{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:57:50Z","timestamp":1791194270429,"version":"4.1.0"},"reference-count":71,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:p>The PTH receptor (PTHR1) is expressed on osteoblasts and responds to PTH or PTHrP in an endocrine or autocrine\/paracrine manner, respectively. A microarray study carried out on PTHR1-positive osteoblasts (Kusa 4b10 cells) identified the cysteine-X-cysteine (CXC) family chemokine ligand 1 (Cxcl1) as a novel immediate PTH\/PTHrP-responsive gene. Cxcl1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation, but a role in bone biology has not been described. Cxcl1 mRNA levels were up-regulated 1 h after either PTH or PTHrP treatment of differentiated Kusa 4b10 osteoblasts (15-fold) and mouse calvarial osteoblasts (160-fold) and in rat metaphyseal bone (5-fold) 1 h after a single sc injection of PTH. Furthermore, PTH treatment stimulated a 10-fold increase in secreted Cxcl1 protein by both Kusa 4b10 cells and calvarial osteoblasts. Immunohistochemistry and PCR demonstrated that CXCR2, the receptor for Cxcl1, is highly expressed in osteoclast precursors (hemopoietic cells) but is predominantly undetectable in the osteoblast lineage, suggesting that osteoblast-derived Cxcl1 may act as a chemoattractant for osteoclast precursors. Confirming this hypothesis, recombinant Cxcl1 dose-dependently stimulated migration of osteoclast precursors in cell culture studies, as did conditioned media from Kusa 4b10 cells treated with PTH. These data indicate that local action through the PTHR1 could stimulate cells of the osteoblast lineage to release a chemokine capable of attracting osteoclast precursors to the bone environment.<\/jats:p>","DOI":"10.1210\/en.2008-1597","type":"journal-article","created":{"date-parts":[[2009,1,16]],"date-time":"2009-01-16T01:46:31Z","timestamp":1232070391000},"page":"2244-2253","source":"Crossref","is-referenced-by-count":66,"title":["The Chemokine Cxcl1 Is a Novel Target Gene of Parathyroid Hormone (PTH)\/PTH-Related Protein in Committed Osteoblasts"],"prefix":"10.1210","volume":"150","author":[{"given":"Do\u0308ne","family":"Onan","sequence":"first","affiliation":[{"name":"Bone Joint and Cancer Unit (D.O., E.H.A., J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Institute, The University of Melbourne, Fitzroy, Victoria 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth H.","family":"Allan","sequence":"additional","affiliation":[{"name":"Bone Joint and Cancer Unit (D.O., E.H.A., J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Institute, The University of Melbourne, Fitzroy, Victoria 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian M. W.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Bone Joint and Cancer Unit (D.O., E.H.A., J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Institute, The University of Melbourne, Fitzroy, Victoria 3065, Australia"},{"name":"Department of Medicine (J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Hospital, The University of Melbourne, Fitzroy, Victoria 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Gooi","sequence":"additional","affiliation":[{"name":"Bone Joint and Cancer Unit (D.O., E.H.A., J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Institute, The University of Melbourne, Fitzroy, Victoria 3065, Australia"},{"name":"Department of Medicine (J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Hospital, The University of Melbourne, Fitzroy, Victoria 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sueli","family":"Pompolo","sequence":"additional","affiliation":[{"name":"Bone Joint and Cancer Unit (D.O., E.H.A., J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Institute, The University of Melbourne, Fitzroy, Victoria 3065, Australia"},{"name":"Department of Medicine (J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Hospital, The University of Melbourne, Fitzroy, Victoria 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Sims","sequence":"additional","affiliation":[{"name":"Bone Joint and Cancer Unit (D.O., E.H.A., J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Institute, The University of Melbourne, Fitzroy, Victoria 3065, Australia"},{"name":"Department of Medicine (J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Hospital, The University of Melbourne, Fitzroy, Victoria 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Bone Joint and Cancer Unit (D.O., E.H.A., J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Institute, The University of Melbourne, Fitzroy, Victoria 3065, Australia"},{"name":"Department of Medicine (J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Hospital, The University of Melbourne, Fitzroy, Victoria 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. John","family":"Martin","sequence":"additional","affiliation":[{"name":"Bone Joint and Cancer Unit (D.O., E.H.A., J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Institute, The University of Melbourne, Fitzroy, Victoria 3065, Australia"},{"name":"Department of Medicine (J.M.W.Q., J.H.G., S.P., N.A.S., M.T.G., T.J.M.), St. Vincent\u2019s Hospital, The University of Melbourne, Fitzroy, Victoria 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2009,1,15]]},"reference":[{"key":"2020071613440283900_R1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.semcdb.2008.07.016","article-title":"Bone