{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:11:33Z","timestamp":1760645493898},"reference-count":64,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:p>In adult male mice homozygous for the juvenile spermatogonial depletion (Utp14bjsd) mutation in the Utp14b gene, type A spermatogonia proliferate, but in the presence of testosterone and at scrotal temperatures, these spermatogonia undergo apoptosis just before differentiation. In an attempt to delineate this apoptotic pathway in jsd mice and specifically address the roles of p53- and Fas ligand (FasL) \/Fas receptor-mediated apoptosis, we produced jsd mice deficient in p53, Fas, or FasL. Already at the age of 5 wk, less degeneration of spermatogenesis was observed in p53-null-jsd mice than jsd single mutants, and in 8- or 12-wk-old mice, the percentage of seminiferous tubules showing differentiated germ cells [tubule differentiation index (TDI)] was 26\u201329% in the p53-null-jsd mice, compared with 2\u20134% in jsd mutants with normal p53. The TDI in jsd mice heterozygous for p53 showed an intermediate TDI of 8\u201313%. The increase in the differentiated tubules in double-mutant and p53 heterozygous jsd mice was mostly attributable to intermediate and type B spermatogonia; few spermatocytes were present. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling staining showed that most of these differentiated spermatogonia still underwent apoptosis, thereby blocking further continuation of spermatogenesis. In contrast, the percentage of tubules that were differentiated was not significantly altered in either adult Fas null-jsd mice or adult FasL defective gld-jsd double mutant mice as compared with jsd single mutants. Furthermore, caspase-9, but not caspase-8 was immunochemically localized in the adult jsd mice spermatogonia undergoing apoptosis. The results show that p53, but not FasL or Fas, is involved in the apoptosis of type A spermatogonia before\/during differentiation in jsd mice that involves the intrinsic pathway of apoptosis. However, apoptosis in the later stages must be a p53-independent process.<\/jats:p>","DOI":"10.1210\/en.2007-1338","type":"journal-article","created":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T01:05:58Z","timestamp":1206061558000},"page":"2773-2781","source":"Crossref","is-referenced-by-count":14,"title":["p53-Dependent Apoptosis in the Inhibition of Spermatogonial Differentiation in Juvenile Spermatogonial Depletion (Utp14bjsd) Mice"],"prefix":"10.1210","volume":"149","author":[{"given":"Gunapala","family":"Shetty","sequence":"first","affiliation":[{"name":"Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan H.","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie C. Y.","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2008,3,20]]},"reference":[{"key":"2020071612200943700_R1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/ar.1091690305","article-title":"Spermatogonial stem-cell renewal in the mouse.","volume":"169","author":"Oakberg","year":"1971","journal-title":"Anat Rec"},{"key":"2020071612200943700_R2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2613.1998.00057.x","article-title":"Stem cells in the testis.","volume":"79","author":"de Rooij","year":"1998","journal-title":"Int J Exp Pathol"},{"key":"2020071612200943700_R3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1095\/biolreprod38.4.899","article-title":"Juvenile spermatogonial depletion (jsd): a genetic defect of germ cell proliferations of male mice.","volume":"38","author":"Beamer","year":"1988","journal-title":"Biol Reprod"},{"key":"2020071612200943700_R4","doi-asserted-by":"crossref","first-page":"11695","DOI":"10.1073\/pnas.0401130101","article-title":"The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b.","volume":"101","author":"Rohozinski","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612200943700_R5","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ng1390","article-title":"An X-to-autosome retrogene is required for spermatogenesis in mice.","volume":"36","author":"Bradley","year":"2004","journal-title":"Nat Genet"},{"key":"2020071612200943700_R6","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.ydbio.2007.01.005","article-title":"Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis.","volume":"304","author":"Zhao","year":"2007","journal-title":"Dev Biol"},{"key":"2020071612200943700_R7","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature00769","article-title":"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.","volume":"417","author":"Dragon","year":"2002","journal-title":"Nature"},{"key":"2020071612200943700_R8","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1095\/biolreprod63.4.1185","article-title":"Juvenile spermatogonial depletion (jsd) mutant seminiferous tubules are capable of supporting transplanted spermatogenesis.","volume":"63","author":"Boettger-Tong","year":"2000","journal-title":"Biol Reprod"},{"key":"2020071612200943700_R9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1095\/biolreprod.107.060087","article-title":"Genetic factors contributing to defective spermatogonial differentiation in juvenile spermatogonial depletion (Utp14b\/jsd) mice.","volume":"77","author":"Bolden-Tiller","year":"2007","journal-title":"Biol Reprod"},{"key":"2020071612200943700_R10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1210\/en.2003-0928","article-title":"Cryptorchidism