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In parallel, the pharmacological activation of hypothalamic AMPK in TB animals markedly reduced the hypothalamic production of inducible nitric oxide synthase, IL-1\u03b2, and TNF-\u03b1 and modulated the expression of proopiomelanocortin, a hypothalamic neuropeptide that is involved in the control of energy homeostasis. Furthermore, the daily oral and intracerebroventricular treatment with biguanide antidiabetic drug metformin also induced AMPK phosphorylation in the central nervous system and increased food intake and life span in anorexic TB rats. Collectively, the findings of this study suggest that hypothalamic AMPK activation reverses cancer anorexia by inhibiting the production of proinflammatory molecules and controlling the neuropeptide expression in the hypothalamus, reflecting in a prolonged life span in TB rats. Thus, our data indicate that hypothalamic AMPK activation presents an attractive opportunity for the treatment of cancer-induced anorexia.<\/jats:p>","DOI":"10.1210\/en.2007-0381","type":"journal-article","created":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T01:03:50Z","timestamp":1187917430000},"page":"5220-5229","source":"Crossref","is-referenced-by-count":43,"title":["A Central Role for Neuronal Adenosine 5\u2032-Monophosphate-Activated Protein Kinase in Cancer-Induced Anorexia"],"prefix":"10.1210","volume":"148","author":[{"given":"Eduardo R.","family":"Ropelle","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, 13083-970 Campinas, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301 R.","family":"Pauli","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, 13083-970 Campinas, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina G.","family":"Zecchin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, 13083-970 Campinas, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian","family":"Ueno","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, 13083-970 Campinas, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cla\u0301udio T.","family":"de Souza","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, 13083-970 Campinas, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseane","family":"Morari","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, 13083-970 Campinas, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel C.","family":"Faria","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, 13083-970 Campinas, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u0301cio A.","family":"Velloso","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas-UNICAMP, 13083-970 Campinas, Sa\u0303o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario J. 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