{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:41:53Z","timestamp":1784115713179,"version":"3.55.0"},"reference-count":66,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,1]]},"abstract":"<jats:p>We recently found that the Japanese red-bellied newt, Cynops pyrrhogaster, actively produces 7\u03b1-hydroxypregnenolone, a previously undescribed amphibian neurosteroid. 7\u03b1-Hydroxypregnenolone stimulates locomotor activity of male newts. Locomotor activity of male newts increases during the breeding period as in other wild animals, but the molecular mechanism for such a change in locomotor activity is poorly understood. Here we show that the adenohypophyseal hormone prolactin (PRL) stimulates 7\u03b1-hydroxypregnenolone synthesis in the brain, thus increasing locomotor activity of breeding male newts. In this study, cytochrome P4507\u03b1 (CYP7B), a steroidogenic enzyme catalyzing the formation of 7\u03b1-hydroxypregnenolone, was first identified to analyze seasonal changes in 7\u03b1-hydroxypregnenolone synthesis. Only males exhibited marked seasonal changes in 7\u03b1-hydroxypregnenolone synthesis and CYP7B expression in the brain, with a maximum level in the spring breeding period when locomotor activity of males increases. Subsequently we identified PRL as a key component of the mechanism regulating 7\u03b1-hydroxypregnenolone synthesis. Hypophysectomy decreased 7\u03b1-hydroxypregnenolone synthesis in the male brain, whereas administration of PRL but not gonadotropins to hypophysectomized males caused a dose-dependent increase in 7\u03b1-hydroxypregnenolone synthesis. To analyze the mode of PRL action, CYP7B and the receptor for PRL were localized in the male brain. PRL receptor was expressed in the neurons expressing CYP7B in the magnocellular preoptic nucleus. Thus, PRL appears to act directly on neurosteroidogenic magnocellular preoptic nucleus neurons to regulate 7\u03b1-hydroxypregnenolone synthesis, thus inducing seasonal locomotor changes in male newts. This is the first report describing the regulation of neurosteroidogenesis in the brain by an adenohypophyseal hormone in any vertebrate.<\/jats:p>","DOI":"10.1210\/en.2009-1229","type":"journal-article","created":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T03:54:03Z","timestamp":1268279643000},"page":"2211-2222","source":"Crossref","is-referenced-by-count":51,"title":["Prolactin Increases the Synthesis of 7\u03b1-Hydroxypregnenolone, a Key Factor for Induction of Locomotor Activity, in Breeding Male Newts"],"prefix":"10.1210","volume":"151","author":[{"given":"Shogo","family":"Haraguchi","sequence":"first","affiliation":[{"name":"Laboratory of Integrative Brain Sciences (S.H., T.K., I.H., K.T.), Department of Biology, Waseda University, and Center for Medical Life Science of Waseda University, Tokyo 162-8480, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Koyama","sequence":"first","affiliation":[{"name":"Laboratory of Integrative Brain Sciences (S.H., T.K., I.H., K.T.), Department of Biology, Waseda University, and Center for Medical Life Science of Waseda University, Tokyo 162-8480, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itaru","family":"Hasunuma","sequence":"first","affiliation":[{"name":"Laboratory of Integrative Brain Sciences (S.H., T.K., I.H., K.T.), Department of Biology, Waseda University, and Center for Medical Life Science of Waseda University, Tokyo 162-8480, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Vaudry","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 413 (H.V.), Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research, University of Rouen, 76821 Mont-Saint-Aignan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Tsutsui","sequence":"first","affiliation":[{"name":"Laboratory of Integrative Brain Sciences (S.H., T.K., I.H., K.T.), Department of Biology, Waseda University, and Center for Medical Life Science of Waseda University, Tokyo 162-8480, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2010,3,10]]},"reference":[{"key":"2020071613052757100_R1","first-page":"1","article-title":"Neurosteroids: of the nervous system, by the nervous system, for the nervous system.","volume":"52","author":"Baulieu","year":"1997","journal-title":"Recent Prog Horm Res"},{"key":"2020071613052757100_R2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/frne.1999.0188","article-title":"Neurosteroids: biosynthesis and function of these novel neuromodulators.","volume":"21","author":"Compagnone","year":"2000","journal-title":"Front 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Biol"},{"key":"2020071613052757100_R40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1023\/A:1015920931701","article-title":"Cytochrome P450: molecular architecture, mechanism, and prospects for rational inhibitor design.","volume":"5","author":"Poulos","year":"1988","journal-title":"Pharm Res"},{"key":"2020071613052757100_R41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1073\/pnas.84.2.407","article-title":"Cytochrome P450c17 (steroid 17\u03b1-hydroxylase\/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.","volume":"84","author":"Chung","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071613052757100_R42","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1126\/science.323973","article-title":"Prolactin-like immunoreactivity: localization in nerve terminals of rat 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