{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:01:15Z","timestamp":1791025275745,"version":"4.1.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:p>Bone sialoprotein (BSP) belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family, whose members play multiple and distinct roles in the development, turnover, and mineralization of bone and dentin. The functions of BSP in bone remodeling are not yet well established. We previously showed that BSP knockout (BSP\u2212\/\u2212) mice exhibit a higher trabecular bone volume, concomitant with lower bone remodeling, than wild-type (BSP+\/+) mice. To determine whether bone turnover can be stimulated in the absence of BSP, we subjected BSP+\/+ and BSP\u2212\/\u2212 mice to catabolic [ovariectomy (OVX)] or anabolic (intermittent PTH administration) hormonal challenges. BSP\u2212\/\u2212 mice progressively develop hypocalcemia and high serum PTH between 2 and 4 months of age. Fifteen and 30 d after OVX, microtomography analysis showed a significant decrease of trabecular bone volume in tibiae of both genotypes. Histomorphometric parameters of bone formation and resorption were significantly increased by OVX. PTH treatment resulted in an increase of trabecular thickness and both bone formation and resorption parameters at all skeletal sites in both genotypes and a decrease of trabecular bone volume in tibiae of BSP+\/+ but not BSP\u2212\/\u2212 mice. PTH increased cortical thickness and bone area in BSP+\/+ but not BSP\u2212\/\u2212 mice and stimulated the bone formation rate specifically in the endosteum of BSP+\/+ mice and the periosteum of BSP\u2212\/\u2212 mice. PTH enhanced the expression of RANKL, MEPE, and DMP1 in both genotypes but increased OPG and OPN expression only in BSP\u2212\/\u2212 mice. In conclusion, despite the low basal turnover, both catabolic and anabolic challenges increase bone formation and resorption in BSP\u2212\/\u2212 mice, suggesting that compensatory pathways are operative in the skeleton of BSP-deficient mice. Although up-regulation of one or several other SIBLINGs is a possible mechanism, further studies are needed to analyze the interplay and cross-regulation involved in compensating for the absence of BSP.<\/jats:p>","DOI":"10.1210\/en.2010-0091","type":"journal-article","created":{"date-parts":[[2010,9,16]],"date-time":"2010-09-16T01:47:29Z","timestamp":1284601649000},"page":"5103-5113","source":"Crossref","is-referenced-by-count":33,"title":["Mice Lacking Bone Sialoprotein (BSP) Lose Bone after Ovariectomy and Display Skeletal Site-Specific Response to Intermittent PTH Treatment"],"prefix":"10.1210","volume":"151","author":[{"given":"Nde\u0301ye Marie\u0300me","family":"Wade-Gueye","sequence":"first","affiliation":[{"name":"Universite\u0301 de Lyon and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 890\/Institut Fe\u0301de\u0301ratif de Recherche 143 (N.M.W.-G., M.B., N.L., A.V.-B., C.F., L.V., M.-H.L.-P., L.M.) F-42023, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Boudiffa","sequence":"first","affiliation":[{"name":"Universite\u0301 de Lyon and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 890\/Institut Fe\u0301de\u0301ratif de Recherche 143 (N.M.W.-G., M.B., N.L., A.V.-B., C.F., L.V., M.-H.L.-P., L.M.) F-42023, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Laroche","sequence":"first","affiliation":[{"name":"Universite\u0301 de Lyon and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 890\/Institut Fe\u0301de\u0301ratif de Recherche 143 (N.M.W.-G., M.B., N.L., A.V.-B., C.F., L.V., M.-H.L.-P., L.M.) F-42023, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Vanden-Bossche","sequence":"first","affiliation":[{"name":"Universite\u0301 de Lyon and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 890\/Institut Fe\u0301de\u0301ratif de Recherche 143 (N.M.W.-G., M.B., N.L., A.V.-B., C.F., L.V., M.-H.L.-P., L.M.) F-42023, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Fournier","sequence":"first","affiliation":[{"name":"Universite\u0301 de Lyon and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 890\/Institut Fe\u0301de\u0301ratif de Recherche 143 (N.M.W.-G., M.B., N.L., A.V.-B., C.F., L.V., M.-H.L.-P., L.M.) F-42023, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Aubin","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics (J.E.A.), University of Toronto, Toronto, Ontario M5S 1A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Vico","sequence":"first","affiliation":[{"name":"Universite\u0301 de Lyon and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 890\/Institut Fe\u0301de\u0301ratif de Recherche 143 (N.M.W.-G., M.B., N.L., A.V.-B., C.F., L.V., M.-H.L.-P., L.M.) F-42023, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-He\u0301le\u0300ne","family":"Lafage-Proust","sequence":"first","affiliation":[{"name":"Universite\u0301 de Lyon and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 890\/Institut Fe\u0301de\u0301ratif de Recherche 143 (N.M.W.-G., M.B., N.L., A.V.-B., C.F., L.V., M.-H.L.-P., L.M.) F-42023, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Malaval","sequence":"first","affiliation":[{"name":"Universite\u0301 de Lyon and Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 890\/Institut Fe\u0301de\u0301ratif de Recherche 143 (N.M.W.-G., M.B., N.L., A.V.-B., C.F., L.V., M.-H.L.-P., L.M.) 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