{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:58:42Z","timestamp":1761058722136},"reference-count":54,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:p>Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by transfer of thyroglobulin-primed in vitro activated splenocytes. Thyroid lesions reach maximal severity 20 d later, and inflammation resolves or progresses to fibrosis by d 60, depending on the extent of thyroid damage at d 20. Depletion of CD8+ T cells inhibits G-EAT resolution. We showed that expression of Fas-associated death domain-like IL-1\u03b2-converting enzyme inhibitory protein (FLIP) transgene (Tg) on thyroid epithelial cells (TECs) of DBA\/1 mice had no effect on G-EAT induction but promoted earlier resolution of G-EAT. However, when CBA\/J wild-type donor cells were transferred to transgenic CBA\/J mice expressing FLIP on TECs, they developed less severe G-EAT than FLIP Tg\u2212 littermates. Both strains expressed similar levels of the FLIP Tg, but endogenous FLIP was up-regulated to a greater extent on infiltrating T cells during G-EAT development in DBA\/1 compared with CBA\/J mice. After transient depletion of CD8+ T cells, FLIP Tg+ and Tg\u2212 CBA\/J recipients both developed severe G-EAT at d 20. Thyroid lesions in CD8-depleted Tg+ recipients were resolving by d 60, whereas lesions in Tg\u2212 littermates did not resolve, and most were fibrotic. FLIP Tg+ recipients had increased apoptosis of CD3+ T cells compared with Tg\u2212 recipients. The results indicate that transgenic FLIP expressed on TECs in CBA\/J mice promotes G-EAT resolution, but induction of G-EAT is inhibited unless CD8+ T cells are transiently depleted.<\/jats:p>","DOI":"10.1210\/en.2007-0939","type":"journal-article","created":{"date-parts":[[2007,9,7]],"date-time":"2007-09-07T00:48:03Z","timestamp":1189126083000},"page":"5734-5745","source":"Crossref","is-referenced-by-count":11,"title":["Expression of Transgenic FLIP on Thyroid Epithelial Cells Inhibits Induction and Promotes Resolution of Granulomatous Experimental Autoimmune Thyroiditis in CBA\/J Mice"],"prefix":"10.1210","volume":"148","author":[{"given":"Yujiang","family":"Fang","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine (Y.F., G.C.S., H.B.-M.), Department of Veterans Affairs Medical Center, Columbia, Missouri 65212"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent 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