remodeling: multiple cellular interactions required for coupling of bone formation and resorption.","volume":"19","author":"Sims","year":"2008","journal-title":"Semin Cell Dev Biol"},{"key":"2020071613440283900_R2","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1136\/bmj.280.6228.1340","article-title":"Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial.","volume":"280","author":"Reeve","year":"1980","journal-title":"Br Med J"},{"key":"2020071613440283900_R3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1196\/annals.1346.043","article-title":"Mechanisms involved in skeletal anabolic therapies.","volume":"1068","author":"Martin","year":"2006","journal-title":"Ann NY Acad Sci"},{"key":"2020071613440283900_R4","first-page":"F197","article-title":"Effects of long-term infusion of physiologic doses of 1\u201334 PTH on bone","volume":"242","author":"Malluche","year":"1982","journal-title":"Am J Physiol"},{"key":"2020071613440283900_R5","doi-asserted-by":"crossref","first-page":"d769","DOI":"10.2741\/A320","article-title":"G-protein coupled receptors in bone","volume":"3","author":"Bowler","year":"1998","journal-title":"Front Biosci"},{"key":"2020071613440283900_R6","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1359\/jbmr.080324","article-title":"EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts.","volume":"23","author":"Allan","year":"2008","journal-title":"J Bone Miner Res"},{"key":"2020071613440283900_R7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1365-2796.2001.00867.x","article-title":"Chemokines in pathology and medicine.","volume":"250","author":"Baggiolini","year":"2001","journal-title":"J Intern Med"},{"key":"2020071613440283900_R8","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0952-7915(00)00096-0","article-title":"Chemokines in tissue-specific and microenvironment-specific lymphocyte homing.","volume":"12","author":"Campbell","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"2020071613440283900_R9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1210\/er.2007-0038","article-title":"Osteoimmunology: interactions of the bone and immune system.","volume":"29","author":"Lorenzo","year":"2008","journal-title":"Endocr Rev"},{"key":"2020071613440283900_R10","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1210\/endo-127-5-2592","article-title":"Macrophage colony stimulating factor restores in vivo bone resorption in the op\/op osteopetrotic mouse.","volume":"127","author":"Felix","year":"1990","journal-title":"Endocrinology"},{"key":"2020071613440283900_R11","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1084\/jem.188.5.997","article-title":"TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts.","volume":"188","author":"Fuller","year":"1998","journal-title":"J Exp Med"},{"key":"2020071613440283900_R12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.","volume":"397","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"2020071613440283900_R13","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1073\/pnas.87.12.4828","article-title":"Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op\/op) mouse.","volume":"87","author":"Wiktor-Jedrzejczak","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071613440283900_R14","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/319516a0","article-title":"Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors.","volume":"319","author":"Bertolini","year":"1986","journal-title":"Nature"},{"key":"2020071613440283900_R15","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.4049\/jimmunol.169.6.3353","article-title":"IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-\u03baB ligand, osteoprotegerin, and receptor activator of NF-\u03baB in mouse calvariae.","volume":"169","author":"Palmqvist","year":"2002","journal-title":"J Immunol"},{"key":"2020071613440283900_R16","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1073\/pnas.85.14.5235","article-title":"Infusions of recombinant human interleukins 1\u03b1 and 1\u03b2 cause hypercalcemia in normal mice.","volume":"85","author":"Sabatini","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071613440283900_R17","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1359\/jbmr.040910","article-title":"CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts.","volume":"19","author":"Yu","year":"2004","journal-title":"J Bone Miner Res"},{"key":"2020071613440283900_R18","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.bone.2005.01.021","article-title":"Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts.","volume":"36","author":"Wright","year":"2005","journal-title":"Bone"},{"key":"2020071613440283900_R19","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/jbmr.5650090721","article-title":"Expression of monocyte chemoattractant protein 1 in human osteoblastic cells stimulated by proinflammatory mediators.","volume":"9","author":"Zhu","year":"1994","journal-title":"J Bone Miner Res"},{"key":"2020071613440283900_R20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0065-2776(08)60509-X","article-title":"Interleukin-8 and related chemotactic cytokines\u2014CXC and CC chemokines.","volume":"55","author":"Baggiolini","year":"1994","journal-title":"Adv