{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:09:42Z","timestamp":1791263382747,"version":"4.1.0"},"reference-count":48,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:p>Prokineticin-1 (PK1) is a recently described protein with a wide range of functions, including tissue-specific angiogenesis, modulation of inflammatory responses, and regulation of hemopoiesis. The aim of this study was to investigate the localization and expression of PK1 and PK receptor-1 (PKR1), their signaling pathways, and the effect of PK1 on expression of the inflammatory mediators cyclooxygenase (COX)-2 and IL-8 in third-trimester placenta. PK1 and PKR1 were highly expressed in term placenta and immunolocalized to syncytiotrophoblasts, cytotrophoblasts, fetal endothelium, and macrophages. PK1 induced a time-dependent increase in expression of IL-8 and COX-2, which was significantly reduced by inhibitors of Gq, cSrc, epidermal growth factor receptor (EGFR), and MAPK kinase. Treatment of third-trimester placenta with 40 nm PK1 induced a rapid phosphorylation of cSrc, EGFR, and ERK1\/2. Phosphorylation of ERK1\/2 in response to PK1 was dependent on sequential phosphorylation of cSrc and EGFR. Using double-immunofluorescent immunohistochemistry, PKR1 colocalized with IL-8 and COX-2 in placenta. These data suggest that PK1 may have a novel role as a mediator of the inflammatory response in placenta.<\/jats:p>","DOI":"10.1210\/en.2007-1695","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T00:39:42Z","timestamp":1206664782000},"page":"3470-3477","source":"Crossref","is-referenced-by-count":45,"title":["Prokineticin-1: A Novel Mediator of the Inflammatory Response in Third-Trimester Human Placenta"],"prefix":"10.1210","volume":"149","author":[{"given":"Fiona C.","family":"Denison","sequence":"first","affiliation":[{"name":"Department of Reproductive and Developmental Sciences (F.C.D., A.E.K.), Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Battersby","sequence":"first","affiliation":[{"name":"Medical Research Council Human Reproductive Sciences Unit (S.B., M.S., H.N.J.), Centre for Reproductive Biology, University 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