{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:17:14Z","timestamp":1790414234958,"version":"4.1.0"},"reference-count":33,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Statins belong to a class of drugs well known for their ability to reduce circulating low-density lipoprotein cholesterol. In addition to cholesterol lowering, they also exhibit potential antiinflammatory and antioxidant properties, suggesting that tissues other than liver may be targeted by statins to exert their beneficial metabolic effects. Adipocytes have received very little attention as a potential target of these drugs, possibly because adipocytes are not a major source of biosynthetic cholesterol. Here, we examine the effects of simvastatin on the secretory pathway, inflammation, and cellular metabolism of adipocytes as well as on whole-body insulin sensitivity. We find that statins have a selective effect on the secretion of the insulin-sensitizing adipokine adiponectin by reducing circulating levels of the high-molecular-weight form of adiponectin specifically with a concomitant increase in intracellular adiponectin levels. However, these effects on adiponectin do not translate into changes in metabolism or whole-body insulin sensitivity, potentially due to additional antiinflammatory properties of statins. In addition, ob\/ob mice treated with statins have reduced adiposity and an altered ultrastructure of the plasma membrane with respect to caveolar histology. Our data demonstrate that statins have major effects on the cellular physiology of the adipocyte on multiple levels.<\/jats:p>","DOI":"10.1210\/en.2009-0603","type":"journal-article","created":{"date-parts":[[2009,10,10]],"date-time":"2009-10-10T00:46:21Z","timestamp":1255135581000},"page":"5262-5272","source":"Crossref","is-referenced-by-count":51,"title":["Impact of Simvastatin on Adipose Tissue: Pleiotropic Effects in Vivo"],"prefix":"10.1210","volume":"150","author":[{"given":"Tayeba","family":"Khan","sequence":"first","affiliation":[{"name":"Departments of Cell Biology (T.K.), Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Hamilton","sequence":"first","affiliation":[{"name":"Touchstone Diabetes Center (M.P.H., D.I.M., P.E.S.), University of Texas Southwestern Medical Center, Dallas, Texas 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy I.","family":"Mundy","sequence":"first","affiliation":[{"name":"Touchstone Diabetes Center (M.P.H., D.I.M., P.E.S.), University of Texas Southwestern Medical Center, Dallas, Texas 75390"},{"name":"Departments of Internal Medicine and Cell Biology (D.I.M., P.E.S.), University of Texas Southwestern Medical Center, Dallas, Texas 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Streamson C.","family":"Chua","sequence":"first","affiliation":[{"name":"Medicine (S.C.C.), Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp E.","family":"Scherer","sequence":"first","affiliation":[{"name":"Touchstone Diabetes Center (M.P.H., D.I.M., P.E.S.), University of Texas Southwestern Medical Center, Dallas, Texas 75390"},{"name":"Departments of Internal Medicine and Cell Biology (D.I.M., P.E.S.), University of Texas Southwestern Medical Center, Dallas, Texas 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2009,10,9]]},"reference":[{"key":"2020071613010707100_R1","unstructured":"Rosenson RS 2008 Lipid lowering with statins. In: Basow DS, ed. UpToDate. Waltham, MA: UpToDate, Inc."},{"key":"2020071613010707100_R2","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.jacc.2008.08.039","article-title":"Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients.","volume":"52","author":"Mills","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2020071613010707100_R3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1161\/01.ATV.0000063385.12476.A7","article-title":"Endothelium-dependent effects of statins.","volume":"23","author":"Wolfrum","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2020071613010707100_R4","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1161\/hq1101.098486","article-title":"Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.","volume":"21","author":"Takemoto","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2020071613010707100_R5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0022-2275(20)36769-9","article-title":"Regulation of cholesterol storage in adipose tissue.","volume":"15","author":"Angel","year":"1974","journal-title":"J Lipid Res"},{"key":"2020071613010707100_R6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1042\/bst0320103","article-title":"Adipocyte cholesterol balance in obesity.","volume":"32","author":"Le Lay","year":"2004","journal-title":"Biochem Soc Trans"},{"key":"2020071613010707100_R7","doi-asserted-by":"crossref","first-page":"9073","DOI":"10.1074\/jbc.M207198200","article-title":"Structure-function studies of the adipocyte-secreted hormone Acrp30\/adiponectin. Implications for metabolic regulation and bioactivity.","volume":"278","author":"Pajvani","year":"2003","journal-title":"J Biol Chem"},{"key":"2020071613010707100_R8","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1210\/en.2007-1561","article-title":"Plasma adiponectin complexes have distinct biochemical characteristics.","volume":"149","author":"Schraw","year":"2008","journal-title":"Endocrinology"},{"key":"2020071613010707100_R9","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2020071613010707100_R10","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.2337\/db08-1750","article-title":"Systemic fate of the adipocyte-derived factor 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