{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:10:00Z","timestamp":1790428200170,"version":"4.1.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"DOI":"10.1210\/en.2010-1010","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T01:55:59Z","timestamp":1305683759000},"page":"3226-3232","source":"Crossref","is-referenced-by-count":93,"title":["Treatment with Bazedoxifene, a Selective Estrogen Receptor Modulator, Causes Regression of Endometriosis in a Mouse Model"],"prefix":"10.1210","volume":"152","author":[{"suffix":"Jr","given":"Jaime","family":"Kulak","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility (J.K., C.F., H.S.T.), Yale University, New Haven, Connecticut 06510;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catha","family":"Fischer","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility (J.K., C.F., H.S.T.), Yale University, New Haven, Connecticut 06510;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Komm","sequence":"additional","affiliation":[{"name":"Pfizer (B.K.), Collegeville, Pennsylvania 19426"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh S.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility (J.K., C.F., H.S.T.), Yale University, New Haven, Connecticut 06510;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2011,5,17]]},"reference":[{"key":"2019041120562961400_B1","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.2214\/ajr.182.6.1821543","article-title":"Cerebellar endometriosis.","volume":"182","author":"Sarma","year":"2004","journal-title":"AJR Am J Roentgenol"},{"key":"2019041120562961400_B2","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis.","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"2019041120562961400_B3","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1634\/stemcells.2006-0828","article-title":"Contribution of bone marrow-derived stem cells to endometrium and endometriosis.","volume":"25","author":"Du","year":"2007","journal-title":"Stem Cells"},{"key":"2019041120562961400_B4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.fertnstert.2008.02.093","article-title":"Pathogenic mechanisms in endometriosis-associated infertility.","volume":"90","author":"Gupta","year":"2008","journal-title":"Fertil Steril"},{"key":"2019041120562961400_B5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1196\/annals.1434.014","article-title":"Stem cells and the pathogenesis of endometriosis.","volume":"1127","author":"Sasson","year":"2008","journal-title":"Ann NY Acad Sci"},{"key":"2019041120562961400_B6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0889-8545(02)00052-9","article-title":"Pathogenesis of endometriosis.","volume":"30","author":"Seli","year":"2003","journal-title":"Obstet Gynecol Clin North Am"},{"key":"2019041120562961400_B7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1196\/annals.1335.030","article-title":"Genetic basis of endometriosis.","volume":"1034","author":"Bischoff","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"2019041120562961400_B8","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/humrep\/14.5.1328","article-title":"HOX gene expression is altered in the endometrium of women with endometriosis.","volume":"14","author":"Taylor","year":"1999","journal-title":"Hum Reprod"},{"key":"2019041120562961400_B9","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/molehr\/gan055","article-title":"Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells.","volume":"14","author":"Penna","year":"2008","journal-title":"Mol Hum Reprod"},{"key":"2019041120562961400_B10","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/1933719110361961","article-title":"Endothelin type A receptor (ETA) expression is regulated by HOXA10 in human endometrial stromal cells.","volume":"17","author":"Penna","year":"2010","journal-title":"Reprod Sci"},{"key":"2019041120562961400_B11","first-page":"CD004753","article-title":"Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis.","volume":"2","author":"Allen","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"2019041120562961400_B12","first-page":"CD005997","article-title":"Hormone therapy for endometriosis and surgical menopause.","volume":"1","author":"Al Kadri","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"2019041120562961400_B13","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1471-0528.2008.01740.x","article-title":"Systematic review of the effects of aromatase inhibitors on pain associated with endometriosis.","volume":"115","author":"Nawathe","year":"2008","journal-title":"BJOG"},{"key":"2019041120562961400_B14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1517\/14656566.9.2.243","article-title":"Treatment strategies for endometriosis.","volume":"9","author":"Rodgers","year":"2008","journal-title":"Expert Opin Pharmacother"},{"key":"2019041120562961400_B15","first-page":"CD001019","article-title":"Modern combined oral contraceptives for pain associated with endometriosis.","volume":"3","author":"Davis","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"2019041120562961400_B16","first-page":"CD000155","article-title":"Ovulation suppression for endometriosis.","volume":"3","author":"Hughes","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"2019041120562961400_B17","first-page":"CD005072","article-title":"Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery.","volume":"4","author":"Abou-Setta","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"2019041120562961400_B18","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1471-0528.2006.00937.x","article-title":"Guidelines for the management of pelvic pain associated with endometriosis: a systematic appraisal of their quality.","volume":"113","author":"Appleyard","year":"2006","journal-title":"BJOG"},{"key":"2019041120562961400_B19","first-page":"CD004753","article-title":"Non-steroidal anti-inflammatory drugs for pain in women with endometriosis.","volume":"4","author":"Allen","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"2019041120562961400_B20","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1056\/NEJM199712043372301","article-title":"Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women.","volume":"337","author":"Delmas","year":"1997","journal-title":"N Engl J