{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:52:38Z","timestamp":1791287558462,"version":"4.1.0"},"reference-count":75,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:p>We previously reported that mice deficient for the transcription factor early B-cell factor (Ebf1) exhibit markedly increased numbers of osteoblasts, bone formation rate, and serum osteocalcin, but the bone marrow of Ebf1\u2212\/\u2212 mice is also striking in its increased marrow adiposity. The purpose of this work was to analyze the metabolic phenotype that accompanies the altered bone morphology of Ebf1\u2212\/\u2212 mice. Whereas marrow adiposity was increased, deposition of white adipose tissue in other regions of the body was severely reduced (sc 40\u201350%, abdominally 80\u201385%). Brown adipose exhibited decreased lipid deposition. Subcutaneous and perigonadal white adipose tissue showed a decrease in mRNA transcripts for peroxisomal proliferator-activated receptor-\u03b32 and CCAAT\/enhancer-binding protein-\u03b2 in Ebf1\u2212\/\u2212 tissue compared with wild type. Circulating levels of leptin were decreased in Ebf1\u2212\/\u2212 animals compared with their littermate controls (down 65-95%), whereas adiponectin remained comparable after 2 wk of age. Serum analysis also found the Ebf1\u2212\/\u2212 animals were hypoglycemic and hypotriglyceridemic. After ip injection of insulin, the serum glucose levels in Ebf1\u2212\/\u2212 mice took longer to recover, and after a glucose challenge the Ebf1\u2212\/\u2212 animals reached serum glucose levels almost twice that of their wild-type counterparts. Measurement of circulating pancreatic hormones revealed normal or reduced insulin levels in the Ebf1\u2212\/\u2212 mice, whereas glucagon was significantly increased (up 1.7- to 8.5-fold). Metabolically the Ebf1\u2212\/\u2212 mice had increased O2 consumption, CO2 production, food and water intake, and activity. Markers for gluconeogenesis, however, were decreased in the Ebf1\u2212\/\u2212 mice compared with controls. In conclusion, the Ebf1-deficient animals exhibit defects in adipose tissue deposition with increased marrow adiposity and impaired glucose mobilization.<\/jats:p>","DOI":"10.1210\/en.2009-0987","type":"journal-article","created":{"date-parts":[[2010,2,20]],"date-time":"2010-02-20T02:10:18Z","timestamp":1266631818000},"page":"1611-1621","source":"Crossref","is-referenced-by-count":60,"title":["Altered Metabolism and Lipodystrophy in the Early B-Cell Factor 1-Deficient Mouse"],"prefix":"10.1210","volume":"151","author":[{"given":"Jackie A.","family":"Fretz","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation (J.A.F., T.N., Y.X., M.C.H.), Yale School of Medicine, New Haven, Connecticut 06520-8071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation (J.A.F., T.N., Y.X., M.C.H.), Yale School of Medicine, New Haven, Connecticut 06520-8071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yougen","family":"Xi","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation (J.A.F., T.N., Y.X., M.C.H.), Yale School of Medicine, New Haven, Connecticut 06520-8071"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J.","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery (D.J.A.), University of Connecticut Health Center, Farmington, Connecticut 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford J.","family":"Rosen","sequence":"first","affiliation":[{"name":"Maine Medical Center Research Institute (C.J.R.), Scarborough, Maine 04074"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Horowitz","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation (J.A.F., T.N., Y.X., M.C.H.), Yale School of Medicine, New Haven, Connecticut 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