Immunol"},{"key":"2020071613440283900_R21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S8756-3282(03)00086-3","article-title":"Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease.","volume":"33","author":"Bendre","year":"2003","journal-title":"Bone"},{"key":"2020071613440283900_R22","doi-asserted-by":"crossref","first-page":"11001","DOI":"10.1158\/0008-5472.CAN-05-2630","article-title":"Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-\u03baB ligand pathway.","volume":"65","author":"Bendre","year":"2005","journal-title":"Cancer Res"},{"key":"2020071613440283900_R23","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1210\/endo.139.10.6247","article-title":"Human osteoclasts and osteoclast-like cells synthesize and release high basal and inflammatory stimulated levels of the potent chemokine interleukin-8.","volume":"139","author":"Rothe","year":"1998","journal-title":"Endocrinology"},{"key":"2020071613440283900_R24","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.4049\/jimmunol.154.11.6065","article-title":"Macrophage inflammatory protein-1\u03b1 and IL-8 stimulate the motility but suppress the resorption of isolated rat osteoclasts.","volume":"154","author":"Fuller","year":"1995","journal-title":"J Immunol"},{"key":"2020071613440283900_R25","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1359\/jbmr.2003.18.8.1404","article-title":"Stromal cell-derived factor-1 (SDF-1) recruits osteoclast precursors by inducing chemotaxis, matrix metalloproteinase-9 (MMP-9) activity, and collagen transmigration.","volume":"18","author":"Yu","year":"2003","journal-title":"J Bone Miner Res"},{"key":"2020071613440283900_R26","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/jcb.10319","article-title":"CCL9\/MIP-1\u03b3 and its receptor CCR1 are the major chemokine ligand\/receptor species expressed by osteoclasts.","volume":"87","author":"Lean","year":"2002","journal-title":"J Cell Biochem"},{"key":"2020071613440283900_R27","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.4049\/jimmunol.173.3.2084","article-title":"MIP-1\u03b3 promotes receptor activator of NF-\u03baB ligand-induced osteoclast formation and survival.","volume":"173","author":"Okamatsu","year":"2004","journal-title":"J Immunol"},{"key":"2020071613440283900_R28","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1182\/blood-2005-08-3365","article-title":"Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1\u03b3) in osteoclastogenesis in vivo and in vitro.","volume":"107","author":"Yang","year":"2006","journal-title":"Blood"},{"key":"2020071613440283900_R29","doi-asserted-by":"crossref","first-page":"33098","DOI":"10.1074\/jbc.M611781200","article-title":"Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre\/osteoclasts.","volume":"282","author":"Li","year":"2007","journal-title":"J Biol Chem"},{"key":"2020071613440283900_R30","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1210\/endo.136.6.7750500","article-title":"Monocyte chemoattractant protein-1 expression and monocyte recruitment in osseous inflammation in the mouse.","volume":"136","author":"Rahimi","year":"1995","journal-title":"Endocrinology"},{"key":"2020071613440283900_R31","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1006\/bbrc.1998.9909","article-title":"Macrophage-inflammatory protein-1\u03b1 regulates preosteoclast differentiation in vitro.","volume":"254","author":"Scheven","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071613440283900_R32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1677\/joe.0.1800193","article-title":"Direct stimulation of osteoclastogenesis by MIP-1\u03b1: evidence obtained from studies using RAW264 cell clone highly responsive to RANKL.","volume":"180","author":"Watanabe","year":"2004","journal-title":"J Endocrinol"},{"key":"2020071613440283900_R33","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.bbrc.2004.11.035","article-title":"KC chemokine expression by TGF-\u03b2 in C3H10T1\/2 cells induced toward osteoblasts.","volume":"326","author":"Bischoff","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071613440283900_R34","doi-asserted-by":"crossref","first-page":"14806","DOI":"10.1016\/S0021-9258(18)63771-8","article-title":"Purification and characterization of recombinant human parathyroid hormone-related protein.","volume":"264","author":"Hammonds Jr","year":"1989","journal-title":"J Biol Chem"},{"key":"2020071613440283900_R35","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/jcb.10614","article-title":"Differentiation potential of a mouse bone marrow stromal cell line.","volume":"90","author":"Allan","year":"2003","journal-title":"J Cell Biochem"},{"key":"2020071613440283900_R36","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1172\/JCI1333","article-title":"Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor.","volume":"101","author":"Horwood","year":"1998","journal-title":"J Clin Invest"},{"key":"2020071613440283900_R37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/jcp.1041420125","article-title":"Effects of interleukin 3 and of granulocyte-macrophage and macrophage colony stimulating factors on osteoclast differentiation from mouse hemopoietic tissue.","volume":"142","author":"Hattersley","year":"1990","journal-title":"J Cell Physiol"},{"key":"2020071613440283900_R38","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S8756-3282(01)00654-8","article-title":"The