rescues spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice.","volume":"145","author":"Shetty","year":"2004","journal-title":"Endocrinology"},{"key":"2020071612200943700_R11","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1442-2042.1997.tb00293.x","article-title":"Cessation of spermatogenesis in juvenile spermatogonial depletion (jsd\/jsd) mice.","volume":"4","author":"Kojima","year":"1997","journal-title":"Int J Urol"},{"key":"2020071612200943700_R12","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis.","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"2020071612200943700_R13","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1126\/science.1076118","article-title":"A Cinderella caspase takes center stage.","volume":"297","author":"Kumar","year":"2002","journal-title":"Science"},{"key":"2020071612200943700_R14","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1128\/MCB.15.6.3032","article-title":"Wild-type human p53 and a temperature-sensitive mutant induce Fas\/APO-1 expression.","volume":"15","author":"Owen-Schaub","year":"1995","journal-title":"Mol Cell Biol"},{"key":"2020071612200943700_R15","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1084\/jem.188.11.2033","article-title":"p53 activates the CD95 (APO-1\/Fas) gene in response to DNA damage by anticancer drugs.","volume":"188","author":"Muller","year":"1998","journal-title":"J Exp Med"},{"key":"2020071612200943700_R16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0092-8674(95)90412-3","article-title":"Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.","volume":"80","author":"Miyashita","year":"1995","journal-title":"Cell"},{"key":"2020071612200943700_R17","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1126\/science.288.5468.1053","article-title":"Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.","volume":"288","author":"Oda","year":"2000","journal-title":"Science"},{"key":"2020071612200943700_R18","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1097-2765(01)00214-3","article-title":"PUMA, a novel proapoptotic gene, is induced by p53.","volume":"7","author":"Nakano","year":"2001","journal-title":"Mol Cell"},{"key":"2020071612200943700_R19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S1097-2765(03)00050-9","article-title":"p53 has a direct apoptogenic role at the mitochondria.","volume":"11","author":"Mihara","year":"2003","journal-title":"Mol Cell"},{"key":"2020071612200943700_R20","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1042\/bst0290684","article-title":"Mechanisms of p53-dependent apoptosis.","volume":"29","author":"Schuler","year":"2001","journal-title":"Biochem Soc Trans"},{"key":"2020071612200943700_R21","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/sj.cdd.4400396","article-title":"The role of the tumor suppressor p53 in spermatogenesis.","volume":"5","author":"Beumer","year":"1998","journal-title":"Cell Death Differ"},{"key":"2020071612200943700_R22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000147881","article-title":"Apoptosis in adult mouse testis induced by experimental cryptorchidism.","volume":"157","author":"Ohta","year":"1996","journal-title":"Acta Anat"},{"key":"2020071612200943700_R23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1006\/dbio.1999.9440","article-title":"Deficiency of Trp53 rescues the male fertility defects of KitW-v mice but has no effect on the survival of melanocytes and mast cells.","volume":"215","author":"Jordan","year":"1999","journal-title":"Dev Biol"},{"key":"2020071612200943700_R24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/jand.2002.23.1.64","article-title":"p53 and Fas are sequential mechanisms of testicular germ cell apoptosis.","volume":"23","author":"Yin","year":"2002","journal-title":"J Androl"},{"key":"2020071612200943700_R25","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1095\/biolreprod.102.014779","article-title":"Functional analysis of the p53 gene in apoptosis induced by heat stress or loss of stem cell factor signaling in mouse male germ cells.","volume":"68","author":"Ohta","year":"2003","journal-title":"Biol Reprod"},{"key":"2020071612200943700_R26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2307\/3579503","article-title":"Radiation-induced cell death in the mouse testis: relationship to apoptosis.","volume":"147","author":"Hasegawa","year":"1997","journal-title":"Radiat Res"},{"key":"2020071612200943700_R27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0960-9822(00)00002-6","article-title":"Tumor spectrum analysis in p53-mutant mice.","volume":"4","author":"Jacks","year":"1994","journal-title":"Curr Biol"},{"key":"2020071612200943700_R28","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/ng1195-294","article-title":"Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.","volume":"11","author":"Adachi","year":"1995","journal-title":"Nat Genet"},{"key":"2020071612200943700_R29","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0092-8674(94)90375-1","article-title":"Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand.","volume":"76","author":"Takahashi","year":"1994","journal-title":"Cell"},{"key":"2020071612200943700_R30","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1210\/en.2006-0159","article-title":"Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle