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Elevated serum estrogen levels as well as enhanced local production of estrogen have been considered primary mediators of how increased body weight promotes breast cancer development in postmenopausal women. Here, we provide an overview of estrogen\u2019s relationship with both obesity and breast cancer as separate entities. Human and relevant preclinical studies are cited. In addition, other growth factors that may be involved in this relationship are considered.<\/jats:p>","DOI":"10.1210\/en.2009-0070","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T20:46:33Z","timestamp":1239914793000},"page":"2537-2542","source":"Crossref","is-referenced-by-count":421,"title":["Obesity and Breast Cancer: The Estrogen Connection"],"prefix":"10.1210","volume":"150","author":[{"given":"Margot P.","family":"Cleary","sequence":"first","affiliation":[{"name":"The Hormel Institute, University of Minnesota, Austin, Minnesota 55912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Grossmann","sequence":"first","affiliation":[{"name":"The Hormel Institute, University of Minnesota, Austin, Minnesota 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