{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:01:47Z","timestamp":1792882907405,"version":"4.5.0"},"reference-count":63,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:p>Preeclampsia (PE), which affects 4\u20138% of human pregnancies, causes significant maternal and neonatal morbidity and mortality. Within the basal plate, placental cytotrophoblasts (CTBs) of fetal origin invade the uterus and extensively remodel the maternal vasculature. In PE, CTB invasion is often shallow, and vascular remodeling is rudimentary. To better understand possible causes, we conducted a global analysis of gene expression at the maternal-fetal interface in placental samples from women with PE (n = 12; 24\u201336 wk) vs. samples from women who delivered due to preterm labor with no evidence of infection (n = 11; 24\u201336 wk), a condition that our previous work showed is associated with normal CTB invasion. Using the HG-U133A&amp;B Affymetrix GeneChip platform, and statistical significance set at log odds-ratio of B &amp;gt;0, 55 genes were differentially expressed in PE. They encoded proteins previously associated with PE [e.g. Flt-1 (vascular endothelial growth factor receptor-1), leptin, CRH, and inhibin] and novel molecules [e.g. sialic acid binding Ig-like lectin 6 (Siglec-6), a potential leptin receptor, and pappalysin-2 (PAPP-A2), a protease that cleaves IGF-binding proteins]. We used quantitative PCR to validate the expression patterns of a subset of the genes. At the protein level, we confirmed PE-related changes in the expression of Siglec-6 and PAPP-A2, which localized to invasive CTBs and syncytiotrophoblasts. Notably, Siglec-6 placental expression is uniquely human, as is spontaneous PE. The functional significance of these novel observations may provide new insights into the pathogenesis of PE, and assaying the circulating levels of these proteins could have clinical utility for predicting and\/or diagnosing PE.<\/jats:p><jats:p>Gene expression analysis of placental basal plates from severe preeclamptic pregnancies and controls revealed differential expression of 55 genes, including Siglec-6 and pappalysin-2.<\/jats:p>","DOI":"10.1210\/en.2008-0990","type":"journal-article","created":{"date-parts":[[2008,9,26]],"date-time":"2008-09-26T00:34:11Z","timestamp":1222389251000},"page":"452-462","source":"Crossref","is-referenced-by-count":147,"title":["Severe Preeclampsia-Related Changes in Gene Expression at the Maternal-Fetal Interface Include Sialic Acid-Binding Immunoglobulin-Like Lectin-6 and Pappalysin-2"],"prefix":"10.1210","volume":"150","author":[{"given":"Virginia D.","family":"Winn","sequence":"first","affiliation":[{"name":"Departments of Obstetrics, Gynecology, and Reproductive Sciences (V.D.W., M.G., R.H.-K.), University of California, San Francisco, San Francisco, California 94143"},{"name":"Department of Obstetrics and Gynecology (V.D.W., A.K., K.K.R.), University of Colorado Denver, Aurora, Colorado 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Gormley","sequence":"first","affiliation":[{"name":"Departments of Obstetrics, Gynecology, and Reproductive Sciences (V.D.W., M.G., R.H.-K.), University of California, San Francisco, San Francisco, California 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes C.","family":"Paquet","sequence":"first","affiliation":[{"name":"Medicine Lung Biology Center (A.C.P., R.-F.Y.), University of California, San Francisco, San Francisco, California 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Kjaer-Sorensen","sequence":"first","affiliation":[{"name":"Department of Molecular Biology (K.K.-S., M.T.O., 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94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Fang","family":"Yeh","sequence":"first","affiliation":[{"name":"Medicine Lung Biology Center (A.C.P., R.-F.Y.), University of California, San Francisco, San Francisco, California 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Overgaard","sequence":"first","affiliation":[{"name":"Department of Molecular Biology (K.K.-S., M.T.O., C.O.), University of Aarhus, DK-8000 Aarhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Varki","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Medicine (A.V.), University of California, San Diego, San Diego, California 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Oxvig","sequence":"first","affiliation":[{"name":"Department of Molecular Biology (K.K.-S., M.T.O., C.O.), University of Aarhus, DK-8000 Aarhus C, 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