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The changes in LRH-1 as well as CK-18 expression were analyzed by confocal immunohistochemistry and Western blot. The results showed that LRH-1 was stage-dependently expressed in the Sertoli cells; no LRH-1-positive signal was detected in the cells obtained from the testes of adult rat on d 60 after birth when mature spermatozoa in the testis was completed. However, the mature Sertoli cells were warmed at the 43 C water bath for 15 min, and the LRH-1 signal was remarkably induced in a time-dependent manner, just like the changes of CK-18 expression in the Sertoli cells, suggesting that the heat-induced dedifferentiation of the mature Sertoli cells might be related to LRH-1 regulation. LRH-1 expression induced by the heat treatment was completely inhibited by the addition of ERK inhibitor U0126 in the culture, indicating that the heat-induced LRH-1 expression in the Sertoli cells may be regulated via ERK1\/2 activation pathway. Testosterone was found to have no such effect on LRH-1 expression in the monkey and rat Sertoli cells.<\/jats:p>","DOI":"10.1210\/en.2006-1004","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T01:53:54Z","timestamp":1166147634000},"page":"1255-1265","source":"Crossref","is-referenced-by-count":42,"title":["Heat Treatment Induces Liver Receptor Homolog-1 Expression in Monkey and Rat Sertoli 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