{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:34:10Z","timestamp":1790256850344,"version":"4.1.0"},"reference-count":51,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:p>Hypothyroidism, together with glandular atrophy, is the usual outcome of destructive autoimmune thyroiditis. The impairment in the thyroid function results either from cell destruction or from Th1 cytokine-induced alteration in hormonogenesis. Here, we investigated the impact of the local immune context on the thyroid function. We used two rat thyroid cell lines (PCCL3 and FRTL-5) and human thyrocytes incubated with IL-1\u03b1\/interferon (IFN) \u03b3 together with IL-4, a Th2 cytokine, or with TGF-\u03b2, or IL-10, two Th3 cytokines. We first observed that IL-4 totally blocked IL-1\u03b1\/interferon \u03b3-induced alteration in dual oxidase and thyroperoxidase expression, and in thyroglobulin secretion. By contrast, TGF-\u03b2 and IL-10 had no such effect. They rather repressed thyrocyte function as do Th1 cytokines. In addition, IL-4 blocked IL-10-induced repression of thyrocyte function, but not that induced by TGF-\u03b2. In conclusion, Th1 cytokine- and IL-10-induced local inhibitory actions on thyroid function can be totally overturned by Th2 cytokines. These data provide new clues about the influence of the immune context on thyrocyte function.<\/jats:p>","DOI":"10.1210\/en.2007-1316","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T01:35:08Z","timestamp":1200015308000},"page":"1534-1542","source":"Crossref","is-referenced-by-count":20,"title":["Differential Interactions between Th1\/Th2, Th1\/Th3, and Th2\/Th3 Cytokines in the Regulation of Thyroperoxidase and Dual Oxidase Expression, and of Thyroglobulin Secretion in Thyrocytes in Vitro"],"prefix":"10.1210","volume":"149","author":[{"given":"Sylvie","family":"Poncin","sequence":"first","affiliation":[{"name":"Unite\u0301 de Morphologie Expe\u0301rimentale, Universite\u0301 catholique de Louvain, B-1200, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Lengele\u0301","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Morphologie Expe\u0301rimentale, Universite\u0301 catholique de Louvain, B-1200, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ides M.","family":"Colin","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Morphologie Expe\u0301rimentale, Universite\u0301 catholique de Louvain, B-1200, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Catherine","family":"Ge\u0301rard","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Morphologie Expe\u0301rimentale, Universite\u0301 catholique de Louvain, B-1200, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2008,1,10]]},"reference":[{"key":"2020071614053869600_R1","first-page":"423","author":"Reed","year":"2002"},{"key":"2020071614053869600_R2","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1172\/JCI14321","article-title":"Thyroid autoimmunity.","volume":"108","author":"Rapoport","year":"2001","journal-title":"J Clin 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