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Moreover, forced expression of ARTN increased tumor size in xenograft models and produced highly proliferative, poorly differentiated, and invasive tumors. The ARTN-stimulated increases in oncogenicity and invasion were mediated by increased expression and activity of AKT1. Small interfering RNA-mediated depletion or antibody inhibition of ARTN significantly reduced oncogenicity and invasion of EC cells. Thus, inhibition of ARTN may be considered as a potential therapeutic strategy to retard progression of EC.<\/jats:p>","DOI":"10.1210\/en.2009-0979","type":"journal-article","created":{"date-parts":[[2010,1,30]],"date-time":"2010-01-30T01:55:44Z","timestamp":1264816544000},"page":"909-920","source":"Crossref","is-referenced-by-count":39,"title":["Artemin Stimulates Oncogenicity and Invasiveness of Human Endometrial Carcinoma Cells"],"prefix":"10.1210","volume":"151","author":[{"given":"Vijay","family":"Pandey","sequence":"first","affiliation":[{"name":"The Liggins Institute (V.P., J.K., J.K.P., M.D.M., D.-X.L., P.E.L.) 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