stimulating hormone mutations.","volume":"147","author":"Shetty","year":"2006","journal-title":"Endocrinology"},{"key":"2020071612200943700_R31","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1095\/biolreprod66.5.1456","article-title":"Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis.","volume":"66","author":"Embree-Ku","year":"2002","journal-title":"Biol Reprod"},{"key":"2020071612200943700_R32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1210\/endo.141.1.7272","article-title":"Enhancement of A spermatogonial proliferation and differentiation in irradiated rats by GnRH antagonist administration.","volume":"141","author":"Shuttlesworth","year":"2000","journal-title":"Endocrinology"},{"key":"2020071612200943700_R33","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2307\/3579959","article-title":"Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice.","volume":"149","author":"Hasegawa","year":"1998","journal-title":"Radiat Res"},{"key":"2020071612200943700_R34","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/jemt.1070320505","article-title":"Theory and practice of stereological techniques applied to the estimation of cell number and nuclear volume in the testis.","volume":"32","author":"Wreford","year":"1995","journal-title":"Microsc Res Tech"},{"key":"2020071612200943700_R35","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1210\/en.2005-0984","article-title":"Both testosterone and FSH independently inhibit spermatogonial differentiation in irradiated rats.","volume":"147","author":"Shetty","year":"2006","journal-title":"Endocrinology"},{"key":"2020071612200943700_R36","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1210\/en.2003-0175","article-title":"Key apoptotic pathways for heat-induced programmed germ cell death in the testis.","volume":"144","author":"Sinha Hikim","year":"2003","journal-title":"Endocrinology"},{"key":"2020071612200943700_R37","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1095\/biolreprod.103.024661","article-title":"Mitochondria-dependent pathway is involved in heat-induced male germ cell death: lessons from mutant mice.","volume":"70","author":"Vera","year":"2004","journal-title":"Biol Reprod"},{"key":"2020071612200943700_R38","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1210\/endo.141.5.7446","article-title":"Gonadotropin-releasing hormone analogs stimulate and testosterone inhibits the recovery of spermatogenesis in irradiated rats.","volume":"141","author":"Shetty","year":"2000","journal-title":"Endocrinology"},{"key":"2020071612200943700_R39","first-page":"147","article-title":"Is p53 haploinsufficient for tumor suppression?","volume":"29","author":"Venkatachalam","year":"2001","journal-title":"Implications for the p53+\/\u2212 mouse model in carcinogenicity testing"},{"key":"2020071612200943700_R40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mrfmmm.2006.10.001","article-title":"Effect of p53 haploinsufficiency on melphalan-induced genotoxic effects in mouse bone marrow and peripheral blood.","volume":"615","author":"Ranaldi","year":"2007","journal-title":"Mutat Res"},{"key":"2020071612200943700_R41","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1210\/endo.142.7.8237","article-title":"Testosterone inhibits spermatogonial differentiation in juvenile spermatogonial depletion mice.","volume":"142","author":"Shetty","year":"2001","journal-title":"Endocrinology"},{"key":"2020071612200943700_R42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1677\/joe.0.0980035","article-title":"Changes in testicular blood flow and testosterone production during aspermatogenesis after irradiation.","volume":"98","author":"Wang","year":"1983","journal-title":"J Endocrinol"},{"key":"2020071612200943700_R43","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1210\/endo.140.4.6629","article-title":"Single exposure to heat induces stage-specific germ cell apoptosis in rats: role of intratesticular testosterone on stage specificity.","volume":"140","author":"Lue","year":"1999","journal-title":"Endocrinology"},{"key":"2020071612200943700_R44","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/jcp.56.5.358","article-title":"Increased apoptosis in gastric mucosa adjacent to intestinal metaplasia.","volume":"56","author":"van Grieken","year":"2003","journal-title":"J Clin Pathol"},{"key":"2020071612200943700_R45","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/(SICI)1097-0142(19970201)79:3<433::AID-CNCR2>3.0.CO;2-J","article-title":"Differential expression of apoptosis receptors on diffuse and intestinal type stomach carcinoma.","volume":"79","author":"Vollmers","year":"1997","journal-title":"Cancer"},{"key":"2020071612200943700_R46","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1210\/endo.138.5.5110","article-title":"The Fas system is a key regulator of germ cell apoptosis in the testis.","volume":"138","author":"Lee","year":"1997","journal-title":"Endocrinology"},{"key":"2020071612200943700_R47","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/0092-8674(93)90326-L","article-title":"Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family.","volume":"75","author":"Suda","year":"1993","journal-title":"Cell"},{"key":"2020071612200943700_R48","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1083\/jcb.133.2.335","article-title":"Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.","volume":"133","author":"French","year":"1996","journal-title":"J