generation of highly enriched osteoclast-lineage cell populations.","volume":"30","author":"Quinn","year":"2002","journal-title":"Bone"},{"key":"2020071613440283900_R39","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.4049\/jimmunol.166.8.4915","article-title":"IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro.","volume":"166","author":"Horwood","year":"2001","journal-title":"J Immunol"},{"key":"2020071613440283900_R40","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1359\/jbmr.080706","article-title":"Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling.","volume":"23","author":"Walker","year":"2008","journal-title":"J Bone Miner Res"},{"key":"2020071613440283900_R41","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/8756-3282(95)00332-2","article-title":"In vivo, human parathyroid hormone fragment (hPTH 1\u201334) transiently stimulates immediate early response gene expression, but not proliferation, in trabecular bone cells of young rats.","volume":"17","author":"Onyia","year":"1995","journal-title":"Bone"},{"key":"2020071613440283900_R42","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bone.2007.03.017","article-title":"Molecular and cellular mechanisms of the anabolic effect of intermittent PTH.","volume":"40","author":"Jilka","year":"2007","journal-title":"Bone"},{"key":"2020071613440283900_R43","first-page":"1834","article-title":"Parathyroid hormone induces c-fos and c-jun messenger RNA in rat osteoblastic cells.","volume":"6","author":"Clohisy","year":"1992","journal-title":"Mol Endocrinol"},{"key":"2020071613440283900_R44","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1172\/JCI118157","article-title":"Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption.","volume":"96","author":"Greenfield","year":"1995","journal-title":"J Clin Invest"},{"key":"2020071613440283900_R45","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00223-004-0239-1","article-title":"Parathyroid hormone induces receptor activity modifying protein-3 (RAMP3) expression primarily via 3\u2032,5\u2032-cyclic adenosine monophosphate signaling in osteoblasts.","volume":"77","author":"Phelps","year":"2005","journal-title":"Calcif Tissue Int"},{"key":"2020071613440283900_R46","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S8756-3282(02)00698-1","article-title":"Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3\u2032,5\u2032-monophosphate-mediated pathway in primary neonatal murine osteoblasts.","volume":"30","author":"Tsingotjidou","year":"2002","journal-title":"Bone"},{"key":"2020071613440283900_R47","doi-asserted-by":"crossref","first-page":"33086","DOI":"10.1074\/jbc.M705194200","article-title":"Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis.","volume":"282","author":"Li","year":"2007","journal-title":"J Biol Chem"},{"key":"2020071613440283900_R48","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.8036519","article-title":"Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog.","volume":"265","author":"Cacalano","year":"1994","journal-title":"Science"},{"key":"2020071613440283900_R49","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1126\/science.7667641","article-title":"Neutrophilia in mice that lack the murine IL-8 receptor homolog.","volume":"269","author":"Shuster","year":"1995","journal-title":"Science"},{"key":"2020071613440283900_R50","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.4049\/jimmunol.154.11.6048","article-title":"Expression and biologic characterization of the murine chemokine KC.","volume":"154","author":"Bozic","year":"1995","journal-title":"J Immunol"},{"key":"2020071613440283900_R51","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.4049\/jimmunol.155.4.2158","article-title":"Chemokine binding and activities mediated by the mouse IL-8 receptor.","volume":"155","author":"Lee","year":"1995","journal-title":"J Immunol"},{"key":"2020071613440283900_R52","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/sj.bjp.0702329","article-title":"Signalling by CXC-chemokine receptors 1 and 2 expressed in CHO cells: a comparison of calcium mobilization, inhibition of adenylyl cyclase and stimulation of GTP\u03b3S binding induced by IL-8 and GRO\u03b1.","volume":"126","author":"Hall","year":"1999","journal-title":"Br J Pharmacol"},{"key":"2020071613440283900_R53","doi-asserted-by":"crossref","first-page":"29355","DOI":"10.1016\/S0021-9258(18)43882-3","article-title":"The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization.","volume":"269","author":"Bozic","year":"1994","journal-title":"J Biol Chem"},{"key":"2020071613440283900_R54","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1182\/blood-2005-09-010116","article-title":"An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals.","volume":"109","author":"Yu","year":"2007","journal-title":"Blood"},{"key":"2020071613440283900_R55","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1172\/JCI117993","article-title":"Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis.","volume":"95","author":"Kasama","year":"1995","journal-title":"J Clin Invest"},{"key":"2020071613440283900_R56","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1172\/JCI1195","article-title":"A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.","volume":"101","author":"Boisvert","year":"1998","journal-title":"J