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CRF-OE mice injected ip with saline showed a 47 and 44% reduction of 30-min and 4-h cumulative food intake response to an overnight fast, respectively, compared with WT. However, the 30-min food intake decrease induced by ip cholecystokinin (3 \u03bcg\/kg) and increase by ghrelin (300 \u03bcg\/kg) were similar in CRF-OE and WT mice. Overnight fasting increased the plasma total ghrelin to similar levels in CRF-OE and WT mice, although CRF-OE mice had a 2-fold reduction of nonfasting ghrelin levels. The number of Fos-immunoreactive cells induced by fasting in the arcuate nucleus was reduced by 5.9-fold in CRF-OE compared with WT mice whereas no significant changes were observed in other hypothalamic nuclei. In contrast, fasted CRF-OE mice displayed a 5.6-fold increase in Fos-immunoreactive cell number in the dorsal motor nucleus of the vagus nerve and a 34% increase in 20-min gastric emptying. These findings indicate that sustained overproduction of hypothalamic CRF in mice interferes with fasting-induced activation of arcuate nucleus neurons and the related hyperphagic response.<\/jats:p><jats:p>Sustained over-production of brain corticotrophin-releasing factor interferes with fasting-activated neuronal activation in the arcuate nucleus and results in reduction of food intake dissociated from gastric emptying.<\/jats:p>","DOI":"10.1210\/en.2008-0723","type":"journal-article","created":{"date-parts":[[2008,9,12]],"date-time":"2008-09-12T00:44:51Z","timestamp":1221180291000},"page":"153-160","source":"Crossref","is-referenced-by-count":33,"title":["Corticotropin-Releasing Factor-Overexpressing Mice Exhibit Reduced Neuronal Activation in the Arcuate Nucleus and Food Intake in Response to Fasting"],"prefix":"10.1210","volume":"150","author":[{"given":"Andreas","family":"Stengel","sequence":"first","affiliation":[{"name":"Center for Ulcer Research and Education (CURE):Digestive 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