Cell Biol"},{"key":"2020071612200943700_R49","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/sj.cdd.4401215","article-title":"Involvement of death receptor Fas in germ cell degeneration in gonads of kit-deficient W-v\/W-v mutant mice.","volume":"10","author":"Sakata","year":"2003","journal-title":"Cell Death Differ"},{"key":"2020071612200943700_R50","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/endo.141.2.7325","article-title":"Sensitivity of testicular germ cells to toxicant-induced apoptosis in gld mice that express a nonfunctional form of Fas ligand.","volume":"141","author":"Richburg","year":"2000","journal-title":"Endocrinology"},{"key":"2020071612200943700_R51","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1210\/endo.140.2.6479","article-title":"The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis.","volume":"140","author":"Lee","year":"1999","journal-title":"Endocrinology"},{"key":"2020071612200943700_R52","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1210\/endo.140.8.6919","article-title":"Leydig cell apoptosis after the administration of ethane dimethanesulfonate to the adult male rat is a Fas-mediated process.","volume":"140","author":"Taylor","year":"1999","journal-title":"Endocrinology"},{"key":"2020071612200943700_R53","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1095\/biolreprod.104.030858","article-title":"The p53 protein influences the sensitivity of testicular germ cells to mono-(2-ethylhexyl) phthalate-induced apoptosis by increasing the membrane levels of Fas and DR5 and decreasing the intracellular amount of c-FLIP.","volume":"72","author":"Chandrasekaran","year":"2005","journal-title":"Biol Reprod"},{"key":"2020071612200943700_R54","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1095\/biolreprod61.3.842","article-title":"Arrest of spermatogonial differentiation in jsd\/jsd, Sl17H\/Sl17H, and cryptorchid mice.","volume":"61","author":"de Rooij","year":"1999","journal-title":"Biol Reprod"},{"key":"2020071612200943700_R55","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1242\/jcs.00739","article-title":"Apoptosis\u2014the p53 network.","volume":"116","author":"Haupt","year":"2003","journal-title":"J Cell Sci"},{"key":"2020071612200943700_R56","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/23730","article-title":"Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis.","volume":"400","author":"Yin","year":"1999","journal-title":"Nature"},{"key":"2020071612200943700_R57","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0092-8674(00)81589-5","article-title":"Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.","volume":"94","author":"Luo","year":"1998","journal-title":"Cell"},{"key":"2020071612200943700_R58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2605.2001.00257.x","article-title":"Defect in germ cells, not in supporting cells, is the cause of male infertility in the jsd mutant mouse: proliferation of spermatogonial stem cells without differentiation.","volume":"24","author":"Ohta","year":"2001","journal-title":"Int J Androl"},{"key":"2020071612200943700_R59","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/taap.1998.8616","article-title":"Induction of apoptosis and changes in nuclear G-actin are mediated by different pathways: the effect of inhibitors of protein and RNA synthesis in isolated rat hepatocytes.","volume":"156","author":"Meijerman","year":"1999","journal-title":"Toxicol Appl Pharmacol"},{"key":"2020071612200943700_R60","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1021\/bi027147i","article-title":"Implications for RNase L in prostate cancer biology.","volume":"42","author":"Silverman","year":"2003","journal-title":"Biochemistry"},{"key":"2020071612200943700_R61","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1101\/gad.1522007","article-title":"NBK\/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.","volume":"21","author":"Shimazu","year":"2007","journal-title":"Genes Dev"},{"key":"2020071612200943700_R62","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1128\/MCB.20.15.5516-5528.2000","article-title":"Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis.","volume":"20","author":"Strezoska","year":"2000","journal-title":"Mol Cell Biol"},{"key":"2020071612200943700_R63","doi-asserted-by":"crossref","first-page":"29617","DOI":"10.1074\/jbc.M204381200","article-title":"Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression.","volume":"277","author":"Strezoska","year":"2002","journal-title":"J Biol Chem"},{"key":"2020071612200943700_R64","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1097-2765(03)00057-1","article-title":"Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing.","volume":"11","author":"Sugimoto","year":"2003","journal-title":"Mol Cell"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/149\/6\/2773\/8998476\/endo2773.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/149\/6\/2773\/8998476\/endo2773.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T19:54:31Z","timestamp":1594929271000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/149\/6\/2773\/2454950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,20]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2007-1338","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,20]]}}}