Clin Invest"},{"key":"2020071613440283900_R57","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.2353\/ajpath.2006.040748","article-title":"Up-regulated expression of the CXCR2 ligand KC\/GRO-\u03b1 in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression.","volume":"168","author":"Boisvert","year":"2006","journal-title":"Am J Pathol"},{"key":"2020071613440283900_R58","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/1529-0131(199805)41:5<900::AID-ART18>3.0.CO;2-K","article-title":"The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis.","volume":"41","author":"Terkeltaub","year":"1998","journal-title":"Arthritis Rheum"},{"key":"2020071613440283900_R59","doi-asserted-by":"crossref","first-page":"893","DOI":"10.4049\/jimmunol.171.2.893","article-title":"Susceptibility to experimental Lyme arthritis correlates with KC and monocyte chemoattractant protein-1 production in joints and requires neutrophil recruitment via CXCR2.","volume":"171","author":"Brown","year":"2003","journal-title":"J Immunol"},{"key":"2020071613440283900_R60","first-page":"791","article-title":"Proinflammatory cytokines and chemokine production and expression by human osteoblasts isolated from patients with rheumatoid arthritis and osteoarthritis.","volume":"26","author":"Lisignoli","year":"1999","journal-title":"J Rheumatol"},{"key":"2020071613440283900_R61","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/jcb.21450","article-title":"Angiogenic CXC chemokine expression during differentiation of human mesenchymal stem cells toward the osteoblastic lineage.","volume":"103","author":"Bischoff","year":"2008","journal-title":"J Cell Biochem"},{"key":"2020071613440283900_R62","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1002\/eji.200526021","article-title":"Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice.","volume":"35","author":"Mihara","year":"2005","journal-title":"Eur J Immunol"},{"key":"2020071613440283900_R63","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.4049\/jimmunol.181.2.1232","article-title":"Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo","volume":"181","author":"Chang","year":"2008","journal-title":"J Immunol"},{"key":"2020071613440283900_R64","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.bone.2008.08.128","article-title":"Osteal macrophages: a new twist on coupling during bone dynamics.","volume":"43","author":"Pettit","year":"2008","journal-title":"Bone"},{"key":"2020071613440283900_R65","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jcp.10188","article-title":"Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and \u03b2-N-acetylhexosaminidase release.","volume":"194","author":"Lisignoli","year":"2003","journal-title":"J Cell Physiol"},{"key":"2020071613440283900_R66","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/jcp.20435","article-title":"CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines significantly induce proliferation and collagen type I expression in osteoblasts from osteoarthritis patients.","volume":"206","author":"Lisignoli","year":"2006","journal-title":"J Cell Physiol"},{"key":"2020071613440283900_R67","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.cub.2007.05.020","article-title":"The chemokine SDF1a coordinates tissue migration through the spatially restricted activation of Cxcr7 and Cxcr4b.","volume":"17","author":"Valentin","year":"2007","journal-title":"Curr Biol"},{"key":"2020071613440283900_R68","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jlb.50.3.279","article-title":"[Ca2+]i changes and respiratory burst in human neutrophils and monocytes induced by NAP-1\/interleukin-8, NAP-2, and gro\/MGSA.","volume":"50","author":"Walz","year":"1991","journal-title":"J Leukoc Biol"},{"key":"2020071613440283900_R69","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.4049\/jimmunol.166.9.5755","article-title":"Combinatorial model of chemokine involvement in glomerular monocyte recruitment: role of CXC chemokine receptor 2 in infiltration during nephrotoxic nephritis.","volume":"166","author":"Zernecke","year":"2001","journal-title":"J Immunol"},{"key":"2020071613440283900_R70","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1189\/jlb.1003479","article-title":"Synergy between proinflammatory ligands of G protein-coupled receptors in neutrophil activation and migration.","volume":"76","author":"Gouwy","year":"2004","journal-title":"J Leukoc Biol"},{"key":"2020071613440283900_R71","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1124\/mol.108.045146","article-title":"Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events.","volume":"74","author":"Gouwy","year":"2008","journal-title":"Mol Pharmacol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/150\/5\/2244\/9005157\/endo2244.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/150\/5\/2244\/9005157\/endo2244.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T16:30:01Z","timestamp":1684859401000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/150\/5\/2244\/2455902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,15]]},"references-count":71,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2008-1597","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,15]]}}}