{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:30:04Z","timestamp":1791286204587,"version":"4.1.0"},"reference-count":50,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11,1]]},"DOI":"10.1210\/en.2007-0589","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T20:35:28Z","timestamp":1186691728000},"page":"5403-5413","source":"Crossref","is-referenced-by-count":59,"title":["Human Placental Development Is Impaired by Abnormal Human Chorionic Gonadotropin Signaling in Trisomy 21 Pregnancies"],"prefix":"10.1210","volume":"148","author":[{"given":"Guillaume","family":"Pidoux","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (G.P., P.G., O.M., J.G., F.F., J.B., D.E.-B., J.-L.F.), Unite\u0301 767, Universite\u0301 Paris Descartes, Paris F-75006, France"},{"name":"Faculte\u0301 des Sciences Pharmaceutiques et Biologiques (G.P., P.G., O.M., F.F., J.B., D.E.-B., J.-L.F.), Universite\u0301 Paris Descartes, Paris F-75006, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Gerbaud","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (G.P., P.G., O.M., J.G., F.F., J.B., D.E.-B., J.-L.F.), Unite\u0301 767, Universite\u0301 Paris Descartes, Paris F-75006, France"},{"name":"Faculte\u0301 des Sciences Pharmaceutiques et Biologiques (G.P., P.G., O.M., F.F., J.B., D.E.-B., J.-L.F.), Universite\u0301 Paris Descartes, Paris F-75006, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Marpeau","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (G.P., P.G., O.M., J.G., F.F., J.B., D.E.-B., J.-L.F.), Unite\u0301 767, Universite\u0301 Paris Descartes, Paris F-75006, France"},{"name":"Faculte\u0301 des Sciences Pharmaceutiques et Biologiques (G.P., P.G., O.M., F.F., J.B., D.E.-B., J.-L.F.), Universite\u0301 Paris Descartes, Paris F-75006, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Guibourdenche","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (G.P., P.G., O.M., J.G., F.F., J.B., D.E.-B., J.-L.F.), Unite\u0301 767, Universite\u0301 Paris Descartes, Paris F-75006, France"},{"name":"Assistance Publique-Ho\u0302pitaux de Paris (J.G.), Ho\u0302pital Cochin, Service de Biochimie Hormonale, Paris F-75014, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (G.P., P.G., O.M., J.G., F.F., J.B., D.E.-B., J.-L.F.), Unite\u0301 767, Universite\u0301 Paris Descartes, Paris F-75006, France"},{"name":"Faculte\u0301 des Sciences Pharmaceutiques et Biologiques (G.P., P.G., O.M., F.F., J.B., D.E.-B., J.-L.F.), Universite\u0301 Paris Descartes, Paris F-75006, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josette","family":"Badet","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (G.P., P.G., O.M., J.G., F.F., J.B., D.E.-B., J.-L.F.), Unite\u0301 767, Universite\u0301 Paris Descartes, Paris F-75006, France"},{"name":"Faculte\u0301 des Sciences Pharmaceutiques et Biologiques (G.P., P.G., O.M., F.F., J.B., D.E.-B., J.-L.F.), Universite\u0301 Paris Descartes, Paris F-75006, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danie\u0300le","family":"Evain-Brion","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (G.P., P.G., O.M., J.G., F.F., J.B., D.E.-B., J.-L.F.), Unite\u0301 767, Universite\u0301 Paris Descartes, Paris F-75006, France"},{"name":"Faculte\u0301 des Sciences Pharmaceutiques et Biologiques (G.P., P.G., O.M., F.F., J.B., D.E.-B., J.-L.F.), Universite\u0301 Paris Descartes, Paris F-75006, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Frendo","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (G.P., P.G., O.M., J.G., F.F., J.B., D.E.-B., J.-L.F.), Unite\u0301 767, Universite\u0301 Paris Descartes, Paris F-75006, France"},{"name":"Faculte\u0301 des Sciences Pharmaceutiques et Biologiques (G.P., P.G., O.M., F.F., J.B., D.E.-B., J.-L.F.), Universite\u0301 Paris Descartes, Paris F-75006, France"},{"name":"Centre National de la Recherche Scientifique (J.-L.F.), Universite\u0301 Paris Descartes, Paris F-75006, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041121503283500_R1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1172\/JCI200422991","article-title":"Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface.","volume":"114","author":"Red-Horse","year":"2004","journal-title":"J Clin Invest"},{"key":"2019041121503283500_R2","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1016\/S0021-9258(19)50712-8","article-title":"Identification of the transcriptionally active genes of the chorionic gonadotropin \u03b2 gene cluster in vivo.","volume":"267","author":"Bo","year":"1992","journal-title":"J Biol Chem"},{"key":"2019041121503283500_R3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/humupd\/dmg043","article-title":"A comparison of placental development and endocrine functions between the human and mouse model.","volume":"9","author":"Malassine\u0301","year":"2003","journal-title":"Hum Reprod