{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:20:43Z","timestamp":1791328843437,"version":"4.3.1"},"reference-count":51,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:p>Although aldosterone was not isolated and chemically characterized until 1953, the mineralocorticoid action of certain steroids, notably deoxycorticosterone (DOC), had been recognized decades earlier. From 1953 until 1990 saw the establishment of the basic biology and clinical (patho)physiology of aldosterone as an epithelial sodium retaining hormone: its biosynthesis in the adrenal glomerulosa; control of its secretion by ACTH, angiotensin II, and plasma [K+]; its action via intracellular mineralocorticoid receptors to promote DNA-directed; RNA-mediated synthesis of proteins responsible for its epithelial effects; and the syndrome of primary aldosteronism, in which secretion of the hormone is relatively autonomous of its normal stimuli. The past 2 decades have been a major extension of our understanding of the pathophysiology of aldosterone and the complexities of mineralocorticoid receptor signaling in particular. This review concludes with a brief consideration of recent findings regarding hormone and receptor, agonists, and antagonists. In 1990 it might reasonably have been argued that we had the overarching framework for understanding the roles of aldosterone and mineralocorticoid receptors, with only the details to be filled in. Two decades later we still do not know the boundaries, and for every answer, two questions are springing up: truly the more we learn, the less we know.<\/jats:p>","DOI":"10.1210\/en.2010-0465","type":"journal-article","created":{"date-parts":[[2010,9,23]],"date-time":"2010-09-23T04:29:23Z","timestamp":1285216163000},"page":"5098-5102","source":"Crossref","is-referenced-by-count":92,"title":["Minireview: Aldosterone and Mineralocorticoid Receptors: Past, Present, and Future"],"prefix":"10.1210","volume":"151","author":[{"given":"John W.","family":"Funder","sequence":"first","affiliation":[{"name":"Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2010,9,22]]},"reference":[{"key":"2020071614015427700_R1","first-page":"57","article-title":"The isolation and chemistry of the adrenal hormones.","author":"Kuizenga","year":"1944","journal-title":"Chem Physiol Horm"},{"key":"2020071614015427700_R2","author":"Coghlan","year":"2009"},{"key":"2020071614015427700_R3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF02155834","article-title":"Isolierung eines neuen krystallisierten hormons aus nebennieren mit besonders hoher wirksamkeit auf den mineralstoffwechsel.","volume":"9","author":"Simpson","year":"1953","journal-title":"Experientia"},{"key":"2020071614015427700_R4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/BF02158515","article-title":"Konstitution des aldosterons, des neuen mineralocorticoids.","volume":"10","author":"Simpson","year":"1954","journal-title":"Experientia"},{"key":"2020071614015427700_R5","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1042\/bj0500370","article-title":"Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues.","volume":"50","author":"Bush","year":"1952","journal-title":"Biochem J"},{"key":"2020071614015427700_R6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1210\/endo-50-2-150","article-title":"A quantitative method for the bioassay of the effect of adrenal cortical hormones on mineral metabolism.","volume":"50","author":"Simpson","year":"1952","journal-title":"Endocrinology"},{"key":"2020071614015427700_R7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF02318502","article-title":"Advances in the field of adrenal cortical hormones.","volume":"10","author":"Wettstein","year":"1954","journal-title":"Experientia"},{"key":"2020071614015427700_R8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1172\/JCI102896","volume":"33","author":"Luetscher Jr","journal-title":"J Clin Invest"},{"key":"2020071614015427700_R9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02156978","article-title":"Isolation of crystalline aldosterone from the urine of patients with congestive heart failure.","volume":"12","author":"Huennekens","year":"1956","journal-title":"Experientia"},{"key":"2020071614015427700_R10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0021-9258(19)57199-X","article-title":"Isolation of aldosterone from the urine of aldosterone from the urine of a child with nephritic syndrome.","volume":"217","author":"Luetscher Jr","year":"1955","journal-title":"J Biol Chem"},{"key":"2020071614015427700_R11","first-page":"3","article-title":"Presidential Address. 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