{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:01:01Z","timestamp":1774645261681,"version":"3.50.1"},"reference-count":34,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5,1]]},"DOI":"10.1210\/en.2007-1458","type":"journal-article","created":{"date-parts":[[2008,1,17]],"date-time":"2008-01-17T20:44:50Z","timestamp":1200602690000},"page":"2443-2450","source":"Crossref","is-referenced-by-count":36,"title":["Severe Obesity and Insulin Resistance due to Deletion of the Maternal Gs\u03b1 Allele Is Reversed by Paternal Deletion of the Gs\u03b1 Imprint Control Region"],"prefix":"10.1210","volume":"149","author":[{"given":"Tao","family":"Xie","sequence":"first","affiliation":[{"name":"Metabolic Diseases Branch (T.X., M.C., J.L., L.S.W.), National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch (T.X., M.C., J.L., L.S.W.), National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Gavrilova","sequence":"additional","affiliation":[{"name":"Mouse Metabolism Core Laboratory (O.G.), National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin W.","family":"Lai","sequence":"additional","affiliation":[{"name":"Reproductive and Adult Endocrinology Program (E.W.L.), National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch (T.X., M.C., J.L., L.S.W.), National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee S.","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Metabolic Diseases Branch (T.X., M.C., J.L., L.S.W.), National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2008,1,17]]},"reference":[{"key":"2019041121315382400_R1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1210\/er.2006-0040","article-title":"Genetics of obesity in humans.","volume":"27","author":"Farooqi","year":"2006","journal-title":"Endocr Rev"},{"key":"2019041121315382400_R2","first-page":"849","author":"Weinstein","year":"2004"},{"key":"2019041121315382400_R3","doi-asserted-by":"crossref","first-page":"7386","DOI":"10.1073\/pnas.0408268102","article-title":"Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.","volume":"102","author":"Chen","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121315382400_R4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0006-291X(02)00833-1","article-title":"Paternal imprinting of G\u03b1s in the human thyroid as the basis of TSH resistance in pseudohypoparathyroidism type 1a.","volume":"296","author":"Germain-Lee","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041121315382400_R5","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1210\/jc.2003-030393","article-title":"The stimulatory G protein \u03b1-subunit Gs\u03b1 is imprinted in human thyroid glands: implications for thyroid function in pseudohypoparathyroidism types 1A and 1B.","volume":"88","author":"Liu","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121315382400_R6","doi-asserted-by":"crossref","first-page":"8715","DOI":"10.1073\/pnas.95.15.8715","article-title":"Variable and tissue-specific hormone resistance in heterotrimeric Gs protein \u03b1-subunit (Gs\u03b1) knockout mice is due to tissue-specific imprinting of the Gs\u03b1 gene.","volume":"95","author":"Yu","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121315382400_R7","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1172\/JCI11887","article-title":"Imprinting of the Gs\u03b1 gene GNAS1 in the pathogenesis of acromegaly","volume":"107","author":"Hayward","year":"2001","journal-title":"J Clin Invest"},{"key":"2019041121315382400_R8","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1210\/jc.2002-020183","article-title":"The Gs\u03b1 gene: predominant maternal origin of transcription in human thyroid gland and gonads.","volume":"87","author":"Mantovani","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121315382400_R9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.pharmthera.2007.03.013","article-title":"Studies of the regulation and function of the Gs\u03b1 gene Gnas using gene targeting technology.","volume":"115","author":"Weinstein","year":"2007","journal-title":"Pharmacol Ther"},{"key":"2019041121315382400_R10","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1210\/en.2005-0681","article-title":"A mouse model of Albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene.","volume":"146","author":"Germain-Lee","year":"2005","journal-title":"Endocrinology"},{"key":"2019041121315382400_R11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1172\/JCI8437","article-title":"Paternal versus maternal transmission of a stimulatory G protein \u03b1 subunit knockout produces opposite effects on energy metabolism.","volume":"105","author":"Yu","year":"2000","journal-title":"J Clin Invest"},{"key":"2019041121315382400_R12","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/ng1397","article-title":"The imprinted signaling protein XL\u03b1s is required for postnatal adaptation to feeding.","volume":"36","author":"Plagge","year":"2004","journal-title":"Nat Genet"},{"key":"2019041121315382400_R13","doi-asserted-by":"crossref","first-page":"18989","DOI":"10.1074\/jbc.M511752200","article-title":"The alternative stimulatory G protein \u03b1-subunit XL\u03b1s is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice.","volume":"281","author":"Xie","year":"2006","journal-title":"J Biol Chem"},{"key":"2019041121315382400_R14","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1128\/MCB.25.8.3019-3026.2005","article-title":"Imprinted Nesp55 influences behavioral reactivity to novel environments.","volume":"25","author":"Plagge","year":"2005","journal-title":"Mol Cell Biol"},{"key":"2019041121315382400_R15","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI10431","article-title":"A GNAS1 imprinting defect in pseudohypoparathyroidism type IB.","volume":"106","author":"Liu","year":"2000","journal-title":"J Clin