Update"},{"key":"2019041121503283500_R4","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1210\/endo.135.1.8013377","article-title":"Gap junctional communication during human trophoblast differentiation: influence of human chorionic gonadotropin.","volume":"135","author":"Cronier","year":"1994","journal-title":"Endocrinology"},{"key":"2019041121503283500_R5","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1210\/endo.132.3.7679981","article-title":"Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts.","volume":"132","author":"Shi","year":"1993","journal-title":"Endocrinology"},{"key":"2019041121503283500_R6","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1053\/plac.2000.0575","article-title":"Modulation of copper\/zinc superoxide dismutase expression and activity with in vitro differentiation of human villous cytotrophoblasts.","volume":"21","author":"Frendo","year":"2000","journal-title":"Placenta"},{"key":"2019041121503283500_R7","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1210\/endo.142.8.8329","article-title":"Overexpression of copper zinc superoxide dismutase impairs human trophoblast cell fusion and differentiation.","volume":"142","author":"Frendo","year":"2001","journal-title":"Endocrinology"},{"key":"2019041121503283500_R8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0012-1606(03)00041-1","article-title":"Cadherin-11 modulates the terminal differentiation and fusion of human trophoblastic cells in vitro.","volume":"257","author":"Getsios","year":"2003","journal-title":"Dev Biol"},{"key":"2019041121503283500_R9","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1242\/jcs.00648","article-title":"Involvement of connexin 43 in human trophoblast cell fusion and differentiation.","volume":"116","author":"Frendo","year":"2003","journal-title":"J Cell Sci"},{"key":"2019041121503283500_R10","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1128\/MCB.23.10.3566-3574.2003","article-title":"Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation.","volume":"23","author":"Frendo","year":"2003","journal-title":"Mol Cell Biol"},{"key":"2019041121503283500_R11","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/35080570","article-title":"Placental development: lessons from mouse mutants.","volume":"2","author":"Rossant","year":"2001","journal-title":"Nat Rev Genet"},{"key":"2019041121503283500_R12","first-page":"3700","article-title":"Defect of villous cytotrophoblast differentiation into syncytiotrophoblast in Down\u2019s syndrome.","volume":"85","author":"Frendo","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121503283500_R13","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1210\/jc.2003-030668","article-title":"Trophoblast production of a weakly bioactive human chorionic gonadotropin in trisomy 21-affected pregnancy.","volume":"89","author":"Frendo","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121503283500_R14","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/ajmg.a.30254","article-title":"Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway.","volume":"130","author":"Wright","year":"2004","journal-title":"Am J Med Genet A"},{"key":"2019041121503283500_R15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/pd.1970070904","article-title":"Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities.","volume":"7","author":"Bogart","year":"1987","journal-title":"Prenat Diagn"},{"key":"2019041121503283500_R16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev.bi.50.070181.002341","article-title":"Glycoprotein hormones: structure and function.","volume":"50","author":"Pierce","year":"1981","journal-title":"Annu Rev Biochem"},{"key":"2019041121503283500_R17","first-page":"650","article-title":"Recent advances in the chemistry and immunochemistry of human chorionic gonadotropin: impact on clinical measurements.","volume":"15","author":"O\u2019Connor","year":"1994","journal-title":"Endocr Rev"},{"key":"2019041121503283500_R18","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1210\/en.2002-220922","article-title":"The central role of human chorionic gonadotropin in the formation of human placental syncytium.","volume":"144","author":"Yang","year":"2003","journal-title":"Endocrinology"},{"key":"2019041121503283500_R19","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1016\/S0021-9258(18)42858-X","article-title":"Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells.","volume":"267","author":"Gudermann","year":"1992","journal-title":"J Biol Chem"},{"key":"2019041121503283500_R20","first-page":"2210","article-title":"Identification and characterization of a luteinizing hormone\/chorionic (LH\/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH\/CG receptor complementary DNA.","volume":"6","author":"Hipkin","year":"1992","journal-title":"Mol