-291X(90)90849-I","article-title":"Temporally defined induction of c-fos in the rat pineal","volume":"166","author":"Carter","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071613594853200_R13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0169-328X(92)90200-U","article-title":"Neurotransmitter-stimulated immediate-early gene responses are organized through differential post-synaptic receptor mechanisms","volume":"16","author":"Carter","year":"1992","journal-title":"Brain Res Mol Brain Res"},{"key":"2020071613594853200_R14","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1074\/jbc.272.11.6979","article-title":"The rat arylalkylamine N-acetyltransferase gene promoter. cAMP activation via a cAMP-responsive element-CCAAT complex","volume":"272","author":"Baler","year":"1997","journal-title":"J Biol Chem"},{"key":"2020071613594853200_R15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1113\/expphysiol.1997.sp004019","article-title":"Rhythms of cellular immediate-early gene expression: more than just an early response","volume":"82","author":"Carter","year":"1997","journal-title":"Exp Physiol"},{"key":"2020071613594853200_R16","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1128\/MCB.21.11.3704-3713.2001","article-title":"Tissue-specific transgenic knockdown of Fos-related antigen 2 (Fra-2) expression mediated by dominant negative Fra-2","volume":"21","author":"Smith","year":"2001","journal-title":"Mol Cell Biol"},{"key":"2020071613594853200_R17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1210\/endo-104-2-385","article-title":"Regulation of pineal melatonin in the Syrian 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culture","volume":"103","author":"Santana","year":"1989","journal-title":"Neurosci Lett"},{"key":"2020071613594853200_R35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1600-079X.1989.tb00437.x","article-title":"Role of postsynaptic \u03b1-adrenergic receptors in the beta-adrenergic stimulation of melatonin production in the Syrian hamster pineal gland in organ culture","volume":"7","author":"Santana","year":"1989","journal-title":"J Pineal Res"},{"key":"2020071613594853200_R36","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1242\/jcs.01589","article-title":"AP-1 subunits: quarrel and harmony among siblings","volume":"117","author":"Hess","year":"2004","journal-title":"J Cell Sci"},{"key":"2020071613594853200_R37","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1128\/MCB.12.11.5015","article-title":"Existence of different Fos\/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: differential role of Fos proteins","volume":"12","author":"Kovary","year":"1992","journal-title":"Mol Cell Biol"},{"key":"2020071613594853200_R38","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1399-3011.1991.tb01433.x","article-title":"Stabilities of leucine zipper dimers estimated by an empirical free energy method","volume":"38","author":"Krystek","year":"1991","journal-title":"Int J Pept Protein Res"},{"key":"2020071613594853200_R39","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0092-8674(89)90755-1","article-title":"jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun","volume":"59","author":"Schutte","year":"1989","journal-title":"Cell"},{"key":"2020071613594853200_R40","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1038\/sj.onc.1204385","article-title":"Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory 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of an estrogen-response element by point mutation in the gene\u2019s flanking sequence","volume":"24","author":"Sarabia","year":"1999","journal-title":"Mol Carcinog"},{"key":"2020071613594853200_R44","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1523\/JNEUROSCI.4988-03.2004","article-title":"Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retina","volume":"24","author":"Fukuhara","year":"2004","journal-title":"J 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