{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:48:48Z","timestamp":1778662128990,"version":"3.51.4"},"reference-count":46,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:p>Interferon (IFN)-\u03b3 has been involved in the pathogenesis of Hashimoto thyroiditis. It is a cytokine released by infiltrating mononuclear cells that mediates its actions mainly through signal transducer and activator of transcription-1 (STAT1) but also through other transcription factors. To dissect the effect of IFN\u03b3 on thyroid morphology and function, we crossed transgenic mice that express IFN\u03b3 specifically in the thyroid gland to mice deficient in STAT1. Lack of STAT1 ameliorated the abnormal thyroid morphology and the primary hypothyroidism typical of IFN\u03b3 transgenic mice but not the suppressed iodine accumulation. Interestingly, lack of STAT1 alone decreased iodine accumulation, seemingly through expression of TGF\u03b2. These results indicate that STAT1 is required to mediate some but not all of the phenotypic changes induced by IFN\u03b3 and that it also regulates iodine accumulation via TGF\u03b2 signaling.<\/jats:p>","DOI":"10.1210\/en.2008-1769","type":"journal-article","created":{"date-parts":[[2009,3,27]],"date-time":"2009-03-27T00:55:22Z","timestamp":1238115322000},"page":"3409-3416","source":"Crossref","is-referenced-by-count":13,"title":["Influence of Signal Transducer and Activator of Transcription-1 Signaling on Thyroid Morphology and Function"],"prefix":"10.1210","volume":"150","author":[{"given":"Hiroaki J.","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Pathology (H.J.K., R.R., M.A.L.-S., C.Y.C., M.K., N.R.R., P.C.), The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Rocchi","sequence":"additional","affiliation":[{"name":"Department of Pathology 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