Endocrinol"},{"key":"2019041121503283500_R21","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1126\/science.2502842","article-title":"Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family.","volume":"245","author":"McFarland","year":"1989","journal-title":"Science"},{"key":"2019041121503283500_R22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000132962","article-title":"Localization of the human luteinizing hormone\/choriogonadotropin receptor gene (LHCGR) to chromosome 2p21.","volume":"54","author":"Rousseau-Merck","year":"1990","journal-title":"Cytogenet Cell Genet"},{"key":"2019041121503283500_R23","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.2502844","article-title":"Cloning and sequencing of porcine LH-hCG receptor cDNA: variants lacking transmembrane domain.","volume":"245","author":"Loosfelt","year":"1989","journal-title":"Science"},{"key":"2019041121503283500_R24","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0006-291X(90)91552-4","article-title":"Cloning and sequencing of human LH\/hCG receptor cDNA.","volume":"172","author":"Minegishi","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121503283500_R25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mce.2007.04.007","article-title":"Molecular characterization of two sea bass gonadotropin receptors: cDNA cloning, expression analysis, and functional activity.","volume":"272","author":"Rocha","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121503283500_R26","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ygcen.2006.04.011","article-title":"Molecular cloning and characterization of FSH and LH receptors in Atlantic salmon (Salmo salar L.).","volume":"149","author":"Maugars","year":"2006","journal-title":"Gen Comp Endocrinol"},{"key":"2019041121503283500_R27","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1095\/biolreprod64.3.1010","article-title":"Molecular biology of channel catfish gonadotropin receptors: 1. Cloning of a functional luteinizing hormone receptor and preovulatory induction of gene expression.","volume":"64","author":"Kumar","year":"2001","journal-title":"Biol Reprod"},{"key":"2019041121503283500_R28","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1095\/biolreprod.104.038190","article-title":"Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors\u2013evidence for their distinct functions in follicle development.","volume":"72","author":"Kwok","year":"2005","journal-title":"Biol Reprod"},{"key":"2019041121503283500_R29","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1210\/endo.138.6.5196","article-title":"Cloning and functional expression of the luteinizing hormone receptor complementary deoxyribonucleic acid from the marmoset monkey testis: absence of sequences encoding exon 10 in other species.","volume":"138","author":"Zhang","year":"1997","journal-title":"Endocrinology"},{"key":"2019041121503283500_R30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/(SICI)1098-2795(200002)55:2<136::AID-MRD2>3.0.CO;2-J","article-title":"Cloning and sequence analysis of the extracellular region of the polar bear (Ursus maritimus) luteinizing hormone receptor (LHr), follicle stimulating hormone receptor (FSHr), and prolactin receptor (PRLr) genes and their expression in the testis of the black bear (Ursus americanus).","volume":"55","author":"Howell-Skalla","year":"2000","journal-title":"Mol Reprod Dev"},{"key":"2019041121503283500_R31","first-page":"2665","article-title":"[Demonstration of a specific fixation of radio-iodinated human chorionic gonadotropin (HCG I-125) in fragments of human placentas].","volume":"278","author":"Alsat","year":"1974","journal-title":"C R Acad Sci Hebd Seances Acad Sci D"},{"key":"2019041121503283500_R32","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1210\/jcem-70-2-421","article-title":"The presence of gonadotropin receptors in nonpregnant human uterus, human placental, fetal membranes, and decidua.","volume":"70","author":"Reshef","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121503283500_R33","first-page":"1236","article-title":"The expression of human chorionic gonadotropin\/human luteinizing hormone receptors in human gestational trophoblastic neoplasms.","volume":"74","author":"Lei","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121503283500_R34","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/jcp.20995","article-title":"Biochemical characterization and modulation of LH\/CG-receptor during human trophoblast differentiation.","volume":"212","author":"Pidoux","year":"2007","journal-title":"J Cell Physiol"},{"key":"2019041121503283500_R35","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jcp.1041540115","article-title":"Increase in epidermal growth factor receptor and its messenger ribonucleic acid levels with differentiation of human trophoblast cells in culture.","volume":"154","author":"Alsat","year":"1993","journal-title":"J Cell