Med"},{"key":"2019041120562961400_B21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1749-6632.1995.tb31392.x","article-title":"Raloxifene is a tissue-selective agonist\/antagonist that functions through the estrogen receptor.","volume":"761","author":"Fuchs-Young","year":"1995","journal-title":"Ann NY Acad Sci"},{"key":"2019041120562961400_B22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1172\/JCI116985","article-title":"Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.","volume":"93","author":"Black","year":"1994","journal-title":"J Clin Invest"},{"key":"2019041120562961400_B23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/08941930591004412","article-title":"Validation of rat endometriosis model by using raloxifene as a positive control for the evaluation of novel SERM compounds.","volume":"18","author":"Yao","year":"2005","journal-title":"J Invest Surg"},{"key":"2019041120562961400_B24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/01.AOG.0000297307.35024.b5","article-title":"Return of chronic pelvic pain from endometriosis after raloxifene treatment: a randomized controlled trial.","volume":"111","author":"Stratton","year":"2008","journal-title":"Obstet Gynecol"},{"key":"2019041120562961400_B25","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1097\/gme.0b013e3181a816be","article-title":"Bazedoxifene effects on the reproductive tract in postmenopausal women at risk for osteoporosis.","volume":"16","author":"Pinkerton","year":"2009","journal-title":"Menopause"},{"key":"2019041120562961400_B26","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1097\/gme.0b013e3181a818db","article-title":"Bazedoxifene, a selective estrogen receptor modulator: effects on the endometrium, ovaries, and breast from a randomized controlled trial in osteoporotic postmenopausal women.","volume":"16","author":"Archer","year":"2009","journal-title":"Menopause"},{"key":"2019041120562961400_B27","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1210\/en.2008-0817","article-title":"The pairing of a selective estrogen receptor modulator, bazedoxifene, with conjugated estrogens as a new paradigm for the treatment of menopausal symptoms and osteoporosis prevention.","volume":"149","author":"Kharode","year":"2008","journal-title":"Endocrinology"},{"key":"2019041120562961400_B28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mce.2008.01.027","article-title":"Activity of three selective estrogen receptor modulators on hormone-dependent responses in the mouse uterus and mammary gland.","volume":"287","author":"Crabtree","year":"2008","journal-title":"Mol Cell Endocrinol"},{"key":"2019041120562961400_B29","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1210\/en.2008-1210","article-title":"Effects of various selective estrogen receptor modulators with or without conjugated estrogens on mouse mammary gland.","volume":"150","author":"Peano","year":"2009","journal-title":"Endocrinology"},{"key":"2019041120562961400_B30","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.fertnstert.2008.03.029","article-title":"Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity.","volume":"93","author":"Rackow","year":"2010","journal-title":"Fertil Steril"},{"key":"2019041120562961400_B31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1095\/biolreprod.108.070391","article-title":"Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium.","volume":"80","author":"Lee","year":"2009","journal-title":"Biol Reprod"},{"key":"2019041120562961400_B32","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1210\/me.2005-0130","article-title":"Emx2 regulates mammalian reproduction by altering endometrial cell proliferation.","volume":"19","author":"Taylor","year":"2005","journal-title":"Mol Endocrinol"},{"key":"2019041120562961400_B33","first-page":"CD000346","article-title":"Gonadotrophin-releasing hormone analogues for pain associated with endometriosis.","volume":"2","author":"Prentice","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"2019041120562961400_B34","first-page":"594","article-title":"Diagnosis and management of endometriosis.","volume":"74","author":"Mounsey","year":"2006","journal-title":"Am Fam Physician"},{"key":"2019041120562961400_B35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0889-8545(02)00057-8","article-title":"Medical management of endometriosis-associated pain.","volume":"30","author":"Mahutte","year":"2003","journal-title":"Obstet Gynecol Clin North Am"},{"key":"2019041120562961400_B36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/humupd\/dmg030","article-title":"Progestogens for endometriosis: forward to the past.","volume":"9","author":"Vercellini","year":"2003","journal-title":"Hum Reprod Update"},{"key":"2019041120562961400_B37","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.fertnstert.2005.07.1315","article-title":"Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain.","volume":"85","author":"Schlaff","year":"2006","journal-title":"Fertil Steril"},{"key":"2019041120562961400_B38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/152460901300039485","article-title":"Medical and surgical therapies for pain associated with endometriosis.","volume":"10","author":"Winkel","year":"2001","journal-title":"J Womens Health Gend Based Med"},{"key":"2019041120562961400_B39","first-page":"709","article-title":"Prolonged GnRH agonist and add-back therapy for symptomatic endometriosis: long-term follow-up.","volume":"99","author":"Surrey","year":"2002","journal-title":"Obstet Gynecol"},{"key":"2019041120562961400_B40","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/humrep\/dep045","article-title":"A call for more transparency of registered clinical trials on endometriosis.","volume":"24","author":"Guo","year":"2009","journal-title":"Hum Reprod"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/152\/8\/3226\/9039693\/endo3226.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T07:43:13Z","timestamp":1555054993000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/152\/8\/3226\/2457319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,17]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2011,5,17]]},"published-print":{"date-parts":[[2011,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2010-1010","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,17]]}}}