{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:26:35Z","timestamp":1791023195416,"version":"4.1.0"},"reference-count":48,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:p>Endocrine disrupters have been associated with reproductive pathologies such as infertility and gynecological tumors. Using a rat model of early postnatal exposure to bisphenol A (BPA), we evaluated the long-term effects on 1) female reproductive performance, 2) uterine homeobox A10 (Hoxa10) and Hoxa10-target gene expression, and 3) ovarian steroid levels and uterine estrogen receptor \u03b1 and progesterone (P) receptor expression. Newborn female rats received vehicle, BPA.05 (0.05 mg\/kg \u00b7 d), BPA20 (20 mg\/kg \u00b7 d), diethylstilbestrol.2 (0.2 \u03bcg\/kg \u00b7 d), or diethylstilbestrol 20 (20 \u03bcg\/kg \u00b7 d) on postnatal d 1, 3, 5, and 7. A significant decrease in the number of implantation sites was assessed in the xenoestrogen-exposed females. To address the molecular effects of postnatal xenoestrogen exposure on the pregnant uterus, we evaluated the expression of implantation-associated genes on d 5 of pregnancy (preimplantation uterus). All xenoestrogen-treated rats showed a lower expression of Hoxa10. In the same animals, two Hoxa10-downstream genes were misregulated in the uterus. \u03b23Integrin, which is up-regulated by Hoxa10 in controls, was decreased, whereas empty spiracles homolog 2, which is down-regulated by Hoxa10, was increased. Furthermore a clear down-regulation of estrogen receptor \u03b1 and P receptor expression was detected without changes in estradiol and P serum levels. The early exposure to BPA produced a lower number of implantation sites in association with a defective uterine environment during the preimplantation period. Alterations in the endocrine-regulated Hoxa10 gene pathways (steroid receptors\u2014Hoxa10\u2014\u03b23integrin\/empty spiracles homolog 2) could explain, at least in part, the BPA effects on the implantation process.<\/jats:p>","DOI":"10.1210\/en.2009-1037","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T03:45:07Z","timestamp":1296618307000},"page":"1101-1111","source":"Crossref","is-referenced-by-count":101,"title":["Neonatal Exposure to Bisphenol A Alters Rat Uterine Implantation-Associated Gene Expression and Reduces the Number of Implantation Sites"],"prefix":"10.1210","volume":"152","author":[{"given":"Jorgelina","family":"Varayoud","sequence":"first","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge G.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica L.","family":"Bosquiazzo","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Lower","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Mu\u00f1oz-de-Toro","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique H.","family":"Luque","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda y Tumores Hormonodependientes, School of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"2020071613312167200_B1","first-page":"i","article-title":"NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol 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