Invest"},{"key":"2019041121315382400_R16","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1128\/MCB.20.16.5808-5817.2000","article-title":"Identification of a methylation imprint mark within the mouse Gnas locus.","volume":"20","author":"Liu","year":"2000","journal-title":"Mol Cell Biol"},{"key":"2019041121315382400_R17","doi-asserted-by":"crossref","first-page":"10038","DOI":"10.1073\/pnas.95.17.10038","article-title":"The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins.","volume":"95","author":"Hayward","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121315382400_R18","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.1073\/pnas.0408262102","article-title":"Identification of the control region for tissue-specific imprinting of the stimulatory G protein \u03b1-subunit.","volume":"102","author":"Liu","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121315382400_R19","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/ng1398","article-title":"A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas.","volume":"36","author":"Williamson","year":"2004","journal-title":"Nat Genet"},{"key":"2019041121315382400_R20","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1093\/clinchem\/32.11.2030","article-title":"Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase.","volume":"32","author":"Eisenhofer","year":"1986","journal-title":"Clin Chem"},{"key":"2019041121315382400_R21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/er.2002-0012","article-title":"Peroxisome proliferator-activated receptor-\u03b3 coactivator 1a (PGC-1\u03b1): transcriptional coactivator and metabolic regulator.","volume":"24","author":"Puigserver","year":"2003","journal-title":"Endocr Rev"},{"key":"2019041121315382400_R22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1017\/S0016672398003528","article-title":"Imprinting of distal mouse chromosome 2 is associated with phenotypic anomalies in utero.","volume":"72","author":"Williamson","year":"1998","journal-title":"Genet Res"},{"issue":"Suppl 3","key":"2019041121315382400_R23","first-page":"50","article-title":"Imprinted genes, placental development and fetal growth","volume":"65","author":"Fowden","year":"2006","journal-title":"Horm Res"},{"key":"2019041121315382400_R24","doi-asserted-by":"crossref","first-page":"19994","DOI":"10.1074\/jbc.M010313200","article-title":"Increased insulin sensitivity in Gs\u03b1 knockout mice.","volume":"276","author":"Yu","year":"2001","journal-title":"J Biol Chem"},{"key":"2019041121315382400_R25","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1172\/JCI24196","article-title":"Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs\u03b1 deficiency.","volume":"115","author":"Chen","year":"2005","journal-title":"J Clin Invest"},{"key":"2019041121315382400_R26","doi-asserted-by":"crossref","first-page":"6316","DOI":"10.1210\/jc.2004-0558","article-title":"Biallelic expression of the Gs\u03b1 gene in human bone and adipose tissue.","volume":"89","author":"Mantovani","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041121315382400_R27","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/ng1731","article-title":"Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster.","volume":"38","author":"Williamson","year":"2006","journal-title":"Nat Genet"},{"key":"2019041121315382400_R28","first-page":"A71","article-title":"Mice with adipose-tissue specific deficiency of the stimulatory G protein \u03b1-subunit Gs\u03b1 are resistant to diet-induced obesity and maintain diet-induced, but not cold-induced, thermogenesis","volume":"55(Suppl 1)","author":"Nguyen","journal-title":"Diabetes"},{"key":"2019041121315382400_R29","doi-asserted-by":"crossref","first-page":"19601","DOI":"10.1073\/pnas.0704796104","article-title":"\u03b2 Cell-specific deficiency of the stimulatory G protein \u03b1-subunit Gs\u03b1 leads to reduced \u03b2 cell mass and insulin-deficient diabetes.","volume":"104","author":"Xie","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121315382400_R30","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.febslet.2007.02.019","article-title":"Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats.","volume":"581","author":"Banno","year":"2007","journal-title":"FEBS Lett"},{"key":"2019041121315382400_R31","doi-asserted-by":"crossref","first-page":"E611","DOI":"10.1152\/ajpendo.00034.2006","article-title":"The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity","volume":"291","author":"Phan","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2019041121315382400_R32","first-page":"R1467","article-title":"Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue","volume":"289","author":"Song","year":"2005","journal-title":"Am J Physiol"},{"key":"2019041121315382400_R33","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cell.2005.08.035","article-title":"Divergence of melanocortin pathways in the control of food intake and energy expenditure.","volume":"123","author":"Balthasar","year":"2005","journal-title":"Cell"},{"key":"2019041121315382400_R34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000090843","article-title":"Regulation of growth and metabolism by imprinted genes.","volume":"113","author":"Smith","year":"2006","journal-title":"Cytogenet Genome Res"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/149\/5\/2443\/9002300\/endo2443.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T18:25:19Z","timestamp":1588271119000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/149\/5\/2443\/2455046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,17]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,1,17]]},"published-print":{"date-parts":[[2008,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2007-1458","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1100038.556192","asserted-by":"object"}]},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,17]]}}}