{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:09:30Z","timestamp":1790896170686,"version":"4.1.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11,1]]},"abstract":"<jats:p>After myocardial infarction (MI), the heart may undergo progressive ventricular remodeling, resulting in a deterioration of cardiac function. TGF-\u03b2 is a key cytokine that both initiates and terminates tissue repair, and its sustained production underlies the development of tissue fibrosis, particularly after MI. We investigated the effects of a novel orally active specific inhibitor of the TGF-\u03b2 receptor 1 (SD-208) in an experimental model of MI. Mice underwent ligation of the left coronary artery to induce MI and were subsequently treated for 30 d after infarction with either SD-208 or a vehicle control. Blockade of TGF-\u03b2 signaling reduced mean arterial pressure in all groups. SD-208 treatment after MI resulted in a trend for reduced ventricular and renal gene expression of TGF-\u03b2-activated kinase-1 (a downstream modulator of TGF-\u03b2 signaling) and a significant decrease in collagen 1, in association with a marked decrease in cardiac mass. Post-MI SD-208 treatment significantly reduced circulating levels of plasma renin activity as well as down-regulating the components of the cardiac and renal renin-angiotensin system (angiotensinogen, angiotensin converting enzyme, and angiotensin II type I receptor). Our findings indicate that blockade of the TGF-\u03b2 signaling pathway results in significant amelioration of deleterious cardiac remodeling after infarction.<\/jats:p>","DOI":"10.1210\/en.2008-0165","type":"journal-article","created":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T01:10:28Z","timestamp":1216948228000},"page":"5828-5834","source":"Crossref","is-referenced-by-count":60,"title":["Transforming Growth Factor-\u03b2 Blockade Down-Regulates the Renin-Angiotensin System and Modifies Cardiac Remodeling after Myocardial Infarction"],"prefix":"10.1210","volume":"149","author":[{"given":"Leigh J.","family":"Ellmers","sequence":"first","affiliation":[{"name":"Christchurch Cardioendocrine Research Group (L.J.E., N.J.A.S., A.P.P., T.G.Y., A.M.R., V.A.C.), Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch 8140, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola J. 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