Physiol"},{"key":"2019041121503283500_R36","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1210\/jcem-73-4-888","article-title":"Insulin and glucose do not affect the glycogen content in isolated and cultured trophoblast cells of human term placenta.","volume":"73","author":"Schmon","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121503283500_R37","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/molehr\/8.11.1005","article-title":"Connexin expression and gap junctional intercellular communication in human first trimester trophoblast.","volume":"8","author":"Cronier","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"2019041121503283500_R38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1210\/endo-108-1-88","article-title":"Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses.","volume":"108","author":"Ascoli","year":"1981","journal-title":"Endocrinology"},{"key":"2019041121503283500_R39","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0003-2697(80)90515-1","article-title":"Ligand: a versatile computerized approach for characterization of ligand-binding systems.","volume":"107","author":"Munson","year":"1980","journal-title":"Anal Biochem"},{"key":"2019041121503283500_R40","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/194495a0","article-title":"Preparation of iodine-131 labelled human growth hormone of high specific activity.","volume":"194","author":"Hunter","year":"1962","journal-title":"Nature"},{"key":"2019041121503283500_R41","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1210\/edrv.23.2.0462","article-title":"The lutropin\/choriogonadotropin receptor, a 2002 perspective.","volume":"23","author":"Ascoli","year":"2002","journal-title":"Endocr Rev"},{"key":"2019041121503283500_R42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1477-7827-3-25","article-title":"A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down\u2019s syndrome pregnancies.","volume":"3","author":"Banerjee","year":"2005","journal-title":"Reprod Biol Endocrinol"},{"key":"2019041121503283500_R43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/molehr\/6.1.5","article-title":"hCG concentration and receptor gene expression in placental tissue from trisomy 18 and 21.","volume":"6","author":"Jauniaux","year":"2000","journal-title":"Mol Hum Reprod"},{"key":"2019041121503283500_R44","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.placenta.2004.07.001","article-title":"Expression of variant luteinizing hormone\/chorionic gonadotropin receptors and degradation of chorionic gonadotropin in human chorionic villous macrophages.","volume":"26","author":"Sonoda","year":"2005","journal-title":"Placenta"},{"key":"2019041121503283500_R45","first-page":"5","article-title":"Clinical importance of vascular LH\/hCG receptors\u2014a review.","volume":"1","author":"Toth","year":"2001","journal-title":"Biol Reprod"},{"key":"2019041121503283500_R46","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1095\/biolreprod53.4.899","article-title":"Human intermediate trophoblasts express chorionic gonadotropin\/luteinizing hormone receptor gene.","volume":"53","author":"Tao","year":"1995","journal-title":"Biol Reprod"},{"key":"2019041121503283500_R47","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.bjc.6690407","article-title":"Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-\u03b1 in human prostate cancer cells.","volume":"80","author":"Seth","year":"1998","journal-title":"Br J Cancer"},{"key":"2019041121503283500_R48","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1172\/JCI28598","article-title":"Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone \u03b2 receptor inhibits mitotic progression.","volume":"116","author":"Ying","year":"2006","journal-title":"J Clin Invest"},{"key":"2019041121503283500_R49","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1172\/JCI2901","article-title":"Mutation in the signal-transducing chain of the interferon-\u03b3 receptor and susceptibility to mycobacterial infection.","volume":"101","author":"Dorman","year":"1998","journal-title":"J Clin Invest"},{"key":"2019041121503283500_R50","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0303-7207(01)00471-3","article-title":"Inherited disorders of GnRH and gonadotropin receptors.","volume":"179","author":"Roux","year":"2001","journal-title":"Mol Cell Endocrinol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/148\/11\/5403\/10726008\/endo5403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T10:09:52Z","timestamp":1629540592000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/148\/11\/5403\/2501401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,1]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2007-0589","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1099384.555633","asserted-by":"object"}]},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,1]]}}}